Incidental Mutation 'R7276:Rgs12'
| ID |
565568 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rgs12
|
| Ensembl Gene |
ENSMUSG00000029101 |
| Gene Name |
regulator of G-protein signaling 12 |
| Synonyms |
4632412M04Rik, 1200016K18Rik |
| MMRRC Submission |
045359-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.247)
|
| Stock # |
R7276 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
35106789-35196988 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 35183715 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1026
(D1026G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030984
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030984]
[ENSMUST00000087684]
[ENSMUST00000114280]
[ENSMUST00000114281]
[ENSMUST00000114283]
[ENSMUST00000114284]
[ENSMUST00000114285]
[ENSMUST00000156339]
|
| AlphaFold |
Q8CGE9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030984
AA Change: D1026G
PolyPhen 2
Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000030984
Gene: ENSMUSG00000029101
AA Change: D1026G
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
29 |
98 |
5.25e-18 |
SMART |
|
PTB
|
224 |
373 |
5.05e-28 |
SMART |
|
low complexity region
|
443 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
697 |
N/A |
INTRINSIC |
|
RGS
|
715 |
832 |
2.84e-41 |
SMART |
|
low complexity region
|
849 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
868 |
880 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
928 |
N/A |
INTRINSIC |
|
RBD
|
962 |
1032 |
3.12e-28 |
SMART |
|
RBD
|
1034 |
1104 |
2.44e-21 |
SMART |
|
GoLoco
|
1187 |
1209 |
9.74e-9 |
SMART |
|
low complexity region
|
1259 |
1280 |
N/A |
INTRINSIC |
|
low complexity region
|
1292 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1359 |
1378 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087684
AA Change: D1026G
PolyPhen 2
Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000084970
Gene: ENSMUSG00000029101
AA Change: D1026G
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
29 |
98 |
5.25e-18 |
SMART |
|
PTB
|
224 |
373 |
5.05e-28 |
SMART |
|
low complexity region
|
443 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
697 |
N/A |
INTRINSIC |
|
RGS
|
715 |
832 |
2.84e-41 |
SMART |
|
Pfam:RGS12_us1
|
836 |
953 |
4.3e-61 |
PFAM |
|
RBD
|
962 |
1032 |
3.12e-28 |
SMART |
|
RBD
|
1034 |
1104 |
2.44e-21 |
SMART |
|
Pfam:RGS12_us2
|
1106 |
1180 |
2.4e-37 |
PFAM |
|
GoLoco
|
1187 |
1209 |
9.74e-9 |
SMART |
|
Pfam:RGS12_usC
|
1238 |
1379 |
9.2e-49 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114280
AA Change: D368G
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000109919
Gene: ENSMUSG00000029101
AA Change: D368G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114281
AA Change: D368G
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000109920
Gene: ENSMUSG00000029101
AA Change: D368G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
GoLoco
|
529 |
551 |
9.74e-9 |
SMART |
|
low complexity region
|
601 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
701 |
720 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114283
AA Change: D368G
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000109922
Gene: ENSMUSG00000029101
AA Change: D368G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
GoLoco
|
529 |
551 |
9.74e-9 |
SMART |
|
low complexity region
|
601 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114284
AA Change: D378G
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000109923
Gene: ENSMUSG00000029101
AA Change: D378G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
49 |
N/A |
INTRINSIC |
|
RGS
|
67 |
184 |
2.84e-41 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
low complexity region
|
220 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
280 |
N/A |
INTRINSIC |
|
RBD
|
314 |
384 |
3.12e-28 |
SMART |
|
RBD
|
386 |
456 |
2.44e-21 |
SMART |
|
GoLoco
|
539 |
561 |
9.74e-9 |
SMART |
|
low complexity region
|
611 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
730 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114285
AA Change: D378G
PolyPhen 2
Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000109924
Gene: ENSMUSG00000029101
AA Change: D378G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
49 |
N/A |
INTRINSIC |
|
RGS
|
67 |
184 |
2.84e-41 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
low complexity region
|
220 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
280 |
N/A |
INTRINSIC |
|
RBD
|
314 |
384 |
3.12e-28 |
SMART |
|
RBD
|
386 |
456 |
2.44e-21 |
SMART |
|
GoLoco
|
539 |
561 |
9.74e-9 |
SMART |
|
low complexity region
|
611 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
707 |
739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150139
|
| SMART Domains |
Protein: ENSMUSP00000117158
Gene: ENSMUSG00000029101
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:RBD
|
2 |
33 |
5e-13 |
BLAST |
|
Pfam:RGS12_us2
|
35 |
80 |
5.8e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156339
|
| SMART Domains |
Protein: ENSMUSP00000115064
Gene: ENSMUSG00000029101
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RGS
|
1 |
30 |
1.3e-7 |
PFAM |
|
low complexity region
|
48 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000116913
Gene: ENSMUSG00000029101
AA Change: D84G
| Domain | Start | End | E-Value | Type |
|---|
|
RBD
|
21 |
91 |
3.12e-28 |
SMART |
|
RBD
|
93 |
163 |
2.44e-21 |
SMART |
|
| Predicted Effect |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (74/74) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930455H04Rik |
T |
C |
3: 116,762,227 (GRCm39) |
V26A |
unknown |
Het |
| 4930546C10Rik |
C |
T |
18: 69,083,093 (GRCm39) |
W40* |
probably null |
Het |
| Abcc5 |
T |
C |
16: 20,195,258 (GRCm39) |
|
probably null |
Het |
| Adamts18 |
T |
A |
8: 114,501,896 (GRCm39) |
M322L |
probably damaging |
Het |
| Ankrd44 |
T |
A |
1: 54,774,239 (GRCm39) |
N406I |
probably benign |
Het |
| Arhgap35 |
T |
G |
7: 16,298,493 (GRCm39) |
T191P |
probably damaging |
Het |
| Atg3 |
G |
A |
16: 44,982,805 (GRCm39) |
E37K |
possibly damaging |
Het |
| Bbs1 |
A |
T |
19: 4,947,738 (GRCm39) |
|
probably null |
Het |
| BC048562 |
A |
G |
9: 108,322,435 (GRCm39) |
N60D |
probably damaging |
Het |
| Btnl9 |
T |
A |
11: 49,066,617 (GRCm39) |
I335F |
probably benign |
Het |
| C7 |
A |
T |
15: 5,041,449 (GRCm39) |
C486S |
probably damaging |
Het |
| Cchcr1 |
C |
A |
17: 35,840,031 (GRCm39) |
Q634K |
possibly damaging |
Het |
| Cd93 |
A |
T |
2: 148,283,660 (GRCm39) |
V562E |
probably damaging |
Het |
| Cemip2 |
A |
G |
19: 21,812,824 (GRCm39) |
I1010V |
probably benign |
Het |
| Cript |
T |
A |
17: 87,341,696 (GRCm39) |
Y50* |
probably null |
Het |
| Dnah14 |
T |
A |
1: 181,513,372 (GRCm39) |
F1908L |
probably benign |
Het |
| Dnah5 |
A |
G |
15: 28,367,984 (GRCm39) |
N2790D |
probably damaging |
Het |
| Eif3h |
C |
A |
15: 51,728,717 (GRCm39) |
|
probably null |
Het |
| Ffar3 |
C |
G |
7: 30,555,273 (GRCm39) |
V16L |
possibly damaging |
Het |
| Gcn1 |
C |
T |
5: 115,749,119 (GRCm39) |
R1884W |
probably damaging |
Het |
| Gpatch1 |
T |
A |
7: 34,996,921 (GRCm39) |
M426L |
probably benign |
Het |
| Hcn2 |
T |
A |
10: 79,564,934 (GRCm39) |
Y449N |
possibly damaging |
Het |
| Hdac10 |
T |
C |
15: 89,012,488 (GRCm39) |
T32A |
probably benign |
Het |
| Hykk |
T |
C |
9: 54,853,502 (GRCm39) |
Y275H |
probably damaging |
Het |
| Igfn1 |
G |
C |
1: 135,926,376 (GRCm39) |
P25A |
possibly damaging |
Het |
| Jph1 |
T |
C |
1: 17,162,266 (GRCm39) |
Q132R |
probably damaging |
Het |
| Kat2b |
T |
A |
17: 53,931,450 (GRCm39) |
D149E |
probably damaging |
Het |
| Knl1 |
A |
T |
2: 118,902,167 (GRCm39) |
K1289N |
probably damaging |
Het |
| Lrrc37a |
G |
A |
11: 103,347,572 (GRCm39) |
S3041L |
unknown |
Het |
| Mtrex |
A |
T |
13: 113,050,973 (GRCm39) |
Y201N |
probably benign |
Het |
| Mtus2 |
C |
T |
5: 148,013,368 (GRCm39) |
R54C |
probably benign |
Het |
| Myo1d |
A |
T |
11: 80,583,898 (GRCm39) |
I38N |
probably damaging |
Het |
| Nasp |
A |
G |
4: 116,471,546 (GRCm39) |
S94P |
probably damaging |
Het |
| Nfat5 |
C |
A |
8: 108,093,731 (GRCm39) |
N657K |
probably benign |
Het |
| Ngfr |
A |
G |
11: 95,465,170 (GRCm39) |
L226P |
probably benign |
Het |
| Nos1 |
T |
C |
5: 118,048,303 (GRCm39) |
S703P |
probably damaging |
Het |
| Nsun7 |
A |
G |
5: 66,434,484 (GRCm39) |
D275G |
probably benign |
Het |
| Oas1d |
A |
G |
5: 121,054,944 (GRCm39) |
N172S |
possibly damaging |
Het |
| Or11h4 |
A |
G |
14: 50,974,187 (GRCm39) |
V144A |
possibly damaging |
Het |
| Or2y17 |
T |
A |
11: 49,231,821 (GRCm39) |
M154K |
probably benign |
Het |
| Or4c11b |
T |
A |
2: 88,625,025 (GRCm39) |
F100I |
probably damaging |
Het |
| Or52e8 |
T |
A |
7: 104,624,857 (GRCm39) |
M116L |
possibly damaging |
Het |
| Papss1 |
A |
G |
3: 131,324,995 (GRCm39) |
E484G |
probably benign |
Het |
| Pcdh15 |
A |
G |
10: 74,160,224 (GRCm39) |
D447G |
probably benign |
Het |
| Phkg2 |
A |
G |
7: 127,181,558 (GRCm39) |
E247G |
possibly damaging |
Het |
| Pramel30 |
A |
G |
4: 144,059,216 (GRCm39) |
E309G |
possibly damaging |
Het |
| Prelid2 |
T |
C |
18: 42,045,487 (GRCm39) |
N141S |
possibly damaging |
Het |
| Psg18 |
T |
C |
7: 18,079,909 (GRCm39) |
M431V |
probably damaging |
Het |
| Psmd12 |
A |
T |
11: 107,394,471 (GRCm39) |
R397* |
probably null |
Het |
| Ralgds |
G |
A |
2: 28,435,884 (GRCm39) |
R503Q |
probably damaging |
Het |
| Rb1cc1 |
G |
A |
1: 6,319,416 (GRCm39) |
C945Y |
probably benign |
Het |
| Scn7a |
G |
A |
2: 66,587,506 (GRCm39) |
P66S |
probably damaging |
Het |
| Supt16 |
T |
C |
14: 52,414,458 (GRCm39) |
E448G |
probably benign |
Het |
| Syt16 |
C |
T |
12: 74,313,483 (GRCm39) |
R470C |
probably damaging |
Het |
| Tas2r114 |
T |
C |
6: 131,666,310 (GRCm39) |
I239M |
probably damaging |
Het |
| Tecpr1 |
C |
T |
5: 144,153,838 (GRCm39) |
W138* |
probably null |
Het |
| Tex101 |
T |
C |
7: 24,369,829 (GRCm39) |
N45S |
probably damaging |
Het |
| Tmx1 |
C |
A |
12: 70,512,917 (GRCm39) |
T275K |
possibly damaging |
Het |
| Trappc8 |
T |
G |
18: 20,951,148 (GRCm39) |
I1434L |
probably damaging |
Het |
| Trappc9 |
G |
T |
15: 72,924,119 (GRCm39) |
H208N |
probably damaging |
Het |
| Trcg1 |
T |
A |
9: 57,149,862 (GRCm39) |
L478Q |
probably damaging |
Het |
| Trim42 |
G |
T |
9: 97,251,625 (GRCm39) |
Y91* |
probably null |
Het |
| Vmn2r114 |
A |
G |
17: 23,509,934 (GRCm39) |
S849P |
probably damaging |
Het |
| Vmn2r120 |
T |
C |
17: 57,831,881 (GRCm39) |
T303A |
probably benign |
Het |
| Vmn2r13 |
A |
G |
5: 109,321,645 (GRCm39) |
W351R |
probably damaging |
Het |
| Vmn2r53 |
T |
C |
7: 12,340,359 (GRCm39) |
D38G |
probably damaging |
Het |
| Vsig8 |
C |
A |
1: 172,390,850 (GRCm39) |
C411* |
probably null |
Het |
| Vwce |
A |
T |
19: 10,641,538 (GRCm39) |
T755S |
possibly damaging |
Het |
| Wwp1 |
T |
C |
4: 19,611,782 (GRCm39) |
S897G |
probably damaging |
Het |
| Zfp111 |
C |
A |
7: 23,898,978 (GRCm39) |
C212F |
probably damaging |
Het |
| Zfp385b |
G |
T |
2: 77,280,624 (GRCm39) |
H193N |
probably damaging |
Het |
| Zfp811 |
T |
C |
17: 33,017,755 (GRCm39) |
E95G |
probably benign |
Het |
|
| Other mutations in Rgs12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01443:Rgs12
|
APN |
5 |
35,132,563 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02296:Rgs12
|
APN |
5 |
35,123,464 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02337:Rgs12
|
APN |
5 |
35,177,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02483:Rgs12
|
APN |
5 |
35,187,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02869:Rgs12
|
APN |
5 |
35,183,227 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02989:Rgs12
|
APN |
5 |
35,122,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0015:Rgs12
|
UTSW |
5 |
35,180,120 (GRCm39) |
unclassified |
probably benign |
|
|
R0015:Rgs12
|
UTSW |
5 |
35,180,120 (GRCm39) |
unclassified |
probably benign |
|
|
R0046:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0046:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Rgs12
|
UTSW |
5 |
35,124,008 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0106:Rgs12
|
UTSW |
5 |
35,124,008 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Rgs12
|
UTSW |
5 |
35,187,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Rgs12
|
UTSW |
5 |
35,187,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Rgs12
|
UTSW |
5 |
35,187,424 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0611:Rgs12
|
UTSW |
5 |
35,176,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0704:Rgs12
|
UTSW |
5 |
35,180,466 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0723:Rgs12
|
UTSW |
5 |
35,181,710 (GRCm39) |
unclassified |
probably benign |
|
|
R1174:Rgs12
|
UTSW |
5 |
35,123,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1538:Rgs12
|
UTSW |
5 |
35,178,511 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1556:Rgs12
|
UTSW |
5 |
35,196,626 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1774:Rgs12
|
UTSW |
5 |
35,123,747 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1791:Rgs12
|
UTSW |
5 |
35,123,456 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1866:Rgs12
|
UTSW |
5 |
35,123,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1872:Rgs12
|
UTSW |
5 |
35,123,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1923:Rgs12
|
UTSW |
5 |
35,189,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Rgs12
|
UTSW |
5 |
35,187,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2107:Rgs12
|
UTSW |
5 |
35,124,079 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3730:Rgs12
|
UTSW |
5 |
35,189,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3731:Rgs12
|
UTSW |
5 |
35,189,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Rgs12
|
UTSW |
5 |
35,189,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3826:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3827:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3829:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3830:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4392:Rgs12
|
UTSW |
5 |
35,189,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4617:Rgs12
|
UTSW |
5 |
35,177,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Rgs12
|
UTSW |
5 |
35,147,156 (GRCm39) |
intron |
probably benign |
|
|
R5213:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Rgs12
|
UTSW |
5 |
35,178,448 (GRCm39) |
unclassified |
probably benign |
|
|
R5480:Rgs12
|
UTSW |
5 |
35,123,455 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5510:Rgs12
|
UTSW |
5 |
35,123,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Rgs12
|
UTSW |
5 |
35,123,696 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5987:Rgs12
|
UTSW |
5 |
35,177,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Rgs12
|
UTSW |
5 |
35,123,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6113:Rgs12
|
UTSW |
5 |
35,177,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6401:Rgs12
|
UTSW |
5 |
35,177,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6736:Rgs12
|
UTSW |
5 |
35,180,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6807:Rgs12
|
UTSW |
5 |
35,180,515 (GRCm39) |
missense |
probably null |
0.27 |
|
R6857:Rgs12
|
UTSW |
5 |
35,187,366 (GRCm39) |
nonsense |
probably null |
|
|
R7082:Rgs12
|
UTSW |
5 |
35,124,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7250:Rgs12
|
UTSW |
5 |
35,122,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7444:Rgs12
|
UTSW |
5 |
35,183,287 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7632:Rgs12
|
UTSW |
5 |
35,122,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Rgs12
|
UTSW |
5 |
35,183,374 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8089:Rgs12
|
UTSW |
5 |
35,177,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8241:Rgs12
|
UTSW |
5 |
35,123,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8797:Rgs12
|
UTSW |
5 |
35,186,915 (GRCm39) |
missense |
|
|
|
R8927:Rgs12
|
UTSW |
5 |
35,123,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8928:Rgs12
|
UTSW |
5 |
35,123,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9073:Rgs12
|
UTSW |
5 |
35,177,753 (GRCm39) |
unclassified |
probably benign |
|
|
R9211:Rgs12
|
UTSW |
5 |
35,123,165 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9485:Rgs12
|
UTSW |
5 |
35,189,614 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9550:Rgs12
|
UTSW |
5 |
35,196,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Rgs12
|
UTSW |
5 |
35,123,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rgs12
|
UTSW |
5 |
35,183,696 (GRCm39) |
missense |
probably benign |
0.44 |
|
Z1177:Rgs12
|
UTSW |
5 |
35,122,198 (GRCm39) |
start gained |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTAGTGCTCCACTCCTGAC -3'
(R):5'- AGCCCATATGTGGTGCCTTC -3'
Sequencing Primer
(F):5'- CAGAGCAGCTGCAGGTG -3'
(R):5'- CCCCGTTGCCAAGACTCTG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation