Incidental Mutation 'R7302:Vmn2r66'
ID |
567046 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r66
|
Ensembl Gene |
ENSMUSG00000094950 |
Gene Name |
vomeronasal 2, receptor 66 |
Synonyms |
F830104D24Rik |
MMRRC Submission |
045406-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R7302 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
84643853-84661228 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 84654423 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Threonine
at position 512
(M512T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000122645
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000124773]
|
AlphaFold |
A0A3B2W842 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000124773
AA Change: M512T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000122645 Gene: ENSMUSG00000094950 AA Change: M512T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
463 |
5e-31 |
PFAM |
Pfam:NCD3G
|
507 |
559 |
6e-21 |
PFAM |
Pfam:7tm_3
|
589 |
827 |
3.8e-52 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
Validation Efficiency |
98% (50/51) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 51 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930474N05Rik |
C |
T |
14: 35,817,306 (GRCm39) |
P69S |
probably benign |
Het |
Adam17 |
A |
G |
12: 21,405,694 (GRCm39) |
|
probably benign |
Het |
Bcl7a |
T |
A |
5: 123,482,757 (GRCm39) |
M22K |
probably benign |
Het |
C6 |
T |
A |
15: 4,826,432 (GRCm39) |
C672S |
probably damaging |
Het |
Capn11 |
C |
T |
17: 45,954,738 (GRCm39) |
R133H |
probably damaging |
Het |
Ccdc102a |
A |
G |
8: 95,640,066 (GRCm39) |
L76P |
probably damaging |
Het |
Cfhr4 |
T |
C |
1: 139,667,436 (GRCm39) |
|
probably null |
Het |
Cotl1 |
T |
G |
8: 120,537,040 (GRCm39) |
I125L |
probably benign |
Het |
Dennd5a |
A |
T |
7: 109,504,906 (GRCm39) |
M868K |
probably damaging |
Het |
Depdc5 |
T |
C |
5: 33,136,852 (GRCm39) |
I1374T |
probably damaging |
Het |
Dhx36 |
T |
C |
3: 62,386,814 (GRCm39) |
Y646C |
probably benign |
Het |
Ecpas |
T |
C |
4: 58,834,593 (GRCm39) |
K762E |
probably benign |
Het |
Egln2 |
A |
G |
7: 26,864,310 (GRCm39) |
V205A |
probably damaging |
Het |
Eri2 |
T |
A |
7: 119,386,009 (GRCm39) |
M229L |
probably benign |
Het |
Fancf |
C |
A |
7: 51,511,452 (GRCm39) |
R184L |
probably damaging |
Het |
Fancl |
A |
T |
11: 26,353,363 (GRCm39) |
E86D |
probably damaging |
Het |
Fignl2 |
T |
C |
15: 100,951,259 (GRCm39) |
D341G |
unknown |
Het |
Gm14410 |
A |
T |
2: 176,885,648 (GRCm39) |
H205Q |
probably damaging |
Het |
Haus1 |
T |
C |
18: 77,848,666 (GRCm39) |
N181D |
probably benign |
Het |
Hmbox1 |
T |
C |
14: 65,066,115 (GRCm39) |
Y285C |
probably damaging |
Het |
Igkv3-9 |
A |
G |
6: 70,565,739 (GRCm39) |
M113V |
probably benign |
Het |
Ivd |
T |
C |
2: 118,701,985 (GRCm39) |
V139A |
probably benign |
Het |
Limch1 |
A |
T |
5: 67,116,942 (GRCm39) |
Y119F |
probably benign |
Het |
Lrp1 |
C |
T |
10: 127,374,856 (GRCm39) |
R4534Q |
probably benign |
Het |
Mbd3l2 |
G |
A |
9: 18,355,738 (GRCm39) |
S21N |
probably benign |
Het |
Mob1b |
A |
G |
5: 88,901,036 (GRCm39) |
N148D |
probably benign |
Het |
Mylk4 |
A |
T |
13: 32,904,548 (GRCm39) |
D195E |
probably benign |
Het |
Ndufa7 |
T |
C |
17: 34,048,687 (GRCm39) |
S50P |
probably benign |
Het |
Nectin4 |
G |
T |
1: 171,214,203 (GRCm39) |
E453* |
probably null |
Het |
Nell1 |
T |
G |
7: 50,506,017 (GRCm39) |
F741L |
probably benign |
Het |
Ntng1 |
T |
A |
3: 109,739,933 (GRCm39) |
H369L |
possibly damaging |
Het |
Plin4 |
T |
A |
17: 56,409,330 (GRCm39) |
M1297L |
probably benign |
Het |
Pnp |
G |
A |
14: 51,188,404 (GRCm39) |
V193M |
probably damaging |
Het |
Ppp1r10 |
T |
G |
17: 36,241,773 (GRCm39) |
S849R |
unknown |
Het |
Rpgrip1 |
A |
G |
14: 52,387,012 (GRCm39) |
E981G |
unknown |
Het |
Sbsn |
T |
C |
7: 30,451,309 (GRCm39) |
F108S |
probably benign |
Het |
Scn11a |
A |
G |
9: 119,636,017 (GRCm39) |
M310T |
probably benign |
Het |
Sf3b1 |
A |
G |
1: 55,055,949 (GRCm39) |
S97P |
probably benign |
Het |
Sgsh |
A |
G |
11: 119,238,525 (GRCm39) |
V313A |
probably benign |
Het |
Slc25a10 |
G |
T |
11: 120,382,782 (GRCm39) |
|
probably benign |
Het |
Slc9a2 |
T |
A |
1: 40,806,828 (GRCm39) |
V705E |
possibly damaging |
Het |
Surf2 |
G |
T |
2: 26,808,894 (GRCm39) |
C116F |
probably damaging |
Het |
Tnks1bp1 |
T |
C |
2: 84,882,698 (GRCm39) |
I175T |
probably benign |
Het |
Tnxb |
C |
T |
17: 34,897,875 (GRCm39) |
T841I |
probably benign |
Het |
Ttll3 |
A |
G |
6: 113,386,246 (GRCm39) |
D693G |
probably damaging |
Het |
Ust |
A |
G |
10: 8,393,973 (GRCm39) |
L64P |
probably damaging |
Het |
Vmn1r77 |
C |
T |
7: 11,775,983 (GRCm39) |
S253F |
possibly damaging |
Het |
Zfp13 |
C |
T |
17: 23,800,036 (GRCm39) |
G89D |
probably damaging |
Het |
Zfp616 |
T |
A |
11: 73,976,205 (GRCm39) |
Y825N |
probably benign |
Het |
Zfp865 |
A |
G |
7: 5,032,252 (GRCm39) |
Y79C |
possibly damaging |
Het |
Zfyve26 |
A |
T |
12: 79,297,942 (GRCm39) |
F1916I |
probably damaging |
Het |
|
Other mutations in Vmn2r66 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00321:Vmn2r66
|
APN |
7 |
84,656,299 (GRCm39) |
missense |
probably benign |
|
IGL01562:Vmn2r66
|
APN |
7 |
84,656,495 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01689:Vmn2r66
|
APN |
7 |
84,657,033 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02237:Vmn2r66
|
APN |
7 |
84,643,908 (GRCm39) |
missense |
probably benign |
|
IGL02415:Vmn2r66
|
APN |
7 |
84,656,020 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02439:Vmn2r66
|
APN |
7 |
84,654,455 (GRCm39) |
splice site |
probably benign |
|
IGL02545:Vmn2r66
|
APN |
7 |
84,655,798 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL02708:Vmn2r66
|
APN |
7 |
84,655,796 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02794:Vmn2r66
|
APN |
7 |
84,644,623 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02885:Vmn2r66
|
APN |
7 |
84,644,723 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02975:Vmn2r66
|
APN |
7 |
84,656,182 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03027:Vmn2r66
|
APN |
7 |
84,644,777 (GRCm39) |
splice site |
probably benign |
|
IGL03081:Vmn2r66
|
APN |
7 |
84,657,138 (GRCm39) |
missense |
probably benign |
|
PIT4131001:Vmn2r66
|
UTSW |
7 |
84,644,301 (GRCm39) |
missense |
probably damaging |
1.00 |
R0098:Vmn2r66
|
UTSW |
7 |
84,654,965 (GRCm39) |
missense |
probably damaging |
1.00 |
R0504:Vmn2r66
|
UTSW |
7 |
84,656,023 (GRCm39) |
missense |
probably damaging |
0.99 |
R0557:Vmn2r66
|
UTSW |
7 |
84,643,972 (GRCm39) |
missense |
probably damaging |
1.00 |
R0617:Vmn2r66
|
UTSW |
7 |
84,644,484 (GRCm39) |
missense |
probably benign |
0.02 |
R0883:Vmn2r66
|
UTSW |
7 |
84,657,070 (GRCm39) |
missense |
probably benign |
|
R1159:Vmn2r66
|
UTSW |
7 |
84,644,613 (GRCm39) |
missense |
probably benign |
0.44 |
R1168:Vmn2r66
|
UTSW |
7 |
84,656,062 (GRCm39) |
missense |
possibly damaging |
0.46 |
R1172:Vmn2r66
|
UTSW |
7 |
84,654,799 (GRCm39) |
missense |
probably benign |
0.04 |
R1175:Vmn2r66
|
UTSW |
7 |
84,654,799 (GRCm39) |
missense |
probably benign |
0.04 |
R1538:Vmn2r66
|
UTSW |
7 |
84,644,166 (GRCm39) |
missense |
possibly damaging |
0.84 |
R1658:Vmn2r66
|
UTSW |
7 |
84,656,955 (GRCm39) |
missense |
probably benign |
0.07 |
R1937:Vmn2r66
|
UTSW |
7 |
84,644,344 (GRCm39) |
missense |
probably damaging |
0.99 |
R1989:Vmn2r66
|
UTSW |
7 |
84,661,201 (GRCm39) |
missense |
probably benign |
0.01 |
R2698:Vmn2r66
|
UTSW |
7 |
84,644,607 (GRCm39) |
missense |
probably damaging |
1.00 |
R2890:Vmn2r66
|
UTSW |
7 |
84,661,027 (GRCm39) |
splice site |
probably null |
|
R3686:Vmn2r66
|
UTSW |
7 |
84,644,397 (GRCm39) |
missense |
probably damaging |
0.96 |
R4152:Vmn2r66
|
UTSW |
7 |
84,654,800 (GRCm39) |
missense |
probably benign |
0.08 |
R4500:Vmn2r66
|
UTSW |
7 |
84,657,162 (GRCm39) |
missense |
probably damaging |
1.00 |
R4618:Vmn2r66
|
UTSW |
7 |
84,644,296 (GRCm39) |
missense |
possibly damaging |
0.62 |
R4656:Vmn2r66
|
UTSW |
7 |
84,661,204 (GRCm39) |
missense |
possibly damaging |
0.87 |
R4668:Vmn2r66
|
UTSW |
7 |
84,643,905 (GRCm39) |
missense |
probably damaging |
1.00 |
R4942:Vmn2r66
|
UTSW |
7 |
84,656,980 (GRCm39) |
missense |
probably damaging |
1.00 |
R5163:Vmn2r66
|
UTSW |
7 |
84,656,017 (GRCm39) |
missense |
probably benign |
0.01 |
R5223:Vmn2r66
|
UTSW |
7 |
84,657,093 (GRCm39) |
missense |
probably benign |
|
R5377:Vmn2r66
|
UTSW |
7 |
84,656,026 (GRCm39) |
missense |
probably damaging |
0.99 |
R5512:Vmn2r66
|
UTSW |
7 |
84,657,149 (GRCm39) |
missense |
probably damaging |
1.00 |
R5611:Vmn2r66
|
UTSW |
7 |
84,654,951 (GRCm39) |
nonsense |
probably null |
|
R5749:Vmn2r66
|
UTSW |
7 |
84,655,979 (GRCm39) |
nonsense |
probably null |
|
R6131:Vmn2r66
|
UTSW |
7 |
84,644,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R6183:Vmn2r66
|
UTSW |
7 |
84,644,766 (GRCm39) |
missense |
possibly damaging |
0.81 |
R6509:Vmn2r66
|
UTSW |
7 |
84,656,054 (GRCm39) |
missense |
probably benign |
0.12 |
R6930:Vmn2r66
|
UTSW |
7 |
84,661,216 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6992:Vmn2r66
|
UTSW |
7 |
84,654,436 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7015:Vmn2r66
|
UTSW |
7 |
84,644,766 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7516:Vmn2r66
|
UTSW |
7 |
84,661,176 (GRCm39) |
missense |
possibly damaging |
0.51 |
R7763:Vmn2r66
|
UTSW |
7 |
84,654,909 (GRCm39) |
missense |
probably benign |
0.01 |
R7814:Vmn2r66
|
UTSW |
7 |
84,656,472 (GRCm39) |
missense |
probably benign |
0.02 |
R8077:Vmn2r66
|
UTSW |
7 |
84,656,093 (GRCm39) |
missense |
probably benign |
|
R8307:Vmn2r66
|
UTSW |
7 |
84,656,270 (GRCm39) |
missense |
probably benign |
|
R8315:Vmn2r66
|
UTSW |
7 |
84,643,932 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8490:Vmn2r66
|
UTSW |
7 |
84,654,794 (GRCm39) |
critical splice donor site |
probably null |
|
R8511:Vmn2r66
|
UTSW |
7 |
84,656,026 (GRCm39) |
missense |
probably damaging |
0.99 |
R8781:Vmn2r66
|
UTSW |
7 |
84,644,355 (GRCm39) |
nonsense |
probably null |
|
R8812:Vmn2r66
|
UTSW |
7 |
84,654,893 (GRCm39) |
missense |
probably damaging |
0.99 |
R9203:Vmn2r66
|
UTSW |
7 |
84,654,950 (GRCm39) |
missense |
probably benign |
0.01 |
R9277:Vmn2r66
|
UTSW |
7 |
84,661,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTTCCTGGGATCTAGAATAATGAG -3'
(R):5'- GATTAAGTGGGCTACAGGTATAGAC -3'
Sequencing Primer
(F):5'- TCAAGAGAGAGAAAGAGAGAGTTTAC -3'
(R):5'- GATTTGCCATGGAATAAATACCTGG -3'
|
Posted On |
2019-06-26 |