Incidental Mutation 'R7252:Dchs2'
ID 563976
Institutional Source Beutler Lab
Gene Symbol Dchs2
Ensembl Gene ENSMUSG00000102692
Gene Name dachsous cadherin related 2
Synonyms LOC229459
MMRRC Submission 045385-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.384) question?
Stock # R7252 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 83035255-83264516 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 83232610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 2198 (N2198K)
Ref Sequence ENSEMBL: ENSMUSP00000141425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000191829]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000191829
AA Change: N2198K

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000141425
Gene: ENSMUSG00000102692
AA Change: N2198K

DomainStartEndE-ValueType
low complexity region 11 30 N/A INTRINSIC
CA 70 149 1.6e-8 SMART
CA 173 278 1.9e-9 SMART
CA 302 395 2e-33 SMART
CA 423 522 3.2e-7 SMART
CA 546 642 1.1e-29 SMART
CA 666 750 5.6e-22 SMART
CA 774 855 1.5e-8 SMART
CA 876 958 4.2e-19 SMART
CA 982 1060 3e-8 SMART
CA 1067 1168 9.3e-7 SMART
CA 1192 1271 1.1e-28 SMART
CA 1299 1379 4e-16 SMART
CA 1403 1486 6.1e-16 SMART
CA 1510 1596 3.5e-18 SMART
CA 1619 1700 4.4e-27 SMART
CA 1724 1805 6.4e-27 SMART
CA 1828 1909 4.3e-29 SMART
CA 1933 2014 3.4e-27 SMART
CA 2038 2116 4.2e-7 SMART
CA 2139 2218 2.5e-15 SMART
CA 2242 2323 2.1e-34 SMART
CA 2346 2423 3e-24 SMART
CA 2447 2525 2e-17 SMART
CA 2549 2641 9.8e-16 SMART
CA 2665 2745 2.3e-24 SMART
CA 2769 2856 5.9e-19 SMART
CA 2880 2959 1e-3 SMART
transmembrane domain 2973 2995 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930480E11Rik G T X: 77,414,311 (GRCm39) M345I probably benign Het
Abcc2 T A 19: 43,816,388 (GRCm39) I1226N probably damaging Het
Adarb2 A G 13: 8,620,216 (GRCm39) E234G probably benign Het
Ankrd52 T C 10: 128,217,865 (GRCm39) S282P probably damaging Het
Arhgef12 A T 9: 42,927,205 (GRCm39) S306R probably benign Het
Baiap2 G T 11: 119,893,865 (GRCm39) A514S probably benign Het
BC030500 T A 8: 59,364,838 (GRCm39) probably null Het
C1qtnf12 T A 4: 156,047,072 (GRCm39) W13R unknown Het
Ccdc158 A G 5: 92,798,647 (GRCm39) V351A probably benign Het
Cct8 T C 16: 87,281,807 (GRCm39) E485G probably benign Het
Cep85 T C 4: 133,875,342 (GRCm39) D542G probably benign Het
Clhc1 T A 11: 29,513,937 (GRCm39) S340R probably benign Het
Cnot4 A T 6: 35,046,362 (GRCm39) D168E probably damaging Het
Cntn5 G A 9: 9,831,640 (GRCm39) T375I probably benign Het
Ctc1 T A 11: 68,917,000 (GRCm39) I298N probably damaging Het
Ddx6 G A 9: 44,535,050 (GRCm39) probably null Het
Defb11 A G 8: 22,395,473 (GRCm39) I68T probably benign Het
Dip2a C T 10: 76,109,036 (GRCm39) V1212I not run Het
Dop1a T A 9: 86,382,874 (GRCm39) I269N probably damaging Het
Efna3 C T 3: 89,223,971 (GRCm39) G73S possibly damaging Het
Fam98b C G 2: 117,094,373 (GRCm39) R228G probably damaging Het
Fancd2 A T 6: 113,533,246 (GRCm39) N521I probably damaging Het
Farsa A G 8: 85,587,957 (GRCm39) D134G probably damaging Het
Fat2 A T 11: 55,202,088 (GRCm39) F329I probably damaging Het
Gm14399 A T 2: 174,974,991 (GRCm39) I43K probably damaging Het
Gpr15 A G 16: 58,538,760 (GRCm39) S110P probably damaging Het
Gpr157 T C 4: 150,183,331 (GRCm39) V167A probably benign Het
Hacd4 A G 4: 88,345,000 (GRCm39) I134T possibly damaging Het
Hpgd T A 8: 56,751,461 (GRCm39) N96K probably damaging Het
Insm2 A T 12: 55,647,305 (GRCm39) T350S probably benign Het
Iqch C T 9: 63,419,518 (GRCm39) probably null Het
Kmt2d A G 15: 98,742,147 (GRCm39) S4338P unknown Het
Krtap9-3 A G 11: 99,488,796 (GRCm39) S29P probably benign Het
Kyat3 T A 3: 142,426,219 (GRCm39) S87T probably benign Het
Minar2 A G 18: 59,199,980 (GRCm39) probably null Het
Mrpl46 T C 7: 78,430,336 (GRCm39) T145A probably benign Het
Neb A G 2: 52,214,973 (GRCm39) probably null Het
Or2aj5 A T 16: 19,425,249 (GRCm39) H55Q probably damaging Het
Or4c124 T A 2: 89,156,629 (GRCm39) probably benign Het
Or6x1 C T 9: 40,098,657 (GRCm39) T82I probably benign Het
Or7g17 A G 9: 18,768,548 (GRCm39) Y200C probably damaging Het
Or9a7 A G 6: 40,521,703 (GRCm39) I70T probably benign Het
Otogl T C 10: 107,657,804 (GRCm39) D1042G probably benign Het
Paxip1 C T 5: 27,965,084 (GRCm39) V659I probably damaging Het
Pfkl A G 10: 77,829,263 (GRCm39) W382R probably damaging Het
Pfn1 A G 11: 70,545,297 (GRCm39) W4R probably damaging Het
Pik3c2b G A 1: 133,022,472 (GRCm39) R1138H probably benign Het
Pkd1l3 A G 8: 110,387,330 (GRCm39) D1758G probably benign Het
Pmpca G C 2: 26,285,046 (GRCm39) E424Q possibly damaging Het
Pramel29 T C 4: 143,939,510 (GRCm39) D9G possibly damaging Het
Prdm12 A G 2: 31,532,386 (GRCm39) N132S possibly damaging Het
Prokr2 T A 2: 132,223,360 (GRCm39) M61L probably benign Het
Ralgapa2 T C 2: 146,184,671 (GRCm39) probably null Het
Ralgps1 A T 2: 33,058,200 (GRCm39) D301E probably benign Het
Rcbtb2 T C 14: 73,404,220 (GRCm39) Y231H probably damaging Het
Rcc2 G A 4: 140,429,586 (GRCm39) C40Y probably benign Het
Relb C A 7: 19,346,538 (GRCm39) E345* probably null Het
Rhbdl3 A C 11: 80,228,411 (GRCm39) M294L possibly damaging Het
Rpl24 G A 16: 55,790,479 (GRCm39) A112T possibly damaging Het
Rsbn1l C T 5: 21,113,196 (GRCm39) R442Q probably damaging Het
Rxfp3 A T 15: 11,036,025 (GRCm39) I449N probably benign Het
Sema4c A C 1: 36,589,096 (GRCm39) C677G probably damaging Het
Sf3b3 A C 8: 111,566,562 (GRCm39) I256S probably damaging Het
Shank1 C T 7: 43,976,585 (GRCm39) A561V unknown Het
Slc39a6 G T 18: 24,734,442 (GRCm39) N82K possibly damaging Het
Slc3a2 T C 19: 8,700,521 (GRCm39) probably benign Het
Stard13 T C 5: 150,986,634 (GRCm39) Q292R probably benign Het
Tgm6 A G 2: 129,986,884 (GRCm39) R451G probably damaging Het
Tspo G T 15: 83,456,466 (GRCm39) G83V probably damaging Het
Ubxn10 T C 4: 138,448,187 (GRCm39) Q163R probably benign Het
Ushbp1 A G 8: 71,847,246 (GRCm39) S129P probably benign Het
Vmn2r23 T A 6: 123,718,540 (GRCm39) V631D probably damaging Het
Vmn2r24 T C 6: 123,764,191 (GRCm39) I356T possibly damaging Het
Vmn2r84 C T 10: 130,222,279 (GRCm39) C647Y probably damaging Het
Vps13a T C 19: 16,638,428 (GRCm39) E2356G probably benign Het
Wdr64 A G 1: 175,603,240 (GRCm39) T614A probably benign Het
Zdhhc16 G T 19: 41,929,990 (GRCm39) W271L probably damaging Het
Zer1 A C 2: 29,991,904 (GRCm39) S652A probably damaging Het
Zfp287 A G 11: 62,615,655 (GRCm39) V224A probably damaging Het
Zfp438 A T 18: 5,214,874 (GRCm39) L28* probably null Het
Zfp830 G A 11: 82,655,534 (GRCm39) A113T probably benign Het
Zfp865 G T 7: 5,037,416 (GRCm39) probably benign Het
Other mutations in Dchs2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1707:Dchs2 UTSW 3 83,034,912 (GRCm39) unclassified probably benign
R5857:Dchs2 UTSW 3 83,177,620 (GRCm39) missense possibly damaging 0.79
R5897:Dchs2 UTSW 3 83,192,717 (GRCm39) missense possibly damaging 0.95
R5959:Dchs2 UTSW 3 83,232,725 (GRCm39) missense probably benign 0.01
R6007:Dchs2 UTSW 3 83,253,534 (GRCm39) missense probably damaging 0.99
R6054:Dchs2 UTSW 3 83,253,543 (GRCm39) missense probably benign 0.00
R6059:Dchs2 UTSW 3 83,263,043 (GRCm39) missense probably benign 0.06
R6075:Dchs2 UTSW 3 83,262,368 (GRCm39) missense possibly damaging 0.68
R6379:Dchs2 UTSW 3 83,262,453 (GRCm39) missense probably damaging 1.00
R6393:Dchs2 UTSW 3 83,037,218 (GRCm39) missense probably damaging 1.00
R6405:Dchs2 UTSW 3 83,261,570 (GRCm39) missense probably benign 0.01
R6432:Dchs2 UTSW 3 83,178,425 (GRCm39) missense possibly damaging 0.96
R6434:Dchs2 UTSW 3 83,176,577 (GRCm39) missense probably damaging 1.00
R6561:Dchs2 UTSW 3 83,036,476 (GRCm39) missense probably benign 0.04
R6798:Dchs2 UTSW 3 83,255,593 (GRCm39) missense probably damaging 1.00
R6801:Dchs2 UTSW 3 83,035,841 (GRCm39) missense probably benign 0.00
R6855:Dchs2 UTSW 3 83,255,501 (GRCm39) missense probably benign 0.08
R6956:Dchs2 UTSW 3 83,261,233 (GRCm39) missense probably benign 0.00
R7090:Dchs2 UTSW 3 83,255,581 (GRCm39) missense probably benign 0.03
R7249:Dchs2 UTSW 3 83,035,336 (GRCm39) nonsense probably null
R7462:Dchs2 UTSW 3 83,253,462 (GRCm39) splice site probably null
R7482:Dchs2 UTSW 3 83,156,032 (GRCm39) missense possibly damaging 0.68
R7487:Dchs2 UTSW 3 83,263,613 (GRCm39) missense probably damaging 0.99
R7529:Dchs2 UTSW 3 83,261,705 (GRCm39) missense possibly damaging 0.89
R7542:Dchs2 UTSW 3 83,176,591 (GRCm39) missense probably benign 0.16
R7544:Dchs2 UTSW 3 83,262,434 (GRCm39) missense probably damaging 1.00
R7547:Dchs2 UTSW 3 83,263,434 (GRCm39) missense probably damaging 0.96
R7587:Dchs2 UTSW 3 83,211,822 (GRCm39) missense probably benign
R7632:Dchs2 UTSW 3 83,255,357 (GRCm39) missense probably benign 0.00
R7694:Dchs2 UTSW 3 83,036,789 (GRCm39) missense probably damaging 1.00
R7701:Dchs2 UTSW 3 83,253,513 (GRCm39) missense possibly damaging 0.83
R7746:Dchs2 UTSW 3 83,035,364 (GRCm39) missense possibly damaging 0.94
R7838:Dchs2 UTSW 3 83,211,834 (GRCm39) missense probably benign 0.01
R7886:Dchs2 UTSW 3 83,212,392 (GRCm39) missense probably damaging 1.00
R8055:Dchs2 UTSW 3 83,037,032 (GRCm39) missense probably benign 0.00
R8068:Dchs2 UTSW 3 83,207,745 (GRCm39) missense probably benign 0.12
R8094:Dchs2 UTSW 3 83,262,929 (GRCm39) missense probably benign 0.02
R8160:Dchs2 UTSW 3 83,178,112 (GRCm39) missense probably benign 0.19
R8166:Dchs2 UTSW 3 83,261,640 (GRCm39) missense probably benign 0.28
R8278:Dchs2 UTSW 3 83,178,310 (GRCm39) missense probably damaging 1.00
R8422:Dchs2 UTSW 3 83,232,570 (GRCm39) missense probably benign 0.30
R8506:Dchs2 UTSW 3 83,208,481 (GRCm39) missense probably benign 0.17
R8517:Dchs2 UTSW 3 83,178,419 (GRCm39) missense probably damaging 0.96
R8528:Dchs2 UTSW 3 83,261,918 (GRCm39) missense probably damaging 0.96
R8693:Dchs2 UTSW 3 83,192,631 (GRCm39) missense probably damaging 1.00
R8708:Dchs2 UTSW 3 83,036,049 (GRCm39) missense probably benign 0.00
R8757:Dchs2 UTSW 3 83,261,567 (GRCm39) missense possibly damaging 0.96
R8768:Dchs2 UTSW 3 83,253,592 (GRCm39) missense probably benign 0.12
R8776:Dchs2 UTSW 3 83,263,701 (GRCm39) missense possibly damaging 0.46
R8776-TAIL:Dchs2 UTSW 3 83,263,701 (GRCm39) missense possibly damaging 0.46
R8802:Dchs2 UTSW 3 83,253,544 (GRCm39) missense probably benign 0.01
R8821:Dchs2 UTSW 3 83,192,670 (GRCm39) missense probably benign 0.00
R8831:Dchs2 UTSW 3 83,192,670 (GRCm39) missense probably benign 0.00
R8897:Dchs2 UTSW 3 83,036,720 (GRCm39) missense probably damaging 1.00
R8957:Dchs2 UTSW 3 83,189,573 (GRCm39) missense
R8973:Dchs2 UTSW 3 83,261,763 (GRCm39) missense possibly damaging 0.86
R8991:Dchs2 UTSW 3 83,036,143 (GRCm39) missense probably benign 0.00
R9015:Dchs2 UTSW 3 83,188,751 (GRCm39) missense possibly damaging 0.86
R9051:Dchs2 UTSW 3 83,261,493 (GRCm39) missense probably benign 0.02
R9117:Dchs2 UTSW 3 83,176,662 (GRCm39) missense probably benign 0.31
R9120:Dchs2 UTSW 3 83,187,535 (GRCm39) missense probably damaging 0.99
R9189:Dchs2 UTSW 3 83,255,561 (GRCm39) missense probably damaging 1.00
R9264:Dchs2 UTSW 3 83,177,784 (GRCm39) missense probably damaging 1.00
R9280:Dchs2 UTSW 3 83,189,255 (GRCm39) missense possibly damaging 0.88
R9293:Dchs2 UTSW 3 83,189,361 (GRCm39) missense possibly damaging 0.90
R9322:Dchs2 UTSW 3 83,189,001 (GRCm39) missense possibly damaging 0.73
R9345:Dchs2 UTSW 3 83,036,101 (GRCm39) missense probably benign 0.00
R9408:Dchs2 UTSW 3 83,192,573 (GRCm39) missense probably benign 0.02
R9432:Dchs2 UTSW 3 83,036,032 (GRCm39) missense possibly damaging 0.65
R9445:Dchs2 UTSW 3 83,146,284 (GRCm39) missense probably damaging 0.99
R9466:Dchs2 UTSW 3 83,176,564 (GRCm39) missense probably damaging 1.00
R9612:Dchs2 UTSW 3 83,178,193 (GRCm39) missense probably damaging 0.97
R9622:Dchs2 UTSW 3 83,263,766 (GRCm39) nonsense probably null
R9679:Dchs2 UTSW 3 83,261,697 (GRCm39) missense probably damaging 0.99
R9722:Dchs2 UTSW 3 83,261,301 (GRCm39) missense probably benign 0.01
R9767:Dchs2 UTSW 3 83,212,206 (GRCm39) missense probably benign 0.01
RF012:Dchs2 UTSW 3 83,262,375 (GRCm39) missense probably benign 0.03
Z1177:Dchs2 UTSW 3 83,178,447 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- GCCTACAAATGTTGGAAATCTGC -3'
(R):5'- TCCTAGGTGCTTTGACATACAG -3'

Sequencing Primer
(F):5'- GTTGGAAATCTGCAAATATCCACAAG -3'
(R):5'- GTGATTGACTGGTAACACACATGCAC -3'
Posted On 2019-06-26