Incidental Mutation 'R7221:Wiz'
ID 561853
Institutional Source Beutler Lab
Gene Symbol Wiz
Ensembl Gene ENSMUSG00000024050
Gene Name widely-interspaced zinc finger motifs
Synonyms
MMRRC Submission 045293-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7221 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 32573029-32608413 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 32578139 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 449 (P449S)
Ref Sequence ENSEMBL: ENSMUSP00000084993 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064694] [ENSMUST00000087703] [ENSMUST00000163107] [ENSMUST00000165912] [ENSMUST00000169488] [ENSMUST00000170617]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000064694
AA Change: P449S

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000069443
Gene: ENSMUSG00000024050
AA Change: P449S

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
ZnF_C2H2 74 96 8.67e-1 SMART
ZnF_C2H2 175 197 4.72e-2 SMART
ZnF_C2H2 348 370 1.67e-2 SMART
low complexity region 401 412 N/A INTRINSIC
low complexity region 439 458 N/A INTRINSIC
ZnF_C2H2 532 554 1.67e-2 SMART
low complexity region 576 588 N/A INTRINSIC
low complexity region 607 623 N/A INTRINSIC
ZnF_C2H2 702 724 1.41e0 SMART
low complexity region 784 793 N/A INTRINSIC
low complexity region 869 887 N/A INTRINSIC
ZnF_C2H2 901 927 1.06e2 SMART
low complexity region 936 956 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000087703
AA Change: P449S

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000084993
Gene: ENSMUSG00000024050
AA Change: P449S

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
ZnF_C2H2 74 96 8.67e-1 SMART
ZnF_C2H2 175 197 4.72e-2 SMART
ZnF_C2H2 348 370 1.67e-2 SMART
low complexity region 401 412 N/A INTRINSIC
low complexity region 439 458 N/A INTRINSIC
ZnF_C2H2 531 553 1.67e-2 SMART
low complexity region 575 587 N/A INTRINSIC
low complexity region 606 622 N/A INTRINSIC
ZnF_C2H2 701 723 1.41e0 SMART
low complexity region 783 792 N/A INTRINSIC
low complexity region 868 886 N/A INTRINSIC
ZnF_C2H2 900 926 1.06e2 SMART
low complexity region 935 955 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163107
SMART Domains Protein: ENSMUSP00000127943
Gene: ENSMUSG00000024050

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165912
SMART Domains Protein: ENSMUSP00000127651
Gene: ENSMUSG00000024050

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
ZnF_C2H2 74 96 8.67e-1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000169488
AA Change: P458S

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000126253
Gene: ENSMUSG00000024050
AA Change: P458S

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
ZnF_C2H2 54 76 4.72e-2 SMART
ZnF_C2H2 227 249 3.52e-1 SMART
low complexity region 294 318 N/A INTRINSIC
ZnF_C2H2 357 379 1.67e-2 SMART
low complexity region 410 421 N/A INTRINSIC
low complexity region 448 467 N/A INTRINSIC
ZnF_C2H2 541 563 1.67e-2 SMART
low complexity region 585 597 N/A INTRINSIC
low complexity region 616 632 N/A INTRINSIC
ZnF_C2H2 711 733 1.41e0 SMART
low complexity region 793 802 N/A INTRINSIC
low complexity region 878 896 N/A INTRINSIC
ZnF_C2H2 910 936 1.06e2 SMART
low complexity region 945 965 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170617
SMART Domains Protein: ENSMUSP00000130517
Gene: ENSMUSG00000024050

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (77/77)
MGI Phenotype PHENOTYPE: Homozygous mutant mice die prenatally. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,836,354 (GRCm39) probably benign Het
Abr A C 11: 76,313,987 (GRCm39) M720R probably benign Het
Acad10 G A 5: 121,768,273 (GRCm39) T761M probably damaging Het
Agxt G T 1: 93,065,623 (GRCm39) G164V possibly damaging Het
Ankar C T 1: 72,689,390 (GRCm39) G1247D probably damaging Het
Bptf A C 11: 106,945,658 (GRCm39) L2527R probably damaging Het
Brinp2 T C 1: 158,094,117 (GRCm39) H195R possibly damaging Het
Cacna2d4 G T 6: 119,213,624 (GRCm39) R14S probably benign Het
Cep126 A T 9: 8,100,988 (GRCm39) C515* probably null Het
Chia1 A T 3: 106,039,236 (GRCm39) N442I probably damaging Het
Clasp2 A G 9: 113,681,825 (GRCm39) D327G probably damaging Het
Cnbd2 T C 2: 156,215,581 (GRCm39) F519L probably benign Het
Cntrl T A 2: 35,041,869 (GRCm39) F1214I possibly damaging Het
Cul9 A T 17: 46,839,491 (GRCm39) M829K probably damaging Het
Cyp4b1 T C 4: 115,493,175 (GRCm39) Q223R possibly damaging Het
Defb37 A T 8: 19,040,988 (GRCm39) M1K probably null Het
Dnah7c A T 1: 46,494,937 (GRCm39) Q55L possibly damaging Het
Efcab3 A G 11: 104,791,432 (GRCm39) N2882S probably benign Het
Eif2b4 A T 5: 31,345,131 (GRCm39) D463E possibly damaging Het
Elapor1 T G 3: 108,382,317 (GRCm39) D232A possibly damaging Het
Elovl1 C T 4: 118,288,811 (GRCm39) H167Y probably damaging Het
Emb T A 13: 117,404,013 (GRCm39) L255Q probably damaging Het
Eogt T C 6: 97,089,685 (GRCm39) Y465C probably damaging Het
Erc2 A G 14: 27,375,115 (GRCm39) H111R probably damaging Het
Fam234b T C 6: 135,205,529 (GRCm39) F498S probably damaging Het
Fgfr3 GAGGCTGGCAGCGTGTACGCAGGC GAGGC 5: 33,890,092 (GRCm39) probably null Het
Flrt3 T A 2: 140,503,090 (GRCm39) E179D probably damaging Het
Fndc3a T C 14: 72,793,597 (GRCm39) R993G probably benign Het
Gm14325 T C 2: 177,476,403 (GRCm39) T14A probably damaging Het
Gm5464 T A 14: 67,106,681 (GRCm39) V106D unknown Het
Gpatch11 T A 17: 79,149,546 (GRCm39) I182N possibly damaging Het
Grm6 A G 11: 50,753,870 (GRCm39) R725G probably damaging Het
Hap1 A T 11: 100,239,655 (GRCm39) M588K probably benign Het
Icam2 A G 11: 106,273,268 (GRCm39) F15L probably benign Het
Ints8 A G 4: 11,225,613 (GRCm39) M648T probably benign Het
Ipo11 A T 13: 107,029,065 (GRCm39) L296Q probably damaging Het
Kirrel1 G A 3: 86,993,704 (GRCm39) Q518* probably null Het
Krt18 G T 15: 101,937,967 (GRCm39) D155Y possibly damaging Het
Lctl A T 9: 64,026,217 (GRCm39) K91* probably null Het
Marf1 C A 16: 13,960,349 (GRCm39) R565L probably damaging Het
Med13 A T 11: 86,178,921 (GRCm39) D1458E probably benign Het
Mroh8 T A 2: 157,071,837 (GRCm39) Y556F probably benign Het
Muc16 C T 9: 18,553,495 (GRCm39) G4266D probably benign Het
Nsrp1 A T 11: 76,939,249 (GRCm39) F182I probably damaging Het
Obox3 A T 7: 15,359,983 (GRCm39) Y229N probably benign Het
Or11h7 A T 14: 50,891,528 (GRCm39) Y278F probably damaging Het
Or2b2 T C 13: 21,887,272 (GRCm39) S34P probably damaging Het
Or2b4 A G 17: 38,116,452 (GRCm39) K139E probably benign Het
Or4a74 T C 2: 89,440,272 (GRCm39) Y58C probably damaging Het
Or4c108 A G 2: 88,803,497 (GRCm39) V246A probably damaging Het
Or4p22 T A 2: 88,317,973 (GRCm39) V299D probably damaging Het
Or8d1 A G 9: 38,766,538 (GRCm39) Y60C probably damaging Het
Pabpc2 T A 18: 39,906,963 (GRCm39) V76D possibly damaging Het
Parp9 T C 16: 35,774,071 (GRCm39) W348R probably benign Het
Pdp1 T C 4: 11,961,004 (GRCm39) T455A probably damaging Het
Phactr2 A C 10: 13,122,783 (GRCm39) D446E possibly damaging Het
Pi4kb T C 3: 94,901,500 (GRCm39) L389P probably damaging Het
Pla2g4f C T 2: 120,131,476 (GRCm39) R749H probably benign Het
Plec A G 15: 76,059,974 (GRCm39) V3321A probably damaging Het
Plod2 T C 9: 92,466,580 (GRCm39) V180A probably damaging Het
Plppr5 A G 3: 117,414,618 (GRCm39) I80V probably damaging Het
Potefam3d T G 8: 69,975,316 (GRCm39) D50A probably benign Het
Rubcn T C 16: 32,687,293 (GRCm39) probably null Het
Sacs T C 14: 61,446,255 (GRCm39) V2767A probably damaging Het
Selenbp2 C G 3: 94,611,133 (GRCm39) Y414* probably null Het
Slc45a4 A T 15: 73,458,259 (GRCm39) M430K probably benign Het
Smg1 A G 7: 117,782,020 (GRCm39) L1145P possibly damaging Het
Spns2 A G 11: 72,347,742 (GRCm39) V316A probably benign Het
Srl T A 16: 4,300,811 (GRCm39) E753D probably damaging Het
Thada T C 17: 84,771,794 (GRCm39) T23A possibly damaging Het
Tmem231 T C 8: 112,660,308 (GRCm39) T31A probably benign Het
Tpr C T 1: 150,321,929 (GRCm39) T2321M possibly damaging Het
Ttn T A 2: 76,772,195 (GRCm39) N2615I unknown Het
Vmn1r41 A G 6: 89,724,034 (GRCm39) I192V probably benign Het
Vmn2r83 A T 10: 79,316,001 (GRCm39) T466S probably benign Het
Vnn1 A G 10: 23,770,952 (GRCm39) D60G probably benign Het
Zic1 A G 9: 91,246,785 (GRCm39) S96P probably damaging Het
Zw10 T A 9: 48,981,012 (GRCm39) S471T probably benign Het
Other mutations in Wiz
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02145:Wiz APN 17 32,575,893 (GRCm39) missense probably benign 0.43
IGL02176:Wiz APN 17 32,575,876 (GRCm39) missense probably damaging 0.96
IGL02212:Wiz APN 17 32,587,109 (GRCm39) missense probably damaging 1.00
IGL02213:Wiz APN 17 32,586,834 (GRCm39) missense probably benign 0.03
IGL02616:Wiz APN 17 32,578,443 (GRCm39) missense probably damaging 1.00
IGL02654:Wiz APN 17 32,578,324 (GRCm39) missense probably damaging 1.00
IGL02833:Wiz APN 17 32,576,853 (GRCm39) missense probably damaging 1.00
IGL03032:Wiz APN 17 32,575,532 (GRCm39) missense probably benign
E0370:Wiz UTSW 17 32,574,092 (GRCm39) missense probably damaging 1.00
IGL03138:Wiz UTSW 17 32,578,093 (GRCm39) missense probably damaging 1.00
PIT4494001:Wiz UTSW 17 32,580,905 (GRCm39) missense probably damaging 1.00
R0197:Wiz UTSW 17 32,575,415 (GRCm39) missense probably damaging 1.00
R0207:Wiz UTSW 17 32,576,007 (GRCm39) missense probably damaging 1.00
R0701:Wiz UTSW 17 32,575,415 (GRCm39) missense probably damaging 1.00
R0883:Wiz UTSW 17 32,575,415 (GRCm39) missense probably damaging 1.00
R1055:Wiz UTSW 17 32,606,616 (GRCm39) missense probably damaging 0.99
R1968:Wiz UTSW 17 32,578,346 (GRCm39) missense probably damaging 1.00
R2225:Wiz UTSW 17 32,575,899 (GRCm39) missense probably damaging 1.00
R2423:Wiz UTSW 17 32,580,859 (GRCm39) missense probably damaging 1.00
R2860:Wiz UTSW 17 32,580,680 (GRCm39) missense probably damaging 1.00
R2861:Wiz UTSW 17 32,580,680 (GRCm39) missense probably damaging 1.00
R3056:Wiz UTSW 17 32,576,671 (GRCm39) missense probably benign 0.01
R3755:Wiz UTSW 17 32,578,106 (GRCm39) missense probably damaging 1.00
R3885:Wiz UTSW 17 32,576,012 (GRCm39) missense possibly damaging 0.48
R3933:Wiz UTSW 17 32,576,872 (GRCm39) missense probably damaging 1.00
R4038:Wiz UTSW 17 32,578,198 (GRCm39) missense probably damaging 1.00
R4118:Wiz UTSW 17 32,588,331 (GRCm39) utr 3 prime probably benign
R4181:Wiz UTSW 17 32,586,959 (GRCm39) missense probably damaging 1.00
R4651:Wiz UTSW 17 32,576,655 (GRCm39) missense probably damaging 1.00
R4822:Wiz UTSW 17 32,575,411 (GRCm39) nonsense probably null
R4891:Wiz UTSW 17 32,576,602 (GRCm39) missense possibly damaging 0.85
R4923:Wiz UTSW 17 32,580,570 (GRCm39) missense probably benign 0.01
R5014:Wiz UTSW 17 32,578,340 (GRCm39) missense probably damaging 1.00
R5194:Wiz UTSW 17 32,596,822 (GRCm39) utr 3 prime probably benign
R5254:Wiz UTSW 17 32,597,470 (GRCm39) splice site probably benign
R5944:Wiz UTSW 17 32,576,671 (GRCm39) missense probably benign 0.01
R6015:Wiz UTSW 17 32,606,574 (GRCm39) missense probably damaging 0.99
R6263:Wiz UTSW 17 32,579,417 (GRCm39) splice site probably null
R6571:Wiz UTSW 17 32,578,298 (GRCm39) missense probably damaging 1.00
R6823:Wiz UTSW 17 32,579,395 (GRCm39) missense probably damaging 0.99
R7014:Wiz UTSW 17 32,580,840 (GRCm39) missense probably damaging 0.98
R7051:Wiz UTSW 17 32,580,507 (GRCm39) missense probably damaging 1.00
R7144:Wiz UTSW 17 32,576,602 (GRCm39) missense possibly damaging 0.85
R7260:Wiz UTSW 17 32,578,085 (GRCm39) missense probably damaging 0.99
R7453:Wiz UTSW 17 32,598,049 (GRCm39) missense probably benign 0.00
R7849:Wiz UTSW 17 32,576,760 (GRCm39) missense probably benign 0.26
R8686:Wiz UTSW 17 32,586,821 (GRCm39) missense probably damaging 1.00
R9150:Wiz UTSW 17 32,586,809 (GRCm39) missense probably benign 0.31
R9298:Wiz UTSW 17 32,580,714 (GRCm39) missense probably benign
R9564:Wiz UTSW 17 32,575,939 (GRCm39) missense probably benign 0.00
R9565:Wiz UTSW 17 32,575,939 (GRCm39) missense probably benign 0.00
U24488:Wiz UTSW 17 32,606,649 (GRCm39) missense probably damaging 1.00
X0026:Wiz UTSW 17 32,606,732 (GRCm39) start codon destroyed probably null 0.94
Z1176:Wiz UTSW 17 32,580,469 (GRCm39) missense probably damaging 1.00
Z1177:Wiz UTSW 17 32,576,752 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TGCCATATCTTCTCGAGGCG -3'
(R):5'- CATCGACACACTTCGGGAGATC -3'

Sequencing Primer
(F):5'- ATATCTTCTCGAGGCGTGCCC -3'
(R):5'- GATCCTGAAGAGACGGACCC -3'
Posted On 2019-06-26