Incidental Mutation 'R7226:Vmn2r95'
ID 562189
Institutional Source Beutler Lab
Gene Symbol Vmn2r95
Ensembl Gene ENSMUSG00000091631
Gene Name vomeronasal 2, receptor 95
Synonyms
MMRRC Submission 045298-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R7226 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 18644366-18672586 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 18672245 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 733 (I733F)
Ref Sequence ENSEMBL: ENSMUSP00000156117 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166327] [ENSMUST00000232090] [ENSMUST00000232464]
AlphaFold A0A338P6T0
Predicted Effect probably benign
Transcript: ENSMUST00000166327
SMART Domains Protein: ENSMUSP00000126106
Gene: ENSMUSG00000091631

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 462 1.8e-35 PFAM
Pfam:NCD3G 509 562 3.2e-20 PFAM
Pfam:7tm_3 594 830 3.2e-51 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000232090
AA Change: I733F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably damaging
Transcript: ENSMUST00000232464
AA Change: I661F

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025B11Rik C T 15: 77,443,189 (GRCm39) V17I unknown Het
Acad8 T A 9: 26,889,726 (GRCm39) K323* probably null Het
Adam18 A T 8: 25,137,824 (GRCm39) C339S probably damaging Het
Anxa7 A G 14: 20,510,263 (GRCm39) F396L probably damaging Het
Ap2m1 T A 16: 20,358,201 (GRCm39) V73D probably damaging Het
Asic2 A T 11: 80,862,340 (GRCm39) I270N probably damaging Het
Atrn T G 2: 130,828,664 (GRCm39) C1070G probably damaging Het
Bag6 A G 17: 35,361,921 (GRCm39) N517S unknown Het
Bhmt1b A G 18: 87,775,590 (GRCm39) D371G possibly damaging Het
Bltp3b A T 10: 89,644,503 (GRCm39) Q1181L probably benign Het
Cavin1 A C 11: 100,861,284 (GRCm39) D3E probably benign Het
Cc2d2b T C 19: 40,779,751 (GRCm39) L571P unknown Het
Ccbe1 A T 18: 66,216,199 (GRCm39) C175S probably damaging Het
Cd19 A G 7: 126,013,995 (GRCm39) L5P unknown Het
Cd46 A G 1: 194,724,314 (GRCm39) S362P possibly damaging Het
Celf5 A G 10: 81,303,863 (GRCm39) S198P probably damaging Het
Cep170b A G 12: 112,704,359 (GRCm39) R706G possibly damaging Het
Chd3 G T 11: 69,260,037 (GRCm39) R61S unknown Het
Cpsf6 A C 10: 117,197,727 (GRCm39) W253G unknown Het
Cyp27a1 G A 1: 74,776,507 (GRCm39) G481D probably damaging Het
Ddr1 C T 17: 36,002,039 (GRCm39) D218N possibly damaging Het
Dhx34 A T 7: 15,932,801 (GRCm39) V1046D probably damaging Het
Dhx9 A T 1: 153,341,423 (GRCm39) D608E probably benign Het
Dnajc6 C A 4: 101,496,569 (GRCm39) A912E probably damaging Het
Ehmt1 T C 2: 24,694,794 (GRCm39) D1051G probably damaging Het
Fam217b C A 2: 178,062,996 (GRCm39) A320E probably benign Het
Farsa T A 8: 85,590,689 (GRCm39) I169N probably benign Het
Fbn2 A G 18: 58,170,142 (GRCm39) C2210R probably damaging Het
Fbxo3 T A 2: 103,880,642 (GRCm39) S251T probably benign Het
Fer1l6 C T 15: 58,462,384 (GRCm39) T813I probably benign Het
Ftl1-ps1 A T 13: 74,555,114 (GRCm39) E131V probably damaging Het
Gins3 T A 8: 96,364,499 (GRCm39) I83N probably damaging Het
Gja3 T C 14: 57,273,350 (GRCm39) T341A probably benign Het
Gja5 A G 3: 96,958,174 (GRCm39) Y77C probably damaging Het
Gm7247 A G 14: 51,602,808 (GRCm39) K48R probably damaging Het
Gsx2 C A 5: 75,236,621 (GRCm39) S67* probably null Het
H2-Q5 T A 17: 35,616,089 (GRCm39) L217Q Het
Impg2 T A 16: 56,087,467 (GRCm39) C1095* probably null Het
Itga7 G T 10: 128,776,801 (GRCm39) W222L probably damaging Het
Kdm2b T A 5: 123,059,512 (GRCm39) D530V possibly damaging Het
Klhdc8a A T 1: 132,230,344 (GRCm39) D153V probably damaging Het
Lin28a C T 4: 133,733,619 (GRCm39) G143S probably damaging Het
Memo1 A G 17: 74,509,338 (GRCm39) L227S probably damaging Het
Mettl27 T A 5: 134,964,657 (GRCm39) V138E probably damaging Het
Mov10 G T 3: 104,708,328 (GRCm39) L474I probably damaging Het
Nat10 T C 2: 103,557,098 (GRCm39) N852S probably benign Het
Nfkbie T C 17: 45,870,153 (GRCm39) V166A possibly damaging Het
Nktr T C 9: 121,575,599 (GRCm39) M369T probably damaging Het
Nlrp9a A T 7: 26,258,149 (GRCm39) N589I probably benign Het
Nrn1 G A 13: 36,914,577 (GRCm39) R8C probably benign Het
Nrsn1 A G 13: 25,437,451 (GRCm39) I159T probably damaging Het
Or1e29 A G 11: 73,667,503 (GRCm39) S217P possibly damaging Het
Or2h15 C T 17: 38,441,324 (GRCm39) G253D probably benign Het
Or5p61 A T 7: 107,758,164 (GRCm39) D305E probably benign Het
Or6c88 G A 10: 129,406,584 (GRCm39) G20D probably benign Het
Osbp T A 19: 11,956,031 (GRCm39) D385E probably benign Het
Pan3 T A 5: 147,463,802 (GRCm39) N547K probably damaging Het
Pip4p2 T A 4: 14,892,464 (GRCm39) D109E probably damaging Het
Pum1 C A 4: 130,499,292 (GRCm39) T1036K probably damaging Het
Rad54l2 C A 9: 106,590,671 (GRCm39) R485L probably damaging Het
Rps26 A T 10: 128,461,087 (GRCm39) F101I unknown Het
Sdsl T C 5: 120,598,702 (GRCm39) N138S probably benign Het
Slc28a2b C A 2: 122,353,013 (GRCm39) R453S probably benign Het
Slc39a6 A T 18: 24,717,084 (GRCm39) H649Q probably damaging Het
Snip1 T A 4: 124,965,273 (GRCm39) F226Y probably benign Het
Srrd T C 5: 112,485,322 (GRCm39) T334A unknown Het
St14 C T 9: 31,011,448 (GRCm39) D448N possibly damaging Het
Tmem270 T A 5: 134,930,538 (GRCm39) Q241L probably benign Het
Tubb4b T C 2: 25,114,180 (GRCm39) D41G probably benign Het
Usf3 T C 16: 44,040,368 (GRCm39) M1616T possibly damaging Het
Zfp976 A T 7: 42,262,684 (GRCm39) C385* probably null Het
Other mutations in Vmn2r95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Vmn2r95 APN 17 18,672,590 (GRCm39) utr 3 prime probably benign
IGL01479:Vmn2r95 APN 17 18,664,124 (GRCm39) missense probably damaging 1.00
IGL01890:Vmn2r95 APN 17 18,671,737 (GRCm39) missense probably damaging 1.00
IGL01986:Vmn2r95 APN 17 18,660,473 (GRCm39) missense probably benign 0.06
IGL02113:Vmn2r95 APN 17 18,660,169 (GRCm39) missense possibly damaging 0.47
IGL02154:Vmn2r95 APN 17 18,672,248 (GRCm39) missense probably benign 0.16
IGL02190:Vmn2r95 APN 17 18,672,038 (GRCm39) missense probably benign 0.00
IGL02412:Vmn2r95 APN 17 18,660,218 (GRCm39) missense probably damaging 1.00
IGL02550:Vmn2r95 APN 17 18,671,994 (GRCm39) missense probably damaging 1.00
IGL02679:Vmn2r95 APN 17 18,664,116 (GRCm39) missense probably damaging 1.00
IGL02691:Vmn2r95 APN 17 18,672,120 (GRCm39) missense probably benign 0.07
IGL02990:Vmn2r95 APN 17 18,672,298 (GRCm39) nonsense probably null
IGL03032:Vmn2r95 APN 17 18,672,575 (GRCm39) missense probably benign 0.00
R0416:Vmn2r95 UTSW 17 18,661,664 (GRCm39) missense probably damaging 1.00
R0448:Vmn2r95 UTSW 17 18,672,005 (GRCm39) missense possibly damaging 0.92
R0514:Vmn2r95 UTSW 17 18,671,844 (GRCm39) missense probably benign
R0519:Vmn2r95 UTSW 17 18,659,765 (GRCm39) missense probably damaging 1.00
R0539:Vmn2r95 UTSW 17 18,672,362 (GRCm39) missense probably damaging 1.00
R1501:Vmn2r95 UTSW 17 18,660,118 (GRCm39) missense probably damaging 0.99
R1598:Vmn2r95 UTSW 17 18,672,575 (GRCm39) missense probably benign 0.03
R1613:Vmn2r95 UTSW 17 18,660,901 (GRCm39) splice site probably benign
R1861:Vmn2r95 UTSW 17 18,672,530 (GRCm39) missense probably damaging 1.00
R1921:Vmn2r95 UTSW 17 18,644,575 (GRCm39) missense probably benign 0.11
R1986:Vmn2r95 UTSW 17 18,671,805 (GRCm39) missense probably benign
R2031:Vmn2r95 UTSW 17 18,659,717 (GRCm39) missense possibly damaging 0.94
R2040:Vmn2r95 UTSW 17 18,661,561 (GRCm39) missense probably damaging 1.00
R3608:Vmn2r95 UTSW 17 18,660,235 (GRCm39) missense possibly damaging 0.47
R3727:Vmn2r95 UTSW 17 18,661,744 (GRCm39) nonsense probably null
R3953:Vmn2r95 UTSW 17 18,660,358 (GRCm39) missense possibly damaging 0.79
R3955:Vmn2r95 UTSW 17 18,660,358 (GRCm39) missense possibly damaging 0.79
R3957:Vmn2r95 UTSW 17 18,660,358 (GRCm39) missense possibly damaging 0.79
R4474:Vmn2r95 UTSW 17 18,672,507 (GRCm39) missense probably damaging 1.00
R4672:Vmn2r95 UTSW 17 18,672,413 (GRCm39) missense probably damaging 1.00
R4850:Vmn2r95 UTSW 17 18,671,915 (GRCm39) missense probably damaging 1.00
R5054:Vmn2r95 UTSW 17 18,671,708 (GRCm39) missense possibly damaging 0.63
R5178:Vmn2r95 UTSW 17 18,660,337 (GRCm39) missense probably benign 0.01
R5980:Vmn2r95 UTSW 17 18,661,624 (GRCm39) missense probably benign
R6183:Vmn2r95 UTSW 17 18,664,192 (GRCm39) missense probably damaging 0.99
R6276:Vmn2r95 UTSW 17 18,671,732 (GRCm39) missense possibly damaging 0.96
R6651:Vmn2r95 UTSW 17 18,660,622 (GRCm39) missense probably damaging 1.00
R6682:Vmn2r95 UTSW 17 18,660,489 (GRCm39) missense probably damaging 1.00
R6797:Vmn2r95 UTSW 17 18,672,551 (GRCm39) utr 3 prime probably benign
R6799:Vmn2r95 UTSW 17 18,659,555 (GRCm39) missense probably damaging 1.00
R6849:Vmn2r95 UTSW 17 18,664,182 (GRCm39) missense probably damaging 1.00
R6849:Vmn2r95 UTSW 17 18,664,181 (GRCm39) missense probably damaging 1.00
R6982:Vmn2r95 UTSW 17 18,672,323 (GRCm39) missense probably damaging 1.00
R7203:Vmn2r95 UTSW 17 18,661,577 (GRCm39) missense probably benign 0.01
R7240:Vmn2r95 UTSW 17 18,672,225 (GRCm39) missense probably benign 0.15
R7383:Vmn2r95 UTSW 17 18,660,734 (GRCm39) missense probably benign 0.06
R7614:Vmn2r95 UTSW 17 18,660,352 (GRCm39) missense probably benign
R7755:Vmn2r95 UTSW 17 18,644,367 (GRCm39) start codon destroyed probably null 0.99
R7942:Vmn2r95 UTSW 17 18,660,529 (GRCm39) missense possibly damaging 0.74
R8355:Vmn2r95 UTSW 17 18,660,352 (GRCm39) missense probably benign
R8455:Vmn2r95 UTSW 17 18,660,352 (GRCm39) missense probably benign
R8478:Vmn2r95 UTSW 17 18,672,544 (GRCm39) missense probably damaging 1.00
R8547:Vmn2r95 UTSW 17 18,664,161 (GRCm39) missense probably damaging 1.00
R8752:Vmn2r95 UTSW 17 18,661,738 (GRCm39) missense probably damaging 0.98
R8788:Vmn2r95 UTSW 17 18,671,790 (GRCm39) missense probably benign 0.09
R8852:Vmn2r95 UTSW 17 18,664,113 (GRCm39) missense possibly damaging 0.95
R9098:Vmn2r95 UTSW 17 18,660,167 (GRCm39) missense possibly damaging 0.88
R9202:Vmn2r95 UTSW 17 18,644,394 (GRCm39) missense probably benign 0.00
R9244:Vmn2r95 UTSW 17 18,672,189 (GRCm39) missense possibly damaging 0.91
R9546:Vmn2r95 UTSW 17 18,661,721 (GRCm39) missense probably benign 0.01
R9665:Vmn2r95 UTSW 17 18,660,607 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r95 UTSW 17 18,660,663 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAAAGCCATCACTGTGGTC -3'
(R):5'- CCCTTTAGTGCTGTGGTAGAC -3'

Sequencing Primer
(F):5'- CACTGTGGTCCTTGCCTTTAAGG -3'
(R):5'- CAGGAAGAAAGGTGATCCAGACAC -3'
Posted On 2019-06-26