Incidental Mutation 'R7289:Rims2'
| ID |
566274 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rims2
|
| Ensembl Gene |
ENSMUSG00000037386 |
| Gene Name |
regulating synaptic membrane exocytosis 2 |
| Synonyms |
RIM2, 2810036I15Rik, Syt3-rs |
| MMRRC Submission |
045396-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.661)
|
| Stock # |
R7289 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
39061681-39547768 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 39301114 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 474
(M474L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048719
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042917]
[ENSMUST00000082054]
[ENSMUST00000227243]
[ENSMUST00000228839]
|
| AlphaFold |
Q9EQZ7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042917
AA Change: M474L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000048719
Gene: ENSMUSG00000037386
AA Change: M474L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
30 |
154 |
9.5e-18 |
PFAM |
|
low complexity region
|
315 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
492 |
498 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
PDZ
|
646 |
725 |
8.27e-16 |
SMART |
|
low complexity region
|
740 |
748 |
N/A |
INTRINSIC |
|
C2
|
790 |
897 |
4.08e-21 |
SMART |
|
low complexity region
|
905 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1130 |
N/A |
INTRINSIC |
|
low complexity region
|
1208 |
1238 |
N/A |
INTRINSIC |
|
C2
|
1432 |
1535 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082054
AA Change: M514L
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000080711
Gene: ENSMUSG00000037386
AA Change: M514L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
76 |
194 |
2.2e-11 |
PFAM |
|
low complexity region
|
355 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
538 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
561 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
580 |
N/A |
INTRINSIC |
|
PDZ
|
686 |
765 |
8.27e-16 |
SMART |
|
low complexity region
|
780 |
788 |
N/A |
INTRINSIC |
|
C2
|
830 |
937 |
4.08e-21 |
SMART |
|
low complexity region
|
945 |
959 |
N/A |
INTRINSIC |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1196 |
N/A |
INTRINSIC |
|
C2
|
1390 |
1493 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227243
AA Change: M474L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228839
AA Change: M282L
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars2 |
G |
A |
17: 45,818,550 (GRCm39) |
D112N |
probably damaging |
Het |
| Abca7 |
T |
A |
10: 79,845,778 (GRCm39) |
I1580K |
probably damaging |
Het |
| Aebp1 |
A |
G |
11: 5,815,059 (GRCm39) |
D234G |
probably damaging |
Het |
| Agap1 |
T |
A |
1: 89,383,153 (GRCm39) |
M1K |
probably null |
Het |
| Agrn |
A |
T |
4: 156,263,389 (GRCm39) |
L345H |
probably damaging |
Het |
| Amfr |
A |
G |
8: 94,725,754 (GRCm39) |
M209T |
possibly damaging |
Het |
| Angel2 |
G |
A |
1: 190,673,371 (GRCm39) |
R338H |
possibly damaging |
Het |
| Ankrd27 |
C |
T |
7: 35,330,674 (GRCm39) |
A866V |
probably damaging |
Het |
| Apc |
G |
A |
18: 34,448,324 (GRCm39) |
R1740Q |
probably damaging |
Het |
| Arhgap32 |
A |
T |
9: 32,168,233 (GRCm39) |
S739C |
possibly damaging |
Het |
| Arhgap32 |
G |
C |
9: 32,168,234 (GRCm39) |
S739T |
probably benign |
Het |
| Arhgef2 |
C |
T |
3: 88,543,192 (GRCm39) |
S418L |
probably benign |
Het |
| Arhgef25 |
T |
C |
10: 127,019,641 (GRCm39) |
T472A |
possibly damaging |
Het |
| Atrnl1 |
C |
T |
19: 57,638,846 (GRCm39) |
S328F |
probably benign |
Het |
| Bahcc1 |
C |
T |
11: 120,171,000 (GRCm39) |
A1514V |
probably benign |
Het |
| Calcoco2 |
C |
T |
11: 95,990,823 (GRCm39) |
E305K |
unknown |
Het |
| Ccn1 |
C |
T |
3: 145,354,428 (GRCm39) |
W161* |
probably null |
Het |
| Cdc42bpa |
A |
T |
1: 179,889,362 (GRCm39) |
K203* |
probably null |
Het |
| Cmc1 |
A |
T |
9: 117,904,250 (GRCm39) |
I47N |
possibly damaging |
Het |
| Cntln |
A |
G |
4: 84,964,540 (GRCm39) |
E656G |
possibly damaging |
Het |
| Dcun1d3 |
T |
C |
7: 119,458,864 (GRCm39) |
K57R |
possibly damaging |
Het |
| Ddx23 |
T |
C |
15: 98,546,492 (GRCm39) |
E559G |
probably damaging |
Het |
| Dennd6a |
G |
A |
14: 26,333,193 (GRCm39) |
R367Q |
probably damaging |
Het |
| Desi2 |
A |
T |
1: 178,083,702 (GRCm39) |
|
probably benign |
Het |
| Dido1 |
T |
C |
2: 180,301,424 (GRCm39) |
D2160G |
unknown |
Het |
| Efcab3 |
T |
C |
11: 104,929,184 (GRCm39) |
M4838T |
probably benign |
Het |
| Epb41 |
A |
G |
4: 131,718,520 (GRCm39) |
|
probably null |
Het |
| Esrrb |
T |
A |
12: 86,517,331 (GRCm39) |
|
probably null |
Het |
| Fabp1 |
C |
A |
6: 71,180,111 (GRCm39) |
T94N |
probably benign |
Het |
| Fam120a |
A |
T |
13: 49,045,482 (GRCm39) |
C785S |
probably damaging |
Het |
| Fam243 |
T |
C |
16: 92,117,710 (GRCm39) |
I193V |
probably damaging |
Het |
| Foxc1 |
A |
G |
13: 31,991,243 (GRCm39) |
Y18C |
probably damaging |
Het |
| Fshr |
T |
C |
17: 89,293,272 (GRCm39) |
T469A |
probably benign |
Het |
| Gm14399 |
T |
A |
2: 174,972,204 (GRCm39) |
H517L |
unknown |
Het |
| Gm39115 |
G |
T |
7: 141,689,297 (GRCm39) |
Q159K |
unknown |
Het |
| Gm7347 |
T |
A |
5: 26,262,306 (GRCm39) |
I72F |
possibly damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,559,466 (GRCm39) |
V2395A |
possibly damaging |
Het |
| Ighv5-17 |
T |
G |
12: 113,822,858 (GRCm39) |
T88P |
probably damaging |
Het |
| Insm2 |
T |
A |
12: 55,647,329 (GRCm39) |
Y358N |
probably damaging |
Het |
| Kazn |
A |
T |
4: 141,844,486 (GRCm39) |
L409Q |
|
Het |
| Kcnj5 |
A |
C |
9: 32,234,045 (GRCm39) |
L90R |
probably damaging |
Het |
| Kcnv2 |
A |
T |
19: 27,311,084 (GRCm39) |
T484S |
probably damaging |
Het |
| Kdm3b |
T |
C |
18: 34,927,557 (GRCm39) |
Y140H |
probably benign |
Het |
| Kifbp |
A |
C |
10: 62,401,895 (GRCm39) |
C261W |
probably damaging |
Het |
| Krt25 |
C |
T |
11: 99,212,098 (GRCm39) |
A180T |
probably benign |
Het |
| Mmp1a |
A |
G |
9: 7,467,294 (GRCm39) |
E290G |
probably damaging |
Het |
| Muc21 |
G |
A |
17: 35,929,761 (GRCm39) |
A1475V |
unknown |
Het |
| Nr3c1 |
T |
C |
18: 39,547,654 (GRCm39) |
T755A |
probably benign |
Het |
| Nr3c1 |
A |
T |
18: 39,555,786 (GRCm39) |
I517N |
probably benign |
Het |
| Nxpe2 |
A |
G |
9: 48,234,339 (GRCm39) |
|
probably null |
Het |
| Oaz1 |
C |
A |
10: 80,662,673 (GRCm39) |
T27K |
possibly damaging |
Het |
| Or4p7 |
A |
T |
2: 88,222,050 (GRCm39) |
H153L |
probably damaging |
Het |
| Or51f5 |
T |
C |
7: 102,424,634 (GRCm39) |
I301T |
probably damaging |
Het |
| Or5t5 |
G |
T |
2: 86,617,034 (GRCm39) |
C320F |
probably benign |
Het |
| Or6z3 |
T |
A |
7: 6,463,777 (GRCm39) |
W90R |
probably benign |
Het |
| Or8k21 |
A |
G |
2: 86,145,369 (GRCm39) |
M87T |
probably benign |
Het |
| Or8s5 |
A |
G |
15: 98,237,943 (GRCm39) |
V309A |
probably damaging |
Het |
| Pafah2 |
A |
T |
4: 134,147,308 (GRCm39) |
K319M |
probably damaging |
Het |
| Pask |
A |
T |
1: 93,259,309 (GRCm39) |
V236E |
probably damaging |
Het |
| Pcdh1 |
T |
C |
18: 38,322,966 (GRCm39) |
T956A |
probably damaging |
Het |
| Pcdhb18 |
C |
A |
18: 37,623,700 (GRCm39) |
N343K |
probably damaging |
Het |
| Pcsk2 |
A |
T |
2: 143,532,343 (GRCm39) |
I164F |
probably damaging |
Het |
| Phf1 |
T |
C |
17: 27,154,289 (GRCm39) |
Y169H |
probably damaging |
Het |
| Pkdrej |
T |
A |
15: 85,705,301 (GRCm39) |
I212F |
probably benign |
Het |
| Pnkp |
T |
A |
7: 44,508,114 (GRCm39) |
W146R |
probably damaging |
Het |
| Prkcb |
A |
T |
7: 122,143,910 (GRCm39) |
I325F |
probably benign |
Het |
| Ptpn21 |
C |
T |
12: 98,670,450 (GRCm39) |
D239N |
probably benign |
Het |
| Ptprb |
A |
G |
10: 116,164,070 (GRCm39) |
T626A |
probably damaging |
Het |
| Pttg1 |
T |
C |
11: 43,311,916 (GRCm39) |
N180D |
probably benign |
Het |
| Raly |
G |
A |
2: 154,703,774 (GRCm39) |
R115Q |
probably damaging |
Het |
| Sash1 |
A |
T |
10: 8,605,960 (GRCm39) |
I810N |
probably damaging |
Het |
| Scnn1g |
T |
A |
7: 121,337,304 (GRCm39) |
L55* |
probably null |
Het |
| Sema6b |
A |
T |
17: 56,432,573 (GRCm39) |
D543E |
possibly damaging |
Het |
| Serpina11 |
C |
T |
12: 103,952,761 (GRCm39) |
G5E |
unknown |
Het |
| Sesn3 |
A |
T |
9: 14,187,848 (GRCm39) |
M1L |
probably benign |
Het |
| Sez6 |
T |
A |
11: 77,865,149 (GRCm39) |
I632N |
possibly damaging |
Het |
| Sgo2b |
A |
T |
8: 64,394,192 (GRCm39) |
I49N |
probably damaging |
Het |
| Slc30a2 |
A |
T |
4: 134,071,524 (GRCm39) |
I86F |
possibly damaging |
Het |
| Slc38a6 |
T |
A |
12: 73,333,786 (GRCm39) |
W30R |
probably benign |
Het |
| Spata31g1 |
A |
T |
4: 42,972,379 (GRCm39) |
T571S |
probably benign |
Het |
| Spata31g1 |
A |
T |
4: 42,973,252 (GRCm39) |
I862F |
possibly damaging |
Het |
| Stk31 |
T |
G |
6: 49,415,393 (GRCm39) |
V576G |
probably benign |
Het |
| Szt2 |
G |
A |
4: 118,233,075 (GRCm39) |
T2297I |
unknown |
Het |
| Tmem208 |
T |
C |
8: 106,061,418 (GRCm39) |
F148S |
possibly damaging |
Het |
| Tprg1l |
A |
G |
4: 154,245,031 (GRCm39) |
L19P |
possibly damaging |
Het |
| Tubg2 |
C |
A |
11: 101,050,897 (GRCm39) |
N207K |
probably damaging |
Het |
| Ube2n |
G |
T |
10: 95,377,612 (GRCm39) |
K130N |
probably benign |
Het |
| Usp36 |
T |
C |
11: 118,164,355 (GRCm39) |
Y384C |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,840,852 (GRCm39) |
L1564* |
probably null |
Het |
| Xkr6 |
A |
T |
14: 64,035,748 (GRCm39) |
D283V |
unknown |
Het |
| Zfp654 |
T |
C |
16: 64,605,523 (GRCm39) |
H352R |
probably benign |
Het |
| Zfp819 |
T |
A |
7: 43,266,506 (GRCm39) |
C330S |
probably damaging |
Het |
| Zfp970 |
G |
T |
2: 177,167,086 (GRCm39) |
C220F |
probably damaging |
Het |
|
| Other mutations in Rims2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Rims2
|
APN |
15 |
39,323,011 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00502:Rims2
|
APN |
15 |
39,370,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00556:Rims2
|
APN |
15 |
39,320,070 (GRCm39) |
splice site |
probably null |
|
|
IGL00811:Rims2
|
APN |
15 |
39,155,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00827:Rims2
|
APN |
15 |
39,335,755 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Rims2
|
APN |
15 |
39,321,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02951:Rims2
|
APN |
15 |
39,398,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03009:Rims2
|
APN |
15 |
39,430,393 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03080:Rims2
|
APN |
15 |
39,399,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Rims2
|
APN |
15 |
39,322,989 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03252:Rims2
|
APN |
15 |
39,315,748 (GRCm39) |
missense |
probably benign |
|
|
IGL03365:Rims2
|
APN |
15 |
39,339,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03393:Rims2
|
APN |
15 |
39,326,009 (GRCm39) |
splice site |
probably null |
|
|
IGL03409:Rims2
|
APN |
15 |
39,320,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
rhyme
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Rims2
|
UTSW |
15 |
39,339,916 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0078:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0367:Rims2
|
UTSW |
15 |
39,326,011 (GRCm39) |
splice site |
probably null |
|
|
R0401:Rims2
|
UTSW |
15 |
39,373,028 (GRCm39) |
splice site |
probably benign |
|
|
R0531:Rims2
|
UTSW |
15 |
39,430,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0791:Rims2
|
UTSW |
15 |
39,543,021 (GRCm39) |
splice site |
probably benign |
|
|
R0838:Rims2
|
UTSW |
15 |
39,544,421 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1201:Rims2
|
UTSW |
15 |
39,479,720 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1318:Rims2
|
UTSW |
15 |
39,381,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1457:Rims2
|
UTSW |
15 |
39,374,710 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1619:Rims2
|
UTSW |
15 |
39,370,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1672:Rims2
|
UTSW |
15 |
39,155,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1743:Rims2
|
UTSW |
15 |
39,543,046 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1766:Rims2
|
UTSW |
15 |
39,325,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1779:Rims2
|
UTSW |
15 |
39,545,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Rims2
|
UTSW |
15 |
39,300,439 (GRCm39) |
nonsense |
probably null |
|
|
R1985:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1986:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2113:Rims2
|
UTSW |
15 |
39,374,722 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2260:Rims2
|
UTSW |
15 |
39,341,962 (GRCm39) |
nonsense |
probably null |
|
|
R2510:Rims2
|
UTSW |
15 |
39,449,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3693:Rims2
|
UTSW |
15 |
39,341,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3937:Rims2
|
UTSW |
15 |
39,301,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4425:Rims2
|
UTSW |
15 |
39,301,320 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4453:Rims2
|
UTSW |
15 |
39,155,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4474:Rims2
|
UTSW |
15 |
39,325,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4518:Rims2
|
UTSW |
15 |
39,300,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Rims2
|
UTSW |
15 |
39,301,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4833:Rims2
|
UTSW |
15 |
39,399,310 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4936:Rims2
|
UTSW |
15 |
39,301,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Rims2
|
UTSW |
15 |
39,317,841 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5001:Rims2
|
UTSW |
15 |
39,315,824 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5054:Rims2
|
UTSW |
15 |
39,381,265 (GRCm39) |
splice site |
probably null |
|
|
R5072:Rims2
|
UTSW |
15 |
39,325,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5171:Rims2
|
UTSW |
15 |
39,300,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5429:Rims2
|
UTSW |
15 |
39,208,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5623:Rims2
|
UTSW |
15 |
39,342,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Rims2
|
UTSW |
15 |
39,208,809 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5685:Rims2
|
UTSW |
15 |
39,300,602 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5784:Rims2
|
UTSW |
15 |
39,399,383 (GRCm39) |
splice site |
probably null |
|
|
R5790:Rims2
|
UTSW |
15 |
39,544,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5822:Rims2
|
UTSW |
15 |
39,339,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5963:Rims2
|
UTSW |
15 |
39,300,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5988:Rims2
|
UTSW |
15 |
39,155,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Rims2
|
UTSW |
15 |
39,538,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6239:Rims2
|
UTSW |
15 |
39,061,758 (GRCm39) |
start codon destroyed |
unknown |
|
|
R6407:Rims2
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6418:Rims2
|
UTSW |
15 |
39,373,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6495:Rims2
|
UTSW |
15 |
39,381,208 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6502:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6753:Rims2
|
UTSW |
15 |
39,430,369 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6855:Rims2
|
UTSW |
15 |
39,208,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6948:Rims2
|
UTSW |
15 |
39,374,737 (GRCm39) |
missense |
probably benign |
|
|
R7058:Rims2
|
UTSW |
15 |
39,449,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Rims2
|
UTSW |
15 |
39,300,473 (GRCm39) |
missense |
probably benign |
|
|
R7217:Rims2
|
UTSW |
15 |
39,339,885 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Rims2
|
UTSW |
15 |
39,300,428 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7459:Rims2
|
UTSW |
15 |
39,381,235 (GRCm39) |
missense |
probably benign |
|
|
R7663:Rims2
|
UTSW |
15 |
39,370,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7792:Rims2
|
UTSW |
15 |
39,061,923 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7836:Rims2
|
UTSW |
15 |
39,544,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8082:Rims2
|
UTSW |
15 |
39,339,919 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8489:Rims2
|
UTSW |
15 |
39,479,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8730:Rims2
|
UTSW |
15 |
39,381,239 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8830:Rims2
|
UTSW |
15 |
39,300,758 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8857:Rims2
|
UTSW |
15 |
39,543,044 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8893:Rims2
|
UTSW |
15 |
39,398,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9010:Rims2
|
UTSW |
15 |
39,315,786 (GRCm39) |
nonsense |
probably null |
|
|
R9030:Rims2
|
UTSW |
15 |
39,339,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Rims2
|
UTSW |
15 |
39,543,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9395:Rims2
|
UTSW |
15 |
39,155,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9451:Rims2
|
UTSW |
15 |
39,300,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Rims2
|
UTSW |
15 |
39,335,832 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0034:Rims2
|
UTSW |
15 |
39,300,930 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,544,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rims2
|
UTSW |
15 |
39,342,086 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,301,165 (GRCm39) |
missense |
probably benign |
0.24 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAACGTAGAGCTGCAATGG -3'
(R):5'- AGCTCCACATCATCACAGCTTG -3'
Sequencing Primer
(F):5'- CGATCGTATTCAATGGAAAGAACTCG -3'
(R):5'- CATCACAGCTTGTATACTCAGGTGTG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation