Incidental Mutation 'R6954:Fcrl2'
ID 568327
Institutional Source Beutler Lab
Gene Symbol Fcrl2
Ensembl Gene ENSMUSG00000015852
Gene Name Fc receptor like 2
Synonyms Fcrls, IFGP2, 2810439C17Rik, Msr2, Fcrh2, moFcRH2sc
MMRRC Submission 045066-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6954 (G1)
Quality Score 46.0073
Status Validated
Chromosome 3
Chromosomal Location 87158318-87171046 bp(-) (GRCm39)
Type of Mutation critical splice donor site
DNA Base Change (assembly) A to G at 87170983 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115780 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090986] [ENSMUST00000146512]
AlphaFold Q9EQY5
Predicted Effect probably benign
Transcript: ENSMUST00000090986
SMART Domains Protein: ENSMUSP00000088508
Gene: ENSMUSG00000015852

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
IGc2 122 186 2.77e-6 SMART
IGc2 226 291 1.09e-4 SMART
IG 315 396 1e-3 SMART
SR 402 503 7.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146512
SMART Domains Protein: ENSMUSP00000115780
Gene: ENSMUSG00000015852

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
Pfam:Ig_2 111 176 6.1e-6 PFAM
Pfam:Ig_3 111 176 1.4e-4 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.5%
Validation Efficiency 98% (57/58)
MGI Phenotype PHENOTYPE: Female homozygous mutant mice are larger than controls and show increased mean body weight, total tissue mass, lean body mass and total body fat. Homozygous mutant mice eshow a decreased mean percentage of CD8 cells in the peripheral blood. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930451I11Rik A T 7: 126,429,809 (GRCm39) probably null Het
Alox5 A C 6: 116,397,241 (GRCm39) Y314* probably null Het
Ap4e1 T C 2: 126,906,871 (GRCm39) S1044P probably benign Het
Ash2l A G 8: 26,312,796 (GRCm39) V391A possibly damaging Het
B4galnt4 A G 7: 140,647,145 (GRCm39) T326A probably benign Het
Ccm2 T A 11: 6,544,239 (GRCm39) I345N probably damaging Het
Cntnap3 G A 13: 64,896,373 (GRCm39) H1034Y probably benign Het
Cpsf1 A G 15: 76,483,696 (GRCm39) L849S probably damaging Het
Ctrb1 A G 8: 112,413,296 (GRCm39) S239P probably damaging Het
Dennd1b T A 1: 139,096,683 (GRCm39) probably benign Het
Dnah17 A G 11: 117,957,258 (GRCm39) I2773T probably damaging Het
Eif2b2 T A 12: 85,272,817 (GRCm39) F267L probably damaging Het
Furin G T 7: 80,046,712 (GRCm39) D181E possibly damaging Het
Gm29106 T A 1: 118,128,317 (GRCm39) C670S probably damaging Het
Gm6309 A T 5: 146,105,300 (GRCm39) D204E possibly damaging Het
Hsf2 T A 10: 57,380,739 (GRCm39) I191N probably damaging Het
Hspa12a T C 19: 58,788,124 (GRCm39) D566G probably benign Het
Igf1 G C 10: 87,700,722 (GRCm39) V49L probably damaging Het
Igfbpl1 C T 4: 45,826,663 (GRCm39) C44Y probably damaging Het
Letm1 G A 5: 33,939,851 (GRCm39) R16C probably benign Het
Lypd8l T A 11: 58,499,314 (GRCm39) Y168F probably benign Het
Marf1 A G 16: 13,956,384 (GRCm39) V819A probably damaging Het
Mfsd4b4 A T 10: 39,767,948 (GRCm39) S428T probably benign Het
Myo1d T C 11: 80,565,783 (GRCm39) I347M probably benign Het
Myo9b A G 8: 71,743,463 (GRCm39) I175V probably damaging Het
Naip5 A T 13: 100,359,922 (GRCm39) V438E probably damaging Het
Nup205 T A 6: 35,185,044 (GRCm39) V768E possibly damaging Het
Or4k6 A T 14: 50,475,567 (GRCm39) Y258* probably null Het
Or9g4b T A 2: 85,616,726 (GRCm39) Y290* probably null Het
Pcdh15 C T 10: 74,481,821 (GRCm39) H1651Y possibly damaging Het
Pdgfra A T 5: 75,334,055 (GRCm39) Q376L possibly damaging Het
Pign T C 1: 105,481,622 (GRCm39) I791M probably benign Het
Pik3c2b T G 1: 132,994,041 (GRCm39) S2A possibly damaging Het
Pip5k1a A T 3: 94,975,558 (GRCm39) I304K probably damaging Het
Pkdrej A T 15: 85,702,054 (GRCm39) L1294* probably null Het
Pprc1 T C 19: 46,052,872 (GRCm39) S797P probably damaging Het
Prob1 A G 18: 35,787,321 (GRCm39) V311A probably benign Het
Prune2 C A 19: 16,977,385 (GRCm39) T40K probably damaging Het
Rif1 T G 2: 52,002,703 (GRCm39) D2052E probably benign Het
Sall1 A G 8: 89,759,519 (GRCm39) V195A probably damaging Het
Scfd1 T C 12: 51,474,729 (GRCm39) probably null Het
Sidt2 A T 9: 45,864,148 (GRCm39) N123K probably benign Het
Slc22a6 G A 19: 8,599,460 (GRCm39) A320T probably benign Het
Slc25a10 A G 11: 120,388,973 (GRCm39) H279R probably benign Het
Slc35b4 A G 6: 34,135,556 (GRCm39) V252A probably benign Het
Slc46a3 T C 5: 147,823,150 (GRCm39) T231A probably benign Het
Stxbp1 T A 2: 32,691,905 (GRCm39) H429L probably damaging Het
Tas2r134 C T 2: 51,517,782 (GRCm39) T87I probably benign Het
Tcstv6 A G 13: 120,307,666 (GRCm39) D20G possibly damaging Het
Tdpoz2 A T 3: 93,559,582 (GRCm39) L130H probably damaging Het
Tmem69 T C 4: 116,411,921 (GRCm39) probably null Het
Tmppe G A 9: 114,234,591 (GRCm39) V297I probably benign Het
Ung G T 5: 114,269,398 (GRCm39) A37S probably benign Het
Vdac1 T C 11: 52,277,200 (GRCm39) Y237H probably damaging Het
Vgll4 T C 6: 114,898,328 (GRCm39) Y11C probably damaging Het
Vmn1r24 A G 6: 57,933,437 (GRCm39) I27T probably benign Het
Zfp280b T A 10: 75,875,522 (GRCm39) M467K probably benign Het
Zkscan4 A G 13: 21,668,535 (GRCm39) I329V probably damaging Het
Other mutations in Fcrl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01568:Fcrl2 APN 3 87,163,986 (GRCm39) missense probably damaging 0.99
IGL01959:Fcrl2 APN 3 87,166,939 (GRCm39) missense probably damaging 0.97
IGL02409:Fcrl2 APN 3 87,160,030 (GRCm39) missense probably benign 0.00
IGL02677:Fcrl2 APN 3 87,166,694 (GRCm39) missense probably benign 0.01
IGL02957:Fcrl2 APN 3 87,169,501 (GRCm39) missense possibly damaging 0.59
IGL02974:Fcrl2 APN 3 87,164,704 (GRCm39) missense possibly damaging 0.89
IGL02992:Fcrl2 APN 3 87,166,773 (GRCm39) missense probably damaging 0.99
BB001:Fcrl2 UTSW 3 87,166,840 (GRCm39) missense probably damaging 0.99
BB011:Fcrl2 UTSW 3 87,166,840 (GRCm39) missense probably damaging 0.99
R0052:Fcrl2 UTSW 3 87,164,085 (GRCm39) missense possibly damaging 0.94
R0052:Fcrl2 UTSW 3 87,164,085 (GRCm39) missense possibly damaging 0.94
R0131:Fcrl2 UTSW 3 87,166,266 (GRCm39) missense possibly damaging 0.90
R1171:Fcrl2 UTSW 3 87,164,167 (GRCm39) missense probably benign 0.24
R1319:Fcrl2 UTSW 3 87,169,484 (GRCm39) critical splice donor site probably null
R1522:Fcrl2 UTSW 3 87,164,014 (GRCm39) missense possibly damaging 0.64
R1696:Fcrl2 UTSW 3 87,166,825 (GRCm39) missense possibly damaging 0.95
R1742:Fcrl2 UTSW 3 87,166,350 (GRCm39) missense possibly damaging 0.76
R2156:Fcrl2 UTSW 3 87,164,648 (GRCm39) missense probably benign 0.43
R2255:Fcrl2 UTSW 3 87,164,655 (GRCm39) nonsense probably null
R2257:Fcrl2 UTSW 3 87,166,928 (GRCm39) missense probably damaging 0.99
R2434:Fcrl2 UTSW 3 87,164,005 (GRCm39) missense probably damaging 1.00
R2680:Fcrl2 UTSW 3 87,164,656 (GRCm39) missense probably damaging 0.99
R3552:Fcrl2 UTSW 3 87,166,717 (GRCm39) missense possibly damaging 0.73
R4866:Fcrl2 UTSW 3 87,170,773 (GRCm39) missense possibly damaging 0.65
R4883:Fcrl2 UTSW 3 87,166,922 (GRCm39) missense possibly damaging 0.48
R5654:Fcrl2 UTSW 3 87,164,851 (GRCm39) missense probably benign
R5771:Fcrl2 UTSW 3 87,170,775 (GRCm39) missense probably damaging 0.98
R5917:Fcrl2 UTSW 3 87,164,094 (GRCm39) missense probably damaging 0.99
R6349:Fcrl2 UTSW 3 87,159,803 (GRCm39) missense probably damaging 0.99
R6562:Fcrl2 UTSW 3 87,164,635 (GRCm39) missense probably benign
R7059:Fcrl2 UTSW 3 87,164,647 (GRCm39) missense possibly damaging 0.82
R7188:Fcrl2 UTSW 3 87,166,830 (GRCm39) missense probably benign 0.13
R7201:Fcrl2 UTSW 3 87,159,934 (GRCm39) missense probably damaging 0.99
R7369:Fcrl2 UTSW 3 87,164,008 (GRCm39) missense possibly damaging 0.59
R7431:Fcrl2 UTSW 3 87,166,233 (GRCm39) missense probably damaging 0.99
R7610:Fcrl2 UTSW 3 87,160,004 (GRCm39) missense probably damaging 1.00
R7924:Fcrl2 UTSW 3 87,166,840 (GRCm39) missense probably damaging 0.99
R8018:Fcrl2 UTSW 3 87,166,933 (GRCm39) nonsense probably null
R8280:Fcrl2 UTSW 3 87,166,364 (GRCm39) nonsense probably null
R8981:Fcrl2 UTSW 3 87,164,677 (GRCm39) missense probably damaging 1.00
R9368:Fcrl2 UTSW 3 87,164,906 (GRCm39) missense possibly damaging 0.59
R9477:Fcrl2 UTSW 3 87,159,803 (GRCm39) missense probably damaging 0.98
R9522:Fcrl2 UTSW 3 87,164,101 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TGAGACTCGAGGCAAGTAGCTC -3'
(R):5'- GCTGCTTAGTAGGGACTGTC -3'

Sequencing Primer
(F):5'- CAAGTAGCTCCCTTTGAGACAGG -3'
(R):5'- GGGACTGTCTCTTGACTACTAAGAAG -3'
Posted On 2019-07-01