Incidental Mutation 'R7239:Ccdc33'
ID 563085
Institutional Source Beutler Lab
Gene Symbol Ccdc33
Ensembl Gene ENSMUSG00000037716
Gene Name coiled-coil domain containing 33
Synonyms LOC382077, 4930535E21Rik
MMRRC Submission 045346-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7239 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 57935960-58026106 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 57940192 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 713 (Q713*)
Ref Sequence ENSEMBL: ENSMUSP00000096279 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042205] [ENSMUST00000098682] [ENSMUST00000119665] [ENSMUST00000215944]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000042205
AA Change: Q528*
SMART Domains Protein: ENSMUSP00000040899
Gene: ENSMUSG00000037716
AA Change: Q528*

DomainStartEndE-ValueType
C2 36 140 5.79e-3 SMART
coiled coil region 413 451 N/A INTRINSIC
coiled coil region 472 560 N/A INTRINSIC
coiled coil region 630 668 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000098682
AA Change: Q713*
SMART Domains Protein: ENSMUSP00000096279
Gene: ENSMUSG00000037716
AA Change: Q713*

DomainStartEndE-ValueType
C2 281 385 5.79e-3 SMART
coiled coil region 598 636 N/A INTRINSIC
coiled coil region 657 745 N/A INTRINSIC
coiled coil region 884 922 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000119665
AA Change: Q527*
SMART Domains Protein: ENSMUSP00000112613
Gene: ENSMUSG00000037716
AA Change: Q527*

DomainStartEndE-ValueType
C2 36 140 5.79e-3 SMART
coiled coil region 413 559 N/A INTRINSIC
coiled coil region 629 667 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000215944
AA Change: Q713*
Meta Mutation Damage Score 0.9752 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 99% (76/77)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510009E07Rik A G 16: 21,472,268 (GRCm39) V144A probably damaging Het
Abca5 A T 11: 110,217,530 (GRCm39) Y109N possibly damaging Het
Abcb5 T C 12: 118,892,460 (GRCm39) Q433R probably benign Het
Adamts7 G A 9: 90,068,610 (GRCm39) probably null Het
Adgrv1 T C 13: 81,624,731 (GRCm39) D3746G possibly damaging Het
Arhgap29 C T 3: 121,782,599 (GRCm39) S159L probably benign Het
Arhgap5 T A 12: 52,564,159 (GRCm39) C377S probably benign Het
Atp1a3 G A 7: 24,700,129 (GRCm39) P77L probably damaging Het
B4galt1 T C 4: 40,812,754 (GRCm39) D257G probably damaging Het
Bin1 T A 18: 32,539,224 (GRCm39) N52K probably damaging Het
Catsperg2 A G 7: 29,409,507 (GRCm39) M562T probably benign Het
Cd96 A T 16: 45,929,477 (GRCm39) L156Q probably damaging Het
Clpb A G 7: 101,360,662 (GRCm39) T231A probably damaging Het
Dnaaf9 C A 2: 130,648,708 (GRCm39) R258L unknown Het
Dnmt3a A T 12: 3,922,850 (GRCm39) Q151L probably benign Het
Dock2 C T 11: 34,181,677 (GRCm39) V1629M probably benign Het
Edem1 G A 6: 108,831,341 (GRCm39) D601N probably benign Het
Eno2 C T 6: 124,745,228 (GRCm39) V20M probably damaging Het
Eny2 A C 15: 44,297,250 (GRCm39) D52A probably benign Het
Esp36 T C 17: 38,728,132 (GRCm39) R93G possibly damaging Het
Fam227a A G 15: 79,518,263 (GRCm39) probably null Het
Fat4 C A 3: 39,037,989 (GRCm39) H3880Q possibly damaging Het
Fbxw24 A T 9: 109,434,598 (GRCm39) V334E possibly damaging Het
Flrt1 T C 19: 7,073,329 (GRCm39) Q406R probably benign Het
Frmpd2 A G 14: 33,274,034 (GRCm39) N1092S probably benign Het
Gm904 C A 13: 50,799,287 (GRCm39) T82K probably benign Het
Gnas G C 2: 174,140,408 (GRCm39) G252R unknown Het
Gpatch2l A G 12: 86,307,349 (GRCm39) probably null Het
H2ac6 A T 13: 23,867,593 (GRCm39) I103N probably damaging Het
Ift74 T C 4: 94,541,187 (GRCm39) V204A probably benign Het
Ikzf4 A G 10: 128,477,113 (GRCm39) L119P probably damaging Het
Ing3 G A 6: 21,952,193 (GRCm39) E56K probably damaging Het
Klhl25 T C 7: 75,516,516 (GRCm39) I474T probably benign Het
Klhl5 T C 5: 65,318,529 (GRCm39) V556A probably damaging Het
Krt14 A T 11: 100,095,081 (GRCm39) M382K probably benign Het
Lmcd1 T C 6: 112,292,745 (GRCm39) V199A possibly damaging Het
Lpcat4 T A 2: 112,073,052 (GRCm39) F200I possibly damaging Het
Lrp1b T C 2: 40,894,725 (GRCm39) T2282A Het
Lrrk1 T C 7: 65,911,903 (GRCm39) T1886A probably benign Het
Meis2 T C 2: 115,889,484 (GRCm39) probably null Het
Mki67 C T 7: 135,301,905 (GRCm39) R1043K possibly damaging Het
Myct1 G T 10: 5,554,601 (GRCm39) R156L possibly damaging Het
Nckap5l G T 15: 99,324,090 (GRCm39) H804Q probably damaging Het
Ndst3 T G 3: 123,400,555 (GRCm39) E450D probably damaging Het
Nipbl A T 15: 8,321,619 (GRCm39) probably null Het
Npy A G 6: 49,800,587 (GRCm39) N4D probably benign Het
Or7g35 A T 9: 19,496,487 (GRCm39) Y218F probably damaging Het
Osgin2 T C 4: 16,008,748 (GRCm39) S18G probably benign Het
Pcdha9 T G 18: 37,131,551 (GRCm39) F207V probably benign Het
Pcdhb13 A T 18: 37,577,697 (GRCm39) I692F probably damaging Het
Pde3b T A 7: 114,015,384 (GRCm39) V200E probably damaging Het
Ppp6r3 A T 19: 3,543,981 (GRCm39) L345I probably benign Het
Psd2 G A 18: 36,113,472 (GRCm39) A315T probably damaging Het
Rnf111 G A 9: 70,376,655 (GRCm39) T328I probably damaging Het
Rnf213 T C 11: 119,349,614 (GRCm39) L3825P Het
Rtl1 C T 12: 109,558,909 (GRCm39) V977I probably benign Het
Scn1a G A 2: 66,108,000 (GRCm39) probably null Het
Slc25a2 G T 18: 37,770,748 (GRCm39) N260K probably benign Het
Sprtn T C 8: 125,626,983 (GRCm39) V121A probably damaging Het
Ssx2ip T G 3: 146,133,771 (GRCm39) L260W probably damaging Het
Syde1 G A 10: 78,424,615 (GRCm39) R406C probably damaging Het
Tab1 A G 15: 80,017,372 (GRCm39) R6G probably benign Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Tenm4 G A 7: 96,385,020 (GRCm39) V526I possibly damaging Het
Tfap2b T C 1: 19,304,404 (GRCm39) F405L probably damaging Het
Trbv13-1 C A 6: 41,093,325 (GRCm39) T87K probably benign Het
Trmt44 G T 5: 35,732,130 (GRCm39) A87E probably benign Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Ttn T C 2: 76,617,634 (GRCm39) D16279G probably damaging Het
Ttn G A 2: 76,711,672 (GRCm39) R8290C unknown Het
Ugt2b37 T A 5: 87,402,590 (GRCm39) I14L probably benign Het
Vmn1r13 A T 6: 57,187,611 (GRCm39) M257L probably benign Het
Vmn1r184 C T 7: 25,966,602 (GRCm39) P116L possibly damaging Het
Zfp426 T C 9: 20,381,887 (GRCm39) T367A probably benign Het
Zfp647 A T 15: 76,795,956 (GRCm39) C235S probably damaging Het
Other mutations in Ccdc33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Ccdc33 APN 9 57,977,257 (GRCm39) splice site probably benign
IGL01403:Ccdc33 APN 9 58,024,668 (GRCm39) missense probably damaging 1.00
IGL01411:Ccdc33 APN 9 58,024,919 (GRCm39) splice site probably benign
IGL01714:Ccdc33 APN 9 57,937,153 (GRCm39) missense possibly damaging 0.91
IGL02028:Ccdc33 APN 9 57,983,861 (GRCm39) missense probably benign 0.13
IGL02158:Ccdc33 APN 9 57,937,702 (GRCm39) missense probably damaging 0.99
IGL02174:Ccdc33 APN 9 57,940,938 (GRCm39) missense probably benign 0.45
IGL02805:Ccdc33 APN 9 58,005,874 (GRCm39) missense probably benign 0.43
R0276:Ccdc33 UTSW 9 57,965,675 (GRCm39) missense probably damaging 0.99
R0537:Ccdc33 UTSW 9 58,024,737 (GRCm39) missense probably damaging 1.00
R0737:Ccdc33 UTSW 9 57,989,331 (GRCm39) missense probably damaging 0.99
R0789:Ccdc33 UTSW 9 58,024,497 (GRCm39) splice site probably benign
R0791:Ccdc33 UTSW 9 57,936,046 (GRCm39) missense possibly damaging 0.66
R0920:Ccdc33 UTSW 9 57,940,955 (GRCm39) missense probably damaging 0.99
R1541:Ccdc33 UTSW 9 58,024,749 (GRCm39) missense probably damaging 0.99
R1759:Ccdc33 UTSW 9 58,024,729 (GRCm39) missense possibly damaging 0.84
R1857:Ccdc33 UTSW 9 57,939,991 (GRCm39) missense possibly damaging 0.66
R1976:Ccdc33 UTSW 9 58,024,445 (GRCm39) nonsense probably null
R1982:Ccdc33 UTSW 9 58,024,451 (GRCm39) missense probably benign 0.07
R2044:Ccdc33 UTSW 9 57,938,395 (GRCm39) missense possibly damaging 0.93
R2224:Ccdc33 UTSW 9 57,989,305 (GRCm39) missense probably damaging 1.00
R2225:Ccdc33 UTSW 9 57,989,305 (GRCm39) missense probably damaging 1.00
R2227:Ccdc33 UTSW 9 57,989,305 (GRCm39) missense probably damaging 1.00
R2369:Ccdc33 UTSW 9 57,983,913 (GRCm39) missense probably benign 0.44
R3899:Ccdc33 UTSW 9 57,940,200 (GRCm39) missense probably damaging 0.99
R4468:Ccdc33 UTSW 9 57,977,155 (GRCm39) missense possibly damaging 0.67
R4468:Ccdc33 UTSW 9 57,937,235 (GRCm39) missense possibly damaging 0.93
R4703:Ccdc33 UTSW 9 57,940,953 (GRCm39) missense possibly damaging 0.86
R4705:Ccdc33 UTSW 9 58,024,840 (GRCm39) missense probably benign 0.01
R4790:Ccdc33 UTSW 9 57,937,240 (GRCm39) missense probably damaging 0.96
R4817:Ccdc33 UTSW 9 57,974,818 (GRCm39) missense probably damaging 0.98
R4879:Ccdc33 UTSW 9 57,974,839 (GRCm39) missense possibly damaging 0.86
R4931:Ccdc33 UTSW 9 57,977,134 (GRCm39) missense probably damaging 1.00
R5015:Ccdc33 UTSW 9 58,025,918 (GRCm39) missense probably damaging 1.00
R5223:Ccdc33 UTSW 9 57,940,267 (GRCm39) missense possibly damaging 0.91
R5327:Ccdc33 UTSW 9 57,993,860 (GRCm39) missense probably benign 0.00
R5528:Ccdc33 UTSW 9 57,936,078 (GRCm39) missense probably benign 0.06
R5534:Ccdc33 UTSW 9 58,024,450 (GRCm39) missense possibly damaging 0.83
R5786:Ccdc33 UTSW 9 57,937,235 (GRCm39) missense possibly damaging 0.93
R5844:Ccdc33 UTSW 9 57,940,489 (GRCm39) splice site probably benign
R5975:Ccdc33 UTSW 9 58,024,761 (GRCm39) missense possibly damaging 0.49
R6120:Ccdc33 UTSW 9 57,993,883 (GRCm39) missense probably damaging 1.00
R6256:Ccdc33 UTSW 9 58,009,201 (GRCm39) splice site probably null
R6363:Ccdc33 UTSW 9 58,021,618 (GRCm39) missense probably benign 0.00
R6610:Ccdc33 UTSW 9 57,976,419 (GRCm39) missense possibly damaging 0.66
R6767:Ccdc33 UTSW 9 57,940,527 (GRCm39) missense possibly damaging 0.96
R7072:Ccdc33 UTSW 9 58,019,267 (GRCm39) makesense probably null
R7121:Ccdc33 UTSW 9 57,988,167 (GRCm39) missense probably benign 0.00
R7182:Ccdc33 UTSW 9 57,941,456 (GRCm39) splice site probably null
R7655:Ccdc33 UTSW 9 58,025,748 (GRCm39) missense probably damaging 0.97
R7656:Ccdc33 UTSW 9 58,025,748 (GRCm39) missense probably damaging 0.97
R7868:Ccdc33 UTSW 9 57,976,374 (GRCm39) missense probably benign
R8215:Ccdc33 UTSW 9 57,939,995 (GRCm39) missense probably benign 0.18
R9139:Ccdc33 UTSW 9 57,983,842 (GRCm39) missense probably benign 0.04
R9204:Ccdc33 UTSW 9 57,938,388 (GRCm39) missense probably benign 0.33
R9280:Ccdc33 UTSW 9 57,965,549 (GRCm39) missense probably benign
R9297:Ccdc33 UTSW 9 57,993,876 (GRCm39) missense possibly damaging 0.85
R9318:Ccdc33 UTSW 9 57,993,876 (GRCm39) missense possibly damaging 0.85
R9361:Ccdc33 UTSW 9 58,024,908 (GRCm39) missense possibly damaging 0.96
R9664:Ccdc33 UTSW 9 57,993,855 (GRCm39) missense possibly damaging 0.85
RF003:Ccdc33 UTSW 9 57,965,574 (GRCm39) missense probably benign 0.18
Z1176:Ccdc33 UTSW 9 58,024,699 (GRCm39) missense probably benign 0.01
Z1177:Ccdc33 UTSW 9 58,025,868 (GRCm39) missense possibly damaging 0.56
Predicted Primers PCR Primer
(F):5'- ACCCACCCATGATAGGCTTC -3'
(R):5'- GCTGGAGTAACTCTCATGGATC -3'

Sequencing Primer
(F):5'- CATGATAGGCTTCCCCTGTGG -3'
(R):5'- ATGGATCCCATGTGTGCCC -3'
Posted On 2019-06-26