Mutagenetix > Incidental Mutation

Incidental Mutation 'R7308:Dync1h1'

567407

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

MAP1C, Loa, Dnec1, Dnchc1, dynein heavy chain, retrograde transport, 9930018I23Rik, Swl

MMRRC Submission

045323-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7308 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

110567886-110633379 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 110631596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 4431 (D4431G)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851] [ENSMUST00000070659] [ENSMUST00000222915]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000018851
AA Change: D4431G

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: D4431G

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000070659

SMART Domains

Protein: ENSMUSP00000068238
Gene: ENSMUSG00000056508

Domain	Start	End	E-Value	Type
low complexity region	196	210	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000222915

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	C	7: 120,022,993 (GRCm39)	I43T	probably benign	Het
Ankar	G	A	1: 72,690,953 (GRCm39)	Q1175*	probably null	Het
Aqr	G	A	2: 113,934,543 (GRCm39)	A1366V	possibly damaging	Het
Arhgap45	G	A	10: 79,862,392 (GRCm39)		probably null	Het
Atf7ip	T	A	6: 136,542,087 (GRCm39)	M607K	probably benign	Het
BC028528	CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT	CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT	3: 95,795,448 (GRCm39)		probably benign	Het
BC028528	ACTGGTTCTGTGGTC	ACTGGTTCTGTGGTCCCTGGTTCTGTGGTC	3: 95,795,481 (GRCm39)		probably benign	Het
BC028528	TCACTGGTTCTGTGGTCACTGGTTCTGTGG	TCACTGGTTCTGTGGCCACTGGTTCTGTGGTCACTGGTTCTGTGG	3: 95,795,464 (GRCm39)		probably benign	Het
Bcar3	T	A	3: 122,302,142 (GRCm39)	V279E	probably benign	Het
Cd96	C	T	16: 45,892,097 (GRCm39)		probably null	Het
Cdca2	G	A	14: 67,932,440 (GRCm39)	P488S	probably benign	Het
Cfhr4	A	G	1: 139,682,041 (GRCm39)	V185A	possibly damaging	Het
Col4a2	T	G	8: 11,456,856 (GRCm39)		probably null	Het
Cyp4a12a	A	G	4: 115,184,955 (GRCm39)	R379G	possibly damaging	Het
Defb34	A	G	8: 19,176,395 (GRCm39)	S29G	probably benign	Het
Dnah11	A	G	12: 117,959,010 (GRCm39)	S2958P	probably damaging	Het
Egfem1	A	T	3: 29,206,015 (GRCm39)	H84L	probably benign	Het
Enah	A	T	1: 181,733,950 (GRCm39)		probably null	Het
Fam178b	G	T	1: 36,698,488 (GRCm39)	Q78K	probably benign	Het
Glb1	A	G	9: 114,302,931 (GRCm39)	N589S	probably damaging	Het
Gm1527	C	T	3: 28,956,429 (GRCm39)	H132Y	probably benign	Het
Gm5799	A	G	14: 43,781,164 (GRCm39)	R22G	possibly damaging	Het
Grip2	T	C	6: 91,755,669 (GRCm39)	D617G	possibly damaging	Het
Hax1	A	T	3: 89,905,873 (GRCm39)	D5E	possibly damaging	Het
Hic1	A	G	11: 75,057,977 (GRCm39)	L304P	probably damaging	Het
Hmox1	T	A	8: 75,823,647 (GRCm39)	I105N	probably damaging	Het
Hormad1	T	C	3: 95,469,866 (GRCm39)	S38P	probably damaging	Het
Hspa4	A	G	11: 53,157,930 (GRCm39)	S558P	possibly damaging	Het
Kcnf1	T	A	12: 17,224,730 (GRCm39)	H497L	probably benign	Het
Kcnma1	C	T	14: 23,381,003 (GRCm39)	D1022N	probably damaging	Het
Kcnt1	T	C	2: 25,790,475 (GRCm39)	F479S	possibly damaging	Het
Krba1	T	C	6: 48,383,273 (GRCm39)	V203A	probably benign	Het
Lct	G	T	1: 128,246,824 (GRCm39)	P233Q	probably benign	Het
Ly75	T	C	2: 60,164,859 (GRCm39)	D773G	probably benign	Het
Malt1	T	C	18: 65,582,680 (GRCm39)		probably null	Het
Man1a2	A	T	3: 100,527,421 (GRCm39)	L333Q	probably damaging	Het
Mtus1	T	C	8: 41,535,965 (GRCm39)	T584A	probably benign	Het
Myof	A	T	19: 37,899,359 (GRCm39)	S1800R	probably damaging	Het
Nbea	A	C	3: 55,998,452 (GRCm39)	C118W	probably damaging	Het
Nsd3	A	T	8: 26,130,740 (GRCm39)	D35V	probably damaging	Het
Ntaq1	T	C	15: 58,016,006 (GRCm39)	V85A	possibly damaging	Het
Or11g24	G	A	14: 50,662,722 (GRCm39)	V249I	possibly damaging	Het
Or2y1c	G	A	11: 49,360,754 (GRCm39)		probably benign	Het
Pcnx3	C	T	19: 5,736,175 (GRCm39)	R217H	possibly damaging	Het
Pcsk4	G	A	10: 80,159,007 (GRCm39)	P462L	probably benign	Het
Pdia5	T	G	16: 35,276,879 (GRCm39)	K96N	probably damaging	Het
Pik3c2a	T	C	7: 115,973,074 (GRCm39)	Y707C	probably damaging	Het
Ppig	A	T	2: 69,579,806 (GRCm39)	N447Y	unknown	Het
Ppp1r9b	T	C	11: 94,895,397 (GRCm39)	L695P	possibly damaging	Het
Proser1	C	T	3: 53,386,125 (GRCm39)	A669V	probably benign	Het
Rdx	A	T	9: 51,980,170 (GRCm39)	K254N	probably damaging	Het
Slc35f2	T	C	9: 53,705,294 (GRCm39)	S95P	probably benign	Het
Slc4a3	T	A	1: 75,534,006 (GRCm39)	S1118T	probably benign	Het
Slf1	G	A	13: 77,199,287 (GRCm39)	P698L	probably benign	Het
Sptbn2	A	G	19: 4,801,602 (GRCm39)	E2338G	probably benign	Het
Taok3	T	A	5: 117,338,216 (GRCm39)	Y91*	probably null	Het
Tbc1d31	C	T	15: 57,816,212 (GRCm39)	L649F	probably damaging	Het
Tdpoz8	A	G	3: 92,981,872 (GRCm39)	T223A	probably benign	Het
Tmem132b	A	T	5: 125,864,710 (GRCm39)	I939F	possibly damaging	Het
Trav17	T	A	14: 54,044,436 (GRCm39)	Y69N	probably benign	Het
Trmt13	T	C	3: 116,388,388 (GRCm39)	D16G	probably benign	Het
Upf2	T	A	2: 5,978,329 (GRCm39)	Y398N	unknown	Het
Vmn1r238	T	C	18: 3,122,875 (GRCm39)	T180A	probably benign	Het
Zfp738	A	T	13: 67,817,672 (GRCm39)	I773N	probably benign	Het
Zscan4e	A	T	7: 11,041,080 (GRCm39)	M264K	probably benign	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,615,538 (GRCm39)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,580,541 (GRCm39)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,592,041 (GRCm39)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,593,299 (GRCm39)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,583,126 (GRCm39)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,605,285 (GRCm39)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,624,562 (GRCm39)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,581,374 (GRCm39)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,625,364 (GRCm39)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,618,630 (GRCm39)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,603,558 (GRCm39)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,599,254 (GRCm39)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,628,993 (GRCm39)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,629,436 (GRCm39)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,607,322 (GRCm39)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,606,644 (GRCm39)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,625,666 (GRCm39)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,625,706 (GRCm39)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,624,327 (GRCm39)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,632,989 (GRCm39)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,595,168 (GRCm39)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,585,644 (GRCm39)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,624,568 (GRCm39)	missense	probably damaging	1.00
Gesund	UTSW	12	110,582,838 (GRCm39)	missense	probably benign	0.35
gymnast	UTSW	12	110,584,802 (GRCm39)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,584,354 (GRCm39)	missense	probably damaging	1.00
Lissom	UTSW	12	110,599,254 (GRCm39)	missense	possibly damaging	0.68
Strong	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
waters	UTSW	12	110,596,113 (GRCm39)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,615,538 (GRCm39)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,583,241 (GRCm39)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,602,880 (GRCm39)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,606,378 (GRCm39)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,585,108 (GRCm39)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,607,414 (GRCm39)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,607,414 (GRCm39)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,616,285 (GRCm39)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,616,285 (GRCm39)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,598,126 (GRCm39)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,606,378 (GRCm39)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,599,222 (GRCm39)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,582,930 (GRCm39)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,618,181 (GRCm39)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,623,626 (GRCm39)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,595,718 (GRCm39)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,578,845 (GRCm39)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,631,647 (GRCm39)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,632,393 (GRCm39)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,615,698 (GRCm39)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,622,791 (GRCm39)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,632,096 (GRCm39)	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110,593,426 (GRCm39)	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,599,362 (GRCm39)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,629,334 (GRCm39)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,580,493 (GRCm39)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,580,493 (GRCm39)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,629,059 (GRCm39)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,591,070 (GRCm39)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,612,738 (GRCm39)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,629,063 (GRCm39)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,592,166 (GRCm39)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,632,857 (GRCm39)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,581,026 (GRCm39)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,616,022 (GRCm39)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,596,420 (GRCm39)	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110,607,316 (GRCm39)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,623,065 (GRCm39)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,607,654 (GRCm39)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,609,681 (GRCm39)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,583,325 (GRCm39)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,607,460 (GRCm39)	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110,607,020 (GRCm39)	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110,609,563 (GRCm39)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,598,109 (GRCm39)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,598,109 (GRCm39)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,595,492 (GRCm39)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,632,399 (GRCm39)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,609,624 (GRCm39)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,584,483 (GRCm39)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,599,333 (GRCm39)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,623,573 (GRCm39)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,615,917 (GRCm39)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,605,278 (GRCm39)	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110,595,201 (GRCm39)	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110,628,975 (GRCm39)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,621,962 (GRCm39)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,615,941 (GRCm39)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,615,941 (GRCm39)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,627,630 (GRCm39)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,606,235 (GRCm39)	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,629,289 (GRCm39)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,584,444 (GRCm39)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,593,326 (GRCm39)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,596,969 (GRCm39)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,607,341 (GRCm39)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,584,366 (GRCm39)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,596,114 (GRCm39)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,595,264 (GRCm39)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,581,502 (GRCm39)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,599,099 (GRCm39)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,627,384 (GRCm39)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,599,254 (GRCm39)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,607,575 (GRCm39)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,632,422 (GRCm39)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,595,496 (GRCm39)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,582,838 (GRCm39)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,612,707 (GRCm39)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,618,087 (GRCm39)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,580,654 (GRCm39)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,584,802 (GRCm39)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,599,212 (GRCm39)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,586,848 (GRCm39)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,594,440 (GRCm39)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,584,427 (GRCm39)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,612,639 (GRCm39)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,583,171 (GRCm39)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,584,354 (GRCm39)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,616,282 (GRCm39)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,624,568 (GRCm39)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,618,087 (GRCm39)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,596,113 (GRCm39)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,624,981 (GRCm39)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,618,614 (GRCm39)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,590,995 (GRCm39)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,605,335 (GRCm39)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,632,521 (GRCm39)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,623,512 (GRCm39)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,568,173 (GRCm39)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,584,196 (GRCm39)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,631,183 (GRCm39)	critical splice donor site	probably null
R7346:Dync1h1	UTSW	12	110,602,076 (GRCm39)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,591,036 (GRCm39)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,600,654 (GRCm39)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,602,887 (GRCm39)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,602,887 (GRCm39)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,632,109 (GRCm39)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,618,011 (GRCm39)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,580,541 (GRCm39)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,597,059 (GRCm39)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,627,327 (GRCm39)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,585,080 (GRCm39)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,632,200 (GRCm39)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,621,893 (GRCm39)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,609,590 (GRCm39)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,582,891 (GRCm39)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,595,168 (GRCm39)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,582,794 (GRCm39)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,602,908 (GRCm39)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,632,226 (GRCm39)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,584,576 (GRCm39)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,583,177 (GRCm39)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,607,018 (GRCm39)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,581,014 (GRCm39)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,583,261 (GRCm39)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,602,333 (GRCm39)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,602,333 (GRCm39)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,583,172 (GRCm39)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,608,477 (GRCm39)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,624,602 (GRCm39)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,584,471 (GRCm39)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,586,805 (GRCm39)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,606,397 (GRCm39)	missense	probably benign
R9036:Dync1h1	UTSW	12	110,606,186 (GRCm39)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,583,310 (GRCm39)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,622,706 (GRCm39)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,625,023 (GRCm39)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,601,937 (GRCm39)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,583,310 (GRCm39)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,582,975 (GRCm39)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,625,137 (GRCm39)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,624,805 (GRCm39)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,615,533 (GRCm39)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,582,975 (GRCm39)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,607,362 (GRCm39)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,596,351 (GRCm39)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,624,951 (GRCm39)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,607,611 (GRCm39)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,603,988 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGTCTGGTCAAAAGCTCTGG -3'
(R):5'- AGCTGCCTGTGGAAAACCTAG -3'

Sequencing Primer
(F):5'- TCAAAAGCTCTGGTGCTGC -3'
(R):5'- GTTGCTAAGACCCCCACTATTGAGG -3'

Posted On

2019-06-26