Incidental Mutation 'R7266:Zswim3'
ID 564915
Institutional Source Beutler Lab
Gene Symbol Zswim3
Ensembl Gene ENSMUSG00000045822
Gene Name zinc finger SWIM-type containing 3
Synonyms 4921517A06Rik
MMRRC Submission 045389-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R7266 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 164647034-164664047 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 164662402 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 294 (I294T)
Ref Sequence ENSEMBL: ENSMUSP00000050970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017908] [ENSMUST00000052107] [ENSMUST00000132282]
AlphaFold Q8CFL8
Predicted Effect probably benign
Transcript: ENSMUST00000017908
SMART Domains Protein: ENSMUSP00000017908
Gene: ENSMUSG00000017764

DomainStartEndE-ValueType
Pfam:SWIM 342 375 2e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000052107
AA Change: I294T

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050970
Gene: ENSMUSG00000045822
AA Change: I294T

DomainStartEndE-ValueType
low complexity region 436 453 N/A INTRINSIC
low complexity region 474 489 N/A INTRINSIC
ZnF_PMZ 546 573 2.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132282
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T A 8: 25,157,639 (GRCm39) I104F probably benign Het
Adgrg7 C T 16: 56,590,674 (GRCm39) V166I probably benign Het
Agfg1 G T 1: 82,859,966 (GRCm39) V278L probably benign Het
Alpk3 A G 7: 80,742,328 (GRCm39) E715G possibly damaging Het
Ap2m1 A G 16: 20,362,095 (GRCm39) Y401C probably damaging Het
Arhgef28 C T 13: 98,101,960 (GRCm39) S838N probably benign Het
Ash2l A T 8: 26,317,233 (GRCm39) Y373* probably null Het
Best2 C T 8: 85,734,393 (GRCm39) V442I probably benign Het
Col4a2 T C 8: 11,475,542 (GRCm39) probably null Het
Fat2 T A 11: 55,175,856 (GRCm39) D1619V probably damaging Het
Fer1l6 A T 15: 58,499,446 (GRCm39) N1272I probably benign Het
Gcc1 T A 6: 28,417,995 (GRCm39) *779C probably null Het
Gm12216 G A 11: 53,750,077 (GRCm39) probably benign Het
Grm2 C T 9: 106,524,370 (GRCm39) V311I Het
Immt T A 6: 71,851,689 (GRCm39) D683E probably benign Het
Itga8 T G 2: 12,237,712 (GRCm39) D336A probably damaging Het
Jhy T C 9: 40,872,453 (GRCm39) T19A probably benign Het
Kcnq2 T C 2: 180,776,885 (GRCm39) M1V probably null Het
Kctd17 A T 15: 78,317,214 (GRCm39) I117F probably damaging Het
Lrp6 T C 6: 134,484,364 (GRCm39) T420A probably damaging Het
Manba T C 3: 135,223,673 (GRCm39) S187P probably damaging Het
Mef2b A T 8: 70,616,938 (GRCm39) D13V probably damaging Het
Mical2 T C 7: 111,902,963 (GRCm39) F145L probably damaging Het
Mphosph8 T A 14: 56,922,497 (GRCm39) D551E possibly damaging Het
Mplkipl1 A G 19: 61,163,973 (GRCm39) V154A possibly damaging Het
Myo10 C G 15: 25,783,067 (GRCm39) R1170G probably damaging Het
Myo16 A C 8: 10,322,687 (GRCm39) Q39P unknown Het
Myo1f A G 17: 33,820,668 (GRCm39) E837G probably benign Het
Nell2 T A 15: 95,333,274 (GRCm39) I128F possibly damaging Het
Or1i2 A G 10: 78,448,448 (GRCm39) V9A probably benign Het
Pcdh15 A T 10: 74,215,222 (GRCm39) R659* probably null Het
Pcdhga1 A G 18: 37,973,028 (GRCm39) Q881R possibly damaging Het
Plekhm2 T G 4: 141,369,770 (GRCm39) E75A possibly damaging Het
Prc1 A G 7: 79,957,405 (GRCm39) K357E possibly damaging Het
Pxk T A 14: 8,146,220 (GRCm38) C377S probably benign Het
Ralgapa2 T C 2: 146,176,488 (GRCm39) E1696G probably damaging Het
Rbbp6 T A 7: 122,600,590 (GRCm39) S1532R unknown Het
Scn5a G T 9: 119,391,626 (GRCm39) A22E probably benign Het
Sctr G A 1: 119,949,955 (GRCm39) R48Q probably benign Het
Siae T C 9: 37,534,309 (GRCm39) V115A probably damaging Het
Slc16a6 A G 11: 109,344,107 (GRCm39) C563R probably benign Het
Sntg1 A C 1: 8,752,243 (GRCm39) V58G possibly damaging Het
Snx11 C T 11: 96,663,985 (GRCm39) V36M probably damaging Het
Stk3 C A 15: 34,959,182 (GRCm39) S330I probably benign Het
Synpo A G 18: 60,762,631 (GRCm39) F92S probably benign Het
Tle1 A G 4: 72,057,924 (GRCm39) probably null Het
Tmem117 A G 15: 94,829,684 (GRCm39) D173G possibly damaging Het
Tmem217b C A 17: 29,738,347 (GRCm39) V140L probably benign Het
Tmprss5 T C 9: 49,025,841 (GRCm39) W338R probably benign Het
Tnfrsf19 T C 14: 61,212,147 (GRCm39) T168A possibly damaging Het
Trhde C T 10: 114,636,776 (GRCm39) G144S possibly damaging Het
Trim56 G T 5: 137,143,097 (GRCm39) Q140K probably damaging Het
Ttn C T 2: 76,562,918 (GRCm39) V28679M probably damaging Het
Ubxn8 G A 8: 34,113,231 (GRCm39) R208C probably damaging Het
Vmn2r72 G T 7: 85,387,482 (GRCm39) S694* probably null Het
Wdr38 T A 2: 38,890,276 (GRCm39) W137R probably damaging Het
Zdhhc6 G T 19: 55,292,932 (GRCm39) N271K probably damaging Het
Zfyve9 A G 4: 108,575,744 (GRCm39) S446P possibly damaging Het
Zmynd8 T C 2: 165,649,492 (GRCm39) Q867R possibly damaging Het
Other mutations in Zswim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Zswim3 APN 2 164,663,011 (GRCm39) missense probably damaging 1.00
IGL01345:Zswim3 APN 2 164,662,057 (GRCm39) missense probably damaging 1.00
IGL01608:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01621:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01634:Zswim3 APN 2 164,661,922 (GRCm39) missense probably damaging 0.99
IGL02165:Zswim3 APN 2 164,663,035 (GRCm39) missense possibly damaging 0.94
IGL02173:Zswim3 APN 2 164,662,759 (GRCm39) missense probably damaging 1.00
IGL02336:Zswim3 APN 2 164,662,297 (GRCm39) missense probably damaging 0.98
IGL02379:Zswim3 APN 2 164,662,602 (GRCm39) splice site probably null
R0321:Zswim3 UTSW 2 164,662,279 (GRCm39) missense possibly damaging 0.83
R1489:Zswim3 UTSW 2 164,661,901 (GRCm39) missense probably benign 0.00
R2126:Zswim3 UTSW 2 164,661,913 (GRCm39) missense probably benign 0.31
R2176:Zswim3 UTSW 2 164,662,614 (GRCm39) missense probably benign 0.08
R2859:Zswim3 UTSW 2 164,662,309 (GRCm39) missense probably damaging 1.00
R3853:Zswim3 UTSW 2 164,662,777 (GRCm39) missense possibly damaging 0.61
R4434:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4435:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4436:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4438:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4805:Zswim3 UTSW 2 164,662,099 (GRCm39) missense possibly damaging 0.52
R5874:Zswim3 UTSW 2 164,662,032 (GRCm39) missense probably benign 0.06
R6417:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6420:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6722:Zswim3 UTSW 2 164,662,544 (GRCm39) splice site probably null
R6786:Zswim3 UTSW 2 164,662,771 (GRCm39) missense probably damaging 1.00
R7467:Zswim3 UTSW 2 164,661,795 (GRCm39) missense possibly damaging 0.59
R7487:Zswim3 UTSW 2 164,662,135 (GRCm39) missense probably damaging 0.99
R7788:Zswim3 UTSW 2 164,661,699 (GRCm39) missense probably damaging 1.00
R8191:Zswim3 UTSW 2 164,662,128 (GRCm39) missense probably damaging 1.00
R8308:Zswim3 UTSW 2 164,663,566 (GRCm39) missense probably damaging 1.00
R8794:Zswim3 UTSW 2 164,662,687 (GRCm39) missense probably damaging 0.98
R9353:Zswim3 UTSW 2 164,662,261 (GRCm39) missense probably damaging 1.00
R9527:Zswim3 UTSW 2 164,662,285 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGCCAGGGCCATATTCTG -3'
(R):5'- GAGTTCCTCATCTAGTAGGACTTGG -3'

Sequencing Primer
(F):5'- AGCCAGGGCCATATTCTGTATGC -3'
(R):5'- CTAGTAGGACTTGGGACATCTCAC -3'
Posted On 2019-06-26