Incidental Mutation 'R7105:Sult1c2'
ID 568476
Institutional Source Beutler Lab
Gene Symbol Sult1c2
Ensembl Gene ENSMUSG00000023122
Gene Name sulfotransferase family, cytosolic, 1C, member 2
Synonyms 1810008N17Rik, ST1C1
MMRRC Submission 045197-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7105 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 54136665-54152986 bp(-) (GRCm39)
Type of Mutation splice site (13 bp from exon)
DNA Base Change (assembly) T to A at 54280917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000024738 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024738]
AlphaFold Q9D939
Predicted Effect probably null
Transcript: ENSMUST00000024738
SMART Domains Protein: ENSMUSP00000024738
Gene: ENSMUSG00000023943

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 46 297 4.7e-93 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 96% (65/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,347,842 (GRCm39) I3565N probably damaging Het
Adam8 T C 7: 139,569,968 (GRCm39) E99G probably benign Het
Adnp2 A C 18: 80,171,366 (GRCm39) H1014Q possibly damaging Het
Agbl4 T A 4: 111,423,920 (GRCm39) N315K probably benign Het
Ankrd33b G T 15: 31,305,214 (GRCm39) N183K probably damaging Het
Arhgef39 A G 4: 43,498,913 (GRCm39) S113P possibly damaging Het
Bdp1 G A 13: 100,206,689 (GRCm39) P618S probably damaging Het
Bhlhe40 C T 6: 108,641,997 (GRCm39) P314S possibly damaging Het
Birc2 A C 9: 7,819,442 (GRCm39) I490S probably damaging Het
Blm T C 7: 80,149,516 (GRCm39) I698V probably benign Het
C4b G A 17: 34,949,885 (GRCm39) T1433M possibly damaging Het
Car12 A G 9: 66,659,688 (GRCm39) T238A probably damaging Het
Cend1 G A 7: 141,007,565 (GRCm39) P85L probably benign Het
Cftr A T 6: 18,318,971 (GRCm39) D1337V probably damaging Het
Chsy3 T A 18: 59,309,491 (GRCm39) M248K probably damaging Het
Chtf8 A G 8: 107,611,883 (GRCm39) F352S probably damaging Het
Cimip4 T A 15: 78,270,318 (GRCm39) D150V possibly damaging Het
Csf2ra T C 19: 61,213,458 (GRCm39) D384G possibly damaging Het
Ctnnbip1 T C 4: 149,630,937 (GRCm39) S59P probably benign Het
Cyth3 A G 5: 143,693,027 (GRCm39) N312D probably benign Het
Dtnb T C 12: 3,698,391 (GRCm39) probably null Het
Duox2 A G 2: 122,120,033 (GRCm39) S826P possibly damaging Het
Enthd1 C T 15: 80,393,410 (GRCm39) A273T probably benign Het
Gm3138 T C 14: 15,632,304 (GRCm39) V159A possibly damaging Het
Hhip T C 8: 80,701,638 (GRCm39) D632G probably benign Het
Igfn1 A T 1: 135,911,956 (GRCm39) C114S probably benign Het
Islr2 T C 9: 58,105,097 (GRCm39) D765G probably damaging Het
Klf14 TCCCC TCCC 6: 30,935,476 (GRCm39) probably null Het
Mapk12 G A 15: 89,015,361 (GRCm39) P362L probably benign Het
Msi1 T G 5: 115,571,929 (GRCm39) F96V probably damaging Het
Mthfd1l T C 10: 4,053,261 (GRCm39) V870A probably benign Het
Nfat5 T C 8: 108,095,823 (GRCm39) S1355P possibly damaging Het
Oplah T C 15: 76,181,887 (GRCm39) N1079D probably damaging Het
Or2ah1 G T 2: 85,654,224 (GRCm39) R303M probably benign Het
Osbpl1a T A 18: 12,900,020 (GRCm39) I645F probably benign Het
Pank4 T C 4: 155,064,624 (GRCm39) S728P probably benign Het
Parp2 TTGCCATAAGTGCTAAATGAAGCC T 14: 51,047,521 (GRCm39) probably null Het
Piezo1 A G 8: 123,208,857 (GRCm39) I2503T unknown Het
Plekhg6 A G 6: 125,355,768 (GRCm39) L12P probably damaging Het
Plekhs1 T A 19: 56,465,647 (GRCm39) F204Y probably damaging Het
Pramel26 T C 4: 143,537,341 (GRCm39) N330S probably benign Het
Pramel32 G A 4: 88,548,339 (GRCm39) S22F probably damaging Het
Prep T A 10: 45,002,159 (GRCm39) I438N probably benign Het
Prss58 T C 6: 40,874,700 (GRCm39) H47R probably damaging Het
Rad51ap2 T G 12: 11,508,278 (GRCm39) D733E possibly damaging Het
Robo1 A T 16: 72,539,049 (GRCm39) I31F probably damaging Het
Setd2 A G 9: 110,377,328 (GRCm39) Y381C probably damaging Het
Slc47a2 A G 11: 61,233,269 (GRCm39) V87A probably benign Het
Slc5a9 T C 4: 111,755,892 (GRCm39) N2S probably benign Het
Spata13 A G 14: 60,991,319 (GRCm39) D1024G probably damaging Het
Stat1 T G 1: 52,190,408 (GRCm39) N554K probably benign Het
Suclg2 T C 6: 95,572,635 (GRCm39) D110G possibly damaging Het
Taf5l A G 8: 124,729,951 (GRCm39) I246T probably damaging Het
Tcof1 A T 18: 60,976,368 (GRCm39) D80E probably damaging Het
Tmem233 T C 5: 116,221,057 (GRCm39) Y63C probably damaging Het
Tshz3 A G 7: 36,469,181 (GRCm39) E390G probably damaging Het
Ttn T C 2: 76,560,610 (GRCm39) T29264A possibly damaging Het
Ubr5 T C 15: 38,009,019 (GRCm39) T1065A Het
Vcp A G 4: 42,985,991 (GRCm39) V341A probably damaging Het
Vmn1r176 A T 7: 23,534,748 (GRCm39) L135* probably null Het
Vmn1r57 T A 7: 5,223,499 (GRCm39) I8N probably damaging Het
Ythdc2 C T 18: 44,967,630 (GRCm39) P209S probably damaging Het
Zfp213 A T 17: 23,777,178 (GRCm39) V288D probably benign Het
Zfp362 T C 4: 128,668,319 (GRCm39) I418V probably damaging Het
Zfp707 C A 15: 75,846,595 (GRCm39) T215K Het
Zfp957 G C 14: 79,450,402 (GRCm39) R466G probably benign Het
Other mutations in Sult1c2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Sult1c2 APN 17 54,140,147 (GRCm39) nonsense probably null
IGL01398:Sult1c2 APN 17 54,269,180 (GRCm39) missense possibly damaging 0.93
IGL01938:Sult1c2 APN 17 54,138,954 (GRCm39) missense probably damaging 1.00
IGL01989:Sult1c2 APN 17 54,281,055 (GRCm39) missense probably benign
IGL02087:Sult1c2 APN 17 54,279,068 (GRCm39) missense possibly damaging 0.60
IGL02312:Sult1c2 APN 17 54,269,458 (GRCm39) missense probably benign 0.00
IGL03130:Sult1c2 APN 17 54,137,099 (GRCm39) missense probably benign 0.38
R0586:Sult1c2 UTSW 17 54,271,113 (GRCm39) splice site probably benign
R0659:Sult1c2 UTSW 17 54,138,806 (GRCm39) missense probably damaging 1.00
R1545:Sult1c2 UTSW 17 54,269,176 (GRCm39) missense possibly damaging 0.80
R1570:Sult1c2 UTSW 17 54,143,991 (GRCm39) missense probably benign 0.00
R1574:Sult1c2 UTSW 17 54,143,927 (GRCm39) critical splice donor site probably null
R1574:Sult1c2 UTSW 17 54,143,927 (GRCm39) critical splice donor site probably null
R1752:Sult1c2 UTSW 17 54,271,777 (GRCm39) missense possibly damaging 0.74
R1822:Sult1c2 UTSW 17 54,280,953 (GRCm39) missense probably damaging 1.00
R2232:Sult1c2 UTSW 17 54,138,848 (GRCm39) missense probably benign 0.01
R2315:Sult1c2 UTSW 17 54,145,521 (GRCm39) missense possibly damaging 0.90
R3522:Sult1c2 UTSW 17 54,279,043 (GRCm39) missense probably damaging 1.00
R4399:Sult1c2 UTSW 17 54,269,538 (GRCm39) missense probably benign 0.00
R4600:Sult1c2 UTSW 17 54,280,983 (GRCm39) missense probably benign 0.39
R4677:Sult1c2 UTSW 17 54,137,137 (GRCm39) missense possibly damaging 0.80
R4896:Sult1c2 UTSW 17 54,139,163 (GRCm39) missense probably benign 0.31
R5066:Sult1c2 UTSW 17 54,281,026 (GRCm39) missense probably damaging 0.96
R5140:Sult1c2 UTSW 17 54,276,743 (GRCm39) missense probably benign
R5334:Sult1c2 UTSW 17 54,271,758 (GRCm39) missense probably damaging 1.00
R5396:Sult1c2 UTSW 17 54,143,939 (GRCm39) missense possibly damaging 0.95
R5656:Sult1c2 UTSW 17 54,271,680 (GRCm39) missense probably benign 0.07
R5744:Sult1c2 UTSW 17 54,280,990 (GRCm39) nonsense probably null
R5941:Sult1c2 UTSW 17 54,138,926 (GRCm39) missense probably benign 0.01
R6163:Sult1c2 UTSW 17 54,280,981 (GRCm39) missense probably benign
R7137:Sult1c2 UTSW 17 54,145,422 (GRCm39) missense probably damaging 0.97
R7836:Sult1c2 UTSW 17 54,271,076 (GRCm39) missense probably damaging 1.00
R8025:Sult1c2 UTSW 17 54,138,837 (GRCm39) missense probably benign
R8416:Sult1c2 UTSW 17 54,269,580 (GRCm39) missense probably benign 0.38
R8519:Sult1c2 UTSW 17 54,276,709 (GRCm39) missense probably damaging 1.00
R9170:Sult1c2 UTSW 17 54,269,200 (GRCm39) missense possibly damaging 0.87
R9353:Sult1c2 UTSW 17 54,271,060 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTAAGGGAGGATCCAGTGGC -3'
(R):5'- CTTTCCTACAGAGCCTGTCAAGTC -3'

Sequencing Primer
(F):5'- CAGTGGCATTGGCTATTGACCC -3'
(R):5'- GAGCCTGTCAAGTCCCCATTCTAAG -3'
Posted On 2019-07-31