Incidental Mutation 'R7223:Or8b41'
ID 561944
Institutional Source Beutler Lab
Gene Symbol Or8b41
Ensembl Gene ENSMUSG00000096409
Gene Name olfactory receptor family 8 subfamily B member 41
Synonyms Olfr890, MOR162-15_p, MOR162-3, GA_x6K02T2PVTD-31822365-31823309
MMRRC Submission 045295-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7223 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38054433-38055377 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38055049 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 201 (V201A)
Ref Sequence ENSEMBL: ENSMUSP00000149829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213458]
AlphaFold Q7TRD9
Predicted Effect probably benign
Transcript: ENSMUST00000079804
AA Change: V206A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: V206A

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 2.3e-48 PFAM
Pfam:7tm_1 46 293 9.6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213458
AA Change: V201A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A T 2: 69,104,487 (GRCm39) V733E probably benign Het
Adam34 A T 8: 44,105,041 (GRCm39) N201K probably benign Het
Aldh3b2 A C 19: 4,029,592 (GRCm39) S322R probably damaging Het
Anpep A T 7: 79,475,058 (GRCm39) L914Q probably damaging Het
Arhgap30 T C 1: 171,235,139 (GRCm39) F535S probably damaging Het
Baiap3 G A 17: 25,462,814 (GRCm39) R1075C probably benign Het
Baz2a G T 10: 127,948,475 (GRCm39) G252V probably damaging Het
Brinp3 T A 1: 146,776,812 (GRCm39) S420T possibly damaging Het
Carmil3 T C 14: 55,733,695 (GRCm39) F359S possibly damaging Het
Ccdc124 A T 8: 71,321,170 (GRCm39) L190Q probably damaging Het
Ccr6 T C 17: 8,474,972 (GRCm39) V59A probably damaging Het
Ccr8 T A 9: 119,923,683 (GRCm39) I266N probably damaging Het
Cdh23 T A 10: 60,167,596 (GRCm39) E1798V probably damaging Het
Cdk5rap2 T C 4: 70,153,684 (GRCm39) N1713S probably benign Het
Cep19 T A 16: 31,922,833 (GRCm39) I33N probably damaging Het
Cers3 A T 7: 66,433,163 (GRCm39) Y196F probably damaging Het
Cidea T C 18: 67,499,491 (GRCm39) I126T probably damaging Het
Copg2 A T 6: 30,789,689 (GRCm39) Y546* probably null Het
Cul3 A T 1: 80,264,717 (GRCm39) V261E probably benign Het
Cyp2g1 A T 7: 26,514,057 (GRCm39) D221V probably damaging Het
Cyp8b1 G A 9: 121,744,163 (GRCm39) H390Y probably damaging Het
Daam1 T C 12: 72,035,717 (GRCm39) F971L probably damaging Het
Dnajc24 G A 2: 105,832,311 (GRCm39) S24L possibly damaging Het
Dpysl3 T C 18: 43,571,107 (GRCm39) S56G probably benign Het
Esp1 A G 17: 41,041,972 (GRCm39) D88G probably benign Het
Fam171b A G 2: 83,708,574 (GRCm39) T359A probably damaging Het
Fam186b T C 15: 99,177,718 (GRCm39) E536G possibly damaging Het
Fbxo3 T C 2: 103,873,357 (GRCm39) V156A possibly damaging Het
Gls2 C A 10: 128,035,063 (GRCm39) H65Q probably benign Het
Gp2 A G 7: 119,050,721 (GRCm39) probably null Het
Gpcpd1 T A 2: 132,375,976 (GRCm39) K435I probably benign Het
Gpx6 T A 13: 21,501,840 (GRCm39) probably null Het
Hps3 A T 3: 20,084,583 (GRCm39) S202T probably benign Het
Htr1d T A 4: 136,170,812 (GRCm39) L347H probably damaging Het
Igfals T C 17: 25,100,208 (GRCm39) L433P probably damaging Het
Ilvbl C T 10: 78,419,530 (GRCm39) H537Y probably benign Het
Iqgap2 A T 13: 95,765,480 (GRCm39) M1530K probably damaging Het
Jarid2 A G 13: 45,049,798 (GRCm39) T247A possibly damaging Het
L3hypdh C T 12: 72,120,783 (GRCm39) V323I possibly damaging Het
Lama3 C T 18: 12,715,665 (GRCm39) T1707I possibly damaging Het
Map6 G T 7: 98,917,232 (GRCm39) A2S probably damaging Het
Mfap3 T A 11: 57,421,066 (GRCm39) I349K probably benign Het
Mybl2 A G 2: 162,914,625 (GRCm39) T248A probably benign Het
N6amt1 A G 16: 87,159,548 (GRCm39) *151W probably null Het
Nhlrc1 A G 13: 47,167,684 (GRCm39) V191A probably benign Het
Nkx2-5 T C 17: 27,058,594 (GRCm39) E120G possibly damaging Het
Or2y10 T A 11: 49,454,925 (GRCm39) M59K probably damaging Het
Or52r1b C A 7: 102,690,839 (GRCm39) T46N possibly damaging Het
Or8k28 T A 2: 86,286,211 (GRCm39) I135F possibly damaging Het
Pcdha8 T G 18: 37,126,201 (GRCm39) L228V probably benign Het
Pcsk2 A G 2: 143,532,253 (GRCm39) T134A possibly damaging Het
Phldb3 G A 7: 24,324,078 (GRCm39) R484Q probably benign Het
Pipox A G 11: 77,772,012 (GRCm39) S371P probably damaging Het
Plekhg1 T C 10: 3,823,343 (GRCm39) S159P Het
Psme4 C T 11: 30,824,226 (GRCm39) P1737S probably benign Het
Pygm G A 19: 6,438,893 (GRCm39) D328N probably benign Het
Rabgef1 A T 5: 130,219,801 (GRCm39) E88V probably benign Het
Rims2 G T 15: 39,300,428 (GRCm39) R245L probably benign Het
Slc38a4 T C 15: 96,908,226 (GRCm39) I172V probably damaging Het
Slc4a10 T A 2: 62,099,009 (GRCm39) Y586N probably damaging Het
Snap91 C T 9: 86,761,610 (GRCm39) probably benign Het
Sorcs1 C T 19: 50,178,480 (GRCm39) V881I probably benign Het
Spef2 A T 15: 9,601,726 (GRCm39) V1512E unknown Het
Sufu T C 19: 46,441,716 (GRCm39) I292T possibly damaging Het
Tet1 T C 10: 62,649,450 (GRCm39) N87D possibly damaging Het
Tmem108 T C 9: 103,376,733 (GRCm39) T239A not run Het
Tmem121 A T 12: 113,152,114 (GRCm39) K111* probably null Het
Tpp2 T A 1: 44,008,048 (GRCm39) D417E probably damaging Het
Tpr G A 1: 150,315,007 (GRCm39) E2025K possibly damaging Het
Trappc3 C T 4: 126,168,945 (GRCm39) A145V possibly damaging Het
Ttn T C 2: 76,721,325 (GRCm39) D6754G probably null Het
Unc13c T A 9: 73,536,473 (GRCm39) M1627L probably benign Het
Ush2a A G 1: 188,542,414 (GRCm39) I3327V probably benign Het
Vmn1r74 C T 7: 11,580,894 (GRCm39) Q65* probably null Het
Wdr18 G A 10: 79,796,202 (GRCm39) R69H probably damaging Het
Zbed5 G T 5: 129,929,279 (GRCm39) D132Y probably damaging Het
Zfp644 A T 5: 106,785,448 (GRCm39) Y366* probably null Het
Zfyve26 T C 12: 79,292,945 (GRCm39) N2068S probably damaging Het
Zic2 T C 14: 122,713,503 (GRCm39) F139S probably damaging Het
Zmynd11 T C 13: 9,760,198 (GRCm39) Q141R probably benign Het
Zrsr2-ps1 A G 11: 22,923,388 (GRCm39) E54G probably benign Het
Zscan10 G A 17: 23,828,456 (GRCm39) D333N probably benign Het
Other mutations in Or8b41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01505:Or8b41 APN 9 38,055,167 (GRCm39) nonsense probably null
IGL01861:Or8b41 APN 9 38,055,046 (GRCm39) missense probably damaging 1.00
IGL02174:Or8b41 APN 9 38,055,081 (GRCm39) missense possibly damaging 0.90
IGL02723:Or8b41 APN 9 38,054,707 (GRCm39) missense probably benign 0.02
IGL03085:Or8b41 APN 9 38,054,479 (GRCm39) missense probably damaging 0.98
FR4449:Or8b41 UTSW 9 38,054,484 (GRCm39) missense probably benign 0.00
FR4737:Or8b41 UTSW 9 38,054,484 (GRCm39) missense probably benign 0.00
R0637:Or8b41 UTSW 9 38,055,178 (GRCm39) missense probably benign 0.00
R1353:Or8b41 UTSW 9 38,055,024 (GRCm39) missense probably benign 0.03
R1813:Or8b41 UTSW 9 38,055,025 (GRCm39) missense possibly damaging 0.78
R5997:Or8b41 UTSW 9 38,055,097 (GRCm39) missense probably damaging 1.00
R6004:Or8b41 UTSW 9 38,055,256 (GRCm39) missense probably damaging 1.00
R6417:Or8b41 UTSW 9 38,054,611 (GRCm39) missense probably damaging 1.00
R6420:Or8b41 UTSW 9 38,054,611 (GRCm39) missense probably damaging 1.00
R6720:Or8b41 UTSW 9 38,054,449 (GRCm39) start codon destroyed probably null 1.00
R7601:Or8b41 UTSW 9 38,054,674 (GRCm39) missense probably benign 0.13
R7671:Or8b41 UTSW 9 38,054,736 (GRCm39) missense probably benign 0.02
R8034:Or8b41 UTSW 9 38,054,973 (GRCm39) missense probably damaging 1.00
R8356:Or8b41 UTSW 9 38,054,981 (GRCm39) nonsense probably null
R8456:Or8b41 UTSW 9 38,054,981 (GRCm39) nonsense probably null
R8696:Or8b41 UTSW 9 38,054,433 (GRCm39) start codon destroyed probably null 0.00
R9487:Or8b41 UTSW 9 38,054,866 (GRCm39) missense probably benign 0.22
R9517:Or8b41 UTSW 9 38,054,623 (GRCm39) missense probably damaging 1.00
Z1176:Or8b41 UTSW 9 38,054,727 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGCAATCTGTAAGCCCCTGC -3'
(R):5'- CATGAATGCTGAAGCTCCATAG -3'

Sequencing Primer
(F):5'- AGGTCACCATGTCCTATCAGG -3'
(R):5'- TGAATGCTGAAGCTCCATAGAAAAG -3'
Posted On 2019-06-26