Incidental Mutation 'R7224:Magi1'
| ID |
562020 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| MMRRC Submission |
045296-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.561)
|
| Stock # |
R7224 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 93660070 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 1175
(I1175T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| PDB Structure |
X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055224
AA Change: I1078T
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
AA Change: I1078T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000089317
AA Change: I1175T
PolyPhen 2
Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
AA Change: I1175T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000093769
AA Change: I959T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: I959T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203519
AA Change: I1090T
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
AA Change: I1090T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203688
AA Change: I959T
PolyPhen 2
Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
AA Change: I959T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204347
AA Change: I1187T
PolyPhen 2
Score 0.154 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
AA Change: I1187T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.4%
|
| Validation Efficiency |
99% (79/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadac |
C |
T |
3: 59,943,275 (GRCm39) |
T60M |
probably benign |
Het |
| Actn4 |
C |
T |
7: 28,661,509 (GRCm39) |
A34T |
probably benign |
Het |
| Acvrl1 |
A |
G |
15: 101,041,245 (GRCm39) |
M466V |
probably benign |
Het |
| Adamts7 |
T |
C |
9: 90,067,868 (GRCm39) |
Y453H |
probably damaging |
Het |
| Amfr |
G |
A |
8: 94,711,484 (GRCm39) |
P351S |
probably damaging |
Het |
| Ankrd26 |
G |
A |
6: 118,516,688 (GRCm39) |
T492M |
probably benign |
Het |
| Anxa6 |
A |
G |
11: 54,876,993 (GRCm39) |
F547L |
probably damaging |
Het |
| Ap5m1 |
T |
G |
14: 49,318,384 (GRCm39) |
Y394D |
unknown |
Het |
| Atic |
G |
A |
1: 71,610,014 (GRCm39) |
V342I |
probably benign |
Het |
| Atl1 |
C |
A |
12: 70,002,127 (GRCm39) |
T362N |
probably benign |
Het |
| Atp10a |
A |
T |
7: 58,447,219 (GRCm39) |
M654L |
probably benign |
Het |
| B3gnt5 |
A |
T |
16: 19,588,503 (GRCm39) |
M241L |
probably benign |
Het |
| Bbs7 |
A |
G |
3: 36,659,877 (GRCm39) |
V186A |
possibly damaging |
Het |
| Brme1 |
A |
G |
8: 84,898,842 (GRCm39) |
T577A |
probably benign |
Het |
| C8b |
T |
C |
4: 104,637,795 (GRCm39) |
L89P |
probably damaging |
Het |
| Capn7 |
G |
T |
14: 31,092,678 (GRCm39) |
E742* |
probably null |
Het |
| Ccdc162 |
G |
A |
10: 41,437,187 (GRCm39) |
R1741C |
probably damaging |
Het |
| Cdhr17 |
T |
C |
5: 17,041,592 (GRCm39) |
V615A |
possibly damaging |
Het |
| Chsy3 |
T |
A |
18: 59,542,047 (GRCm39) |
L395H |
probably damaging |
Het |
| Cnot9 |
A |
G |
1: 74,556,388 (GRCm39) |
T62A |
probably benign |
Het |
| Cyfip1 |
AGTGT |
AGT |
7: 55,577,937 (GRCm39) |
|
probably null |
Het |
| Cyp2d12 |
T |
A |
15: 82,441,849 (GRCm39) |
|
probably null |
Het |
| Dnah7a |
A |
G |
1: 53,436,420 (GRCm39) |
V3974A |
probably benign |
Het |
| Dync1h1 |
G |
A |
12: 110,584,196 (GRCm39) |
G533D |
possibly damaging |
Het |
| Eddm13 |
T |
G |
7: 6,271,801 (GRCm39) |
M77R |
probably benign |
Het |
| Elfn1 |
A |
G |
5: 139,958,228 (GRCm39) |
S411G |
probably benign |
Het |
| Enpp3 |
T |
C |
10: 24,652,782 (GRCm39) |
D725G |
possibly damaging |
Het |
| Fmnl1 |
T |
C |
11: 103,073,595 (GRCm39) |
|
probably null |
Het |
| Fndc8 |
T |
C |
11: 82,783,151 (GRCm39) |
M44T |
probably benign |
Het |
| Gcgr |
A |
T |
11: 120,425,538 (GRCm39) |
|
probably benign |
Het |
| Ggt1 |
T |
A |
10: 75,410,110 (GRCm39) |
V14D |
possibly damaging |
Het |
| Gigyf2 |
A |
G |
1: 87,331,447 (GRCm39) |
I198M |
unknown |
Het |
| Gm40460 |
GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG |
GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG |
7: 141,794,171 (GRCm39) |
|
probably benign |
Het |
| Gm6034 |
T |
A |
17: 36,367,331 (GRCm39) |
S59T |
unknown |
Het |
| Gm6408 |
G |
A |
5: 146,421,180 (GRCm39) |
V270I |
probably benign |
Het |
| Gpr20 |
A |
T |
15: 73,567,981 (GRCm39) |
I136N |
probably damaging |
Het |
| Ide |
T |
C |
19: 37,268,160 (GRCm39) |
E565G |
|
Het |
| Igsf9 |
T |
C |
1: 172,322,349 (GRCm39) |
S515P |
probably damaging |
Het |
| Kbtbd12 |
G |
A |
6: 88,590,965 (GRCm39) |
R416* |
probably null |
Het |
| Kcnd3 |
A |
T |
3: 105,576,400 (GRCm39) |
I615F |
probably damaging |
Het |
| Kcnk7 |
A |
T |
19: 5,756,805 (GRCm39) |
M265L |
probably benign |
Het |
| Klhdc1 |
G |
A |
12: 69,309,923 (GRCm39) |
S275N |
probably damaging |
Het |
| Ldc1 |
C |
G |
4: 130,112,992 (GRCm39) |
A135P |
probably damaging |
Het |
| Lrba |
A |
C |
3: 86,302,553 (GRCm39) |
N1871T |
probably damaging |
Het |
| Lrrk1 |
A |
G |
7: 65,982,134 (GRCm39) |
V169A |
probably damaging |
Het |
| Man1a2 |
T |
C |
3: 100,489,369 (GRCm39) |
T537A |
possibly damaging |
Het |
| Mrpl17 |
T |
C |
7: 105,459,209 (GRCm39) |
N129S |
probably damaging |
Het |
| Mup5 |
G |
A |
4: 61,750,622 (GRCm39) |
R174C |
probably damaging |
Het |
| Ndufaf1 |
G |
A |
2: 119,488,877 (GRCm39) |
R216C |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,224,671 (GRCm39) |
|
probably null |
Het |
| Olfml3 |
T |
C |
3: 103,643,176 (GRCm39) |
K402E |
probably damaging |
Het |
| Or52m2 |
A |
T |
7: 102,263,974 (GRCm39) |
M74K |
probably damaging |
Het |
| Or5a1 |
T |
C |
19: 12,097,912 (GRCm39) |
T55A |
probably benign |
Het |
| Or8b12b |
G |
A |
9: 37,684,711 (GRCm39) |
G252D |
possibly damaging |
Het |
| Osbpl8 |
C |
T |
10: 111,110,872 (GRCm39) |
P458L |
possibly damaging |
Het |
| Pcdh20 |
T |
C |
14: 88,706,511 (GRCm39) |
E263G |
possibly damaging |
Het |
| Pkd1l1 |
A |
G |
11: 8,895,241 (GRCm39) |
L623P |
|
Het |
| Plxdc1 |
T |
C |
11: 97,823,153 (GRCm39) |
T363A |
possibly damaging |
Het |
| Pole3 |
T |
C |
4: 62,442,287 (GRCm39) |
D111G |
unknown |
Het |
| R3hdm2 |
T |
A |
10: 127,294,022 (GRCm39) |
L172Q |
probably damaging |
Het |
| Rbm33 |
T |
C |
5: 28,599,322 (GRCm39) |
V90A |
|
Het |
| Rcbtb1 |
C |
G |
14: 59,465,828 (GRCm39) |
I390M |
probably damaging |
Het |
| Romo1 |
G |
A |
2: 155,986,295 (GRCm39) |
|
probably benign |
Het |
| Sars1 |
A |
G |
3: 108,335,519 (GRCm39) |
Y410H |
probably damaging |
Het |
| Sesn2 |
T |
C |
4: 132,224,724 (GRCm39) |
T327A |
probably benign |
Het |
| Slc30a5 |
A |
G |
13: 100,945,762 (GRCm39) |
V530A |
probably damaging |
Het |
| Slc30a9 |
G |
A |
5: 67,473,044 (GRCm39) |
E43K |
probably benign |
Het |
| Slc38a2 |
A |
C |
15: 96,589,240 (GRCm39) |
L418W |
probably damaging |
Het |
| Snx14 |
T |
C |
9: 88,276,614 (GRCm39) |
E557G |
possibly damaging |
Het |
| Spata33 |
T |
A |
8: 123,948,737 (GRCm39) |
I123K |
probably damaging |
Het |
| Tdrd3 |
A |
T |
14: 87,714,839 (GRCm39) |
H170L |
probably damaging |
Het |
| Trpm1 |
A |
G |
7: 63,868,854 (GRCm39) |
|
probably null |
Het |
| Tsr3 |
A |
T |
17: 25,461,569 (GRCm39) |
E302D |
probably benign |
Het |
| Ttll11 |
A |
G |
2: 35,792,685 (GRCm39) |
I386T |
probably damaging |
Het |
| Usp2 |
C |
T |
9: 43,987,266 (GRCm39) |
T188M |
possibly damaging |
Het |
| Usp44 |
A |
G |
10: 93,681,855 (GRCm39) |
I102V |
probably benign |
Het |
| Wasf1 |
A |
G |
10: 40,802,546 (GRCm39) |
N67S |
probably benign |
Het |
| Zfp445 |
T |
C |
9: 122,681,208 (GRCm39) |
N911S |
probably benign |
Het |
| Zfp467 |
A |
G |
6: 48,421,903 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAGACAAGCTCATGGAGTC -3'
(R):5'- AGCTCACATTCTCCTGGTAGC -3'
Sequencing Primer
(F):5'- CATGGAGTCATGCCAGGG -3'
(R):5'- ACGTACTACTTGTATAGCATGCC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation