Incidental Mutation 'R7266:Tnfrsf19'
ID 564953
Institutional Source Beutler Lab
Gene Symbol Tnfrsf19
Ensembl Gene ENSMUSG00000060548
Gene Name tumor necrosis factor receptor superfamily, member 19
Synonyms TAJ, TRADE, TAJ-ALPHA, Troy
MMRRC Submission 045389-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7266 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 61201324-61283939 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 61212147 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 168 (T168A)
Ref Sequence ENSEMBL: ENSMUSP00000106865 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111234] [ENSMUST00000111236] [ENSMUST00000224371] [ENSMUST00000225730]
AlphaFold Q9JLL3
Predicted Effect possibly damaging
Transcript: ENSMUST00000111234
AA Change: T168A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000106865
Gene: ENSMUSG00000060548
AA Change: T168A

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
TNFR 34 72 1.75e0 SMART
TNFR 75 114 3.32e-1 SMART
transmembrane domain 169 191 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000111236
AA Change: T168A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000106867
Gene: ENSMUSG00000060548
AA Change: T168A

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
TNFR 34 72 1.75e0 SMART
TNFR 75 114 3.32e-1 SMART
transmembrane domain 169 191 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224371
AA Change: T168A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000225730
AA Change: T168A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice exhibit no obvious physical abnormalities or alterations in behavior, locomotion, or fecundity, however neurons are more resistant to the suppressive action of myelin inhibitors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T A 8: 25,157,639 (GRCm39) I104F probably benign Het
Adgrg7 C T 16: 56,590,674 (GRCm39) V166I probably benign Het
Agfg1 G T 1: 82,859,966 (GRCm39) V278L probably benign Het
Alpk3 A G 7: 80,742,328 (GRCm39) E715G possibly damaging Het
Ap2m1 A G 16: 20,362,095 (GRCm39) Y401C probably damaging Het
Arhgef28 C T 13: 98,101,960 (GRCm39) S838N probably benign Het
Ash2l A T 8: 26,317,233 (GRCm39) Y373* probably null Het
Best2 C T 8: 85,734,393 (GRCm39) V442I probably benign Het
Col4a2 T C 8: 11,475,542 (GRCm39) probably null Het
Fat2 T A 11: 55,175,856 (GRCm39) D1619V probably damaging Het
Fer1l6 A T 15: 58,499,446 (GRCm39) N1272I probably benign Het
Gcc1 T A 6: 28,417,995 (GRCm39) *779C probably null Het
Gm12216 G A 11: 53,750,077 (GRCm39) probably benign Het
Grm2 C T 9: 106,524,370 (GRCm39) V311I Het
Immt T A 6: 71,851,689 (GRCm39) D683E probably benign Het
Itga8 T G 2: 12,237,712 (GRCm39) D336A probably damaging Het
Jhy T C 9: 40,872,453 (GRCm39) T19A probably benign Het
Kcnq2 T C 2: 180,776,885 (GRCm39) M1V probably null Het
Kctd17 A T 15: 78,317,214 (GRCm39) I117F probably damaging Het
Lrp6 T C 6: 134,484,364 (GRCm39) T420A probably damaging Het
Manba T C 3: 135,223,673 (GRCm39) S187P probably damaging Het
Mef2b A T 8: 70,616,938 (GRCm39) D13V probably damaging Het
Mical2 T C 7: 111,902,963 (GRCm39) F145L probably damaging Het
Mphosph8 T A 14: 56,922,497 (GRCm39) D551E possibly damaging Het
Mplkipl1 A G 19: 61,163,973 (GRCm39) V154A possibly damaging Het
Myo10 C G 15: 25,783,067 (GRCm39) R1170G probably damaging Het
Myo16 A C 8: 10,322,687 (GRCm39) Q39P unknown Het
Myo1f A G 17: 33,820,668 (GRCm39) E837G probably benign Het
Nell2 T A 15: 95,333,274 (GRCm39) I128F possibly damaging Het
Or1i2 A G 10: 78,448,448 (GRCm39) V9A probably benign Het
Pcdh15 A T 10: 74,215,222 (GRCm39) R659* probably null Het
Pcdhga1 A G 18: 37,973,028 (GRCm39) Q881R possibly damaging Het
Plekhm2 T G 4: 141,369,770 (GRCm39) E75A possibly damaging Het
Prc1 A G 7: 79,957,405 (GRCm39) K357E possibly damaging Het
Pxk T A 14: 8,146,220 (GRCm38) C377S probably benign Het
Ralgapa2 T C 2: 146,176,488 (GRCm39) E1696G probably damaging Het
Rbbp6 T A 7: 122,600,590 (GRCm39) S1532R unknown Het
Scn5a G T 9: 119,391,626 (GRCm39) A22E probably benign Het
Sctr G A 1: 119,949,955 (GRCm39) R48Q probably benign Het
Siae T C 9: 37,534,309 (GRCm39) V115A probably damaging Het
Slc16a6 A G 11: 109,344,107 (GRCm39) C563R probably benign Het
Sntg1 A C 1: 8,752,243 (GRCm39) V58G possibly damaging Het
Snx11 C T 11: 96,663,985 (GRCm39) V36M probably damaging Het
Stk3 C A 15: 34,959,182 (GRCm39) S330I probably benign Het
Synpo A G 18: 60,762,631 (GRCm39) F92S probably benign Het
Tle1 A G 4: 72,057,924 (GRCm39) probably null Het
Tmem117 A G 15: 94,829,684 (GRCm39) D173G possibly damaging Het
Tmem217b C A 17: 29,738,347 (GRCm39) V140L probably benign Het
Tmprss5 T C 9: 49,025,841 (GRCm39) W338R probably benign Het
Trhde C T 10: 114,636,776 (GRCm39) G144S possibly damaging Het
Trim56 G T 5: 137,143,097 (GRCm39) Q140K probably damaging Het
Ttn C T 2: 76,562,918 (GRCm39) V28679M probably damaging Het
Ubxn8 G A 8: 34,113,231 (GRCm39) R208C probably damaging Het
Vmn2r72 G T 7: 85,387,482 (GRCm39) S694* probably null Het
Wdr38 T A 2: 38,890,276 (GRCm39) W137R probably damaging Het
Zdhhc6 G T 19: 55,292,932 (GRCm39) N271K probably damaging Het
Zfyve9 A G 4: 108,575,744 (GRCm39) S446P possibly damaging Het
Zmynd8 T C 2: 165,649,492 (GRCm39) Q867R possibly damaging Het
Zswim3 T C 2: 164,662,402 (GRCm39) I294T probably benign Het
Other mutations in Tnfrsf19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Tnfrsf19 APN 14 61,261,631 (GRCm39) missense possibly damaging 0.53
IGL01564:Tnfrsf19 APN 14 61,212,058 (GRCm39) missense possibly damaging 0.85
IGL01878:Tnfrsf19 APN 14 61,234,093 (GRCm39) missense probably damaging 0.98
IGL02220:Tnfrsf19 APN 14 61,210,941 (GRCm39) unclassified probably benign
IGL02378:Tnfrsf19 APN 14 61,208,451 (GRCm39) missense probably benign 0.00
IGL02546:Tnfrsf19 APN 14 61,210,987 (GRCm39) missense possibly damaging 0.86
IGL02583:Tnfrsf19 APN 14 61,261,659 (GRCm39) missense probably damaging 0.98
IGL03037:Tnfrsf19 APN 14 61,261,721 (GRCm39) missense possibly damaging 0.83
IGL03221:Tnfrsf19 APN 14 61,262,227 (GRCm39) missense probably benign 0.06
R0241:Tnfrsf19 UTSW 14 61,211,041 (GRCm39) missense possibly damaging 0.93
R0373:Tnfrsf19 UTSW 14 61,209,485 (GRCm39) missense possibly damaging 0.47
R1521:Tnfrsf19 UTSW 14 61,242,555 (GRCm39) missense probably damaging 0.99
R3038:Tnfrsf19 UTSW 14 61,209,512 (GRCm39) missense probably benign
R4346:Tnfrsf19 UTSW 14 61,209,429 (GRCm39) critical splice donor site probably null
R4997:Tnfrsf19 UTSW 14 61,208,658 (GRCm39) missense probably benign
R5756:Tnfrsf19 UTSW 14 61,262,224 (GRCm39) missense probably benign
R5869:Tnfrsf19 UTSW 14 61,208,627 (GRCm39) missense possibly damaging 0.70
R6110:Tnfrsf19 UTSW 14 61,208,588 (GRCm39) missense probably benign 0.08
R7047:Tnfrsf19 UTSW 14 61,242,667 (GRCm39) nonsense probably null
R7491:Tnfrsf19 UTSW 14 61,242,654 (GRCm39) missense possibly damaging 0.75
R7729:Tnfrsf19 UTSW 14 61,212,183 (GRCm39) missense possibly damaging 0.70
R7936:Tnfrsf19 UTSW 14 61,208,382 (GRCm39) missense probably benign 0.22
R8358:Tnfrsf19 UTSW 14 61,208,634 (GRCm39) missense probably benign 0.25
R8535:Tnfrsf19 UTSW 14 61,208,417 (GRCm39) missense probably benign 0.25
R8693:Tnfrsf19 UTSW 14 61,208,451 (GRCm39) missense probably benign
R9028:Tnfrsf19 UTSW 14 61,242,650 (GRCm39) missense probably benign 0.26
R9468:Tnfrsf19 UTSW 14 61,261,623 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GAACTCTTGGGTGACAATGC -3'
(R):5'- AGACAGCTAGTGACCATGGG -3'

Sequencing Primer
(F):5'- CTTGGGTGACAATGCTAACAAGCTC -3'
(R):5'- ACTCTCAGGTACCAGCAA -3'
Posted On 2019-06-26