Incidental Mutation 'R7295:Il22b'
ID 566683
Institutional Source Beutler Lab
Gene Symbol Il22b
Ensembl Gene ENSMUSG00000090461
Gene Name interleukin 22B
Synonyms Iltifb, IL-TIFb
MMRRC Submission 045363-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7295 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 118125534-118130943 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 118130848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 16 (L16*)
Ref Sequence ENSEMBL: ENSMUSP00000128415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163808]
AlphaFold Q9JJY8
Predicted Effect probably null
Transcript: ENSMUST00000163808
AA Change: L16*
SMART Domains Protein: ENSMUSP00000128415
Gene: ENSMUSG00000090461
AA Change: L16*

DomainStartEndE-ValueType
IL10 49 179 5.21e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
a A T 2: 154,887,678 (GRCm39) D46V probably damaging Het
Acp7 A T 7: 28,328,955 (GRCm39) F75Y possibly damaging Het
Adamts19 T A 18: 58,970,955 (GRCm39) Y180N probably damaging Het
Adck1 G T 12: 88,397,815 (GRCm39) D150Y probably damaging Het
Alb T A 5: 90,610,693 (GRCm39) probably null Het
Baat A T 4: 49,490,275 (GRCm39) Y270N probably damaging Het
Bmp7 A T 2: 172,781,690 (GRCm39) I58N probably damaging Het
Bpifb9a C T 2: 154,109,616 (GRCm39) T504M probably damaging Het
Cbfa2t3 T G 8: 123,364,768 (GRCm39) D338A probably benign Het
Ccnd2 A T 6: 127,125,725 (GRCm39) C104S possibly damaging Het
Clip1 G T 5: 123,765,419 (GRCm39) Q713K probably benign Het
Ddx28 G A 8: 106,737,476 (GRCm39) S194L probably benign Het
Dync1h1 T C 12: 110,631,183 (GRCm39) probably null Het
Edil3 T A 13: 89,279,902 (GRCm39) Y193* probably null Het
Eprs1 A G 1: 185,150,407 (GRCm39) probably null Het
Ercc6l2 T G 13: 63,967,589 (GRCm39) I63R probably damaging Het
Fam171a2 T C 11: 102,329,064 (GRCm39) E565G possibly damaging Het
Fbn1 T A 2: 125,177,407 (GRCm39) D1810V probably damaging Het
Foxj2 T C 6: 122,817,190 (GRCm39) S506P probably benign Het
Frmpd1 A G 4: 45,285,700 (GRCm39) E1507G probably damaging Het
Gfm1 G A 3: 67,347,514 (GRCm39) V258I probably benign Het
Gphn T C 12: 78,538,876 (GRCm39) V174A probably benign Het
Gtpbp3 C A 8: 71,942,139 (GRCm39) S123R possibly damaging Het
H2bc8 T C 13: 23,755,943 (GRCm39) S113P probably benign Het
Hbs1l T C 10: 21,186,051 (GRCm39) V491A probably benign Het
Hoxc12 A G 15: 102,846,810 (GRCm39) N234S probably damaging Het
Kcnj5 T C 9: 32,234,087 (GRCm39) D76G probably damaging Het
Klhl11 A G 11: 100,363,068 (GRCm39) Y163H probably damaging Het
Lonp1 G T 17: 56,929,495 (GRCm39) Q181K possibly damaging Het
Mgst1 A T 6: 138,124,754 (GRCm39) I23F probably benign Het
Muc21 G A 17: 35,929,761 (GRCm39) A1475V unknown Het
Myocos T C 1: 162,484,687 (GRCm39) R41G unknown Het
Myod1 A G 7: 46,027,643 (GRCm39) D261G probably benign Het
Nop14 C T 5: 34,796,376 (GRCm39) R781Q probably damaging Het
Nsmaf A G 4: 6,438,083 (GRCm39) V63A probably benign Het
Ntsr1 A T 2: 180,142,725 (GRCm39) H172L probably damaging Het
Or4k6 T C 14: 50,476,073 (GRCm39) K90E probably damaging Het
Or8b1c A T 9: 38,384,739 (GRCm39) E232V probably benign Het
Pcdha11 T C 18: 37,139,979 (GRCm39) V536A probably damaging Het
Pcdha6 T A 18: 37,101,189 (GRCm39) N127K probably damaging Het
Prps1l1 T A 12: 35,035,679 (GRCm39) C265S probably benign Het
Prune2 A G 19: 17,097,261 (GRCm39) S922G probably benign Het
Qpctl A T 7: 18,883,055 (GRCm39) M19K probably benign Het
Rad51 C T 2: 118,964,599 (GRCm39) T230I possibly damaging Het
Rad9b A G 5: 122,472,341 (GRCm39) F246L possibly damaging Het
Rarb A T 14: 16,508,932 (GRCm38) probably null Het
Sdcbp2 T C 2: 151,429,321 (GRCm39) S214P possibly damaging Het
Slc22a1 T A 17: 12,875,892 (GRCm39) M441L probably benign Het
Slc35f1 G A 10: 52,938,637 (GRCm39) V190I probably benign Het
Spon1 A T 7: 113,629,475 (GRCm39) Q373L possibly damaging Het
Ssbp2 T A 13: 91,842,122 (GRCm39) probably null Het
Sult1e1 T A 5: 87,726,512 (GRCm39) R201* probably null Het
Traj32 T A 14: 54,423,606 (GRCm39) L16Q Het
Ttc16 T C 2: 32,664,437 (GRCm39) I67V probably null Het
Ttn T A 2: 76,556,899 (GRCm39) K30035N probably damaging Het
Ttn T A 2: 76,776,473 (GRCm39) Y1607F unknown Het
Usp16 G A 16: 87,268,977 (GRCm39) R290H probably benign Het
Utp3 G C 5: 88,702,376 (GRCm39) probably benign Het
Xpnpep3 A G 15: 81,298,735 (GRCm39) H56R probably damaging Het
Zfp592 G T 7: 80,674,070 (GRCm39) D345Y probably damaging Het
Zfp931 A T 2: 177,709,824 (GRCm39) Y187* probably null Het
Other mutations in Il22b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01796:Il22b APN 10 118,126,069 (GRCm39) missense possibly damaging 0.70
IGL02149:Il22b APN 10 118,130,902 (GRCm39) utr 5 prime probably benign
IGL02965:Il22b APN 10 118,130,762 (GRCm39) missense probably damaging 0.98
R0310:Il22b UTSW 10 118,129,090 (GRCm39) missense probably benign 0.41
R0730:Il22b UTSW 10 118,130,142 (GRCm39) missense probably benign 0.01
R1078:Il22b UTSW 10 118,126,056 (GRCm39) makesense probably null
R4067:Il22b UTSW 10 118,126,115 (GRCm39) missense probably damaging 0.99
R4158:Il22b UTSW 10 118,129,037 (GRCm39) missense probably damaging 1.00
R4911:Il22b UTSW 10 118,130,894 (GRCm39) start codon destroyed probably null 0.99
R5433:Il22b UTSW 10 118,130,789 (GRCm39) missense probably damaging 0.96
R5778:Il22b UTSW 10 118,130,768 (GRCm39) nonsense probably null
R9313:Il22b UTSW 10 118,130,138 (GRCm39) missense probably damaging 1.00
R9485:Il22b UTSW 10 118,130,314 (GRCm39) missense probably benign
R9566:Il22b UTSW 10 118,130,860 (GRCm39) missense probably damaging 1.00
R9796:Il22b UTSW 10 118,130,081 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- GATAAAGCGCCCCTAAAGAGTTTG -3'
(R):5'- TTGCATCTACCATAACTGTGTGC -3'

Sequencing Primer
(F):5'- AAAGAGTTTGCACGCGCTTC -3'
(R):5'- ATAACTGTGTGCTCACTTACCATG -3'
Posted On 2019-06-26