Incidental Mutation 'R7311:Vmn2r73'
| ID |
567584 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r73
|
| Ensembl Gene |
ENSMUSG00000070458 |
| Gene Name |
vomeronasal 2, receptor 73 |
| Synonyms |
EG620928 |
| MMRRC Submission |
045367-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R7311 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 85521192 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 259
(S259P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
| AlphaFold |
D3Z7M3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077478
AA Change: S259P
PolyPhen 2
Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: S259P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001K19Rik |
A |
G |
12: 110,635,184 (GRCm39) |
V118A |
probably benign |
Het |
| Accsl |
C |
T |
2: 93,696,160 (GRCm39) |
G146D |
possibly damaging |
Het |
| Acsm1 |
A |
T |
7: 119,237,305 (GRCm39) |
H206L |
probably damaging |
Het |
| Acta2 |
A |
G |
19: 34,219,186 (GRCm39) |
Y339H |
probably damaging |
Het |
| Adcy2 |
T |
C |
13: 68,779,073 (GRCm39) |
D989G |
probably damaging |
Het |
| Ahnak |
G |
A |
19: 8,979,507 (GRCm39) |
A264T |
probably benign |
Het |
| Ahnak |
A |
G |
19: 8,987,191 (GRCm39) |
D2825G |
possibly damaging |
Het |
| Akt1 |
G |
T |
12: 112,623,587 (GRCm39) |
T291K |
probably damaging |
Het |
| Arhgap24 |
A |
G |
5: 103,040,551 (GRCm39) |
D589G |
probably damaging |
Het |
| B4galnt3 |
G |
A |
6: 120,192,396 (GRCm39) |
Q447* |
probably null |
Het |
| BC024063 |
C |
T |
10: 81,945,993 (GRCm39) |
R538C |
possibly damaging |
Het |
| Bod1l |
A |
G |
5: 41,951,676 (GRCm39) |
S2912P |
possibly damaging |
Het |
| Bysl |
A |
G |
17: 47,912,710 (GRCm39) |
V360A |
possibly damaging |
Het |
| C1qb |
A |
G |
4: 136,607,877 (GRCm39) |
V162A |
possibly damaging |
Het |
| Ccdc57 |
G |
A |
11: 120,764,567 (GRCm39) |
P736L |
probably benign |
Het |
| Cep290 |
T |
A |
10: 100,373,580 (GRCm39) |
F1287I |
probably damaging |
Het |
| Cntn1 |
T |
C |
15: 92,130,156 (GRCm39) |
|
probably null |
Het |
| Col6a3 |
C |
T |
1: 90,750,013 (GRCm39) |
G274R |
probably damaging |
Het |
| Cplane1 |
G |
T |
15: 8,210,399 (GRCm39) |
V291F |
probably damaging |
Het |
| Cyb5r4 |
T |
C |
9: 86,937,835 (GRCm39) |
C285R |
probably damaging |
Het |
| Cyp4f39 |
G |
A |
17: 32,708,629 (GRCm39) |
C392Y |
probably damaging |
Het |
| Dcun1d3 |
A |
T |
7: 119,458,734 (GRCm39) |
D100E |
probably damaging |
Het |
| Dhx58 |
A |
T |
11: 100,588,997 (GRCm39) |
D516E |
probably benign |
Het |
| Dock5 |
T |
A |
14: 68,065,951 (GRCm39) |
I351F |
probably benign |
Het |
| Elmod2 |
A |
C |
8: 84,046,041 (GRCm39) |
|
probably null |
Het |
| Endov |
G |
A |
11: 119,398,077 (GRCm39) |
A281T |
probably benign |
Het |
| Epyc |
A |
G |
10: 97,485,562 (GRCm39) |
M1V |
probably null |
Het |
| Espnl |
T |
A |
1: 91,251,290 (GRCm39) |
H128Q |
probably damaging |
Het |
| Fam20a |
A |
T |
11: 109,565,454 (GRCm39) |
C452* |
probably null |
Het |
| Fam241b |
A |
G |
10: 61,944,733 (GRCm39) |
V88A |
probably damaging |
Het |
| Fbxl9 |
A |
G |
8: 106,042,299 (GRCm39) |
|
probably benign |
Het |
| Fgd3 |
A |
T |
13: 49,450,166 (GRCm39) |
S28T |
possibly damaging |
Het |
| Fmn1 |
C |
A |
2: 113,356,025 (GRCm39) |
P920Q |
unknown |
Het |
| Gpr139 |
G |
C |
7: 118,744,089 (GRCm39) |
D165E |
probably benign |
Het |
| Hoxb1 |
A |
G |
11: 96,257,927 (GRCm39) |
T286A |
possibly damaging |
Het |
| Ifi204 |
T |
A |
1: 173,587,134 (GRCm39) |
E174D |
probably benign |
Het |
| Igf2bp2 |
A |
G |
16: 21,880,632 (GRCm39) |
I555T |
possibly damaging |
Het |
| Ighv1-85 |
A |
G |
12: 115,963,799 (GRCm39) |
I67T |
probably damaging |
Het |
| Ihh |
G |
C |
1: 74,990,306 (GRCm39) |
P23R |
unknown |
Het |
| Irx2 |
T |
C |
13: 72,779,396 (GRCm39) |
S227P |
probably damaging |
Het |
| Itga4 |
A |
G |
2: 79,086,526 (GRCm39) |
I68V |
probably benign |
Het |
| Jsrp1 |
T |
A |
10: 80,647,906 (GRCm39) |
T51S |
probably benign |
Het |
| Khdc4 |
T |
C |
3: 88,619,002 (GRCm39) |
S569P |
probably damaging |
Het |
| Kifc2 |
G |
T |
15: 76,547,010 (GRCm39) |
G306V |
probably damaging |
Het |
| L3mbtl2 |
T |
A |
15: 81,551,588 (GRCm39) |
S85T |
possibly damaging |
Het |
| Lama1 |
T |
C |
17: 68,074,380 (GRCm39) |
S944P |
|
Het |
| Lama4 |
T |
A |
10: 38,902,631 (GRCm39) |
C202S |
probably damaging |
Het |
| Morc3 |
G |
A |
16: 93,646,061 (GRCm39) |
D218N |
probably damaging |
Het |
| Mrtfb |
T |
A |
16: 13,223,718 (GRCm39) |
Y866* |
probably null |
Het |
| Myorg |
A |
G |
4: 41,498,577 (GRCm39) |
I351T |
probably damaging |
Het |
| N4bp2l1 |
G |
A |
5: 150,496,389 (GRCm39) |
T179I |
probably damaging |
Het |
| Narf |
A |
G |
11: 121,139,976 (GRCm39) |
E270G |
probably benign |
Het |
| Nsd2 |
A |
G |
5: 34,049,380 (GRCm39) |
D1205G |
probably damaging |
Het |
| Or10x1 |
T |
C |
1: 174,196,759 (GRCm39) |
V92A |
probably benign |
Het |
| Or5an11 |
T |
C |
19: 12,246,068 (GRCm39) |
V158A |
probably benign |
Het |
| Parl |
T |
C |
16: 20,106,625 (GRCm39) |
T195A |
probably benign |
Het |
| Phrf1 |
A |
G |
7: 140,820,846 (GRCm39) |
I158V |
unknown |
Het |
| Phtf1 |
T |
C |
3: 103,904,980 (GRCm39) |
F543L |
possibly damaging |
Het |
| Plod2 |
T |
A |
9: 92,466,611 (GRCm39) |
D190E |
probably damaging |
Het |
| Polr1a |
G |
T |
6: 71,927,863 (GRCm39) |
K871N |
possibly damaging |
Het |
| Ppp2r5a |
A |
T |
1: 191,089,998 (GRCm39) |
I252K |
probably damaging |
Het |
| Ptgir |
T |
A |
7: 16,640,973 (GRCm39) |
D88E |
probably damaging |
Het |
| Raly |
T |
C |
2: 154,699,340 (GRCm39) |
V48A |
probably damaging |
Het |
| Ripor1 |
T |
A |
8: 106,344,447 (GRCm39) |
L527* |
probably null |
Het |
| Rnf213 |
T |
C |
11: 119,307,373 (GRCm39) |
S678P |
|
Het |
| Rpf1 |
T |
A |
3: 146,212,918 (GRCm39) |
Q306L |
probably benign |
Het |
| Rpl14 |
T |
C |
9: 120,403,171 (GRCm39) |
I122T |
probably damaging |
Het |
| Scn9a |
C |
A |
2: 66,314,748 (GRCm39) |
A1657S |
possibly damaging |
Het |
| Serpinb10 |
A |
G |
1: 107,474,477 (GRCm39) |
Y213C |
probably damaging |
Het |
| Slc25a23 |
A |
G |
17: 57,359,827 (GRCm39) |
L308P |
probably damaging |
Het |
| Smg9 |
T |
A |
7: 24,120,058 (GRCm39) |
M387K |
probably benign |
Het |
| Socs3 |
G |
A |
11: 117,858,614 (GRCm39) |
P148L |
probably benign |
Het |
| Susd3 |
A |
G |
13: 49,401,906 (GRCm39) |
L14P |
probably benign |
Het |
| Syt14 |
T |
A |
1: 192,662,858 (GRCm39) |
M80L |
probably benign |
Het |
| Tmprss2 |
T |
A |
16: 97,369,616 (GRCm39) |
Y386F |
possibly damaging |
Het |
| Tmx3 |
T |
A |
18: 90,558,195 (GRCm39) |
S416T |
probably benign |
Het |
| Treh |
A |
G |
9: 44,597,245 (GRCm39) |
T555A |
probably benign |
Het |
| Ttc5 |
T |
G |
14: 51,003,400 (GRCm39) |
Q428P |
probably damaging |
Het |
| Vps4b |
A |
T |
1: 106,719,434 (GRCm39) |
V38E |
probably damaging |
Het |
| Wdr83 |
C |
A |
8: 85,802,890 (GRCm39) |
R177L |
probably benign |
Het |
| Zfp780b |
A |
G |
7: 27,662,588 (GRCm39) |
F656L |
possibly damaging |
Het |
| Zfp995 |
A |
T |
17: 22,099,641 (GRCm39) |
F198I |
probably benign |
Het |
| Zswim8 |
A |
T |
14: 20,771,552 (GRCm39) |
Y1495F |
probably damaging |
Het |
|
| Other mutations in Vmn2r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
|
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGACAGTTCAGATTGCTGG -3'
(R):5'- CATGGTGTCCTTAGTGGTCC -3'
Sequencing Primer
(F):5'- CCTAGAGGTGTGATCATGT -3'
(R):5'- TCCTTAGTGGTCCATTTCAGATG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation