Incidental Mutation 'R0637:Zfp366'
ID 56775
Institutional Source Beutler Lab
Gene Symbol Zfp366
Ensembl Gene ENSMUSG00000050919
Gene Name zinc finger protein 366
Synonyms DC-SCRIPT
MMRRC Submission 038826-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.331) question?
Stock # R0637 (G1)
Quality Score 174
Status Validated
Chromosome 13
Chromosomal Location 99321331-99383540 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 99365474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 212 (R212S)
Ref Sequence ENSEMBL: ENSMUSP00000060040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056558]
AlphaFold Q6NS86
Predicted Effect probably damaging
Transcript: ENSMUST00000056558
AA Change: R212S

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000060040
Gene: ENSMUSG00000050919
AA Change: R212S

DomainStartEndE-ValueType
low complexity region 159 175 N/A INTRINSIC
low complexity region 183 196 N/A INTRINSIC
ZnF_C2H2 250 272 1.18e-2 SMART
ZnF_C2H2 278 300 4.05e-1 SMART
ZnF_C2H2 306 328 1.79e-2 SMART
ZnF_C2H2 334 356 1.53e-1 SMART
ZnF_C2H2 362 384 1.89e-1 SMART
ZnF_C2H2 390 412 1.22e-4 SMART
ZnF_C2H2 418 440 1.36e-2 SMART
ZnF_C2H2 446 468 1.1e-2 SMART
ZnF_C2H2 474 496 8.34e-3 SMART
ZnF_C2H2 502 524 5.42e-2 SMART
ZnF_C2H2 530 553 2.4e-3 SMART
low complexity region 615 623 N/A INTRINSIC
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 94.9%
Validation Efficiency 100% (68/68)
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit perimembranous and muscular ventricular septal defects (VSD), and overriding aorta. Short snout, micrognathia, micropthalmia, hypoplastic thymus, and hydronephrosis are also observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat1 C T 9: 53,498,831 (GRCm39) D285N probably damaging Het
Aldh3a1 G A 11: 61,106,304 (GRCm39) probably benign Het
Alms1 A G 6: 85,600,015 (GRCm39) T2083A possibly damaging Het
Atrip C T 9: 108,890,241 (GRCm39) M143I possibly damaging Het
Aup1 T A 6: 83,033,842 (GRCm39) V344D probably damaging Het
Baiap2 G A 11: 119,891,405 (GRCm39) V511M probably benign Het
Bnip2 T A 9: 69,910,955 (GRCm39) probably null Het
Cacna1i A T 15: 80,256,855 (GRCm39) Y1083F probably damaging Het
Cbr4 T C 8: 61,943,740 (GRCm39) probably benign Het
Ces2b C T 8: 105,561,237 (GRCm39) probably benign Het
Chd1 A G 17: 15,962,550 (GRCm39) N769S possibly damaging Het
Clca3b A T 3: 144,533,701 (GRCm39) V558D probably benign Het
Col12a1 T C 9: 79,564,017 (GRCm39) D1736G probably benign Het
Cpne8 C A 15: 90,532,824 (GRCm39) C61F probably damaging Het
Cxcr1 A G 1: 74,231,998 (GRCm39) I8T probably benign Het
D630003M21Rik T G 2: 158,037,327 (GRCm39) probably benign Het
Dcaf17 T A 2: 70,890,763 (GRCm39) D99E probably damaging Het
Fbf1 C T 11: 116,050,880 (GRCm39) probably benign Het
Fgfr2 T A 7: 129,773,354 (GRCm39) H570L possibly damaging Het
Gars1 G A 6: 55,046,472 (GRCm39) probably null Het
Gm10309 A G 17: 86,806,463 (GRCm39) probably benign Het
Gm17333 AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA 16: 77,649,766 (GRCm39) noncoding transcript Het
Gm9892 G A 8: 52,649,860 (GRCm39) Q78* probably null Het
Has1 A G 17: 18,064,125 (GRCm39) Y505H possibly damaging Het
Hivep3 T A 4: 119,989,738 (GRCm39) L2063* probably null Het
Il1rl1 CTTGTTGTTGTTGTTGTTG CTTGTTGTTGTTGTTGTTGTTG 1: 40,481,734 (GRCm39) probably benign Het
Itgb3 T C 11: 104,549,702 (GRCm39) V614A probably benign Het
Lrrc23 A G 6: 124,755,321 (GRCm39) probably benign Het
Lrrc63 A T 14: 75,335,660 (GRCm39) probably benign Het
Mfhas1 C T 8: 36,057,180 (GRCm39) R357* probably null Het
Mink1 C A 11: 70,492,502 (GRCm39) N123K probably damaging Het
Mtmr4 A G 11: 87,501,890 (GRCm39) H591R probably benign Het
Nav3 T C 10: 109,606,058 (GRCm39) T923A probably benign Het
Ncapg A G 5: 45,844,666 (GRCm39) T554A probably damaging Het
Nfe2l1 T C 11: 96,718,514 (GRCm39) Y7C probably damaging Het
Nol8 C T 13: 49,815,923 (GRCm39) A677V possibly damaging Het
Obscn A T 11: 58,942,470 (GRCm39) M4904K probably damaging Het
Obscn G T 11: 58,973,602 (GRCm39) L1910I probably damaging Het
Or8b41 T C 9: 38,055,178 (GRCm39) F244S probably benign Het
Pcdhb15 T A 18: 37,608,619 (GRCm39) V617E probably damaging Het
Pelp1 T C 11: 70,286,530 (GRCm39) T533A possibly damaging Het
Pgrmc1 T C X: 35,865,924 (GRCm39) F160S probably damaging Het
Pink1 G T 4: 138,045,357 (GRCm39) P239Q probably damaging Het
Pramel25 A T 4: 143,520,479 (GRCm39) Y77F probably benign Het
Prr27 A G 5: 87,999,005 (GRCm39) probably benign Het
Rbpms G A 8: 34,296,864 (GRCm39) P138S probably damaging Het
Rcc2 T C 4: 140,445,055 (GRCm39) probably benign Het
Rgs3 T C 4: 62,564,910 (GRCm39) probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Robo1 C T 16: 72,798,839 (GRCm39) T933M probably benign Het
Sinhcaf A G 6: 148,832,163 (GRCm39) probably benign Het
Steap4 T C 5: 8,028,398 (GRCm39) probably benign Het
Tenm3 T C 8: 48,689,560 (GRCm39) Y2009C probably damaging Het
Tnr A C 1: 159,677,905 (GRCm39) T97P possibly damaging Het
Topaz1 T A 9: 122,620,542 (GRCm39) L1320* probably null Het
Topaz1 A G 9: 122,626,727 (GRCm39) M1452V probably benign Het
Trank1 T G 9: 111,219,509 (GRCm39) F2082C probably damaging Het
Trim24 C A 6: 37,935,494 (GRCm39) probably null Het
Tspoap1 T A 11: 87,668,066 (GRCm39) probably benign Het
Ubr4 T C 4: 139,126,926 (GRCm39) L483P probably damaging Het
Vmn2r2 T A 3: 64,033,999 (GRCm39) T508S probably benign Het
Vps18 C T 2: 119,124,386 (GRCm39) R438C probably damaging Het
Zkscan4 T A 13: 21,665,477 (GRCm39) C122S probably damaging Het
Other mutations in Zfp366
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp366 APN 13 99,383,080 (GRCm39) utr 3 prime probably benign
IGL01626:Zfp366 APN 13 99,364,920 (GRCm39) missense probably damaging 0.99
IGL02227:Zfp366 APN 13 99,370,696 (GRCm39) missense possibly damaging 0.85
IGL03074:Zfp366 APN 13 99,382,913 (GRCm39) missense probably benign
R0126:Zfp366 UTSW 13 99,365,129 (GRCm39) missense probably benign 0.14
R0145:Zfp366 UTSW 13 99,366,048 (GRCm39) missense probably damaging 1.00
R0234:Zfp366 UTSW 13 99,370,768 (GRCm39) missense probably damaging 1.00
R0234:Zfp366 UTSW 13 99,370,768 (GRCm39) missense probably damaging 1.00
R0376:Zfp366 UTSW 13 99,370,759 (GRCm39) missense probably benign 0.00
R0537:Zfp366 UTSW 13 99,365,786 (GRCm39) missense probably damaging 1.00
R0838:Zfp366 UTSW 13 99,365,118 (GRCm39) missense possibly damaging 0.73
R1386:Zfp366 UTSW 13 99,383,063 (GRCm39) missense probably damaging 0.98
R1422:Zfp366 UTSW 13 99,365,804 (GRCm39) missense probably damaging 1.00
R1669:Zfp366 UTSW 13 99,366,069 (GRCm39) missense probably damaging 0.99
R1839:Zfp366 UTSW 13 99,365,000 (GRCm39) missense probably damaging 0.98
R3751:Zfp366 UTSW 13 99,365,352 (GRCm39) missense probably damaging 1.00
R4782:Zfp366 UTSW 13 99,382,991 (GRCm39) missense probably damaging 1.00
R4908:Zfp366 UTSW 13 99,370,609 (GRCm39) missense possibly damaging 0.68
R4992:Zfp366 UTSW 13 99,366,003 (GRCm39) missense possibly damaging 0.62
R5040:Zfp366 UTSW 13 99,364,875 (GRCm39) missense probably damaging 1.00
R5086:Zfp366 UTSW 13 99,365,451 (GRCm39) missense probably benign 0.00
R5186:Zfp366 UTSW 13 99,382,676 (GRCm39) missense probably benign 0.00
R5249:Zfp366 UTSW 13 99,366,117 (GRCm39) missense probably damaging 1.00
R5450:Zfp366 UTSW 13 99,366,093 (GRCm39) missense probably damaging 1.00
R6838:Zfp366 UTSW 13 99,382,685 (GRCm39) missense possibly damaging 0.83
R6838:Zfp366 UTSW 13 99,365,015 (GRCm39) missense possibly damaging 0.93
R7250:Zfp366 UTSW 13 99,366,076 (GRCm39) missense probably damaging 1.00
R7378:Zfp366 UTSW 13 99,366,023 (GRCm39) missense probably damaging 1.00
R7571:Zfp366 UTSW 13 99,382,895 (GRCm39) missense probably benign 0.03
R7624:Zfp366 UTSW 13 99,382,804 (GRCm39) missense probably benign
R7653:Zfp366 UTSW 13 99,365,709 (GRCm39) missense probably damaging 1.00
R8367:Zfp366 UTSW 13 99,380,551 (GRCm39) missense possibly damaging 0.95
R9510:Zfp366 UTSW 13 99,365,874 (GRCm39) missense probably damaging 1.00
R9658:Zfp366 UTSW 13 99,365,435 (GRCm39) missense probably benign 0.13
R9734:Zfp366 UTSW 13 99,365,352 (GRCm39) missense probably damaging 1.00
Z1176:Zfp366 UTSW 13 99,382,858 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCCAGGAGACCTTGATGGATTCCC -3'
(R):5'- GCTGTTTGAAGAGTTTCCCACAACG -3'

Sequencing Primer
(F):5'- AGCTTCGATTGCTCAGGAGAG -3'
(R):5'- TTTCCCACAACGGGAGC -3'
Posted On 2013-07-11