Incidental Mutation 'R0575:Dcun1d1'
ID 56187
Institutional Source Beutler Lab
Gene Symbol Dcun1d1
Ensembl Gene ENSMUSG00000027708
Gene Name defective in cullin neddylation 1 domain containing 1
Synonyms Rp42, Tes3, SCCRO, DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae), pTes3
MMRRC Submission 038765-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.700) question?
Stock # R0575 (G1)
Quality Score 159
Status Validated
Chromosome 3
Chromosomal Location 35946254-35991594 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 35951934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143716 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108182] [ENSMUST00000148465] [ENSMUST00000178098] [ENSMUST00000197489] [ENSMUST00000200661] [ENSMUST00000198389]
AlphaFold Q9QZ73
Predicted Effect probably benign
Transcript: ENSMUST00000108182
SMART Domains Protein: ENSMUSP00000103817
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 9 50 1.6e-12 PFAM
Pfam:Cullin_binding 136 247 2.2e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000148465
SMART Domains Protein: ENSMUSP00000115420
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 2.5e-8 PFAM
Pfam:Cullin_binding 119 214 9.4e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178098
SMART Domains Protein: ENSMUSP00000137324
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 3e-8 PFAM
Pfam:Cullin_binding 119 233 6.7e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196261
Predicted Effect probably benign
Transcript: ENSMUST00000197489
SMART Domains Protein: ENSMUSP00000142690
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 9 50 7.5e-11 PFAM
PDB:3TDZ|B 62 89 9e-12 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000197546
Predicted Effect probably benign
Transcript: ENSMUST00000200661
SMART Domains Protein: ENSMUSP00000143716
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 5e-9 PFAM
Pfam:Cullin_binding 121 220 9.9e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000198389
SMART Domains Protein: ENSMUSP00000143243
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 3e-8 PFAM
Pfam:Cullin_binding 119 233 6.7e-43 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.0%
Validation Efficiency 100% (30/30)
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik C T 14: 54,828,709 (GRCm39) S264N possibly damaging Het
Acsm1 G A 7: 119,258,424 (GRCm39) probably null Het
Adsl C T 15: 80,847,886 (GRCm39) A93V probably damaging Het
Agbl5 A T 5: 31,051,798 (GRCm39) S539C probably damaging Het
Aggf1 T A 13: 95,504,905 (GRCm39) T285S probably benign Het
Anapc11 A G 11: 120,490,192 (GRCm39) D36G probably benign Het
Ankrd44 G A 1: 54,801,469 (GRCm39) A286V probably damaging Het
Atf7ip2 G T 16: 10,055,075 (GRCm39) G281C probably damaging Het
Birc6 A G 17: 74,996,232 (GRCm39) K4475E probably damaging Het
Ccbe1 T A 18: 66,227,066 (GRCm39) probably benign Het
Cyp26b1 A G 6: 84,552,288 (GRCm39) probably benign Het
Dtwd2 C A 18: 49,831,539 (GRCm39) C156F probably damaging Het
Efcab6 T G 15: 83,851,901 (GRCm39) I326L probably benign Het
Extl1 TGCGTTGCACCGATACCGGG TG 4: 134,084,988 (GRCm39) probably benign Het
F5 C A 1: 164,003,813 (GRCm39) Q203K probably damaging Het
Frs3 A G 17: 48,014,648 (GRCm39) H447R possibly damaging Het
Gmds T G 13: 32,124,566 (GRCm39) Q264P probably damaging Het
Golgb1 T A 16: 36,739,171 (GRCm39) D2503E probably benign Het
Lgi4 G A 7: 30,759,518 (GRCm39) G25R probably benign Het
Or2y1b G A 11: 49,208,880 (GRCm39) C169Y probably damaging Het
Or5b107 T A 19: 13,142,751 (GRCm39) Y124* probably null Het
Pcdh20 A G 14: 88,705,048 (GRCm39) S751P probably damaging Het
Pcnx4 A G 12: 72,614,010 (GRCm39) T652A probably benign Het
Pom121l2 T G 13: 22,168,338 (GRCm39) F870V probably damaging Het
Prob1 T C 18: 35,787,774 (GRCm39) D160G possibly damaging Het
Spa17 T C 9: 37,514,689 (GRCm39) K133E probably damaging Het
Strbp T A 2: 37,530,885 (GRCm39) D123V possibly damaging Het
Tnxb A G 17: 34,936,180 (GRCm39) T3586A possibly damaging Het
Zfp518a T A 19: 40,900,759 (GRCm39) H229Q probably damaging Het
Other mutations in Dcun1d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Dcun1d1 APN 3 35,970,455 (GRCm39) missense possibly damaging 0.80
IGL00927:Dcun1d1 APN 3 35,975,114 (GRCm39) splice site probably benign
IGL03092:Dcun1d1 APN 3 35,975,141 (GRCm39) missense possibly damaging 0.88
IGL03214:Dcun1d1 APN 3 35,973,220 (GRCm39) missense probably damaging 1.00
deacon UTSW 3 35,951,934 (GRCm39) splice site probably benign
Preacher UTSW 3 35,951,940 (GRCm39) critical splice donor site probably null
LCD18:Dcun1d1 UTSW 3 35,992,154 (GRCm39) unclassified probably benign
R1006:Dcun1d1 UTSW 3 35,951,930 (GRCm39) splice site probably benign
R1820:Dcun1d1 UTSW 3 35,973,153 (GRCm39) nonsense probably null
R4714:Dcun1d1 UTSW 3 35,949,819 (GRCm39) missense probably damaging 1.00
R5849:Dcun1d1 UTSW 3 35,970,333 (GRCm39) intron probably benign
R6681:Dcun1d1 UTSW 3 35,949,819 (GRCm39) missense probably damaging 1.00
R7312:Dcun1d1 UTSW 3 35,951,940 (GRCm39) critical splice donor site probably null
R8344:Dcun1d1 UTSW 3 35,951,703 (GRCm39) missense probably benign 0.05
R9049:Dcun1d1 UTSW 3 35,951,998 (GRCm39) missense probably benign 0.02
R9351:Dcun1d1 UTSW 3 35,975,185 (GRCm39) missense probably benign
X0018:Dcun1d1 UTSW 3 35,975,293 (GRCm39) start codon destroyed probably null 0.99
Predicted Primers PCR Primer
(F):5'- GTTGGGAAAAGTTAGTCCAGCATTTGC -3'
(R):5'- ATCCGCATCAGAACACCCTGTGAG -3'

Sequencing Primer
(F):5'- GACATGCTGAAATTAATGATGCCTTG -3'
(R):5'- GAGGTAAGCCAGACTGTTCTTCC -3'
Posted On 2013-07-11