Incidental Mutation 'R7276:Vmn2r114'
| ID |
565610 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r114
|
| Ensembl Gene |
ENSMUSG00000091945 |
| Gene Name |
vomeronasal 2, receptor 114 |
| Synonyms |
EG666002 |
| MMRRC Submission |
045359-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.142)
|
| Stock # |
R7276 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
23509908-23531287 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23509934 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 849
(S849P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127505
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168033]
|
| AlphaFold |
E9Q281 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168033
AA Change: S849P
PolyPhen 2
Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000127505
Gene: ENSMUSG00000091945
AA Change: S849P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
154 |
470 |
1.5e-24 |
PFAM |
|
Pfam:NCD3G
|
511 |
564 |
1.5e-18 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
1.4e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (74/74) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930455H04Rik |
T |
C |
3: 116,762,227 (GRCm39) |
V26A |
unknown |
Het |
| 4930546C10Rik |
C |
T |
18: 69,083,093 (GRCm39) |
W40* |
probably null |
Het |
| Abcc5 |
T |
C |
16: 20,195,258 (GRCm39) |
|
probably null |
Het |
| Adamts18 |
T |
A |
8: 114,501,896 (GRCm39) |
M322L |
probably damaging |
Het |
| Ankrd44 |
T |
A |
1: 54,774,239 (GRCm39) |
N406I |
probably benign |
Het |
| Arhgap35 |
T |
G |
7: 16,298,493 (GRCm39) |
T191P |
probably damaging |
Het |
| Atg3 |
G |
A |
16: 44,982,805 (GRCm39) |
E37K |
possibly damaging |
Het |
| Bbs1 |
A |
T |
19: 4,947,738 (GRCm39) |
|
probably null |
Het |
| BC048562 |
A |
G |
9: 108,322,435 (GRCm39) |
N60D |
probably damaging |
Het |
| Btnl9 |
T |
A |
11: 49,066,617 (GRCm39) |
I335F |
probably benign |
Het |
| C7 |
A |
T |
15: 5,041,449 (GRCm39) |
C486S |
probably damaging |
Het |
| Cchcr1 |
C |
A |
17: 35,840,031 (GRCm39) |
Q634K |
possibly damaging |
Het |
| Cd93 |
A |
T |
2: 148,283,660 (GRCm39) |
V562E |
probably damaging |
Het |
| Cemip2 |
A |
G |
19: 21,812,824 (GRCm39) |
I1010V |
probably benign |
Het |
| Cript |
T |
A |
17: 87,341,696 (GRCm39) |
Y50* |
probably null |
Het |
| Dnah14 |
T |
A |
1: 181,513,372 (GRCm39) |
F1908L |
probably benign |
Het |
| Dnah5 |
A |
G |
15: 28,367,984 (GRCm39) |
N2790D |
probably damaging |
Het |
| Eif3h |
C |
A |
15: 51,728,717 (GRCm39) |
|
probably null |
Het |
| Ffar3 |
C |
G |
7: 30,555,273 (GRCm39) |
V16L |
possibly damaging |
Het |
| Gcn1 |
C |
T |
5: 115,749,119 (GRCm39) |
R1884W |
probably damaging |
Het |
| Gpatch1 |
T |
A |
7: 34,996,921 (GRCm39) |
M426L |
probably benign |
Het |
| Hcn2 |
T |
A |
10: 79,564,934 (GRCm39) |
Y449N |
possibly damaging |
Het |
| Hdac10 |
T |
C |
15: 89,012,488 (GRCm39) |
T32A |
probably benign |
Het |
| Hykk |
T |
C |
9: 54,853,502 (GRCm39) |
Y275H |
probably damaging |
Het |
| Igfn1 |
G |
C |
1: 135,926,376 (GRCm39) |
P25A |
possibly damaging |
Het |
| Jph1 |
T |
C |
1: 17,162,266 (GRCm39) |
Q132R |
probably damaging |
Het |
| Kat2b |
T |
A |
17: 53,931,450 (GRCm39) |
D149E |
probably damaging |
Het |
| Knl1 |
A |
T |
2: 118,902,167 (GRCm39) |
K1289N |
probably damaging |
Het |
| Lrrc37a |
G |
A |
11: 103,347,572 (GRCm39) |
S3041L |
unknown |
Het |
| Mtrex |
A |
T |
13: 113,050,973 (GRCm39) |
Y201N |
probably benign |
Het |
| Mtus2 |
C |
T |
5: 148,013,368 (GRCm39) |
R54C |
probably benign |
Het |
| Myo1d |
A |
T |
11: 80,583,898 (GRCm39) |
I38N |
probably damaging |
Het |
| Nasp |
A |
G |
4: 116,471,546 (GRCm39) |
S94P |
probably damaging |
Het |
| Nfat5 |
C |
A |
8: 108,093,731 (GRCm39) |
N657K |
probably benign |
Het |
| Ngfr |
A |
G |
11: 95,465,170 (GRCm39) |
L226P |
probably benign |
Het |
| Nos1 |
T |
C |
5: 118,048,303 (GRCm39) |
S703P |
probably damaging |
Het |
| Nsun7 |
A |
G |
5: 66,434,484 (GRCm39) |
D275G |
probably benign |
Het |
| Oas1d |
A |
G |
5: 121,054,944 (GRCm39) |
N172S |
possibly damaging |
Het |
| Or11h4 |
A |
G |
14: 50,974,187 (GRCm39) |
V144A |
possibly damaging |
Het |
| Or2y17 |
T |
A |
11: 49,231,821 (GRCm39) |
M154K |
probably benign |
Het |
| Or4c11b |
T |
A |
2: 88,625,025 (GRCm39) |
F100I |
probably damaging |
Het |
| Or52e8 |
T |
A |
7: 104,624,857 (GRCm39) |
M116L |
possibly damaging |
Het |
| Papss1 |
A |
G |
3: 131,324,995 (GRCm39) |
E484G |
probably benign |
Het |
| Pcdh15 |
A |
G |
10: 74,160,224 (GRCm39) |
D447G |
probably benign |
Het |
| Phkg2 |
A |
G |
7: 127,181,558 (GRCm39) |
E247G |
possibly damaging |
Het |
| Pramel30 |
A |
G |
4: 144,059,216 (GRCm39) |
E309G |
possibly damaging |
Het |
| Prelid2 |
T |
C |
18: 42,045,487 (GRCm39) |
N141S |
possibly damaging |
Het |
| Psg18 |
T |
C |
7: 18,079,909 (GRCm39) |
M431V |
probably damaging |
Het |
| Psmd12 |
A |
T |
11: 107,394,471 (GRCm39) |
R397* |
probably null |
Het |
| Ralgds |
G |
A |
2: 28,435,884 (GRCm39) |
R503Q |
probably damaging |
Het |
| Rb1cc1 |
G |
A |
1: 6,319,416 (GRCm39) |
C945Y |
probably benign |
Het |
| Rgs12 |
A |
G |
5: 35,183,715 (GRCm39) |
D1026G |
probably benign |
Het |
| Scn7a |
G |
A |
2: 66,587,506 (GRCm39) |
P66S |
probably damaging |
Het |
| Supt16 |
T |
C |
14: 52,414,458 (GRCm39) |
E448G |
probably benign |
Het |
| Syt16 |
C |
T |
12: 74,313,483 (GRCm39) |
R470C |
probably damaging |
Het |
| Tas2r114 |
T |
C |
6: 131,666,310 (GRCm39) |
I239M |
probably damaging |
Het |
| Tecpr1 |
C |
T |
5: 144,153,838 (GRCm39) |
W138* |
probably null |
Het |
| Tex101 |
T |
C |
7: 24,369,829 (GRCm39) |
N45S |
probably damaging |
Het |
| Tmx1 |
C |
A |
12: 70,512,917 (GRCm39) |
T275K |
possibly damaging |
Het |
| Trappc8 |
T |
G |
18: 20,951,148 (GRCm39) |
I1434L |
probably damaging |
Het |
| Trappc9 |
G |
T |
15: 72,924,119 (GRCm39) |
H208N |
probably damaging |
Het |
| Trcg1 |
T |
A |
9: 57,149,862 (GRCm39) |
L478Q |
probably damaging |
Het |
| Trim42 |
G |
T |
9: 97,251,625 (GRCm39) |
Y91* |
probably null |
Het |
| Vmn2r120 |
T |
C |
17: 57,831,881 (GRCm39) |
T303A |
probably benign |
Het |
| Vmn2r13 |
A |
G |
5: 109,321,645 (GRCm39) |
W351R |
probably damaging |
Het |
| Vmn2r53 |
T |
C |
7: 12,340,359 (GRCm39) |
D38G |
probably damaging |
Het |
| Vsig8 |
C |
A |
1: 172,390,850 (GRCm39) |
C411* |
probably null |
Het |
| Vwce |
A |
T |
19: 10,641,538 (GRCm39) |
T755S |
possibly damaging |
Het |
| Wwp1 |
T |
C |
4: 19,611,782 (GRCm39) |
S897G |
probably damaging |
Het |
| Zfp111 |
C |
A |
7: 23,898,978 (GRCm39) |
C212F |
probably damaging |
Het |
| Zfp385b |
G |
T |
2: 77,280,624 (GRCm39) |
H193N |
probably damaging |
Het |
| Zfp811 |
T |
C |
17: 33,017,755 (GRCm39) |
E95G |
probably benign |
Het |
|
| Other mutations in Vmn2r114 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00157:Vmn2r114
|
APN |
17 |
23,510,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r114
|
APN |
17 |
23,510,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r114
|
APN |
17 |
23,509,957 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00990:Vmn2r114
|
APN |
17 |
23,509,939 (GRCm39) |
missense |
probably benign |
|
|
IGL01838:Vmn2r114
|
APN |
17 |
23,515,956 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01990:Vmn2r114
|
APN |
17 |
23,529,355 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01994:Vmn2r114
|
APN |
17 |
23,529,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02153:Vmn2r114
|
APN |
17 |
23,510,782 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02453:Vmn2r114
|
APN |
17 |
23,530,108 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02621:Vmn2r114
|
APN |
17 |
23,529,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02938:Vmn2r114
|
APN |
17 |
23,510,263 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03130:Vmn2r114
|
APN |
17 |
23,515,970 (GRCm39) |
splice site |
probably benign |
|
|
IGL03325:Vmn2r114
|
APN |
17 |
23,510,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Vmn2r114
|
UTSW |
17 |
23,510,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0109:Vmn2r114
|
UTSW |
17 |
23,529,549 (GRCm39) |
nonsense |
probably null |
|
|
R0164:Vmn2r114
|
UTSW |
17 |
23,528,800 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0310:Vmn2r114
|
UTSW |
17 |
23,509,917 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0583:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R0677:Vmn2r114
|
UTSW |
17 |
23,529,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1127:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R1147:Vmn2r114
|
UTSW |
17 |
23,530,037 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1147:Vmn2r114
|
UTSW |
17 |
23,530,037 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1157:Vmn2r114
|
UTSW |
17 |
23,529,314 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1323:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R1347:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R1435:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R1437:Vmn2r114
|
UTSW |
17 |
23,510,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1585:Vmn2r114
|
UTSW |
17 |
23,510,675 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1641:Vmn2r114
|
UTSW |
17 |
23,515,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1748:Vmn2r114
|
UTSW |
17 |
23,527,035 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1954:Vmn2r114
|
UTSW |
17 |
23,530,086 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2081:Vmn2r114
|
UTSW |
17 |
23,510,083 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2103:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R2113:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R2134:Vmn2r114
|
UTSW |
17 |
23,510,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2149:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R2424:Vmn2r114
|
UTSW |
17 |
23,515,842 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2847:Vmn2r114
|
UTSW |
17 |
23,509,948 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2848:Vmn2r114
|
UTSW |
17 |
23,509,948 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2893:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R3017:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R3018:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R3019:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R3020:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R3021:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R4628:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R4668:Vmn2r114
|
UTSW |
17 |
23,529,447 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4840:Vmn2r114
|
UTSW |
17 |
23,510,353 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4841:Vmn2r114
|
UTSW |
17 |
23,529,336 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4842:Vmn2r114
|
UTSW |
17 |
23,529,336 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4856:Vmn2r114
|
UTSW |
17 |
23,527,008 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4886:Vmn2r114
|
UTSW |
17 |
23,527,008 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4992:Vmn2r114
|
UTSW |
17 |
23,510,765 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5182:Vmn2r114
|
UTSW |
17 |
23,510,632 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5223:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R5405:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R5449:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R5615:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
R5834:Vmn2r114
|
UTSW |
17 |
23,529,599 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6150:Vmn2r114
|
UTSW |
17 |
23,510,269 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6277:Vmn2r114
|
UTSW |
17 |
23,509,954 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6403:Vmn2r114
|
UTSW |
17 |
23,528,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6589:Vmn2r114
|
UTSW |
17 |
23,510,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Vmn2r114
|
UTSW |
17 |
23,529,220 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6747:Vmn2r114
|
UTSW |
17 |
23,528,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6837:Vmn2r114
|
UTSW |
17 |
23,529,176 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6911:Vmn2r114
|
UTSW |
17 |
23,510,104 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6950:Vmn2r114
|
UTSW |
17 |
23,529,137 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7482:Vmn2r114
|
UTSW |
17 |
23,510,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Vmn2r114
|
UTSW |
17 |
23,527,035 (GRCm39) |
missense |
probably null |
0.96 |
|
R7523:Vmn2r114
|
UTSW |
17 |
23,529,611 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7563:Vmn2r114
|
UTSW |
17 |
23,510,000 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7585:Vmn2r114
|
UTSW |
17 |
23,510,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7593:Vmn2r114
|
UTSW |
17 |
23,510,817 (GRCm39) |
nonsense |
probably null |
|
|
R7611:Vmn2r114
|
UTSW |
17 |
23,515,944 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7641:Vmn2r114
|
UTSW |
17 |
23,527,177 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7651:Vmn2r114
|
UTSW |
17 |
23,509,986 (GRCm39) |
nonsense |
probably null |
|
|
R7970:Vmn2r114
|
UTSW |
17 |
23,530,186 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8737:Vmn2r114
|
UTSW |
17 |
23,529,142 (GRCm39) |
missense |
probably benign |
0.36 |
|
R8802:Vmn2r114
|
UTSW |
17 |
23,528,836 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8847:Vmn2r114
|
UTSW |
17 |
23,528,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8991:Vmn2r114
|
UTSW |
17 |
23,529,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9138:Vmn2r114
|
UTSW |
17 |
23,510,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9173:Vmn2r114
|
UTSW |
17 |
23,510,527 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9175:Vmn2r114
|
UTSW |
17 |
23,527,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9657:Vmn2r114
|
UTSW |
17 |
23,510,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9670:Vmn2r114
|
UTSW |
17 |
23,531,098 (GRCm39) |
missense |
|
|
|
X0065:Vmn2r114
|
UTSW |
17 |
23,529,931 (GRCm39) |
missense |
probably benign |
0.34 |
|
Z1088:Vmn2r114
|
UTSW |
17 |
23,509,906 (GRCm39) |
makesense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCCAGTGTAAAGATTTTGTCAC -3'
(R):5'- AGTGTCTGGGTCACTTTCATC -3'
Sequencing Primer
(F):5'- CAGGCCATGATTATATCTGCAGAGAC -3'
(R):5'- TCCCTGTTTACCATAGCACCAAAGG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation