Incidental Mutation 'R7323:Vmn2r72'
| ID |
568283 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r72
|
| Ensembl Gene |
ENSMUSG00000051877 |
| Gene Name |
vomeronasal 2, receptor 72 |
| Synonyms |
EG244114, Vmn2r72-ps |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R7323 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85386992-85404189 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85399771 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 426
(D426V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133014
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063425]
|
| AlphaFold |
D3Z4N8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063425
AA Change: D426V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: D426V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
564 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
594 |
832 |
4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (73/73) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930524J08Rik |
C |
A |
5: 100,126,945 (GRCm39) |
A9E |
unknown |
Het |
| 6030452D12Rik |
A |
T |
8: 107,227,411 (GRCm39) |
|
probably null |
Het |
| Abcb11 |
C |
A |
2: 69,117,979 (GRCm39) |
Q466H |
probably damaging |
Het |
| Adam20 |
A |
G |
8: 41,248,421 (GRCm39) |
D177G |
probably benign |
Het |
| Ampd1 |
A |
T |
3: 102,992,696 (GRCm39) |
Q150L |
probably benign |
Het |
| Angpt2 |
A |
C |
8: 18,755,840 (GRCm39) |
M209R |
probably benign |
Het |
| Aoc2 |
G |
A |
11: 101,219,371 (GRCm39) |
R598Q |
probably damaging |
Het |
| Arap1 |
A |
G |
7: 101,049,418 (GRCm39) |
D960G |
probably damaging |
Het |
| Bhlhe40 |
G |
C |
6: 108,642,242 (GRCm39) |
L395F |
probably benign |
Het |
| Cacna1i |
T |
C |
15: 80,275,854 (GRCm39) |
C1882R |
possibly damaging |
Het |
| Ccr6 |
A |
G |
17: 8,475,611 (GRCm39) |
N272S |
possibly damaging |
Het |
| Ces1f |
A |
T |
8: 93,998,472 (GRCm39) |
W175R |
probably damaging |
Het |
| Ces3a |
A |
C |
8: 105,782,239 (GRCm39) |
H364P |
possibly damaging |
Het |
| Cfap54 |
T |
C |
10: 92,637,000 (GRCm39) |
M3130V |
probably benign |
Het |
| Clca3b |
G |
A |
3: 144,531,681 (GRCm39) |
P708S |
possibly damaging |
Het |
| Cps1 |
A |
T |
1: 67,197,028 (GRCm39) |
T360S |
probably benign |
Het |
| Cramp1 |
A |
T |
17: 25,201,379 (GRCm39) |
M701K |
possibly damaging |
Het |
| Dnah1 |
A |
G |
14: 31,020,664 (GRCm39) |
I1235T |
probably damaging |
Het |
| Efcab3 |
T |
C |
11: 104,920,837 (GRCm39) |
L4676P |
probably benign |
Het |
| Ergic1 |
A |
G |
17: 26,860,644 (GRCm39) |
E244G |
probably damaging |
Het |
| Fignl2 |
C |
A |
15: 100,951,382 (GRCm39) |
R300L |
unknown |
Het |
| Fry |
T |
C |
5: 150,419,814 (GRCm39) |
M628T |
|
Het |
| Fscn3 |
A |
G |
6: 28,431,544 (GRCm39) |
T292A |
possibly damaging |
Het |
| Fsip2 |
A |
T |
2: 82,819,860 (GRCm39) |
I5198L |
probably benign |
Het |
| Gm4181 |
T |
A |
14: 51,869,990 (GRCm39) |
R104W |
probably damaging |
Het |
| Gnl1 |
G |
A |
17: 36,294,305 (GRCm39) |
R308H |
probably benign |
Het |
| Gtf2h4 |
G |
T |
17: 35,980,857 (GRCm39) |
L271I |
probably damaging |
Het |
| Helq |
GTTT |
GTT |
5: 100,931,051 (GRCm39) |
|
probably null |
Het |
| Hhatl |
A |
T |
9: 121,618,652 (GRCm39) |
W117R |
probably benign |
Het |
| Hlx |
A |
G |
1: 184,462,993 (GRCm39) |
F220L |
probably benign |
Het |
| Il31ra |
T |
C |
13: 112,688,497 (GRCm39) |
I27V |
probably damaging |
Het |
| Itga8 |
T |
G |
2: 12,266,940 (GRCm39) |
D165A |
probably damaging |
Het |
| Krt33a |
A |
C |
11: 99,902,801 (GRCm39) |
V341G |
probably benign |
Het |
| Lrrc3c |
A |
G |
11: 98,490,266 (GRCm39) |
M208V |
possibly damaging |
Het |
| Mapk8ip3 |
A |
T |
17: 25,120,135 (GRCm39) |
S947T |
probably benign |
Het |
| Muc5b |
A |
G |
7: 141,412,444 (GRCm39) |
I1797V |
unknown |
Het |
| Myh2 |
A |
T |
11: 67,088,191 (GRCm39) |
T1936S |
probably benign |
Het |
| Nr1h2 |
T |
C |
7: 44,199,746 (GRCm39) |
Y391C |
possibly damaging |
Het |
| Or1l8 |
T |
A |
2: 36,817,986 (GRCm39) |
I47F |
probably damaging |
Het |
| Or4c114 |
A |
T |
2: 88,904,811 (GRCm39) |
I208K |
probably damaging |
Het |
| Or4e2 |
A |
G |
14: 52,688,670 (GRCm39) |
I267V |
probably benign |
Het |
| Or5d40 |
A |
G |
2: 88,015,952 (GRCm39) |
T244A |
possibly damaging |
Het |
| Phf3 |
A |
G |
1: 30,852,211 (GRCm39) |
M1064T |
probably benign |
Het |
| Pkd1 |
A |
G |
17: 24,794,025 (GRCm39) |
E1904G |
probably benign |
Het |
| Polrmt |
A |
G |
10: 79,576,483 (GRCm39) |
V491A |
probably benign |
Het |
| Ppm1j |
C |
A |
3: 104,691,429 (GRCm39) |
R306S |
probably damaging |
Het |
| Prkd2 |
T |
C |
7: 16,581,547 (GRCm39) |
F134S |
probably benign |
Het |
| Prpf8 |
C |
A |
11: 75,382,610 (GRCm39) |
Q439K |
probably benign |
Het |
| Prss50 |
A |
T |
9: 110,692,800 (GRCm39) |
I307F |
possibly damaging |
Het |
| Rgs20 |
A |
G |
1: 4,982,535 (GRCm39) |
|
probably null |
Het |
| Rnf144b |
A |
G |
13: 47,393,258 (GRCm39) |
E199G |
probably damaging |
Het |
| Slc12a4 |
C |
T |
8: 106,682,347 (GRCm39) |
G121S |
probably damaging |
Het |
| Slc22a26 |
A |
T |
19: 7,768,259 (GRCm39) |
V233E |
probably damaging |
Het |
| Slc27a2 |
T |
G |
2: 126,395,124 (GRCm39) |
L17R |
probably benign |
Het |
| Slc6a17 |
A |
G |
3: 107,398,794 (GRCm39) |
V269A |
probably benign |
Het |
| Srp54c |
T |
C |
12: 55,304,237 (GRCm39) |
V395A |
probably benign |
Het |
| Sspo |
A |
T |
6: 48,438,581 (GRCm39) |
S1550C |
possibly damaging |
Het |
| Tet1 |
A |
G |
10: 62,715,818 (GRCm39) |
|
probably benign |
Het |
| Themis |
A |
T |
10: 28,609,497 (GRCm39) |
H88L |
probably benign |
Het |
| Tmem63b |
G |
A |
17: 45,971,773 (GRCm39) |
T814M |
possibly damaging |
Het |
| Tnc |
G |
A |
4: 63,889,469 (GRCm39) |
T1679I |
probably damaging |
Het |
| Tnfrsf11a |
A |
G |
1: 105,772,456 (GRCm39) |
D581G |
probably damaging |
Het |
| Trim30d |
A |
C |
7: 104,132,555 (GRCm39) |
V244G |
probably benign |
Het |
| Trpv1 |
T |
C |
11: 73,151,163 (GRCm39) |
S784P |
possibly damaging |
Het |
| Tulp1 |
G |
A |
17: 28,575,398 (GRCm39) |
T103M |
probably damaging |
Het |
| Ubap2l |
A |
C |
3: 89,922,713 (GRCm39) |
V775G |
unknown |
Het |
| Vmn2r69 |
A |
C |
7: 85,060,972 (GRCm39) |
I204R |
possibly damaging |
Het |
| Vmn2r93 |
G |
A |
17: 18,533,497 (GRCm39) |
W467* |
probably null |
Het |
| Wbp2nl |
T |
C |
15: 82,198,542 (GRCm39) |
*360Q |
probably null |
Het |
| Xylt1 |
G |
A |
7: 117,191,274 (GRCm39) |
|
probably null |
Het |
| Zc3h6 |
T |
G |
2: 128,835,331 (GRCm39) |
N123K |
unknown |
Het |
| Zfp853 |
T |
C |
5: 143,275,110 (GRCm39) |
Q185R |
unknown |
Het |
|
| Other mutations in Vmn2r72 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00931:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01019:Vmn2r72
|
APN |
7 |
85,387,542 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL01445:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02076:Vmn2r72
|
APN |
7 |
85,387,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02082:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02086:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02089:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02125:Vmn2r72
|
APN |
7 |
85,399,919 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02146:Vmn2r72
|
APN |
7 |
85,387,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02272:Vmn2r72
|
APN |
7 |
85,399,901 (GRCm39) |
missense |
probably benign |
|
|
IGL02514:Vmn2r72
|
APN |
7 |
85,387,907 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02662:Vmn2r72
|
APN |
7 |
85,387,391 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02697:Vmn2r72
|
APN |
7 |
85,387,879 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02733:Vmn2r72
|
APN |
7 |
85,401,021 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03070:Vmn2r72
|
APN |
7 |
85,401,249 (GRCm39) |
splice site |
probably benign |
|
|
IGL03150:Vmn2r72
|
APN |
7 |
85,400,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03159:Vmn2r72
|
APN |
7 |
85,404,162 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03333:Vmn2r72
|
APN |
7 |
85,400,075 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0081:Vmn2r72
|
UTSW |
7 |
85,401,044 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0090:Vmn2r72
|
UTSW |
7 |
85,404,084 (GRCm39) |
missense |
probably benign |
|
|
R0655:Vmn2r72
|
UTSW |
7 |
85,387,319 (GRCm39) |
nonsense |
probably null |
|
|
R0778:Vmn2r72
|
UTSW |
7 |
85,398,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1169:Vmn2r72
|
UTSW |
7 |
85,400,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1172:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1173:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1175:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1248:Vmn2r72
|
UTSW |
7 |
85,398,396 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1302:Vmn2r72
|
UTSW |
7 |
85,387,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1506:Vmn2r72
|
UTSW |
7 |
85,398,419 (GRCm39) |
missense |
probably benign |
|
|
R1632:Vmn2r72
|
UTSW |
7 |
85,401,000 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1775:Vmn2r72
|
UTSW |
7 |
85,387,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r72
|
UTSW |
7 |
85,398,369 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r72
|
UTSW |
7 |
85,387,444 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2290:Vmn2r72
|
UTSW |
7 |
85,387,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2424:Vmn2r72
|
UTSW |
7 |
85,400,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2655:Vmn2r72
|
UTSW |
7 |
85,400,477 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2860:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2861:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2862:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3009:Vmn2r72
|
UTSW |
7 |
85,398,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3797:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3798:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3902:Vmn2r72
|
UTSW |
7 |
85,398,943 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R3959:Vmn2r72
|
UTSW |
7 |
85,400,339 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3974:Vmn2r72
|
UTSW |
7 |
85,399,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4399:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4421:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Vmn2r72
|
UTSW |
7 |
85,387,036 (GRCm39) |
nonsense |
probably null |
|
|
R4522:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4523:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4533:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4691:Vmn2r72
|
UTSW |
7 |
85,387,119 (GRCm39) |
nonsense |
probably null |
|
|
R4781:Vmn2r72
|
UTSW |
7 |
85,387,069 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4863:Vmn2r72
|
UTSW |
7 |
85,399,806 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4952:Vmn2r72
|
UTSW |
7 |
85,400,317 (GRCm39) |
missense |
probably benign |
|
|
R4991:Vmn2r72
|
UTSW |
7 |
85,400,338 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4995:Vmn2r72
|
UTSW |
7 |
85,387,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5095:Vmn2r72
|
UTSW |
7 |
85,387,061 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5174:Vmn2r72
|
UTSW |
7 |
85,387,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5276:Vmn2r72
|
UTSW |
7 |
85,387,462 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5395:Vmn2r72
|
UTSW |
7 |
85,400,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5560:Vmn2r72
|
UTSW |
7 |
85,401,150 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5933:Vmn2r72
|
UTSW |
7 |
85,387,058 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6354:Vmn2r72
|
UTSW |
7 |
85,399,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6362:Vmn2r72
|
UTSW |
7 |
85,400,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6594:Vmn2r72
|
UTSW |
7 |
85,398,892 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6794:Vmn2r72
|
UTSW |
7 |
85,387,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7113:Vmn2r72
|
UTSW |
7 |
85,399,011 (GRCm39) |
splice site |
probably null |
|
|
R7189:Vmn2r72
|
UTSW |
7 |
85,404,125 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7266:Vmn2r72
|
UTSW |
7 |
85,387,482 (GRCm39) |
nonsense |
probably null |
|
|
R7426:Vmn2r72
|
UTSW |
7 |
85,400,348 (GRCm39) |
missense |
probably benign |
|
|
R7606:Vmn2r72
|
UTSW |
7 |
85,400,362 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7651:Vmn2r72
|
UTSW |
7 |
85,401,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Vmn2r72
|
UTSW |
7 |
85,404,098 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7753:Vmn2r72
|
UTSW |
7 |
85,399,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7843:Vmn2r72
|
UTSW |
7 |
85,398,838 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8157:Vmn2r72
|
UTSW |
7 |
85,400,441 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8254:Vmn2r72
|
UTSW |
7 |
85,400,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Vmn2r72
|
UTSW |
7 |
85,401,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8444:Vmn2r72
|
UTSW |
7 |
85,387,383 (GRCm39) |
missense |
probably benign |
|
|
R8989:Vmn2r72
|
UTSW |
7 |
85,404,134 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9015:Vmn2r72
|
UTSW |
7 |
85,398,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9080:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Vmn2r72
|
UTSW |
7 |
85,400,411 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9317:Vmn2r72
|
UTSW |
7 |
85,404,022 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9509:Vmn2r72
|
UTSW |
7 |
85,404,075 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r72
|
UTSW |
7 |
85,398,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCATACTAATGTCGACTGTGTC -3'
(R):5'- TTGCCACCATCTAATTGTAAAACGC -3'
Sequencing Primer
(F):5'- AATGTCGACTGTGTCATATTACATG -3'
(R):5'- GTAAAACGCTGAAGAATTGTCCC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation