Incidental Mutation 'R7271:Or4k77'
ID 565275
Institutional Source Beutler Lab
Gene Symbol Or4k77
Ensembl Gene ENSMUSG00000109322
Gene Name olfactory receptor family 4 subfamily K member 77
Synonyms MOR248-19, Olfr1283, GA_x6K02T2Q125-72420217-72421134
MMRRC Submission 045356-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.526) question?
Stock # R7271 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111198979-111199896 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111199693 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 239 (T239A)
Ref Sequence ENSEMBL: ENSMUSP00000145495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090328] [ENSMUST00000204064] [ENSMUST00000216637]
AlphaFold Q7TQY4
Predicted Effect probably damaging
Transcript: ENSMUST00000090328
AA Change: T239A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000087800
Gene: ENSMUSG00000109322
AA Change: T239A

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 3.6e-49 PFAM
Pfam:7tm_1 41 287 3.9e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204064
AA Change: T239A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145495
Gene: ENSMUSG00000109322
AA Change: T239A

DomainStartEndE-ValueType
Pfam:7tm_4 30 298 2.1e-39 PFAM
Pfam:7tm_1 40 286 7.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216637
AA Change: T239A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.7982 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg1l C T 10: 42,291,544 (GRCm39) probably null Het
Ahnak2 A T 12: 112,780,802 (GRCm38) V70E Het
Alpk3 A G 7: 80,728,202 (GRCm39) E444G possibly damaging Het
Amer2 T A 14: 60,617,123 (GRCm39) D439E possibly damaging Het
Ano6 A G 15: 95,811,781 (GRCm39) Y222C probably damaging Het
Atp4a A C 7: 30,421,944 (GRCm39) K827Q probably benign Het
Atp9a G A 2: 168,576,047 (GRCm39) Het
Casp7 T A 19: 56,424,793 (GRCm39) C171S probably damaging Het
Ccdc9b T A 2: 118,591,164 (GRCm39) probably null Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Cdkl1 A G 12: 69,795,585 (GRCm39) L315S probably benign Het
Cfap91 A G 16: 38,148,708 (GRCm39) I240T probably damaging Het
Crybg1 G T 10: 43,873,619 (GRCm39) S1163* probably null Het
Csmd1 A T 8: 17,077,295 (GRCm39) W121R probably damaging Het
Cyyr1 A T 16: 85,262,493 (GRCm39) M88K possibly damaging Het
Dlc1 T C 8: 37,049,954 (GRCm39) Q587R probably damaging Het
Dock2 T C 11: 34,223,750 (GRCm39) E1128G possibly damaging Het
Dynap T A 18: 70,374,320 (GRCm39) T69S possibly damaging Het
Esr1 T C 10: 4,733,874 (GRCm39) C225R probably damaging Het
Fbxo31 C T 8: 122,305,503 (GRCm39) probably benign Het
Fndc11 G A 2: 180,863,893 (GRCm39) V233I possibly damaging Het
Fto T C 8: 92,211,818 (GRCm39) F381S probably damaging Het
Gtf2ird1 A G 5: 134,433,758 (GRCm39) L223P probably benign Het
Ifi214 A T 1: 173,357,042 (GRCm39) H20Q probably damaging Het
Impa2 T A 18: 67,439,806 (GRCm39) I101N probably damaging Het
Kidins220 A T 12: 25,061,570 (GRCm39) T854S probably benign Het
Lamb1 T A 12: 31,337,423 (GRCm39) C385S probably damaging Het
Lrrc8c A G 5: 105,755,853 (GRCm39) S543G probably benign Het
Manba A T 3: 135,248,137 (GRCm39) Y342F probably damaging Het
Map3k1 T C 13: 111,893,231 (GRCm39) D758G probably benign Het
Mtor G T 4: 148,630,942 (GRCm39) A2300S possibly damaging Het
Musk T A 4: 58,373,409 (GRCm39) M793K probably damaging Het
Nup133 A C 8: 124,649,153 (GRCm39) I563S probably benign Het
Or10ab4 G A 7: 107,654,423 (GRCm39) R78Q probably damaging Het
Or10ag55-ps1 T A 2: 87,114,725 (GRCm39) N30K probably benign Het
Or8g21 A T 9: 38,905,953 (GRCm39) Y259* probably null Het
Pcdh12 C A 18: 38,416,100 (GRCm39) V342F probably damaging Het
Pcdhb4 T A 18: 37,441,222 (GRCm39) H177Q possibly damaging Het
Pcnx2 G A 8: 126,613,690 (GRCm39) A587V probably benign Het
Phkb C T 8: 86,770,418 (GRCm39) P896S probably damaging Het
Prss36 A G 7: 127,543,877 (GRCm39) S165P probably benign Het
Prss43 A G 9: 110,657,671 (GRCm39) D190G probably damaging Het
Psmd14 T C 2: 61,591,356 (GRCm39) V53A probably damaging Het
Sel1l3 T G 5: 53,273,704 (GRCm39) H1054P probably damaging Het
Selenoh T C 2: 84,500,631 (GRCm39) R70G probably damaging Het
Serpinb9d A G 13: 33,378,617 (GRCm39) Q21R probably benign Het
Slc29a1 T C 17: 45,899,288 (GRCm39) E262G probably benign Het
Slc7a14 A G 3: 31,278,384 (GRCm39) L407P probably damaging Het
Smyd4 T C 11: 75,281,325 (GRCm39) V266A possibly damaging Het
Spata31d1a T A 13: 59,849,913 (GRCm39) R738S probably benign Het
Speer4a2 G A 5: 26,292,993 (GRCm39) T67I probably benign Het
Srcin1 C T 11: 97,442,715 (GRCm39) G38S probably damaging Het
Stab2 A T 10: 86,838,972 (GRCm39) probably null Het
Syde2 A G 3: 145,726,031 (GRCm39) N1308D possibly damaging Het
Trip11 A T 12: 101,850,611 (GRCm39) M1151K probably damaging Het
Ttll4 A T 1: 74,727,820 (GRCm39) I861F possibly damaging Het
Zfp319 G A 8: 96,058,471 (GRCm39) probably benign Het
Zfp518b T C 5: 38,831,907 (GRCm39) N33D probably benign Het
Zfp874a T A 13: 67,591,415 (GRCm39) I90F probably benign Het
Zmiz2 G T 11: 6,349,593 (GRCm39) V412L probably damaging Het
Other mutations in Or4k77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02337:Or4k77 APN 2 111,199,496 (GRCm39) missense probably benign 0.22
IGL02716:Or4k77 APN 2 111,199,126 (GRCm39) missense probably benign 0.04
R0090:Or4k77 UTSW 2 111,199,639 (GRCm39) missense probably damaging 1.00
R0141:Or4k77 UTSW 2 111,199,835 (GRCm39) missense probably damaging 1.00
R0371:Or4k77 UTSW 2 111,199,498 (GRCm39) missense probably benign 0.00
R0417:Or4k77 UTSW 2 111,199,450 (GRCm39) missense possibly damaging 0.57
R1673:Or4k77 UTSW 2 111,199,552 (GRCm39) missense probably benign 0.11
R1970:Or4k77 UTSW 2 111,199,421 (GRCm39) missense probably benign 0.19
R2069:Or4k77 UTSW 2 111,199,440 (GRCm39) missense probably benign 0.43
R3897:Or4k77 UTSW 2 111,199,106 (GRCm39) missense possibly damaging 0.87
R4408:Or4k77 UTSW 2 111,199,625 (GRCm39) missense possibly damaging 0.63
R5397:Or4k77 UTSW 2 111,199,285 (GRCm39) missense probably benign 0.00
R5888:Or4k77 UTSW 2 111,199,088 (GRCm39) missense probably benign
R6281:Or4k77 UTSW 2 111,199,894 (GRCm39) makesense probably null
R6323:Or4k77 UTSW 2 111,199,046 (GRCm39) missense possibly damaging 0.94
R6801:Or4k77 UTSW 2 111,199,394 (GRCm39) missense probably benign 0.22
R7219:Or4k77 UTSW 2 111,199,882 (GRCm39) missense probably benign
R7438:Or4k77 UTSW 2 111,199,707 (GRCm39) missense probably damaging 1.00
R7761:Or4k77 UTSW 2 111,199,138 (GRCm39) missense probably benign 0.00
R7792:Or4k77 UTSW 2 111,199,748 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTTGGTGATGAAATTAGCCTGC -3'
(R):5'- CCACTAAGAATGTGGATAAAATGGTGC -3'

Sequencing Primer
(F):5'- GCCTGCATGAATACTGATACACTGG -3'
(R):5'- CCAGAATTCACATGTGATTTATCAGC -3'
Posted On 2019-06-26