Incidental Mutation 'R7232:Slit3'
| ID |
562569 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Slit3
|
| Ensembl Gene |
ENSMUSG00000056427 |
| Gene Name |
slit guidance ligand 3 |
| Synonyms |
Slit1, b2b2362.1Clo |
| MMRRC Submission |
045303-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.871)
|
| Stock # |
R7232 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
35012283-35599334 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 35501516 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 417
(T417A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066857
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069837]
|
| AlphaFold |
Q9WVB4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000069837
AA Change: T417A
PolyPhen 2
Score 0.866 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000066857
Gene: ENSMUSG00000056427
AA Change: T417A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
23 |
N/A |
INTRINSIC |
|
LRRNT
|
33 |
65 |
2.12e-8 |
SMART |
|
LRR
|
59 |
83 |
1.37e2 |
SMART |
|
LRR_TYP
|
84 |
107 |
1.12e-3 |
SMART |
|
LRR_TYP
|
108 |
131 |
7.78e-3 |
SMART |
|
LRR_TYP
|
132 |
155 |
5.42e-2 |
SMART |
|
LRR
|
156 |
179 |
5.88e0 |
SMART |
|
LRR
|
180 |
203 |
7.55e-1 |
SMART |
|
LRRCT
|
215 |
264 |
1.33e-6 |
SMART |
|
LRRNT
|
279 |
311 |
6.79e-7 |
SMART |
|
LRR
|
305 |
329 |
1.16e2 |
SMART |
|
LRR
|
330 |
353 |
1.26e1 |
SMART |
|
LRR_TYP
|
354 |
377 |
2.79e-4 |
SMART |
|
LRR
|
378 |
401 |
4.05e-1 |
SMART |
|
LRR
|
402 |
425 |
4.05e-1 |
SMART |
|
LRRCT
|
437 |
486 |
7.75e-8 |
SMART |
|
LRRNT
|
504 |
536 |
1.95e-7 |
SMART |
|
LRR_TYP
|
556 |
579 |
7.49e-5 |
SMART |
|
LRR
|
581 |
603 |
6.41e1 |
SMART |
|
LRR_TYP
|
604 |
627 |
2.53e-2 |
SMART |
|
LRR
|
628 |
651 |
1.76e-1 |
SMART |
|
LRRCT
|
663 |
712 |
2.52e-7 |
SMART |
|
LRRNT
|
724 |
756 |
3e-8 |
SMART |
|
LRR
|
774 |
797 |
2.14e0 |
SMART |
|
LRR_TYP
|
798 |
821 |
2.95e-3 |
SMART |
|
LRR_TYP
|
822 |
845 |
2.43e-4 |
SMART |
|
LRRCT
|
857 |
906 |
1.12e-13 |
SMART |
|
EGF
|
919 |
953 |
6.86e-4 |
SMART |
|
EGF
|
958 |
994 |
8.84e-7 |
SMART |
|
EGF
|
999 |
1032 |
1.13e-4 |
SMART |
|
EGF
|
1037 |
1072 |
2.3e-5 |
SMART |
|
EGF_CA
|
1074 |
1110 |
5.92e-8 |
SMART |
|
EGF
|
1122 |
1155 |
3.79e-6 |
SMART |
|
LamG
|
1178 |
1314 |
3.16e-34 |
SMART |
|
EGF
|
1331 |
1365 |
2.19e-2 |
SMART |
|
EGF
|
1371 |
1403 |
1.13e-4 |
SMART |
|
EGF
|
1411 |
1444 |
5.57e-4 |
SMART |
|
CT
|
1455 |
1523 |
4.56e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.1917 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
99% (80/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
G |
A |
7: 40,642,603 (GRCm39) |
G91S |
probably damaging |
Het |
| Adam21 |
T |
G |
12: 81,607,330 (GRCm39) |
N144T |
probably damaging |
Het |
| Adgrg7 |
T |
C |
16: 56,597,515 (GRCm39) |
|
probably null |
Het |
| Angpt4 |
T |
C |
2: 151,771,460 (GRCm39) |
S259P |
possibly damaging |
Het |
| Aqr |
A |
C |
2: 113,936,363 (GRCm39) |
L1320R |
probably damaging |
Het |
| Arhgef10 |
G |
A |
8: 14,990,323 (GRCm39) |
G266D |
probably benign |
Het |
| Bop1 |
A |
G |
15: 76,337,546 (GRCm39) |
V693A |
probably damaging |
Het |
| Cd86 |
CA |
CAA |
16: 36,426,917 (GRCm39) |
|
probably null |
Het |
| Cdc5l |
A |
G |
17: 45,738,863 (GRCm39) |
|
probably null |
Het |
| Cfap46 |
C |
A |
7: 139,197,493 (GRCm39) |
R2126L |
unknown |
Het |
| Chek2 |
T |
C |
5: 111,008,781 (GRCm39) |
V304A |
probably damaging |
Het |
| Cntnap4 |
T |
A |
8: 113,391,731 (GRCm39) |
|
probably null |
Het |
| Ctps1 |
C |
A |
4: 120,405,321 (GRCm39) |
G374C |
probably damaging |
Het |
| Defa27 |
A |
T |
8: 21,805,625 (GRCm39) |
I22F |
probably damaging |
Het |
| Dnah14 |
T |
C |
1: 181,584,928 (GRCm39) |
S3220P |
probably damaging |
Het |
| Dop1b |
T |
G |
16: 93,557,373 (GRCm39) |
|
probably null |
Het |
| Dpysl5 |
G |
A |
5: 30,949,642 (GRCm39) |
V471I |
probably benign |
Het |
| Duoxa1 |
T |
A |
2: 122,135,728 (GRCm39) |
I124F |
probably damaging |
Het |
| Eif4enif1 |
A |
G |
11: 3,165,678 (GRCm39) |
E85G |
possibly damaging |
Het |
| Eogt |
T |
A |
6: 97,096,944 (GRCm39) |
I355F |
probably damaging |
Het |
| Epha7 |
T |
A |
4: 28,951,279 (GRCm39) |
V800E |
probably damaging |
Het |
| Evi5l |
A |
G |
8: 4,255,906 (GRCm39) |
Q633R |
possibly damaging |
Het |
| Fam170a |
T |
C |
18: 50,414,728 (GRCm39) |
Y125H |
probably damaging |
Het |
| Fbxo15 |
T |
C |
18: 84,980,747 (GRCm39) |
Y241H |
probably damaging |
Het |
| Gbe1 |
T |
C |
16: 70,233,828 (GRCm39) |
I235T |
possibly damaging |
Het |
| Gfra3 |
C |
T |
18: 34,844,234 (GRCm39) |
R102Q |
probably damaging |
Het |
| Gjd4 |
C |
T |
18: 9,280,380 (GRCm39) |
G233S |
probably damaging |
Het |
| Gm29106 |
C |
T |
1: 118,127,291 (GRCm39) |
P328S |
probably damaging |
Het |
| Hgfac |
G |
T |
5: 35,204,258 (GRCm39) |
R507L |
probably damaging |
Het |
| Jakmip3 |
A |
G |
7: 138,609,355 (GRCm39) |
K153R |
probably benign |
Het |
| Kcnc1 |
T |
A |
7: 46,077,383 (GRCm39) |
V395E |
probably damaging |
Het |
| Krt6b |
T |
C |
15: 101,586,577 (GRCm39) |
D304G |
probably damaging |
Het |
| Ldha |
T |
C |
7: 46,500,323 (GRCm39) |
Y174H |
probably benign |
Het |
| Lgi4 |
G |
A |
7: 30,766,776 (GRCm39) |
V268M |
possibly damaging |
Het |
| Lpar3 |
T |
G |
3: 145,947,061 (GRCm39) |
|
probably null |
Het |
| Lrp3 |
T |
C |
7: 34,905,477 (GRCm39) |
D103G |
probably damaging |
Het |
| Marchf5 |
G |
A |
19: 37,194,713 (GRCm39) |
|
probably null |
Het |
| Muc5b |
A |
T |
7: 141,419,866 (GRCm39) |
H4115L |
possibly damaging |
Het |
| Myh13 |
G |
A |
11: 67,239,672 (GRCm39) |
D741N |
probably damaging |
Het |
| Naglu |
A |
T |
11: 100,967,252 (GRCm39) |
I401F |
probably damaging |
Het |
| Ncam2 |
T |
A |
16: 81,309,759 (GRCm39) |
N416K |
probably damaging |
Het |
| Ncan |
A |
G |
8: 70,564,738 (GRCm39) |
L292S |
probably damaging |
Het |
| Nkiras1 |
T |
C |
14: 18,276,732 (GRCm38) |
V7A |
probably damaging |
Het |
| Nlrp4c |
T |
A |
7: 6,068,708 (GRCm39) |
L203* |
probably null |
Het |
| Nscme3l |
A |
T |
19: 5,553,659 (GRCm39) |
S41T |
possibly damaging |
Het |
| Onecut2 |
T |
A |
18: 64,474,633 (GRCm39) |
W395R |
probably damaging |
Het |
| Or10a2 |
T |
A |
7: 106,673,062 (GRCm39) |
I9K |
probably benign |
Het |
| Pak6 |
T |
A |
2: 118,524,003 (GRCm39) |
V386E |
probably damaging |
Het |
| Pias2 |
A |
G |
18: 77,220,931 (GRCm39) |
S396G |
probably benign |
Het |
| Plxna2 |
T |
A |
1: 194,394,568 (GRCm39) |
L483H |
probably damaging |
Het |
| Prss36 |
G |
T |
7: 127,534,763 (GRCm39) |
R484S |
probably benign |
Het |
| Ptpn21 |
A |
T |
12: 98,654,996 (GRCm39) |
V657E |
probably benign |
Het |
| Rassf2 |
T |
C |
2: 131,838,332 (GRCm39) |
E318G |
probably damaging |
Het |
| Rp1 |
A |
C |
1: 4,298,824 (GRCm39) |
S623A |
unknown |
Het |
| Runx2 |
G |
A |
17: 45,125,079 (GRCm39) |
P80L |
probably damaging |
Het |
| Scn11a |
T |
A |
9: 119,588,982 (GRCm39) |
E1308V |
probably damaging |
Het |
| Serpina3c |
A |
T |
12: 104,115,771 (GRCm39) |
S258T |
possibly damaging |
Het |
| Sostdc1 |
C |
A |
12: 36,367,310 (GRCm39) |
A162E |
possibly damaging |
Het |
| Sox13 |
A |
T |
1: 133,312,129 (GRCm39) |
|
probably null |
Het |
| Sox8 |
G |
T |
17: 25,786,514 (GRCm39) |
S396R |
probably benign |
Het |
| Sult2a3 |
A |
T |
7: 13,816,685 (GRCm39) |
F164L |
possibly damaging |
Het |
| Susd2 |
T |
C |
10: 75,475,685 (GRCm39) |
Y438C |
probably damaging |
Het |
| Tas2r106 |
T |
G |
6: 131,655,810 (GRCm39) |
T14P |
probably damaging |
Het |
| Tcf25 |
T |
A |
8: 124,127,800 (GRCm39) |
|
probably null |
Het |
| Tenm3 |
G |
A |
8: 48,688,970 (GRCm39) |
R2206W |
probably damaging |
Het |
| Tep1 |
A |
G |
14: 51,081,789 (GRCm39) |
L471P |
unknown |
Het |
| Ticrr |
A |
T |
7: 79,343,490 (GRCm39) |
K1118N |
probably damaging |
Het |
| Tlr5 |
G |
A |
1: 182,801,064 (GRCm39) |
E123K |
probably benign |
Het |
| Ttn |
ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG |
ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG |
2: 76,746,150 (GRCm39) |
|
probably benign |
Het |
| U2surp |
A |
G |
9: 95,375,770 (GRCm39) |
V141A |
probably benign |
Het |
| Unc79 |
T |
A |
12: 103,100,734 (GRCm39) |
S2050T |
possibly damaging |
Het |
| Usp13 |
A |
G |
3: 32,920,020 (GRCm39) |
D235G |
probably benign |
Het |
| Vcam1 |
T |
C |
3: 115,919,628 (GRCm39) |
T213A |
possibly damaging |
Het |
| Vmn2r60 |
T |
A |
7: 41,786,166 (GRCm39) |
I323N |
possibly damaging |
Het |
| Vps13b |
A |
G |
15: 35,877,703 (GRCm39) |
I2892M |
probably damaging |
Het |
| Wnt5a |
T |
A |
14: 28,240,329 (GRCm39) |
S160T |
probably benign |
Het |
| Zar1 |
G |
A |
5: 72,738,294 (GRCm39) |
P36L |
possibly damaging |
Het |
| Zfp773 |
A |
T |
7: 7,135,984 (GRCm39) |
M204K |
probably benign |
Het |
| Zhx1 |
T |
C |
15: 57,916,465 (GRCm39) |
T594A |
probably benign |
Het |
|
| Other mutations in Slit3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00731:Slit3
|
APN |
11 |
35,512,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Slit3
|
APN |
11 |
35,501,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01612:Slit3
|
APN |
11 |
35,591,211 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02145:Slit3
|
APN |
11 |
35,520,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02146:Slit3
|
APN |
11 |
35,125,675 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02430:Slit3
|
APN |
11 |
35,068,601 (GRCm39) |
splice site |
probably null |
|
|
IGL02528:Slit3
|
APN |
11 |
35,469,801 (GRCm39) |
missense |
probably benign |
|
|
IGL02530:Slit3
|
APN |
11 |
35,598,969 (GRCm39) |
makesense |
probably null |
|
|
IGL02640:Slit3
|
APN |
11 |
35,591,172 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02819:Slit3
|
APN |
11 |
35,062,417 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Slit3
|
APN |
11 |
35,539,874 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03150:Slit3
|
APN |
11 |
35,399,084 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03161:Slit3
|
APN |
11 |
35,591,241 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03336:Slit3
|
APN |
11 |
35,560,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Bloated
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
Quellung
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02988:Slit3
|
UTSW |
11 |
35,598,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4791001:Slit3
|
UTSW |
11 |
35,552,072 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0334:Slit3
|
UTSW |
11 |
35,469,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0385:Slit3
|
UTSW |
11 |
35,591,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0840:Slit3
|
UTSW |
11 |
35,514,263 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Slit3
|
UTSW |
11 |
35,012,462 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1364:Slit3
|
UTSW |
11 |
35,560,934 (GRCm39) |
missense |
probably benign |
|
|
R1476:Slit3
|
UTSW |
11 |
35,577,126 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1508:Slit3
|
UTSW |
11 |
35,461,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Slit3
|
UTSW |
11 |
35,125,733 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1692:Slit3
|
UTSW |
11 |
35,550,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1696:Slit3
|
UTSW |
11 |
35,566,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1727:Slit3
|
UTSW |
11 |
35,520,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1752:Slit3
|
UTSW |
11 |
35,455,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1970:Slit3
|
UTSW |
11 |
35,521,668 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2077:Slit3
|
UTSW |
11 |
35,435,575 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2126:Slit3
|
UTSW |
11 |
35,579,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Slit3
|
UTSW |
11 |
35,503,088 (GRCm39) |
splice site |
probably null |
|
|
R2162:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R2873:Slit3
|
UTSW |
11 |
35,435,620 (GRCm39) |
nonsense |
probably null |
|
|
R3813:Slit3
|
UTSW |
11 |
35,566,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3831:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3832:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3833:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3839:Slit3
|
UTSW |
11 |
35,399,064 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4152:Slit3
|
UTSW |
11 |
35,589,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4387:Slit3
|
UTSW |
11 |
35,574,875 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4795:Slit3
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4910:Slit3
|
UTSW |
11 |
35,523,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Slit3
|
UTSW |
11 |
35,579,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5106:Slit3
|
UTSW |
11 |
35,503,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5218:Slit3
|
UTSW |
11 |
35,575,002 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5338:Slit3
|
UTSW |
11 |
35,512,975 (GRCm39) |
missense |
probably benign |
|
|
R5354:Slit3
|
UTSW |
11 |
35,566,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5436:Slit3
|
UTSW |
11 |
35,598,738 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5896:Slit3
|
UTSW |
11 |
35,598,932 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5933:Slit3
|
UTSW |
11 |
35,520,578 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5963:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Slit3
|
UTSW |
11 |
35,461,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6153:Slit3
|
UTSW |
11 |
35,591,310 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6484:Slit3
|
UTSW |
11 |
35,552,125 (GRCm39) |
missense |
probably benign |
|
|
R6526:Slit3
|
UTSW |
11 |
35,552,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6797:Slit3
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6887:Slit3
|
UTSW |
11 |
35,435,633 (GRCm39) |
splice site |
probably null |
|
|
R7067:Slit3
|
UTSW |
11 |
35,399,057 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7150:Slit3
|
UTSW |
11 |
35,461,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Slit3
|
UTSW |
11 |
35,490,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7418:Slit3
|
UTSW |
11 |
35,577,255 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7545:Slit3
|
UTSW |
11 |
35,591,139 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7727:Slit3
|
UTSW |
11 |
35,574,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Slit3
|
UTSW |
11 |
35,591,235 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8177:Slit3
|
UTSW |
11 |
35,469,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8179:Slit3
|
UTSW |
11 |
35,554,903 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8416:Slit3
|
UTSW |
11 |
35,399,062 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8417:Slit3
|
UTSW |
11 |
35,501,438 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8476:Slit3
|
UTSW |
11 |
35,520,596 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8785:Slit3
|
UTSW |
11 |
35,560,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8955:Slit3
|
UTSW |
11 |
35,589,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9040:Slit3
|
UTSW |
11 |
35,594,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9068:Slit3
|
UTSW |
11 |
35,574,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Slit3
|
UTSW |
11 |
35,012,463 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9266:Slit3
|
UTSW |
11 |
35,598,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9539:Slit3
|
UTSW |
11 |
35,589,155 (GRCm39) |
nonsense |
probably null |
|
|
R9636:Slit3
|
UTSW |
11 |
35,594,088 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0028:Slit3
|
UTSW |
11 |
35,455,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Slit3
|
UTSW |
11 |
35,598,751 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGAAACTCAAGGCCACGTG -3'
(R):5'- CAACCCTGAATGCTTGGTGC -3'
Sequencing Primer
(F):5'- CTCAAGGCCACGTGGATGAG -3'
(R):5'- CAGTTAAGTGCTTTGAGCTTCATC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation