Incidental Mutation 'R7219:Tnxb'
ID 561698
Institutional Source Beutler Lab
Gene Symbol Tnxb
Ensembl Gene ENSMUSG00000033327
Gene Name tenascin XB
Synonyms Tnx, TN-MHC
MMRRC Submission 045291-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7219 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 34879431-34938789 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34898039 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 896 (T896A)
Ref Sequence ENSEMBL: ENSMUSP00000127487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087399] [ENSMUST00000168533]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000087399
AA Change: T896A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000084661
Gene: ENSMUSG00000033327
AA Change: T896A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 33 44 N/A INTRINSIC
low complexity region 69 89 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
EGF 173 201 1.59e1 SMART
EGF 204 232 7.41e0 SMART
EGF 235 263 2.64e1 SMART
EGF 266 294 2.64e1 SMART
EGF 297 325 9.13e0 SMART
EGF 328 356 2.07e1 SMART
EGF_like 359 387 3.16e1 SMART
EGF_like 390 418 4.64e1 SMART
EGF_like 421 449 3.29e1 SMART
EGF_like 452 480 7.09e1 SMART
EGF 483 511 1.15e1 SMART
EGF 514 542 1.91e1 SMART
EGF_like 545 573 4.11e1 SMART
EGF 576 604 7.95e0 SMART
EGF 607 635 1.23e1 SMART
EGF_like 638 666 4.93e1 SMART
EGF_like 674 702 5.24e1 SMART
EGF 705 733 2.29e1 SMART
FN3 736 816 4.12e-3 SMART
FN3 827 904 1.21e-9 SMART
FN3 1047 1126 3.97e-5 SMART
FN3 1142 1223 3.62e-8 SMART
low complexity region 1230 1241 N/A INTRINSIC
FN3 1242 1320 2.31e-6 SMART
FN3 1351 1431 8.77e-7 SMART
FN3 1460 1539 3.01e-5 SMART
FN3 1556 1636 2.76e-4 SMART
FN3 1657 1736 5.78e-7 SMART
FN3 1752 1832 4.7e-7 SMART
FN3 1851 1929 1.95e-4 SMART
FN3 1955 2034 4.56e-5 SMART
FN3 2066 2145 2.23e-8 SMART
FN3 2164 2244 7.75e-8 SMART
FN3 2279 2358 8.5e-5 SMART
FN3 2387 2467 2.94e-8 SMART
FN3 2501 2580 1.7e-4 SMART
low complexity region 2588 2598 N/A INTRINSIC
FN3 2607 2687 6.75e-8 SMART
FN3 2716 2795 7.4e-5 SMART
FN3 2822 2902 1.35e-7 SMART
FN3 2931 3010 5.61e-5 SMART
FN3 3026 3106 6.01e-5 SMART
FN3 3120 3199 6.45e-5 SMART
FN3 3214 3293 9.54e-8 SMART
FN3 3316 3396 2.81e-5 SMART
FN3 3416 3502 1.98e-5 SMART
FN3 3518 3596 5.65e-10 SMART
FN3 3607 3682 7.63e-7 SMART
FN3 3695 3770 6.54e-6 SMART
FBG 3787 3997 8.88e-125 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168533
AA Change: T896A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000127487
Gene: ENSMUSG00000033327
AA Change: T896A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 33 44 N/A INTRINSIC
low complexity region 69 89 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
EGF 173 201 1.59e1 SMART
EGF 204 232 7.41e0 SMART
EGF 235 263 2.64e1 SMART
EGF 266 294 2.64e1 SMART
EGF 297 325 9.13e0 SMART
EGF 328 356 2.07e1 SMART
EGF_like 359 387 3.16e1 SMART
EGF_like 390 418 4.64e1 SMART
EGF_like 421 449 3.29e1 SMART
EGF_like 452 480 7.09e1 SMART
EGF 483 511 1.15e1 SMART
EGF 514 542 1.91e1 SMART
EGF_like 545 573 4.11e1 SMART
EGF 576 604 7.95e0 SMART
EGF 607 635 1.23e1 SMART
EGF_like 638 666 4.93e1 SMART
EGF_like 674 702 5.24e1 SMART
EGF 705 733 2.29e1 SMART
FN3 736 816 4.12e-3 SMART
FN3 827 904 1.21e-9 SMART
FN3 924 1003 3.97e-5 SMART
FN3 1019 1100 3.62e-8 SMART
low complexity region 1107 1118 N/A INTRINSIC
FN3 1119 1197 2.31e-6 SMART
FN3 1228 1308 8.77e-7 SMART
FN3 1337 1416 3.01e-5 SMART
FN3 1433 1513 2.76e-4 SMART
FN3 1534 1613 5.78e-7 SMART
FN3 1629 1709 4.7e-7 SMART
FN3 1728 1806 1.95e-4 SMART
FN3 1832 1911 4.56e-5 SMART
FN3 1943 2022 2.23e-8 SMART
FN3 2051 2130 5.61e-5 SMART
FN3 2146 2226 6.01e-5 SMART
FN3 2240 2319 6.45e-5 SMART
FN3 2334 2413 9.54e-8 SMART
FN3 2436 2516 2.81e-5 SMART
FN3 2536 2622 1.98e-5 SMART
FN3 2638 2716 5.65e-10 SMART
FN3 2727 2802 7.63e-7 SMART
FN3 2815 2890 6.54e-6 SMART
FBG 2907 3117 8.88e-125 SMART
Meta Mutation Damage Score 0.1287 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 97% (77/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T C 16: 4,667,508 (GRCm39) S300P unknown Het
Abhd17a T A 10: 80,420,008 (GRCm39) K226* probably null Het
Alkbh7 T A 17: 57,305,508 (GRCm39) H108Q probably damaging Het
Ankrd44 A C 1: 54,806,069 (GRCm39) H112Q probably damaging Het
Capn3 A G 2: 120,333,935 (GRCm39) E790G probably damaging Het
Cd47 C A 16: 49,728,440 (GRCm39) N330K possibly damaging Het
Cd55 A G 1: 130,390,343 (GRCm39) S22P possibly damaging Het
Cdc25a A G 9: 109,718,154 (GRCm39) I373V probably damaging Het
Cfap43 T C 19: 47,779,912 (GRCm39) I514V probably benign Het
Cfap73 A T 5: 120,768,200 (GRCm39) M186K probably benign Het
Chd9 A G 8: 91,728,394 (GRCm39) D1270G unknown Het
Ciita A G 16: 10,330,121 (GRCm39) T802A probably benign Het
Dlgap2 A G 8: 14,793,296 (GRCm39) E430G probably benign Het
Dlx1 C A 2: 71,360,513 (GRCm39) S59* probably null Het
Dnaaf3 T C 7: 4,531,076 (GRCm39) N119S probably damaging Het
Dnah11 T G 12: 118,004,830 (GRCm39) I2164L possibly damaging Het
Dnah11 T C 12: 118,090,624 (GRCm39) K1079R probably benign Het
Dnah12 C T 14: 26,576,837 (GRCm39) T3029I probably damaging Het
Dppa3 A T 6: 122,606,918 (GRCm39) Y136F probably damaging Het
Enox1 T A 14: 77,958,284 (GRCm39) M611K probably benign Het
Fam149a A T 8: 45,803,600 (GRCm39) I378N possibly damaging Het
Farp2 T C 1: 93,488,040 (GRCm39) F89S probably damaging Het
Fbn2 C T 18: 58,186,099 (GRCm39) V1750M probably benign Het
Frs3 A G 17: 48,013,620 (GRCm39) T181A probably damaging Het
Heatr4 T A 12: 84,004,644 (GRCm39) I726F possibly damaging Het
Ighg1 T G 12: 113,290,216 (GRCm39) E375A Het
Ikzf4 G T 10: 128,470,252 (GRCm39) Q476K possibly damaging Het
Kcnh1 G T 1: 192,187,945 (GRCm39) C829F probably benign Het
Krtap19-4 T C 16: 88,681,797 (GRCm39) Y53C unknown Het
Loricrin C A 3: 91,988,705 (GRCm39) G194C unknown Het
Lrp1 A C 10: 127,393,097 (GRCm39) D2720E probably benign Het
Lrp4 A G 2: 91,322,368 (GRCm39) Y1068C probably damaging Het
Mbnl1 A G 3: 60,511,244 (GRCm39) N67D probably benign Het
Mrpl21 A G 19: 3,336,998 (GRCm39) E123G probably benign Het
Mst1 A T 9: 107,958,485 (GRCm39) D65V probably damaging Het
Myo15b T A 11: 115,767,921 (GRCm39) probably null Het
Myo5a A G 9: 75,028,052 (GRCm39) Y79C probably damaging Het
Oas1c A T 5: 120,940,957 (GRCm39) W279R probably damaging Het
Or4f4-ps1 A T 2: 111,330,532 (GRCm39) M312L probably benign Het
Or4k77 A T 2: 111,199,882 (GRCm39) I302L probably benign Het
Or51f5 A G 7: 102,430,913 (GRCm39) I77V probably benign Het
Pcdh9 C T 14: 93,253,216 (GRCm39) G1149D possibly damaging Het
Pcid2 G A 8: 13,129,907 (GRCm39) T283I probably benign Het
Pdhx A G 2: 102,858,760 (GRCm39) V348A probably benign Het
Pi16 C A 17: 29,538,208 (GRCm39) P7Q possibly damaging Het
Psmb3 T A 11: 97,602,023 (GRCm39) M131K probably null Het
Raph1 A G 1: 60,542,032 (GRCm39) Y309H unknown Het
Rasgrf1 A G 9: 89,866,341 (GRCm39) N593S probably damaging Het
Rbm38 A C 2: 172,863,990 (GRCm39) E53A possibly damaging Het
Rufy3 A G 5: 88,797,715 (GRCm39) T631A probably benign Het
Sbno1 A T 5: 124,543,722 (GRCm39) D272E probably benign Het
Scamp1 T A 13: 94,361,415 (GRCm39) Y207F probably damaging Het
Scn8a T A 15: 100,866,984 (GRCm39) S263R probably damaging Het
Setbp1 T G 18: 78,798,960 (GRCm39) T1407P probably damaging Het
Skor2 T C 18: 76,948,096 (GRCm39) L606P possibly damaging Het
Slc35f6 A G 5: 30,814,796 (GRCm39) N241S probably benign Het
Slc36a2 T G 11: 55,059,744 (GRCm39) D247A probably benign Het
Smim10l1 T A 6: 133,084,895 (GRCm39) F87L unknown Het
Son T C 16: 91,461,889 (GRCm39) S2265P unknown Het
Spta1 A G 1: 174,050,203 (GRCm39) N1748D probably damaging Het
Sptbn2 A G 19: 4,774,201 (GRCm39) D84G probably damaging Het
Tasor2 T A 13: 3,640,521 (GRCm39) L205F probably damaging Het
Tbc1d24 G A 17: 24,404,266 (GRCm39) R293C probably damaging Het
Tex15 A G 8: 34,036,268 (GRCm39) T65A probably benign Het
Thyn1 A G 9: 26,916,506 (GRCm39) Y97C probably damaging Het
Tmem64 T C 4: 15,266,700 (GRCm39) L250P probably damaging Het
Tnfrsf9 A T 4: 151,019,991 (GRCm39) K217N probably damaging Het
Trpm1 T A 7: 63,854,333 (GRCm39) I285N possibly damaging Het
Try5 T A 6: 41,288,637 (GRCm39) D194V probably damaging Het
U2surp G A 9: 95,372,215 (GRCm39) R316* probably null Het
Ubr2 G T 17: 47,246,360 (GRCm39) S1618* probably null Het
Ugp2 T C 11: 21,273,271 (GRCm39) I449M probably damaging Het
Umodl1 A G 17: 31,201,236 (GRCm39) probably null Het
Vmn2r31 C T 7: 7,390,105 (GRCm39) V538I probably benign Het
Vmn2r31 A T 7: 7,397,397 (GRCm39) M287K probably damaging Het
Wwc2 A G 8: 48,311,919 (GRCm39) V748A unknown Het
Zfp800 A C 6: 28,243,662 (GRCm39) H434Q probably benign Het
Zfp869 A G 8: 70,159,356 (GRCm39) C406R probably damaging Het
Zhx1 A G 15: 57,917,733 (GRCm39) V171A probably benign Het
Other mutations in Tnxb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Tnxb APN 17 34,904,603 (GRCm39) missense probably damaging 1.00
IGL00424:Tnxb APN 17 34,933,666 (GRCm39) missense probably damaging 1.00
IGL00486:Tnxb APN 17 34,911,356 (GRCm39) missense probably damaging 1.00
IGL00952:Tnxb APN 17 34,932,102 (GRCm39) missense probably damaging 1.00
IGL00974:Tnxb APN 17 34,937,707 (GRCm39) critical splice donor site probably null
IGL01017:Tnxb APN 17 34,912,782 (GRCm39) missense probably damaging 0.98
IGL01082:Tnxb APN 17 34,933,584 (GRCm39) missense probably damaging 0.97
IGL01397:Tnxb APN 17 34,933,647 (GRCm39) missense probably damaging 0.99
IGL01473:Tnxb APN 17 34,904,675 (GRCm39) missense probably damaging 0.99
IGL01642:Tnxb APN 17 34,937,488 (GRCm39) missense probably damaging 1.00
IGL01774:Tnxb APN 17 34,907,813 (GRCm39) missense probably damaging 1.00
IGL01971:Tnxb APN 17 34,891,271 (GRCm39) missense probably damaging 1.00
IGL02016:Tnxb APN 17 34,891,249 (GRCm39) missense probably damaging 0.98
IGL02160:Tnxb APN 17 34,933,719 (GRCm39) missense probably benign 0.01
IGL02473:Tnxb APN 17 34,936,736 (GRCm39) missense probably damaging 1.00
IGL02666:Tnxb APN 17 34,903,913 (GRCm39) missense probably benign 0.20
IGL02831:Tnxb APN 17 34,922,545 (GRCm39) missense possibly damaging 0.93
IGL02838:Tnxb APN 17 34,908,606 (GRCm39) missense possibly damaging 0.74
IGL02965:Tnxb APN 17 34,928,628 (GRCm39) missense possibly damaging 0.93
IGL03155:Tnxb APN 17 34,932,569 (GRCm39) missense probably damaging 1.00
IGL03194:Tnxb APN 17 34,914,921 (GRCm39) nonsense probably null
IGL03215:Tnxb APN 17 34,911,499 (GRCm39) missense possibly damaging 0.66
IGL03256:Tnxb APN 17 34,907,694 (GRCm39) missense probably damaging 1.00
BB008:Tnxb UTSW 17 34,907,672 (GRCm39) missense probably damaging 1.00
BB018:Tnxb UTSW 17 34,907,672 (GRCm39) missense probably damaging 1.00
E0370:Tnxb UTSW 17 34,897,917 (GRCm39) missense probably damaging 1.00
R0006:Tnxb UTSW 17 34,901,266 (GRCm39) missense probably benign 0.07
R0049:Tnxb UTSW 17 34,928,542 (GRCm39) missense possibly damaging 0.93
R0050:Tnxb UTSW 17 34,892,299 (GRCm39) missense probably damaging 1.00
R0233:Tnxb UTSW 17 34,918,007 (GRCm39) missense probably benign 0.32
R0233:Tnxb UTSW 17 34,918,007 (GRCm39) missense probably benign 0.32
R0311:Tnxb UTSW 17 34,935,958 (GRCm39) missense probably damaging 0.97
R0326:Tnxb UTSW 17 34,917,153 (GRCm39) missense probably benign 0.32
R0387:Tnxb UTSW 17 34,902,548 (GRCm39) missense probably benign 0.30
R0396:Tnxb UTSW 17 34,890,707 (GRCm39) missense probably damaging 1.00
R0511:Tnxb UTSW 17 34,937,219 (GRCm39) missense probably damaging 0.96
R0540:Tnxb UTSW 17 34,890,892 (GRCm39) missense probably damaging 1.00
R0563:Tnxb UTSW 17 34,935,921 (GRCm39) missense probably benign 0.05
R0575:Tnxb UTSW 17 34,936,180 (GRCm39) missense possibly damaging 0.91
R0586:Tnxb UTSW 17 34,891,118 (GRCm39) missense probably damaging 1.00
R0607:Tnxb UTSW 17 34,890,892 (GRCm39) missense probably damaging 1.00
R0622:Tnxb UTSW 17 34,937,703 (GRCm39) missense probably damaging 1.00
R0624:Tnxb UTSW 17 34,902,522 (GRCm39) missense probably damaging 1.00
R0709:Tnxb UTSW 17 34,908,328 (GRCm39) missense probably damaging 1.00
R0898:Tnxb UTSW 17 34,889,719 (GRCm39) missense probably damaging 1.00
R0970:Tnxb UTSW 17 34,917,917 (GRCm39) missense possibly damaging 0.85
R0972:Tnxb UTSW 17 34,904,117 (GRCm39) missense probably damaging 1.00
R1118:Tnxb UTSW 17 34,904,017 (GRCm39) missense probably damaging 1.00
R1119:Tnxb UTSW 17 34,904,017 (GRCm39) missense probably damaging 1.00
R1226:Tnxb UTSW 17 34,907,903 (GRCm39) missense probably damaging 1.00
R1296:Tnxb UTSW 17 34,890,551 (GRCm39) missense probably damaging 1.00
R1297:Tnxb UTSW 17 34,929,140 (GRCm39) missense probably damaging 0.96
R1349:Tnxb UTSW 17 34,929,267 (GRCm39) missense possibly damaging 0.67
R1356:Tnxb UTSW 17 34,914,446 (GRCm39) missense possibly damaging 0.53
R1372:Tnxb UTSW 17 34,929,267 (GRCm39) missense possibly damaging 0.67
R1521:Tnxb UTSW 17 34,930,477 (GRCm39) missense probably damaging 1.00
R1522:Tnxb UTSW 17 34,937,612 (GRCm39) missense probably damaging 1.00
R1532:Tnxb UTSW 17 34,929,804 (GRCm39) missense probably damaging 1.00
R1735:Tnxb UTSW 17 34,936,944 (GRCm39) missense probably damaging 1.00
R1778:Tnxb UTSW 17 34,902,548 (GRCm39) missense probably benign 0.30
R1802:Tnxb UTSW 17 34,922,863 (GRCm39) missense probably damaging 0.98
R1824:Tnxb UTSW 17 34,911,307 (GRCm39) nonsense probably null
R1838:Tnxb UTSW 17 34,897,884 (GRCm39) missense probably damaging 0.96
R1863:Tnxb UTSW 17 34,889,848 (GRCm39) missense probably damaging 1.00
R1865:Tnxb UTSW 17 34,922,431 (GRCm39) nonsense probably null
R1867:Tnxb UTSW 17 34,890,821 (GRCm39) missense probably damaging 1.00
R1883:Tnxb UTSW 17 34,908,539 (GRCm39) missense probably benign 0.01
R1884:Tnxb UTSW 17 34,908,539 (GRCm39) missense probably benign 0.01
R1889:Tnxb UTSW 17 34,914,799 (GRCm39) missense probably damaging 0.97
R1969:Tnxb UTSW 17 34,898,055 (GRCm39) missense probably benign 0.20
R1989:Tnxb UTSW 17 34,912,859 (GRCm39) missense probably damaging 1.00
R1989:Tnxb UTSW 17 34,902,351 (GRCm39) missense probably benign 0.08
R1991:Tnxb UTSW 17 34,901,225 (GRCm39) missense probably damaging 1.00
R1991:Tnxb UTSW 17 34,890,878 (GRCm39) missense probably damaging 1.00
R1992:Tnxb UTSW 17 34,890,878 (GRCm39) missense probably damaging 1.00
R2001:Tnxb UTSW 17 34,911,553 (GRCm39) missense possibly damaging 0.82
R2018:Tnxb UTSW 17 34,890,724 (GRCm39) missense probably benign 0.04
R2030:Tnxb UTSW 17 34,937,443 (GRCm39) missense probably damaging 1.00
R2037:Tnxb UTSW 17 34,918,179 (GRCm39) missense probably damaging 1.00
R2103:Tnxb UTSW 17 34,901,225 (GRCm39) missense probably damaging 1.00
R2116:Tnxb UTSW 17 34,891,201 (GRCm39) missense probably damaging 1.00
R2206:Tnxb UTSW 17 34,928,391 (GRCm39) missense possibly damaging 0.86
R2207:Tnxb UTSW 17 34,928,391 (GRCm39) missense possibly damaging 0.86
R2215:Tnxb UTSW 17 34,923,114 (GRCm39) missense possibly damaging 0.93
R2413:Tnxb UTSW 17 34,937,252 (GRCm39) missense probably damaging 0.99
R2680:Tnxb UTSW 17 34,922,594 (GRCm39) missense possibly damaging 0.51
R2910:Tnxb UTSW 17 34,891,424 (GRCm39) missense probably damaging 1.00
R2984:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R3120:Tnxb UTSW 17 34,911,329 (GRCm39) missense possibly damaging 0.86
R3429:Tnxb UTSW 17 34,922,561 (GRCm39) missense probably damaging 0.98
R3429:Tnxb UTSW 17 34,891,605 (GRCm39) nonsense probably null
R3552:Tnxb UTSW 17 34,937,695 (GRCm39) missense probably damaging 1.00
R3698:Tnxb UTSW 17 34,909,407 (GRCm39) critical splice donor site probably null
R3720:Tnxb UTSW 17 34,931,938 (GRCm39) missense possibly damaging 0.95
R3841:Tnxb UTSW 17 34,917,897 (GRCm39) missense possibly damaging 0.72
R3848:Tnxb UTSW 17 34,909,369 (GRCm39) missense possibly damaging 0.82
R3886:Tnxb UTSW 17 34,937,885 (GRCm39) missense probably damaging 1.00
R4074:Tnxb UTSW 17 34,890,845 (GRCm39) missense probably benign 0.22
R4159:Tnxb UTSW 17 34,930,491 (GRCm39) missense probably damaging 0.99
R4160:Tnxb UTSW 17 34,930,491 (GRCm39) missense probably damaging 0.99
R4161:Tnxb UTSW 17 34,930,491 (GRCm39) missense probably damaging 0.99
R4181:Tnxb UTSW 17 34,928,428 (GRCm39) missense possibly damaging 0.93
R4210:Tnxb UTSW 17 34,929,951 (GRCm39) missense possibly damaging 0.84
R4275:Tnxb UTSW 17 34,917,205 (GRCm39) missense probably damaging 0.98
R4329:Tnxb UTSW 17 34,912,838 (GRCm39) missense probably damaging 1.00
R4394:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R4395:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R4397:Tnxb UTSW 17 34,897,636 (GRCm39) nonsense probably null
R4540:Tnxb UTSW 17 34,922,309 (GRCm39) missense possibly damaging 0.86
R4673:Tnxb UTSW 17 34,891,514 (GRCm39) missense probably damaging 0.99
R4719:Tnxb UTSW 17 34,908,394 (GRCm39) missense probably damaging 1.00
R4725:Tnxb UTSW 17 34,918,041 (GRCm39) missense probably damaging 0.99
R4753:Tnxb UTSW 17 34,914,909 (GRCm39) missense possibly damaging 0.71
R4777:Tnxb UTSW 17 34,890,917 (GRCm39) missense probably damaging 1.00
R4837:Tnxb UTSW 17 34,936,981 (GRCm39) missense probably damaging 0.98
R4898:Tnxb UTSW 17 34,914,566 (GRCm39) missense possibly damaging 0.95
R4938:Tnxb UTSW 17 34,932,606 (GRCm39) missense probably damaging 1.00
R5044:Tnxb UTSW 17 34,936,457 (GRCm39) missense probably damaging 1.00
R5100:Tnxb UTSW 17 34,929,902 (GRCm39) missense probably damaging 0.99
R5223:Tnxb UTSW 17 34,923,052 (GRCm39) missense possibly damaging 0.51
R5269:Tnxb UTSW 17 34,922,582 (GRCm39) missense possibly damaging 0.95
R5333:Tnxb UTSW 17 34,909,205 (GRCm39) missense probably damaging 1.00
R5454:Tnxb UTSW 17 34,928,599 (GRCm39) missense possibly damaging 0.71
R5470:Tnxb UTSW 17 34,935,947 (GRCm39) missense probably null 1.00
R5475:Tnxb UTSW 17 34,908,567 (GRCm39) missense probably damaging 1.00
R5574:Tnxb UTSW 17 34,929,998 (GRCm39) missense probably benign
R5596:Tnxb UTSW 17 34,907,778 (GRCm39) missense probably damaging 1.00
R5599:Tnxb UTSW 17 34,909,179 (GRCm39) missense probably benign 0.22
R5599:Tnxb UTSW 17 34,909,176 (GRCm39) missense probably damaging 1.00
R5615:Tnxb UTSW 17 34,902,392 (GRCm39) missense probably damaging 1.00
R5620:Tnxb UTSW 17 34,936,504 (GRCm39) nonsense probably null
R5625:Tnxb UTSW 17 34,904,185 (GRCm39) missense probably benign 0.30
R5734:Tnxb UTSW 17 34,917,884 (GRCm39) missense possibly damaging 0.53
R5896:Tnxb UTSW 17 34,891,126 (GRCm39) missense probably damaging 1.00
R5961:Tnxb UTSW 17 34,937,609 (GRCm39) missense probably damaging 1.00
R5974:Tnxb UTSW 17 34,904,681 (GRCm39) missense probably damaging 1.00
R6091:Tnxb UTSW 17 34,929,338 (GRCm39) missense probably damaging 0.98
R6134:Tnxb UTSW 17 34,890,986 (GRCm39) missense probably damaging 0.96
R6325:Tnxb UTSW 17 34,911,398 (GRCm39) missense probably damaging 1.00
R6358:Tnxb UTSW 17 34,897,968 (GRCm39) missense probably damaging 0.98
R6362:Tnxb UTSW 17 34,913,362 (GRCm39) missense probably damaging 1.00
R6432:Tnxb UTSW 17 34,936,891 (GRCm39) missense probably damaging 1.00
R6461:Tnxb UTSW 17 34,890,872 (GRCm39) missense probably damaging 1.00
R6467:Tnxb UTSW 17 34,912,898 (GRCm39) missense probably damaging 1.00
R6476:Tnxb UTSW 17 34,909,166 (GRCm39) missense probably damaging 0.98
R6477:Tnxb UTSW 17 34,938,513 (GRCm39) missense probably damaging 1.00
R6631:Tnxb UTSW 17 34,937,222 (GRCm39) missense probably damaging 1.00
R6774:Tnxb UTSW 17 34,928,606 (GRCm39) nonsense probably null
R6787:Tnxb UTSW 17 34,929,710 (GRCm39) missense probably benign 0.02
R6805:Tnxb UTSW 17 34,917,127 (GRCm39) missense possibly damaging 0.93
R6860:Tnxb UTSW 17 34,932,131 (GRCm39) missense probably damaging 0.99
R6883:Tnxb UTSW 17 34,937,493 (GRCm39) missense probably damaging 1.00
R7049:Tnxb UTSW 17 34,936,242 (GRCm39) critical splice donor site probably null
R7107:Tnxb UTSW 17 34,890,314 (GRCm39) missense unknown
R7172:Tnxb UTSW 17 34,914,994 (GRCm39) missense probably damaging 1.00
R7206:Tnxb UTSW 17 34,923,075 (GRCm39) missense possibly damaging 0.71
R7237:Tnxb UTSW 17 34,901,170 (GRCm39) missense possibly damaging 0.82
R7257:Tnxb UTSW 17 34,935,475 (GRCm39) missense probably benign 0.44
R7269:Tnxb UTSW 17 34,914,428 (GRCm39) missense probably damaging 1.00
R7302:Tnxb UTSW 17 34,897,875 (GRCm39) missense probably benign 0.41
R7372:Tnxb UTSW 17 34,936,228 (GRCm39) missense possibly damaging 0.72
R7384:Tnxb UTSW 17 34,937,492 (GRCm39) missense probably damaging 1.00
R7447:Tnxb UTSW 17 34,937,444 (GRCm39) missense probably damaging 1.00
R7449:Tnxb UTSW 17 34,922,335 (GRCm39) missense possibly damaging 0.93
R7480:Tnxb UTSW 17 34,934,747 (GRCm39) missense probably damaging 0.96
R7506:Tnxb UTSW 17 34,934,665 (GRCm39) missense possibly damaging 0.89
R7586:Tnxb UTSW 17 34,935,382 (GRCm39) missense probably damaging 0.98
R7688:Tnxb UTSW 17 34,890,880 (GRCm39) missense probably benign 0.23
R7690:Tnxb UTSW 17 34,908,501 (GRCm39) missense probably damaging 1.00
R7690:Tnxb UTSW 17 34,908,494 (GRCm39) missense probably benign 0.03
R7732:Tnxb UTSW 17 34,913,254 (GRCm39) missense probably damaging 1.00
R7735:Tnxb UTSW 17 34,890,398 (GRCm39) missense unknown
R7760:Tnxb UTSW 17 34,931,911 (GRCm39) missense probably damaging 0.96
R7874:Tnxb UTSW 17 34,930,417 (GRCm39) missense probably damaging 1.00
R7909:Tnxb UTSW 17 34,911,428 (GRCm39) missense probably benign 0.02
R7922:Tnxb UTSW 17 34,933,577 (GRCm39) missense probably damaging 1.00
R7931:Tnxb UTSW 17 34,907,672 (GRCm39) missense probably damaging 1.00
R7949:Tnxb UTSW 17 34,936,103 (GRCm39) missense probably damaging 1.00
R7953:Tnxb UTSW 17 34,929,077 (GRCm39) missense probably benign 0.03
R7953:Tnxb UTSW 17 34,928,509 (GRCm39) missense possibly damaging 0.86
R7977:Tnxb UTSW 17 34,929,194 (GRCm39) missense possibly damaging 0.92
R7985:Tnxb UTSW 17 34,935,984 (GRCm39) critical splice donor site probably null
R7987:Tnxb UTSW 17 34,929,194 (GRCm39) missense possibly damaging 0.92
R8040:Tnxb UTSW 17 34,935,532 (GRCm39) missense probably damaging 1.00
R8053:Tnxb UTSW 17 34,923,153 (GRCm39) missense probably damaging 0.98
R8074:Tnxb UTSW 17 34,922,955 (GRCm39) missense probably benign 0.32
R8089:Tnxb UTSW 17 34,891,763 (GRCm39) missense unknown
R8169:Tnxb UTSW 17 34,918,181 (GRCm39) missense possibly damaging 0.96
R8348:Tnxb UTSW 17 34,929,102 (GRCm39) missense possibly damaging 0.92
R8352:Tnxb UTSW 17 34,908,381 (GRCm39) missense probably damaging 1.00
R8362:Tnxb UTSW 17 34,931,946 (GRCm39) missense probably damaging 0.99
R8452:Tnxb UTSW 17 34,908,381 (GRCm39) missense probably damaging 1.00
R8527:Tnxb UTSW 17 34,907,634 (GRCm39) missense probably damaging 1.00
R8754:Tnxb UTSW 17 34,934,882 (GRCm39) missense probably damaging 1.00
R8813:Tnxb UTSW 17 34,938,136 (GRCm39) missense probably damaging 1.00
R8936:Tnxb UTSW 17 34,904,646 (GRCm39) missense probably damaging 1.00
R8986:Tnxb UTSW 17 34,897,646 (GRCm39) missense possibly damaging 0.66
R9001:Tnxb UTSW 17 34,922,410 (GRCm39) missense probably benign 0.32
R9215:Tnxb UTSW 17 34,891,564 (GRCm39) missense unknown
R9226:Tnxb UTSW 17 34,904,766 (GRCm39) missense probably damaging 1.00
R9276:Tnxb UTSW 17 34,929,134 (GRCm39) missense possibly damaging 0.60
R9279:Tnxb UTSW 17 34,898,088 (GRCm39) missense possibly damaging 0.46
R9363:Tnxb UTSW 17 34,917,294 (GRCm39) missense possibly damaging 0.93
R9367:Tnxb UTSW 17 34,931,993 (GRCm39) missense probably damaging 1.00
R9494:Tnxb UTSW 17 34,904,796 (GRCm39) missense probably damaging 1.00
R9606:Tnxb UTSW 17 34,914,578 (GRCm39) missense possibly damaging 0.82
R9650:Tnxb UTSW 17 34,930,629 (GRCm39) missense probably damaging 0.99
R9677:Tnxb UTSW 17 34,917,878 (GRCm39) missense possibly damaging 0.93
R9690:Tnxb UTSW 17 34,936,171 (GRCm39) missense probably damaging 1.00
R9761:Tnxb UTSW 17 34,903,987 (GRCm39) missense probably benign 0.32
X0004:Tnxb UTSW 17 34,922,389 (GRCm39) missense possibly damaging 0.71
X0010:Tnxb UTSW 17 34,890,908 (GRCm39) missense probably damaging 1.00
X0019:Tnxb UTSW 17 34,913,163 (GRCm39) missense possibly damaging 0.51
X0063:Tnxb UTSW 17 34,922,482 (GRCm39) missense probably damaging 0.98
X0064:Tnxb UTSW 17 34,913,006 (GRCm39) missense probably damaging 1.00
Z1177:Tnxb UTSW 17 34,937,700 (GRCm39) missense probably damaging 0.99
Z1177:Tnxb UTSW 17 34,902,305 (GRCm39) missense probably damaging 1.00
Z1177:Tnxb UTSW 17 34,890,740 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CGACCACACTGGATCTTAGC -3'
(R):5'- GACTCTGAGAACCTAAAGGCTG -3'

Sequencing Primer
(F):5'- CACACTGGATCTTAGCTGGCTG -3'
(R):5'- GAGAACCTAAAGGCTGTTTCCCTG -3'
Posted On 2019-06-26