Incidental Mutation 'R7283:Bicra'
ID 565796
Institutional Source Beutler Lab
Gene Symbol Bicra
Ensembl Gene ENSMUSG00000070808
Gene Name BRD4 interacting chromatin remodeling complex associated protein
Synonyms Gltscr1
MMRRC Submission 045361-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R7283 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 15704597-15781846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 15706425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 1339 (T1339A)
Ref Sequence ENSEMBL: ENSMUSP00000092416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000098799] [ENSMUST00000210781]
AlphaFold F8VPZ9
Predicted Effect probably damaging
Transcript: ENSMUST00000094821
AA Change: T1339A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: T1339A

DomainStartEndE-ValueType
low complexity region 86 96 N/A INTRINSIC
low complexity region 140 155 N/A INTRINSIC
internal_repeat_1 156 298 1.03e-6 PROSPERO
low complexity region 308 323 N/A INTRINSIC
low complexity region 427 443 N/A INTRINSIC
internal_repeat_1 479 614 1.03e-6 PROSPERO
low complexity region 619 638 N/A INTRINSIC
low complexity region 642 676 N/A INTRINSIC
low complexity region 719 732 N/A INTRINSIC
low complexity region 756 782 N/A INTRINSIC
low complexity region 790 819 N/A INTRINSIC
low complexity region 827 843 N/A INTRINSIC
low complexity region 852 906 N/A INTRINSIC
low complexity region 940 950 N/A INTRINSIC
low complexity region 987 1006 N/A INTRINSIC
Pfam:GLTSCR1 1094 1202 4.6e-43 PFAM
low complexity region 1232 1251 N/A INTRINSIC
low complexity region 1275 1294 N/A INTRINSIC
low complexity region 1349 1371 N/A INTRINSIC
low complexity region 1460 1473 N/A INTRINSIC
low complexity region 1535 1555 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000098799
SMART Domains Protein: ENSMUSP00000096397
Gene: ENSMUSG00000074364

DomainStartEndE-ValueType
Pfam:EHD_N 24 56 4.1e-19 PFAM
Pfam:MMR_HSR1 60 220 2.2e-7 PFAM
Pfam:Dynamin_N 61 221 2.4e-14 PFAM
EH 443 536 2.96e-36 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000210781
AA Change: T1339A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (72/72)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833439L19Rik A G 13: 54,700,504 (GRCm39) V278A probably benign Het
Abcc3 C T 11: 94,247,873 (GRCm39) A1207T probably benign Het
Abce1 C A 8: 80,411,885 (GRCm39) G592* probably null Het
Acad10 A C 5: 121,787,538 (GRCm39) V137G possibly damaging Het
Adcy3 A G 12: 4,253,563 (GRCm39) I672V not run Het
Adgrb1 A T 15: 74,452,512 (GRCm39) Q1166L possibly damaging Het
Ankrd44 A T 1: 54,768,955 (GRCm39) N465K probably damaging Het
Avpr1b A G 1: 131,537,469 (GRCm39) T418A probably benign Het
Azin1 G A 15: 38,501,652 (GRCm39) T33I probably damaging Het
Bltp2 A G 11: 78,165,654 (GRCm39) Q1346R probably damaging Het
Cacna1s A G 1: 136,001,446 (GRCm39) Y299C probably damaging Het
Clip1 A C 5: 123,751,857 (GRCm39) C641W Het
Clip3 T C 7: 30,005,237 (GRCm39) S524P probably damaging Het
Cnpy4 A T 5: 138,191,144 (GRCm39) H240L probably benign Het
Cyp2b19 T C 7: 26,466,339 (GRCm39) Y381H probably damaging Het
Cyp3a13 T A 5: 137,903,818 (GRCm39) N280I probably benign Het
Diaph3 A G 14: 87,104,020 (GRCm39) F788S probably damaging Het
Drc7 A G 8: 95,798,207 (GRCm39) N484S probably damaging Het
Erap1 G A 13: 74,821,903 (GRCm39) probably null Het
Fat4 A T 3: 38,943,842 (GRCm39) I912F probably damaging Het
Hsd3b3 T A 3: 98,649,673 (GRCm39) K217* probably null Het
Igkv12-89 A G 6: 68,812,061 (GRCm39) V36A probably damaging Het
Invs T A 4: 48,392,526 (GRCm39) probably null Het
Ipo8 T A 6: 148,725,979 (GRCm39) Y30F possibly damaging Het
Kctd14 T C 7: 97,100,693 (GRCm39) M1T probably null Het
Klrb1c A T 6: 128,761,220 (GRCm39) C136S probably benign Het
Morn2 A G 17: 80,604,688 (GRCm39) E48G probably damaging Het
Myh1 A T 11: 67,092,670 (GRCm39) probably null Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nfxl1 A G 5: 72,686,393 (GRCm39) S603P probably benign Het
Nlrc3 G A 16: 3,765,741 (GRCm39) A351V probably benign Het
Nlrp4f G A 13: 65,343,352 (GRCm39) R76* probably null Het
Or1e1f T C 11: 73,855,634 (GRCm39) S67P probably damaging Het
Or52n1 G T 7: 104,382,800 (GRCm39) T257K probably damaging Het
Or5h22 A T 16: 58,894,555 (GRCm39) M296K probably benign Het
Or7e176 A C 9: 20,171,555 (GRCm39) I140L probably damaging Het
Or8k41 A T 2: 86,313,483 (GRCm39) I201N probably damaging Het
Papolg A G 11: 23,817,394 (GRCm39) V601A not run Het
Pde4dip T C 3: 97,666,198 (GRCm39) T349A probably benign Het
Pdlim5 T C 3: 142,017,741 (GRCm39) probably null Het
Pkhd1l1 A G 15: 44,366,676 (GRCm39) N718S probably benign Het
Plcxd3 A G 15: 4,546,401 (GRCm39) H135R probably damaging Het
Plxna2 A T 1: 194,327,191 (GRCm39) Y375F probably damaging Het
Prkca C T 11: 108,231,471 (GRCm39) probably null Het
Prkdc A G 16: 15,535,628 (GRCm39) S1663G probably benign Het
Ptbp3 T C 4: 59,514,384 (GRCm39) T80A probably benign Het
Ptpn4 C T 1: 119,610,261 (GRCm39) V696I possibly damaging Het
Pygl A T 12: 70,263,342 (GRCm39) W175R possibly damaging Het
Rftn1 A G 17: 50,354,469 (GRCm39) Y298H probably damaging Het
Rit2 A G 18: 31,449,892 (GRCm39) probably null Het
Runx1t1 G A 4: 13,846,935 (GRCm39) G240R probably damaging Het
Scn10a A G 9: 119,493,845 (GRCm39) probably null Het
Serpina16 A C 12: 103,638,691 (GRCm39) probably null Het
Slc17a3 A T 13: 24,039,831 (GRCm39) M290L Het
Slc6a4 A T 11: 76,901,522 (GRCm39) M86L probably benign Het
Spag7 A T 11: 70,556,139 (GRCm39) V46E probably benign Het
Spata31h1 G A 10: 82,127,131 (GRCm39) R1960W possibly damaging Het
Sptlc1 T C 13: 53,498,914 (GRCm39) I271V probably benign Het
Stk17b A C 1: 53,796,674 (GRCm39) H364Q probably benign Het
Strc T C 2: 121,209,933 (GRCm39) H130R probably damaging Het
Stxbp1 T A 2: 32,705,026 (GRCm39) D148V probably damaging Het
Tirap G A 9: 35,100,225 (GRCm39) P153L probably damaging Het
Tmco3 G A 8: 13,369,605 (GRCm39) probably null Het
Tmem51 T A 4: 141,759,094 (GRCm39) D218V probably damaging Het
Trim40 A T 17: 37,193,554 (GRCm39) D218E probably benign Het
Ttc21b T C 2: 66,039,062 (GRCm39) D934G probably damaging Het
Vmn2r26 T C 6: 124,002,914 (GRCm39) L108P probably damaging Het
Washc2 C A 6: 116,204,379 (GRCm39) P429Q probably damaging Het
Wipi1 A G 11: 109,502,137 (GRCm39) M1T probably null Het
Zfp438 A G 18: 5,214,712 (GRCm39) V82A probably damaging Het
Zfp853 G C 5: 143,273,493 (GRCm39) A724G unknown Het
Other mutations in Bicra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Bicra APN 7 15,730,502 (GRCm39) missense possibly damaging 0.70
IGL01521:Bicra APN 7 15,723,113 (GRCm39) missense probably benign 0.18
IGL01690:Bicra APN 7 15,721,678 (GRCm39) missense probably benign 0.09
IGL01721:Bicra APN 7 15,722,624 (GRCm39) missense probably benign
IGL01994:Bicra APN 7 15,706,741 (GRCm39) missense possibly damaging 0.46
IGL02084:Bicra APN 7 15,721,663 (GRCm39) missense probably benign 0.09
IGL02312:Bicra APN 7 15,727,066 (GRCm39) missense possibly damaging 0.85
IGL02686:Bicra APN 7 15,721,840 (GRCm39) missense probably benign 0.02
IGL02727:Bicra APN 7 15,713,390 (GRCm39) missense possibly damaging 0.95
IGL03031:Bicra APN 7 15,709,726 (GRCm39) missense probably benign 0.16
R0003:Bicra UTSW 7 15,705,812 (GRCm39) missense probably benign
R0025:Bicra UTSW 7 15,721,436 (GRCm39) missense possibly damaging 0.53
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0417:Bicra UTSW 7 15,706,247 (GRCm39) missense probably damaging 1.00
R0437:Bicra UTSW 7 15,722,687 (GRCm39) missense possibly damaging 0.73
R0547:Bicra UTSW 7 15,706,173 (GRCm39) missense probably damaging 1.00
R0688:Bicra UTSW 7 15,723,247 (GRCm39) missense probably damaging 1.00
R0855:Bicra UTSW 7 15,705,929 (GRCm39) missense probably damaging 1.00
R1448:Bicra UTSW 7 15,722,284 (GRCm39) missense possibly damaging 0.86
R1637:Bicra UTSW 7 15,706,614 (GRCm39) missense probably benign 0.19
R1899:Bicra UTSW 7 15,721,676 (GRCm39) missense possibly damaging 0.53
R2035:Bicra UTSW 7 15,730,338 (GRCm39) missense possibly damaging 0.53
R2247:Bicra UTSW 7 15,723,159 (GRCm39) missense probably benign 0.33
R2471:Bicra UTSW 7 15,706,257 (GRCm39) missense probably benign 0.04
R2484:Bicra UTSW 7 15,722,605 (GRCm39) missense possibly damaging 0.96
R3437:Bicra UTSW 7 15,723,223 (GRCm39) missense possibly damaging 0.85
R3551:Bicra UTSW 7 15,713,658 (GRCm39) missense probably benign 0.33
R4816:Bicra UTSW 7 15,722,831 (GRCm39) missense possibly damaging 0.53
R4901:Bicra UTSW 7 15,721,526 (GRCm39) missense possibly damaging 0.53
R5035:Bicra UTSW 7 15,713,349 (GRCm39) missense possibly damaging 0.90
R5078:Bicra UTSW 7 15,709,382 (GRCm39) missense probably damaging 1.00
R5094:Bicra UTSW 7 15,709,296 (GRCm39) missense probably damaging 1.00
R5195:Bicra UTSW 7 15,713,878 (GRCm39) missense possibly damaging 0.93
R5496:Bicra UTSW 7 15,721,766 (GRCm39) missense probably benign 0.33
R5780:Bicra UTSW 7 15,713,679 (GRCm39) missense possibly damaging 0.96
R6541:Bicra UTSW 7 15,713,054 (GRCm39) missense probably benign 0.00
R6560:Bicra UTSW 7 15,723,119 (GRCm39) missense possibly damaging 0.53
R6575:Bicra UTSW 7 15,713,056 (GRCm39) missense probably benign 0.25
R6854:Bicra UTSW 7 15,722,687 (GRCm39) missense probably benign 0.18
R6967:Bicra UTSW 7 15,706,130 (GRCm39) missense probably damaging 0.97
R7454:Bicra UTSW 7 15,706,059 (GRCm39) missense probably benign 0.30
R7462:Bicra UTSW 7 15,713,060 (GRCm39) missense possibly damaging 0.84
R7488:Bicra UTSW 7 15,723,367 (GRCm39) critical splice acceptor site probably null
R7506:Bicra UTSW 7 15,722,138 (GRCm39) missense possibly damaging 0.96
R7534:Bicra UTSW 7 15,705,860 (GRCm39) missense probably damaging 0.98
R7915:Bicra UTSW 7 15,722,447 (GRCm39) missense probably benign
R8063:Bicra UTSW 7 15,712,969 (GRCm39) missense probably benign
R8147:Bicra UTSW 7 15,722,395 (GRCm39) missense possibly damaging 0.93
R8699:Bicra UTSW 7 15,723,113 (GRCm39) missense probably benign 0.18
R8784:Bicra UTSW 7 15,705,875 (GRCm39) missense probably damaging 1.00
R8859:Bicra UTSW 7 15,721,737 (GRCm39) missense possibly damaging 0.73
R8971:Bicra UTSW 7 15,721,481 (GRCm39) missense probably benign 0.08
R9487:Bicra UTSW 7 15,705,717 (GRCm39) missense probably damaging 0.99
R9614:Bicra UTSW 7 15,705,880 (GRCm39) missense probably damaging 1.00
R9721:Bicra UTSW 7 15,713,101 (GRCm39) missense probably damaging 1.00
R9777:Bicra UTSW 7 15,705,987 (GRCm39) missense probably benign 0.09
X0064:Bicra UTSW 7 15,709,700 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCCATGTTTTCTCGGTAG -3'
(R):5'- TGCCCACCAAGCTAGTGATC -3'

Sequencing Primer
(F):5'- AGGTCTTGCGTAGTGGTAGAC -3'
(R):5'- CAAGCTAGTGATCCGGCAC -3'
Posted On 2019-06-26