Incidental Mutation 'R7311:Polr1a'
| ID |
567579 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Polr1a
|
| Ensembl Gene |
ENSMUSG00000049553 |
| Gene Name |
polymerase (RNA) I polypeptide A |
| Synonyms |
2900087K15Rik, 3010014K16Rik, 194kDa, mRPA1, Rpo1-4, RPA194 |
| MMRRC Submission |
045367-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7311 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
71886037-71956419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 71927863 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 871
(K871N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000060858
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055296]
[ENSMUST00000206556]
|
| AlphaFold |
O35134 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000055296
AA Change: K871N
PolyPhen 2
Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000060858
Gene: ENSMUSG00000049553
AA Change: K871N
| Domain | Start | End | E-Value | Type |
|---|
|
RPOLA_N
|
302 |
649 |
8.97e-137 |
SMART |
|
Pfam:RNA_pol_Rpb1_4
|
846 |
958 |
1.3e-26 |
PFAM |
|
Pfam:RNA_pol_Rpb1_5
|
965 |
1669 |
7e-103 |
PFAM |
|
low complexity region
|
1698 |
1708 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206513
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206556
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]
|
| Allele List at MGI |
All alleles(18) : Gene trapped(18) |
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001K19Rik |
A |
G |
12: 110,635,184 (GRCm39) |
V118A |
probably benign |
Het |
| Accsl |
C |
T |
2: 93,696,160 (GRCm39) |
G146D |
possibly damaging |
Het |
| Acsm1 |
A |
T |
7: 119,237,305 (GRCm39) |
H206L |
probably damaging |
Het |
| Acta2 |
A |
G |
19: 34,219,186 (GRCm39) |
Y339H |
probably damaging |
Het |
| Adcy2 |
T |
C |
13: 68,779,073 (GRCm39) |
D989G |
probably damaging |
Het |
| Ahnak |
G |
A |
19: 8,979,507 (GRCm39) |
A264T |
probably benign |
Het |
| Ahnak |
A |
G |
19: 8,987,191 (GRCm39) |
D2825G |
possibly damaging |
Het |
| Akt1 |
G |
T |
12: 112,623,587 (GRCm39) |
T291K |
probably damaging |
Het |
| Arhgap24 |
A |
G |
5: 103,040,551 (GRCm39) |
D589G |
probably damaging |
Het |
| B4galnt3 |
G |
A |
6: 120,192,396 (GRCm39) |
Q447* |
probably null |
Het |
| BC024063 |
C |
T |
10: 81,945,993 (GRCm39) |
R538C |
possibly damaging |
Het |
| Bod1l |
A |
G |
5: 41,951,676 (GRCm39) |
S2912P |
possibly damaging |
Het |
| Bysl |
A |
G |
17: 47,912,710 (GRCm39) |
V360A |
possibly damaging |
Het |
| C1qb |
A |
G |
4: 136,607,877 (GRCm39) |
V162A |
possibly damaging |
Het |
| Ccdc57 |
G |
A |
11: 120,764,567 (GRCm39) |
P736L |
probably benign |
Het |
| Cep290 |
T |
A |
10: 100,373,580 (GRCm39) |
F1287I |
probably damaging |
Het |
| Cntn1 |
T |
C |
15: 92,130,156 (GRCm39) |
|
probably null |
Het |
| Col6a3 |
C |
T |
1: 90,750,013 (GRCm39) |
G274R |
probably damaging |
Het |
| Cplane1 |
G |
T |
15: 8,210,399 (GRCm39) |
V291F |
probably damaging |
Het |
| Cyb5r4 |
T |
C |
9: 86,937,835 (GRCm39) |
C285R |
probably damaging |
Het |
| Cyp4f39 |
G |
A |
17: 32,708,629 (GRCm39) |
C392Y |
probably damaging |
Het |
| Dcun1d3 |
A |
T |
7: 119,458,734 (GRCm39) |
D100E |
probably damaging |
Het |
| Dhx58 |
A |
T |
11: 100,588,997 (GRCm39) |
D516E |
probably benign |
Het |
| Dock5 |
T |
A |
14: 68,065,951 (GRCm39) |
I351F |
probably benign |
Het |
| Elmod2 |
A |
C |
8: 84,046,041 (GRCm39) |
|
probably null |
Het |
| Endov |
G |
A |
11: 119,398,077 (GRCm39) |
A281T |
probably benign |
Het |
| Epyc |
A |
G |
10: 97,485,562 (GRCm39) |
M1V |
probably null |
Het |
| Espnl |
T |
A |
1: 91,251,290 (GRCm39) |
H128Q |
probably damaging |
Het |
| Fam20a |
A |
T |
11: 109,565,454 (GRCm39) |
C452* |
probably null |
Het |
| Fam241b |
A |
G |
10: 61,944,733 (GRCm39) |
V88A |
probably damaging |
Het |
| Fbxl9 |
A |
G |
8: 106,042,299 (GRCm39) |
|
probably benign |
Het |
| Fgd3 |
A |
T |
13: 49,450,166 (GRCm39) |
S28T |
possibly damaging |
Het |
| Fmn1 |
C |
A |
2: 113,356,025 (GRCm39) |
P920Q |
unknown |
Het |
| Gpr139 |
G |
C |
7: 118,744,089 (GRCm39) |
D165E |
probably benign |
Het |
| Hoxb1 |
A |
G |
11: 96,257,927 (GRCm39) |
T286A |
possibly damaging |
Het |
| Ifi204 |
T |
A |
1: 173,587,134 (GRCm39) |
E174D |
probably benign |
Het |
| Igf2bp2 |
A |
G |
16: 21,880,632 (GRCm39) |
I555T |
possibly damaging |
Het |
| Ighv1-85 |
A |
G |
12: 115,963,799 (GRCm39) |
I67T |
probably damaging |
Het |
| Ihh |
G |
C |
1: 74,990,306 (GRCm39) |
P23R |
unknown |
Het |
| Irx2 |
T |
C |
13: 72,779,396 (GRCm39) |
S227P |
probably damaging |
Het |
| Itga4 |
A |
G |
2: 79,086,526 (GRCm39) |
I68V |
probably benign |
Het |
| Jsrp1 |
T |
A |
10: 80,647,906 (GRCm39) |
T51S |
probably benign |
Het |
| Khdc4 |
T |
C |
3: 88,619,002 (GRCm39) |
S569P |
probably damaging |
Het |
| Kifc2 |
G |
T |
15: 76,547,010 (GRCm39) |
G306V |
probably damaging |
Het |
| L3mbtl2 |
T |
A |
15: 81,551,588 (GRCm39) |
S85T |
possibly damaging |
Het |
| Lama1 |
T |
C |
17: 68,074,380 (GRCm39) |
S944P |
|
Het |
| Lama4 |
T |
A |
10: 38,902,631 (GRCm39) |
C202S |
probably damaging |
Het |
| Morc3 |
G |
A |
16: 93,646,061 (GRCm39) |
D218N |
probably damaging |
Het |
| Mrtfb |
T |
A |
16: 13,223,718 (GRCm39) |
Y866* |
probably null |
Het |
| Myorg |
A |
G |
4: 41,498,577 (GRCm39) |
I351T |
probably damaging |
Het |
| N4bp2l1 |
G |
A |
5: 150,496,389 (GRCm39) |
T179I |
probably damaging |
Het |
| Narf |
A |
G |
11: 121,139,976 (GRCm39) |
E270G |
probably benign |
Het |
| Nsd2 |
A |
G |
5: 34,049,380 (GRCm39) |
D1205G |
probably damaging |
Het |
| Or10x1 |
T |
C |
1: 174,196,759 (GRCm39) |
V92A |
probably benign |
Het |
| Or5an11 |
T |
C |
19: 12,246,068 (GRCm39) |
V158A |
probably benign |
Het |
| Parl |
T |
C |
16: 20,106,625 (GRCm39) |
T195A |
probably benign |
Het |
| Phrf1 |
A |
G |
7: 140,820,846 (GRCm39) |
I158V |
unknown |
Het |
| Phtf1 |
T |
C |
3: 103,904,980 (GRCm39) |
F543L |
possibly damaging |
Het |
| Plod2 |
T |
A |
9: 92,466,611 (GRCm39) |
D190E |
probably damaging |
Het |
| Ppp2r5a |
A |
T |
1: 191,089,998 (GRCm39) |
I252K |
probably damaging |
Het |
| Ptgir |
T |
A |
7: 16,640,973 (GRCm39) |
D88E |
probably damaging |
Het |
| Raly |
T |
C |
2: 154,699,340 (GRCm39) |
V48A |
probably damaging |
Het |
| Ripor1 |
T |
A |
8: 106,344,447 (GRCm39) |
L527* |
probably null |
Het |
| Rnf213 |
T |
C |
11: 119,307,373 (GRCm39) |
S678P |
|
Het |
| Rpf1 |
T |
A |
3: 146,212,918 (GRCm39) |
Q306L |
probably benign |
Het |
| Rpl14 |
T |
C |
9: 120,403,171 (GRCm39) |
I122T |
probably damaging |
Het |
| Scn9a |
C |
A |
2: 66,314,748 (GRCm39) |
A1657S |
possibly damaging |
Het |
| Serpinb10 |
A |
G |
1: 107,474,477 (GRCm39) |
Y213C |
probably damaging |
Het |
| Slc25a23 |
A |
G |
17: 57,359,827 (GRCm39) |
L308P |
probably damaging |
Het |
| Smg9 |
T |
A |
7: 24,120,058 (GRCm39) |
M387K |
probably benign |
Het |
| Socs3 |
G |
A |
11: 117,858,614 (GRCm39) |
P148L |
probably benign |
Het |
| Susd3 |
A |
G |
13: 49,401,906 (GRCm39) |
L14P |
probably benign |
Het |
| Syt14 |
T |
A |
1: 192,662,858 (GRCm39) |
M80L |
probably benign |
Het |
| Tmprss2 |
T |
A |
16: 97,369,616 (GRCm39) |
Y386F |
possibly damaging |
Het |
| Tmx3 |
T |
A |
18: 90,558,195 (GRCm39) |
S416T |
probably benign |
Het |
| Treh |
A |
G |
9: 44,597,245 (GRCm39) |
T555A |
probably benign |
Het |
| Ttc5 |
T |
G |
14: 51,003,400 (GRCm39) |
Q428P |
probably damaging |
Het |
| Vmn2r73 |
A |
G |
7: 85,521,192 (GRCm39) |
S259P |
possibly damaging |
Het |
| Vps4b |
A |
T |
1: 106,719,434 (GRCm39) |
V38E |
probably damaging |
Het |
| Wdr83 |
C |
A |
8: 85,802,890 (GRCm39) |
R177L |
probably benign |
Het |
| Zfp780b |
A |
G |
7: 27,662,588 (GRCm39) |
F656L |
possibly damaging |
Het |
| Zfp995 |
A |
T |
17: 22,099,641 (GRCm39) |
F198I |
probably benign |
Het |
| Zswim8 |
A |
T |
14: 20,771,552 (GRCm39) |
Y1495F |
probably damaging |
Het |
|
| Other mutations in Polr1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01363:Polr1a
|
APN |
6 |
71,925,470 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL01834:Polr1a
|
APN |
6 |
71,925,446 (GRCm39) |
missense |
probably benign |
|
|
IGL01902:Polr1a
|
APN |
6 |
71,940,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02101:Polr1a
|
APN |
6 |
71,927,786 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02325:Polr1a
|
APN |
6 |
71,897,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02398:Polr1a
|
APN |
6 |
71,913,540 (GRCm39) |
splice site |
probably benign |
|
|
IGL02528:Polr1a
|
APN |
6 |
71,941,701 (GRCm39) |
missense |
probably benign |
|
|
IGL02555:Polr1a
|
APN |
6 |
71,897,441 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02613:Polr1a
|
APN |
6 |
71,944,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02693:Polr1a
|
APN |
6 |
71,940,830 (GRCm39) |
splice site |
probably benign |
|
|
IGL02892:Polr1a
|
APN |
6 |
71,908,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL03059:Polr1a
|
APN |
6 |
71,913,496 (GRCm39) |
missense |
probably benign |
|
|
IGL03174:Polr1a
|
APN |
6 |
71,954,331 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
D4043:Polr1a
|
UTSW |
6 |
71,918,401 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0092:Polr1a
|
UTSW |
6 |
71,944,439 (GRCm39) |
splice site |
probably benign |
|
|
R0217:Polr1a
|
UTSW |
6 |
71,940,687 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0267:Polr1a
|
UTSW |
6 |
71,951,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0329:Polr1a
|
UTSW |
6 |
71,943,400 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0330:Polr1a
|
UTSW |
6 |
71,943,400 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0352:Polr1a
|
UTSW |
6 |
71,897,747 (GRCm39) |
splice site |
probably benign |
|
|
R0411:Polr1a
|
UTSW |
6 |
71,955,405 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0446:Polr1a
|
UTSW |
6 |
71,927,648 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0846:Polr1a
|
UTSW |
6 |
71,901,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1035:Polr1a
|
UTSW |
6 |
71,944,900 (GRCm39) |
missense |
probably benign |
|
|
R1294:Polr1a
|
UTSW |
6 |
71,889,886 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1460:Polr1a
|
UTSW |
6 |
71,918,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1657:Polr1a
|
UTSW |
6 |
71,918,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1846:Polr1a
|
UTSW |
6 |
71,953,172 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1862:Polr1a
|
UTSW |
6 |
71,886,187 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1865:Polr1a
|
UTSW |
6 |
71,943,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Polr1a
|
UTSW |
6 |
71,944,898 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1937:Polr1a
|
UTSW |
6 |
71,913,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2063:Polr1a
|
UTSW |
6 |
71,913,269 (GRCm39) |
splice site |
probably null |
|
|
R2071:Polr1a
|
UTSW |
6 |
71,953,058 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2084:Polr1a
|
UTSW |
6 |
71,927,793 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2377:Polr1a
|
UTSW |
6 |
71,949,810 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2410:Polr1a
|
UTSW |
6 |
71,951,866 (GRCm39) |
missense |
probably benign |
|
|
R3001:Polr1a
|
UTSW |
6 |
71,890,000 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Polr1a
|
UTSW |
6 |
71,942,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3002:Polr1a
|
UTSW |
6 |
71,942,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3002:Polr1a
|
UTSW |
6 |
71,890,000 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3924:Polr1a
|
UTSW |
6 |
71,906,434 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Polr1a
|
UTSW |
6 |
71,953,175 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4125:Polr1a
|
UTSW |
6 |
71,942,690 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4271:Polr1a
|
UTSW |
6 |
71,930,006 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4440:Polr1a
|
UTSW |
6 |
71,927,832 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4667:Polr1a
|
UTSW |
6 |
71,894,805 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4769:Polr1a
|
UTSW |
6 |
71,927,852 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4801:Polr1a
|
UTSW |
6 |
71,953,054 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Polr1a
|
UTSW |
6 |
71,953,054 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4828:Polr1a
|
UTSW |
6 |
71,943,385 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4911:Polr1a
|
UTSW |
6 |
71,886,213 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5071:Polr1a
|
UTSW |
6 |
71,908,693 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5165:Polr1a
|
UTSW |
6 |
71,944,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5223:Polr1a
|
UTSW |
6 |
71,944,891 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5239:Polr1a
|
UTSW |
6 |
71,890,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5546:Polr1a
|
UTSW |
6 |
71,906,350 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5599:Polr1a
|
UTSW |
6 |
71,944,346 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5696:Polr1a
|
UTSW |
6 |
71,906,410 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5850:Polr1a
|
UTSW |
6 |
71,903,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6274:Polr1a
|
UTSW |
6 |
71,931,874 (GRCm39) |
splice site |
probably null |
|
|
R6526:Polr1a
|
UTSW |
6 |
71,906,427 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6578:Polr1a
|
UTSW |
6 |
71,953,025 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6660:Polr1a
|
UTSW |
6 |
71,944,358 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6892:Polr1a
|
UTSW |
6 |
71,941,696 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7274:Polr1a
|
UTSW |
6 |
71,897,500 (GRCm39) |
nonsense |
probably null |
|
|
R7291:Polr1a
|
UTSW |
6 |
71,918,440 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7431:Polr1a
|
UTSW |
6 |
71,903,643 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7479:Polr1a
|
UTSW |
6 |
71,913,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7607:Polr1a
|
UTSW |
6 |
71,890,005 (GRCm39) |
missense |
probably benign |
|
|
R7739:Polr1a
|
UTSW |
6 |
71,931,819 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7746:Polr1a
|
UTSW |
6 |
71,918,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7764:Polr1a
|
UTSW |
6 |
71,930,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Polr1a
|
UTSW |
6 |
71,892,126 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8029:Polr1a
|
UTSW |
6 |
71,889,940 (GRCm39) |
nonsense |
probably null |
|
|
R8057:Polr1a
|
UTSW |
6 |
71,908,644 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8144:Polr1a
|
UTSW |
6 |
71,927,600 (GRCm39) |
missense |
probably benign |
|
|
R8170:Polr1a
|
UTSW |
6 |
71,897,733 (GRCm39) |
missense |
probably benign |
|
|
R8320:Polr1a
|
UTSW |
6 |
71,918,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8328:Polr1a
|
UTSW |
6 |
71,897,718 (GRCm39) |
missense |
probably benign |
|
|
R8331:Polr1a
|
UTSW |
6 |
71,953,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Polr1a
|
UTSW |
6 |
71,941,651 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8511:Polr1a
|
UTSW |
6 |
71,897,504 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8709:Polr1a
|
UTSW |
6 |
71,951,832 (GRCm39) |
missense |
probably benign |
|
|
R8745:Polr1a
|
UTSW |
6 |
71,931,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8784:Polr1a
|
UTSW |
6 |
71,927,612 (GRCm39) |
missense |
probably benign |
|
|
R9055:Polr1a
|
UTSW |
6 |
71,892,053 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9088:Polr1a
|
UTSW |
6 |
71,908,767 (GRCm39) |
missense |
probably benign |
0.26 |
|
R9211:Polr1a
|
UTSW |
6 |
71,943,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9228:Polr1a
|
UTSW |
6 |
71,931,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9240:Polr1a
|
UTSW |
6 |
71,940,661 (GRCm39) |
nonsense |
probably null |
|
|
R9267:Polr1a
|
UTSW |
6 |
71,942,542 (GRCm39) |
missense |
probably benign |
|
|
R9302:Polr1a
|
UTSW |
6 |
71,901,683 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9744:Polr1a
|
UTSW |
6 |
71,906,372 (GRCm39) |
missense |
probably benign |
0.05 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAACCACGCCCTCCTTTGG -3'
(R):5'- TTGCATGAAACCAAGGCCTTCC -3'
Sequencing Primer
(F):5'- GCCCTCCTTTGGCTAGAGC -3'
(R):5'- TGAGCTCTTCACAAAGACGGATTC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation