Incidental Mutation 'R7265:Myo1g'
ID 564882
Institutional Source Beutler Lab
Gene Symbol Myo1g
Ensembl Gene ENSMUSG00000020437
Gene Name myosin IG
Synonyms E430002D17Rik
MMRRC Submission 045355-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7265 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 6456548-6470960 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 6460933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 704 (T704A)
Ref Sequence ENSEMBL: ENSMUSP00000003459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003459] [ENSMUST00000144725]
AlphaFold Q5SUA5
Predicted Effect possibly damaging
Transcript: ENSMUST00000003459
AA Change: T704A

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000003459
Gene: ENSMUSG00000020437
AA Change: T704A

DomainStartEndE-ValueType
MYSc 9 714 N/A SMART
IQ 715 737 2.79e0 SMART
Pfam:Myosin_TH1 821 1024 2.8e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144725
SMART Domains Protein: ENSMUSP00000120975
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Blast:MYSc 9 43 8e-14 BLAST
low complexity region 48 60 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced B cell spreading, migration and homing and impaired T cell motility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb3 A G 11: 30,948,495 (GRCm39) E57G probably benign Het
B3glct A G 5: 149,632,785 (GRCm39) D45G probably benign Het
BC034090 C A 1: 155,101,073 (GRCm39) C397F probably damaging Het
Bicd1 A G 6: 149,415,374 (GRCm39) K696E probably damaging Het
Btnl4 C T 17: 34,694,868 (GRCm39) C15Y probably benign Het
Cabin1 T C 10: 75,557,257 (GRCm39) N300S Het
Chia1 T A 3: 106,036,239 (GRCm39) L273Q probably damaging Het
Coq2 A G 5: 100,808,136 (GRCm39) S222P possibly damaging Het
Dgkb T C 12: 38,234,931 (GRCm39) V432A possibly damaging Het
Dpp3 A G 19: 4,973,797 (GRCm39) F92S probably damaging Het
Elapor2 T C 5: 9,496,975 (GRCm39) V813A possibly damaging Het
Emcn T C 3: 137,122,839 (GRCm39) S183P probably damaging Het
Emcn T A 3: 137,124,837 (GRCm39) W217R probably damaging Het
Enpp2 A C 15: 54,773,429 (GRCm39) probably null Het
Epb41 T C 4: 131,695,145 (GRCm39) E14G unknown Het
Fhip1b G T 7: 105,033,432 (GRCm39) R609S probably benign Het
Grk4 A G 5: 34,873,608 (GRCm39) R225G probably damaging Het
Insl6 A T 19: 29,298,945 (GRCm39) W156R possibly damaging Het
Ints3 A T 3: 90,311,290 (GRCm39) probably null Het
Jarid2 G A 13: 45,055,748 (GRCm39) G318D probably benign Het
Kif16b A T 2: 142,556,650 (GRCm39) L596H probably damaging Het
Lctl T A 9: 64,034,203 (GRCm39) Y281N probably damaging Het
Letm1 A T 5: 33,935,992 (GRCm39) C34S possibly damaging Het
Lrrc32 T C 7: 98,148,644 (GRCm39) S475P probably damaging Het
Lrrc37a T A 11: 103,389,767 (GRCm39) D1886V probably benign Het
Macf1 A T 4: 123,301,670 (GRCm39) I944K probably benign Het
Mark4 T C 7: 19,185,650 (GRCm39) D28G probably benign Het
Mecom C A 3: 30,034,282 (GRCm39) A465S possibly damaging Het
Muc16 A G 9: 18,567,768 (GRCm39) S1584P unknown Het
Mycbp2 A G 14: 103,434,679 (GRCm39) probably null Het
Myo18b G A 5: 112,959,938 (GRCm39) R1372W probably damaging Het
Myo1c T C 11: 75,560,616 (GRCm39) I706T possibly damaging Het
Nwd1 A G 8: 73,419,556 (GRCm39) K914E probably benign Het
Or5ac20 T A 16: 59,104,287 (GRCm39) D191V probably damaging Het
Or8b101 A T 9: 38,020,227 (GRCm39) I77L possibly damaging Het
Or8k23 C T 2: 86,186,088 (GRCm39) V213I probably benign Het
Otub2 C T 12: 103,366,480 (GRCm39) S99L probably damaging Het
Pak5 G A 2: 135,943,105 (GRCm39) S345L probably benign Het
Pcdhb20 A T 18: 37,638,616 (GRCm39) I381F possibly damaging Het
Pcdhga7 A G 18: 37,849,969 (GRCm39) T659A probably damaging Het
Phf8-ps G A 17: 33,285,971 (GRCm39) T277I probably damaging Het
Pik3c2a T A 7: 115,987,321 (GRCm39) K533N probably damaging Het
Pkd1l1 T A 11: 8,879,402 (GRCm39) Q933L Het
Ppp4r3a A T 12: 101,019,770 (GRCm39) M395K possibly damaging Het
Pramel11 C A 4: 143,621,991 (GRCm39) V455L probably benign Het
Ptpn20 A G 14: 33,336,481 (GRCm39) T107A probably benign Het
Scaf8 T A 17: 3,227,900 (GRCm39) D376E unknown Het
Scn11a C A 9: 119,644,331 (GRCm39) C143F probably damaging Het
Sctr G A 1: 119,949,955 (GRCm39) R48Q probably benign Het
Sec13 A T 6: 113,712,097 (GRCm39) Y79* probably null Het
Sez6 T A 11: 77,853,691 (GRCm39) I287N probably damaging Het
Slc52a3 T A 2: 151,846,336 (GRCm39) I99K possibly damaging Het
Slco4c1 T G 1: 96,799,518 (GRCm39) H106P probably damaging Het
Tada2b A G 5: 36,633,952 (GRCm39) Y209H probably damaging Het
Tas1r2 T A 4: 139,396,963 (GRCm39) D796E probably benign Het
Tdrd12 A T 7: 35,187,147 (GRCm39) M581K Het
Thnsl1 A G 2: 21,217,269 (GRCm39) E341G probably damaging Het
Tlk2 C T 11: 105,075,070 (GRCm39) R11* probably null Het
Tmco6 T C 18: 36,872,396 (GRCm39) probably null Het
Trmt44 A T 5: 35,721,647 (GRCm39) H505Q probably benign Het
Trpc1 T C 9: 95,590,328 (GRCm39) M710V probably benign Het
Ttc21b T C 2: 66,040,517 (GRCm39) E858G possibly damaging Het
Twsg1 C T 17: 66,236,782 (GRCm39) D83N possibly damaging Het
Umod G T 7: 119,065,296 (GRCm39) Q578K probably benign Het
Vmn2r6 T C 3: 64,464,195 (GRCm39) N213S probably benign Het
Vmn2r88 G A 14: 51,655,776 (GRCm39) V662I Het
Zfp414 C A 17: 33,850,253 (GRCm39) D217E probably benign Het
Other mutations in Myo1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Myo1g APN 11 6,465,856 (GRCm39) missense possibly damaging 0.70
IGL01608:Myo1g APN 11 6,466,780 (GRCm39) missense possibly damaging 0.61
IGL01679:Myo1g APN 11 6,468,006 (GRCm39) missense possibly damaging 0.90
IGL01830:Myo1g APN 11 6,464,522 (GRCm39) nonsense probably null
IGL02332:Myo1g APN 11 6,470,766 (GRCm39) missense possibly damaging 0.61
IGL02813:Myo1g APN 11 6,468,743 (GRCm39) makesense probably null
IGL02988:Myo1g APN 11 6,458,183 (GRCm39) splice site probably benign
IGL03178:Myo1g APN 11 6,462,181 (GRCm39) missense probably damaging 1.00
R0004:Myo1g UTSW 11 6,465,901 (GRCm39) missense probably damaging 1.00
R0334:Myo1g UTSW 11 6,461,084 (GRCm39) splice site probably benign
R0513:Myo1g UTSW 11 6,460,203 (GRCm39) missense probably benign 0.00
R0730:Myo1g UTSW 11 6,470,794 (GRCm39) missense probably damaging 1.00
R1054:Myo1g UTSW 11 6,468,987 (GRCm39) missense probably damaging 1.00
R1434:Myo1g UTSW 11 6,459,372 (GRCm39) missense probably benign 0.00
R1500:Myo1g UTSW 11 6,470,811 (GRCm39) missense probably benign
R1513:Myo1g UTSW 11 6,465,140 (GRCm39) missense probably damaging 0.99
R1720:Myo1g UTSW 11 6,462,490 (GRCm39) missense probably benign 0.44
R1774:Myo1g UTSW 11 6,465,988 (GRCm39) missense probably damaging 1.00
R1809:Myo1g UTSW 11 6,462,283 (GRCm39) missense probably benign 0.02
R1957:Myo1g UTSW 11 6,462,159 (GRCm39) critical splice donor site probably null
R1978:Myo1g UTSW 11 6,470,829 (GRCm39) missense possibly damaging 0.53
R2212:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R2438:Myo1g UTSW 11 6,461,542 (GRCm39) missense probably damaging 1.00
R2566:Myo1g UTSW 11 6,462,539 (GRCm39) critical splice acceptor site probably null
R3158:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3159:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3413:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R3816:Myo1g UTSW 11 6,460,926 (GRCm39) missense probably benign 0.02
R3872:Myo1g UTSW 11 6,464,886 (GRCm39) missense possibly damaging 0.94
R3946:Myo1g UTSW 11 6,470,760 (GRCm39) missense possibly damaging 0.89
R4551:Myo1g UTSW 11 6,467,874 (GRCm39) missense probably damaging 1.00
R4625:Myo1g UTSW 11 6,462,240 (GRCm39) missense probably damaging 1.00
R4630:Myo1g UTSW 11 6,469,047 (GRCm39) missense probably damaging 1.00
R4700:Myo1g UTSW 11 6,466,785 (GRCm39) splice site probably null
R4713:Myo1g UTSW 11 6,466,080 (GRCm39) missense probably null 1.00
R4964:Myo1g UTSW 11 6,465,976 (GRCm39) missense probably damaging 1.00
R5183:Myo1g UTSW 11 6,458,243 (GRCm39) missense probably damaging 1.00
R5191:Myo1g UTSW 11 6,465,105 (GRCm39) missense probably benign
R5192:Myo1g UTSW 11 6,464,816 (GRCm39) missense probably damaging 1.00
R5726:Myo1g UTSW 11 6,459,420 (GRCm39) missense probably benign 0.06
R5841:Myo1g UTSW 11 6,457,000 (GRCm39) missense probably benign 0.05
R5942:Myo1g UTSW 11 6,464,888 (GRCm39) missense probably damaging 1.00
R6225:Myo1g UTSW 11 6,469,168 (GRCm39) missense probably damaging 1.00
R6517:Myo1g UTSW 11 6,462,509 (GRCm39) missense probably damaging 0.99
R6563:Myo1g UTSW 11 6,467,146 (GRCm39) missense possibly damaging 0.91
R7214:Myo1g UTSW 11 6,461,055 (GRCm39) missense probably damaging 1.00
R7258:Myo1g UTSW 11 6,459,416 (GRCm39) missense possibly damaging 0.92
R7750:Myo1g UTSW 11 6,464,849 (GRCm39) missense probably damaging 1.00
R8683:Myo1g UTSW 11 6,467,569 (GRCm39) critical splice donor site probably null
R8910:Myo1g UTSW 11 6,468,009 (GRCm39) missense possibly damaging 0.66
R9035:Myo1g UTSW 11 6,464,916 (GRCm39) missense probably damaging 1.00
R9103:Myo1g UTSW 11 6,466,153 (GRCm39) missense possibly damaging 0.88
R9162:Myo1g UTSW 11 6,460,897 (GRCm39) missense probably damaging 0.98
R9487:Myo1g UTSW 11 6,456,913 (GRCm39) missense probably benign
X0017:Myo1g UTSW 11 6,466,077 (GRCm39) critical splice donor site probably null
X0061:Myo1g UTSW 11 6,467,967 (GRCm39) missense probably damaging 1.00
Z1176:Myo1g UTSW 11 6,469,045 (GRCm39) missense probably damaging 1.00
Z1177:Myo1g UTSW 11 6,467,935 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAACATCCTACAAGCCAGG -3'
(R):5'- ACTGCCTGATGCCAAGTACC -3'

Sequencing Primer
(F):5'- CATGGCTTCAAGATATCAGGAACGC -3'
(R):5'- AAGTACCACCATCATGTCCTGTGG -3'
Posted On 2019-06-26