Incidental Mutation 'R7323:Fscn3'
ID 568277
Institutional Source Beutler Lab
Gene Symbol Fscn3
Ensembl Gene ENSMUSG00000029707
Gene Name fascin actin-bundling protein 3
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R7323 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 28427888-28438621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 28431544 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 292 (T292A)
Ref Sequence ENSEMBL: ENSMUSP00000031719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020717] [ENSMUST00000031719] [ENSMUST00000064377]
AlphaFold Q9QXW4
Predicted Effect probably benign
Transcript: ENSMUST00000020717
SMART Domains Protein: ENSMUSP00000020717
Gene: ENSMUSG00000020440

DomainStartEndE-ValueType
ARF 1 180 5.83e-121 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000031719
AA Change: T292A

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000031719
Gene: ENSMUSG00000029707
AA Change: T292A

DomainStartEndE-ValueType
Pfam:Fascin 24 138 1e-29 PFAM
SCOP:d1dfca2 146 260 2e-48 SMART
Pfam:Fascin 271 381 2.1e-26 PFAM
SCOP:d1dfca4 386 498 3e-53 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000064377
SMART Domains Protein: ENSMUSP00000067395
Gene: ENSMUSG00000029708

DomainStartEndE-ValueType
coiled coil region 13 61 N/A INTRINSIC
low complexity region 93 109 N/A INTRINSIC
low complexity region 130 153 N/A INTRINSIC
coiled coil region 156 315 N/A INTRINSIC
low complexity region 408 418 N/A INTRINSIC
low complexity region 432 443 N/A INTRINSIC
low complexity region 479 491 N/A INTRINSIC
Blast:H2B 492 590 3e-8 BLAST
low complexity region 613 631 N/A INTRINSIC
coiled coil region 659 701 N/A INTRINSIC
Grip 719 766 8.28e-20 SMART
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (73/73)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930524J08Rik C A 5: 100,126,945 (GRCm39) A9E unknown Het
6030452D12Rik A T 8: 107,227,411 (GRCm39) probably null Het
Abcb11 C A 2: 69,117,979 (GRCm39) Q466H probably damaging Het
Adam20 A G 8: 41,248,421 (GRCm39) D177G probably benign Het
Ampd1 A T 3: 102,992,696 (GRCm39) Q150L probably benign Het
Angpt2 A C 8: 18,755,840 (GRCm39) M209R probably benign Het
Aoc2 G A 11: 101,219,371 (GRCm39) R598Q probably damaging Het
Arap1 A G 7: 101,049,418 (GRCm39) D960G probably damaging Het
Bhlhe40 G C 6: 108,642,242 (GRCm39) L395F probably benign Het
Cacna1i T C 15: 80,275,854 (GRCm39) C1882R possibly damaging Het
Ccr6 A G 17: 8,475,611 (GRCm39) N272S possibly damaging Het
Ces1f A T 8: 93,998,472 (GRCm39) W175R probably damaging Het
Ces3a A C 8: 105,782,239 (GRCm39) H364P possibly damaging Het
Cfap54 T C 10: 92,637,000 (GRCm39) M3130V probably benign Het
Clca3b G A 3: 144,531,681 (GRCm39) P708S possibly damaging Het
Cps1 A T 1: 67,197,028 (GRCm39) T360S probably benign Het
Cramp1 A T 17: 25,201,379 (GRCm39) M701K possibly damaging Het
Dnah1 A G 14: 31,020,664 (GRCm39) I1235T probably damaging Het
Efcab3 T C 11: 104,920,837 (GRCm39) L4676P probably benign Het
Ergic1 A G 17: 26,860,644 (GRCm39) E244G probably damaging Het
Fignl2 C A 15: 100,951,382 (GRCm39) R300L unknown Het
Fry T C 5: 150,419,814 (GRCm39) M628T Het
Fsip2 A T 2: 82,819,860 (GRCm39) I5198L probably benign Het
Gm4181 T A 14: 51,869,990 (GRCm39) R104W probably damaging Het
Gnl1 G A 17: 36,294,305 (GRCm39) R308H probably benign Het
Gtf2h4 G T 17: 35,980,857 (GRCm39) L271I probably damaging Het
Helq GTTT GTT 5: 100,931,051 (GRCm39) probably null Het
Hhatl A T 9: 121,618,652 (GRCm39) W117R probably benign Het
Hlx A G 1: 184,462,993 (GRCm39) F220L probably benign Het
Il31ra T C 13: 112,688,497 (GRCm39) I27V probably damaging Het
Itga8 T G 2: 12,266,940 (GRCm39) D165A probably damaging Het
Krt33a A C 11: 99,902,801 (GRCm39) V341G probably benign Het
Lrrc3c A G 11: 98,490,266 (GRCm39) M208V possibly damaging Het
Mapk8ip3 A T 17: 25,120,135 (GRCm39) S947T probably benign Het
Muc5b A G 7: 141,412,444 (GRCm39) I1797V unknown Het
Myh2 A T 11: 67,088,191 (GRCm39) T1936S probably benign Het
Nr1h2 T C 7: 44,199,746 (GRCm39) Y391C possibly damaging Het
Or1l8 T A 2: 36,817,986 (GRCm39) I47F probably damaging Het
Or4c114 A T 2: 88,904,811 (GRCm39) I208K probably damaging Het
Or4e2 A G 14: 52,688,670 (GRCm39) I267V probably benign Het
Or5d40 A G 2: 88,015,952 (GRCm39) T244A possibly damaging Het
Phf3 A G 1: 30,852,211 (GRCm39) M1064T probably benign Het
Pkd1 A G 17: 24,794,025 (GRCm39) E1904G probably benign Het
Polrmt A G 10: 79,576,483 (GRCm39) V491A probably benign Het
Ppm1j C A 3: 104,691,429 (GRCm39) R306S probably damaging Het
Prkd2 T C 7: 16,581,547 (GRCm39) F134S probably benign Het
Prpf8 C A 11: 75,382,610 (GRCm39) Q439K probably benign Het
Prss50 A T 9: 110,692,800 (GRCm39) I307F possibly damaging Het
Rgs20 A G 1: 4,982,535 (GRCm39) probably null Het
Rnf144b A G 13: 47,393,258 (GRCm39) E199G probably damaging Het
Slc12a4 C T 8: 106,682,347 (GRCm39) G121S probably damaging Het
Slc22a26 A T 19: 7,768,259 (GRCm39) V233E probably damaging Het
Slc27a2 T G 2: 126,395,124 (GRCm39) L17R probably benign Het
Slc6a17 A G 3: 107,398,794 (GRCm39) V269A probably benign Het
Srp54c T C 12: 55,304,237 (GRCm39) V395A probably benign Het
Sspo A T 6: 48,438,581 (GRCm39) S1550C possibly damaging Het
Tet1 A G 10: 62,715,818 (GRCm39) probably benign Het
Themis A T 10: 28,609,497 (GRCm39) H88L probably benign Het
Tmem63b G A 17: 45,971,773 (GRCm39) T814M possibly damaging Het
Tnc G A 4: 63,889,469 (GRCm39) T1679I probably damaging Het
Tnfrsf11a A G 1: 105,772,456 (GRCm39) D581G probably damaging Het
Trim30d A C 7: 104,132,555 (GRCm39) V244G probably benign Het
Trpv1 T C 11: 73,151,163 (GRCm39) S784P possibly damaging Het
Tulp1 G A 17: 28,575,398 (GRCm39) T103M probably damaging Het
Ubap2l A C 3: 89,922,713 (GRCm39) V775G unknown Het
Vmn2r69 A C 7: 85,060,972 (GRCm39) I204R possibly damaging Het
Vmn2r72 T A 7: 85,399,771 (GRCm39) D426V probably benign Het
Vmn2r93 G A 17: 18,533,497 (GRCm39) W467* probably null Het
Wbp2nl T C 15: 82,198,542 (GRCm39) *360Q probably null Het
Xylt1 G A 7: 117,191,274 (GRCm39) probably null Het
Zc3h6 T G 2: 128,835,331 (GRCm39) N123K unknown Het
Zfp853 T C 5: 143,275,110 (GRCm39) Q185R unknown Het
Other mutations in Fscn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01290:Fscn3 APN 6 28,430,505 (GRCm39) missense probably benign 0.43
IGL01312:Fscn3 APN 6 28,434,469 (GRCm39) missense probably damaging 0.99
IGL01634:Fscn3 APN 6 28,430,537 (GRCm39) missense probably damaging 1.00
IGL01899:Fscn3 APN 6 28,436,078 (GRCm39) missense probably damaging 1.00
IGL01928:Fscn3 APN 6 28,430,181 (GRCm39) missense possibly damaging 0.65
IGL02334:Fscn3 APN 6 28,428,153 (GRCm39) splice site probably null
IGL02959:Fscn3 APN 6 28,435,997 (GRCm39) missense possibly damaging 0.93
IGL03201:Fscn3 APN 6 28,430,604 (GRCm39) missense probably benign 0.07
IGL03202:Fscn3 APN 6 28,434,451 (GRCm39) missense probably benign 0.10
IGL03227:Fscn3 APN 6 28,434,429 (GRCm39) missense probably benign 0.00
0152:Fscn3 UTSW 6 28,429,966 (GRCm39) unclassified probably benign
R1478:Fscn3 UTSW 6 28,430,567 (GRCm39) missense probably benign
R1502:Fscn3 UTSW 6 28,435,622 (GRCm39) missense probably benign 0.05
R1955:Fscn3 UTSW 6 28,430,235 (GRCm39) missense possibly damaging 0.82
R2122:Fscn3 UTSW 6 28,430,388 (GRCm39) missense probably benign 0.18
R2135:Fscn3 UTSW 6 28,431,583 (GRCm39) missense probably benign 0.02
R3713:Fscn3 UTSW 6 28,428,091 (GRCm39) missense possibly damaging 0.89
R3715:Fscn3 UTSW 6 28,428,091 (GRCm39) missense possibly damaging 0.89
R3778:Fscn3 UTSW 6 28,430,031 (GRCm39) missense possibly damaging 0.72
R4572:Fscn3 UTSW 6 28,430,634 (GRCm39) splice site probably null
R4745:Fscn3 UTSW 6 28,435,627 (GRCm39) missense probably damaging 0.98
R4764:Fscn3 UTSW 6 28,436,200 (GRCm39) makesense probably null
R4794:Fscn3 UTSW 6 28,430,595 (GRCm39) missense probably damaging 1.00
R5738:Fscn3 UTSW 6 28,430,030 (GRCm39) missense possibly damaging 0.56
R5951:Fscn3 UTSW 6 28,436,173 (GRCm39) missense possibly damaging 0.88
R5994:Fscn3 UTSW 6 28,430,294 (GRCm39) missense probably benign
R6595:Fscn3 UTSW 6 28,430,174 (GRCm39) missense probably damaging 1.00
R7738:Fscn3 UTSW 6 28,434,445 (GRCm39) missense probably benign 0.01
R7840:Fscn3 UTSW 6 28,430,175 (GRCm39) missense probably damaging 1.00
R8169:Fscn3 UTSW 6 28,430,328 (GRCm39) missense possibly damaging 0.79
R8991:Fscn3 UTSW 6 28,434,472 (GRCm39) missense probably benign
R9111:Fscn3 UTSW 6 28,430,310 (GRCm39) missense probably damaging 0.98
R9350:Fscn3 UTSW 6 28,430,432 (GRCm39) nonsense probably null
R9370:Fscn3 UTSW 6 28,434,535 (GRCm39) missense probably benign
R9410:Fscn3 UTSW 6 28,430,432 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TATTCTGAGCTAGCATAAGGTGG -3'
(R):5'- TATCGATTGAGCTGGGCCTC -3'

Sequencing Primer
(F):5'- CTGAGCTAGCATAAGGTGGAGGAG -3'
(R):5'- GAGCTGGGCCTCTTTAGCTC -3'
Posted On 2019-06-26