Incidental Mutation 'R7257:Rnf123'
| ID |
564345 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rnf123
|
| Ensembl Gene |
ENSMUSG00000041528 |
| Gene Name |
ring finger protein 123 |
| Synonyms |
KPC1 |
| MMRRC Submission |
045318-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.171)
|
| Stock # |
R7257 (G1)
|
| Quality Score |
219.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
107928869-107957183 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 107946228 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 316
(T316S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125745
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047746]
[ENSMUST00000160249]
[ENSMUST00000160649]
[ENSMUST00000161828]
[ENSMUST00000162355]
[ENSMUST00000162516]
[ENSMUST00000174504]
[ENSMUST00000178267]
|
| AlphaFold |
Q5XPI3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047746
AA Change: T316S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000040803
Gene: ENSMUSG00000041528
AA Change: T316S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160249
AA Change: T316S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000124548
Gene: ENSMUSG00000041528
AA Change: T316S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160649
AA Change: T316S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125495
Gene: ENSMUSG00000041528
AA Change: T316S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161828
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162355
AA Change: T316S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125745
Gene: ENSMUSG00000041528
AA Change: T316S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162516
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174504
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000178267
AA Change: T316S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000136953
Gene: ENSMUSG00000041528
AA Change: T316S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.1533 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (77/77) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abtb1 |
A |
T |
6: 88,816,434 (GRCm39) |
V120E |
probably benign |
Het |
| Acot11 |
G |
A |
4: 106,615,599 (GRCm39) |
T284M |
probably damaging |
Het |
| Adk |
G |
T |
14: 21,102,739 (GRCm39) |
K11N |
probably damaging |
Het |
| Akr1c14 |
T |
A |
13: 4,138,966 (GRCm39) |
N316K |
probably benign |
Het |
| AL732309.1 |
A |
T |
2: 25,135,851 (GRCm39) |
V121D |
probably benign |
Het |
| Amh |
C |
A |
10: 80,642,487 (GRCm39) |
Q257K |
probably benign |
Het |
| Antxrl |
T |
G |
14: 33,787,806 (GRCm39) |
H276Q |
probably benign |
Het |
| Atp5po |
G |
A |
16: 91,723,755 (GRCm39) |
T105M |
probably damaging |
Het |
| Atxn2 |
T |
G |
5: 121,923,880 (GRCm39) |
N734K |
possibly damaging |
Het |
| B3gat3 |
T |
A |
19: 8,903,102 (GRCm39) |
V153D |
probably benign |
Het |
| Brd2 |
A |
G |
17: 34,332,796 (GRCm39) |
V528A |
probably damaging |
Het |
| Camk2g |
T |
C |
14: 20,797,907 (GRCm39) |
S335G |
probably benign |
Het |
| Cbln2 |
T |
A |
18: 86,734,859 (GRCm39) |
W211R |
probably damaging |
Het |
| Cry2 |
A |
T |
2: 92,243,326 (GRCm39) |
I505N |
possibly damaging |
Het |
| Ddx55 |
T |
A |
5: 124,698,784 (GRCm39) |
C249S |
possibly damaging |
Het |
| Dglucy |
A |
G |
12: 100,808,997 (GRCm39) |
T232A |
probably damaging |
Het |
| Dhx32 |
A |
G |
7: 133,361,206 (GRCm39) |
Y76H |
probably benign |
Het |
| Dmac2l |
T |
C |
12: 69,788,443 (GRCm39) |
I114T |
probably damaging |
Het |
| Dock7 |
T |
A |
4: 98,861,649 (GRCm39) |
N1356I |
unknown |
Het |
| Dock8 |
T |
A |
19: 25,104,449 (GRCm39) |
N710K |
probably benign |
Het |
| Dync1i2 |
T |
A |
2: 71,079,700 (GRCm39) |
N391K |
possibly damaging |
Het |
| Ect2 |
A |
G |
3: 27,192,684 (GRCm39) |
S420P |
probably damaging |
Het |
| Efcab5 |
T |
A |
11: 77,028,605 (GRCm39) |
E242V |
probably damaging |
Het |
| Fam83g |
T |
A |
11: 61,575,579 (GRCm39) |
Y74N |
probably damaging |
Het |
| Fbxo34 |
T |
A |
14: 47,738,329 (GRCm39) |
|
probably null |
Het |
| Flt4 |
A |
G |
11: 49,516,836 (GRCm39) |
T208A |
probably benign |
Het |
| Fxyd5 |
T |
A |
7: 30,734,576 (GRCm39) |
H183L |
unknown |
Het |
| Gpr150 |
T |
G |
13: 76,204,585 (GRCm39) |
D120A |
probably benign |
Het |
| Grm7 |
A |
G |
6: 110,623,079 (GRCm39) |
Y84C |
probably damaging |
Het |
| Ighmbp2 |
A |
G |
19: 3,316,405 (GRCm39) |
S562P |
probably damaging |
Het |
| Itga7 |
A |
G |
10: 128,780,282 (GRCm39) |
Y530C |
possibly damaging |
Het |
| Itpr3 |
T |
A |
17: 27,337,535 (GRCm39) |
D2448E |
probably benign |
Het |
| Mmp17 |
C |
A |
5: 129,672,697 (GRCm39) |
H216Q |
probably benign |
Het |
| Mns1 |
C |
T |
9: 72,360,097 (GRCm39) |
R416W |
probably damaging |
Het |
| Mog |
A |
G |
17: 37,334,019 (GRCm39) |
S25P |
unknown |
Het |
| Myh2 |
A |
G |
11: 67,071,976 (GRCm39) |
K568R |
possibly damaging |
Het |
| Myh7 |
A |
T |
14: 55,209,947 (GRCm39) |
|
probably null |
Het |
| Mymk |
A |
T |
2: 26,957,380 (GRCm39) |
W79R |
probably damaging |
Het |
| Ncoa4 |
T |
G |
14: 31,899,326 (GRCm39) |
L623R |
probably damaging |
Het |
| Oca2 |
G |
A |
7: 55,929,286 (GRCm39) |
|
probably benign |
Het |
| Odam |
A |
C |
5: 88,035,404 (GRCm39) |
S123R |
probably benign |
Het |
| Or14c39 |
T |
A |
7: 86,344,012 (GRCm39) |
M116K |
probably damaging |
Het |
| Or2w1 |
A |
G |
13: 21,317,427 (GRCm39) |
T161A |
probably benign |
Het |
| Or51f1d |
T |
C |
7: 102,700,837 (GRCm39) |
F111L |
probably benign |
Het |
| Or5d16 |
A |
G |
2: 87,773,915 (GRCm39) |
F19S |
probably damaging |
Het |
| Or6c69 |
T |
A |
10: 129,748,156 (GRCm39) |
|
probably benign |
Het |
| Or6c8b |
C |
T |
10: 128,882,324 (GRCm39) |
V203M |
probably benign |
Het |
| Ovch2 |
C |
T |
7: 107,393,640 (GRCm39) |
C162Y |
probably damaging |
Het |
| Padi1 |
C |
A |
4: 140,556,782 (GRCm39) |
G142C |
probably damaging |
Het |
| Pcdhga4 |
A |
G |
18: 37,820,451 (GRCm39) |
I667V |
probably damaging |
Het |
| Pfas |
A |
T |
11: 68,883,785 (GRCm39) |
V624E |
probably damaging |
Het |
| Phb1 |
A |
T |
11: 95,568,917 (GRCm39) |
E184V |
probably damaging |
Het |
| Phlpp2 |
G |
T |
8: 110,666,820 (GRCm39) |
M1116I |
probably benign |
Het |
| Pip5kl1 |
T |
C |
2: 32,470,443 (GRCm39) |
|
probably null |
Het |
| Pitpnm2 |
T |
A |
5: 124,263,419 (GRCm39) |
I824F |
possibly damaging |
Het |
| Pla2g4c |
G |
A |
7: 13,059,669 (GRCm39) |
S2N |
possibly damaging |
Het |
| Pla2r1 |
A |
T |
2: 60,257,969 (GRCm39) |
|
probably null |
Het |
| Pole2 |
T |
C |
12: 69,249,684 (GRCm39) |
D521G |
probably damaging |
Het |
| Ptch1 |
T |
C |
13: 63,721,108 (GRCm39) |
K54E |
not run |
Het |
| Rapgef2 |
A |
T |
3: 78,989,934 (GRCm39) |
L931Q |
probably damaging |
Het |
| Rassf3 |
G |
A |
10: 121,248,924 (GRCm39) |
Q206* |
probably null |
Het |
| Rnf138 |
T |
A |
18: 21,141,750 (GRCm39) |
|
probably null |
Het |
| Septin3 |
G |
A |
15: 82,173,414 (GRCm39) |
A249T |
probably damaging |
Het |
| Slc35a4 |
A |
T |
18: 36,812,669 (GRCm39) |
D3V |
unknown |
Het |
| Sltm |
T |
A |
9: 70,451,247 (GRCm39) |
|
probably null |
Het |
| Smarca2 |
C |
T |
19: 26,631,864 (GRCm39) |
Q560* |
probably null |
Het |
| Tcl1b1 |
A |
T |
12: 105,130,790 (GRCm39) |
D91V |
probably damaging |
Het |
| Tirap |
A |
T |
9: 35,100,330 (GRCm39) |
V118E |
probably damaging |
Het |
| Tlr5 |
T |
A |
1: 182,801,798 (GRCm39) |
Y367* |
probably null |
Het |
| Tmcc1 |
A |
G |
6: 116,084,299 (GRCm39) |
F5L |
probably benign |
Het |
| Tnxb |
A |
G |
17: 34,935,475 (GRCm39) |
M2592V |
probably benign |
Het |
| Trim66 |
T |
A |
7: 109,059,451 (GRCm39) |
E931V |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,571,438 (GRCm39) |
I26485T |
probably damaging |
Het |
| Veph1 |
C |
A |
3: 66,065,703 (GRCm39) |
V455L |
probably benign |
Het |
| Vmn1r125 |
A |
T |
7: 21,006,750 (GRCm39) |
H216L |
probably damaging |
Het |
| Wdr17 |
T |
A |
8: 55,085,522 (GRCm39) |
E1200D |
probably benign |
Het |
| Zbtb37 |
T |
A |
1: 160,860,231 (GRCm39) |
N25Y |
probably damaging |
Het |
|
| Other mutations in Rnf123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00950:Rnf123
|
APN |
9 |
107,944,594 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01358:Rnf123
|
APN |
9 |
107,946,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01464:Rnf123
|
APN |
9 |
107,929,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01637:Rnf123
|
APN |
9 |
107,935,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01669:Rnf123
|
APN |
9 |
107,935,555 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01905:Rnf123
|
APN |
9 |
107,948,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL02070:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02072:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02073:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02074:Rnf123
|
APN |
9 |
107,944,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02079:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02231:Rnf123
|
APN |
9 |
107,943,598 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02281:Rnf123
|
APN |
9 |
107,948,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02336:Rnf123
|
APN |
9 |
107,939,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Rnf123
|
APN |
9 |
107,943,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02565:Rnf123
|
APN |
9 |
107,929,411 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02571:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02572:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02574:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02586:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02589:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02600:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02601:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02602:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02603:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02609:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02628:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,947,988 (GRCm39) |
splice site |
probably benign |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02630:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02631:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02632:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02650:Rnf123
|
APN |
9 |
107,946,947 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02690:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02691:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02692:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02693:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02713:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02736:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02929:Rnf123
|
APN |
9 |
107,946,275 (GRCm39) |
missense |
probably benign |
|
|
R1175:Rnf123
|
UTSW |
9 |
107,954,572 (GRCm39) |
missense |
probably benign |
|
|
R1465:Rnf123
|
UTSW |
9 |
107,948,665 (GRCm39) |
splice site |
probably benign |
|
|
R1502:Rnf123
|
UTSW |
9 |
107,945,709 (GRCm39) |
splice site |
probably null |
|
|
R1682:Rnf123
|
UTSW |
9 |
107,954,597 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1817:Rnf123
|
UTSW |
9 |
107,940,125 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1855:Rnf123
|
UTSW |
9 |
107,938,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2394:Rnf123
|
UTSW |
9 |
107,940,735 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2483:Rnf123
|
UTSW |
9 |
107,940,720 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3896:Rnf123
|
UTSW |
9 |
107,946,302 (GRCm39) |
splice site |
probably benign |
|
|
R3940:Rnf123
|
UTSW |
9 |
107,941,234 (GRCm39) |
splice site |
probably benign |
|
|
R4206:Rnf123
|
UTSW |
9 |
107,941,162 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4641:Rnf123
|
UTSW |
9 |
107,935,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Rnf123
|
UTSW |
9 |
107,929,638 (GRCm39) |
splice site |
probably null |
|
|
R4767:Rnf123
|
UTSW |
9 |
107,929,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Rnf123
|
UTSW |
9 |
107,933,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Rnf123
|
UTSW |
9 |
107,940,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5274:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5275:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5276:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5294:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5295:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5394:Rnf123
|
UTSW |
9 |
107,947,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5717:Rnf123
|
UTSW |
9 |
107,944,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6186:Rnf123
|
UTSW |
9 |
107,947,157 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6449:Rnf123
|
UTSW |
9 |
107,933,252 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6502:Rnf123
|
UTSW |
9 |
107,945,531 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6944:Rnf123
|
UTSW |
9 |
107,940,822 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7003:Rnf123
|
UTSW |
9 |
107,940,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7088:Rnf123
|
UTSW |
9 |
107,935,735 (GRCm39) |
missense |
probably null |
1.00 |
|
R7092:Rnf123
|
UTSW |
9 |
107,945,799 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7100:Rnf123
|
UTSW |
9 |
107,933,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Rnf123
|
UTSW |
9 |
107,947,607 (GRCm39) |
splice site |
probably null |
|
|
R7468:Rnf123
|
UTSW |
9 |
107,946,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7517:Rnf123
|
UTSW |
9 |
107,947,473 (GRCm39) |
nonsense |
probably null |
|
|
R7577:Rnf123
|
UTSW |
9 |
107,947,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Rnf123
|
UTSW |
9 |
107,940,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Rnf123
|
UTSW |
9 |
107,945,706 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8754:Rnf123
|
UTSW |
9 |
107,948,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Rnf123
|
UTSW |
9 |
107,946,272 (GRCm39) |
missense |
probably benign |
|
|
R9052:Rnf123
|
UTSW |
9 |
107,936,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9156:Rnf123
|
UTSW |
9 |
107,940,227 (GRCm39) |
splice site |
probably benign |
|
|
R9170:Rnf123
|
UTSW |
9 |
107,948,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9332:Rnf123
|
UTSW |
9 |
107,944,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9385:Rnf123
|
UTSW |
9 |
107,929,467 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9394:Rnf123
|
UTSW |
9 |
107,942,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Rnf123
|
UTSW |
9 |
107,937,008 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9717:Rnf123
|
UTSW |
9 |
107,954,963 (GRCm39) |
missense |
probably benign |
0.43 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,940,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,935,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTTCCTTAGCCTGGGACATC -3'
(R):5'- TCCAGGCAGTGCTAAGTGTG -3'
Sequencing Primer
(F):5'- TTCCTTAGCCTGGGACATCACAAC -3'
(R):5'- TAAGTGTGGAGCTGGACCC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation