Incidental Mutation 'R7184:Zscan10'
ID |
568569 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zscan10
|
Ensembl Gene |
ENSMUSG00000023902 |
Gene Name |
zinc finger and SCAN domain containing 10 |
Synonyms |
Zscan10, Zfp206 |
MMRRC Submission |
045236-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.212)
|
Stock # |
R7184 (G1)
|
Quality Score |
143.008 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
23819830-23829993 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to G
at 23826003 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000120876
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095595]
[ENSMUST00000115509]
[ENSMUST00000117606]
[ENSMUST00000118369]
[ENSMUST00000120967]
[ENSMUST00000122285]
[ENSMUST00000123866]
[ENSMUST00000129227]
[ENSMUST00000138487]
[ENSMUST00000148062]
|
AlphaFold |
Q3URR7 |
Predicted Effect |
probably null
Transcript: ENSMUST00000095595
|
SMART Domains |
Protein: ENSMUSP00000093255 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
145 |
1.28e-34 |
SMART |
low complexity region
|
173 |
194 |
N/A |
INTRINSIC |
ZnF_C2H2
|
343 |
366 |
4.4e-2 |
SMART |
ZnF_C2H2
|
378 |
400 |
5.59e-4 |
SMART |
ZnF_C2H2
|
406 |
428 |
1.25e-1 |
SMART |
ZnF_C2H2
|
434 |
456 |
2.05e-2 |
SMART |
ZnF_C2H2
|
478 |
500 |
2.75e-3 |
SMART |
low complexity region
|
507 |
521 |
N/A |
INTRINSIC |
ZnF_C2H2
|
524 |
547 |
1.82e-3 |
SMART |
ZnF_C2H2
|
553 |
575 |
3.16e-3 |
SMART |
ZnF_C2H2
|
581 |
603 |
1.95e-3 |
SMART |
ZnF_C2H2
|
609 |
631 |
4.17e-3 |
SMART |
ZnF_C2H2
|
637 |
659 |
1.56e-2 |
SMART |
ZnF_C2H2
|
665 |
687 |
2.4e-3 |
SMART |
ZnF_C2H2
|
693 |
715 |
1.98e-4 |
SMART |
ZnF_C2H2
|
726 |
748 |
1.58e-3 |
SMART |
ZnF_C2H2
|
754 |
776 |
6.42e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115509
|
SMART Domains |
Protein: ENSMUSP00000111171 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
148 |
3.37e-34 |
SMART |
ZnF_C2H2
|
233 |
256 |
4.4e-2 |
SMART |
ZnF_C2H2
|
268 |
290 |
5.59e-4 |
SMART |
ZnF_C2H2
|
296 |
318 |
1.25e-1 |
SMART |
ZnF_C2H2
|
324 |
346 |
2.05e-2 |
SMART |
ZnF_C2H2
|
368 |
390 |
2.75e-3 |
SMART |
low complexity region
|
397 |
411 |
N/A |
INTRINSIC |
ZnF_C2H2
|
414 |
437 |
1.82e-3 |
SMART |
ZnF_C2H2
|
443 |
465 |
3.16e-3 |
SMART |
ZnF_C2H2
|
471 |
493 |
1.95e-3 |
SMART |
ZnF_C2H2
|
499 |
521 |
4.17e-3 |
SMART |
ZnF_C2H2
|
527 |
549 |
1.56e-2 |
SMART |
ZnF_C2H2
|
555 |
577 |
2.4e-3 |
SMART |
ZnF_C2H2
|
583 |
605 |
1.98e-4 |
SMART |
ZnF_C2H2
|
616 |
638 |
1.58e-3 |
SMART |
ZnF_C2H2
|
644 |
666 |
6.42e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000117606
|
SMART Domains |
Protein: ENSMUSP00000112460 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
147 |
1.73e-31 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000118369
|
SMART Domains |
Protein: ENSMUSP00000113757 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
152 |
1.59e-30 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000120967
|
SMART Domains |
Protein: ENSMUSP00000113386 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
145 |
1.28e-34 |
SMART |
low complexity region
|
173 |
194 |
N/A |
INTRINSIC |
ZnF_C2H2
|
346 |
368 |
5.59e-4 |
SMART |
ZnF_C2H2
|
374 |
396 |
1.25e-1 |
SMART |
ZnF_C2H2
|
402 |
424 |
2.05e-2 |
SMART |
ZnF_C2H2
|
446 |
468 |
2.75e-3 |
SMART |
low complexity region
|
475 |
489 |
N/A |
INTRINSIC |
ZnF_C2H2
|
492 |
515 |
1.82e-3 |
SMART |
ZnF_C2H2
|
521 |
543 |
3.16e-3 |
SMART |
ZnF_C2H2
|
549 |
571 |
1.95e-3 |
SMART |
ZnF_C2H2
|
577 |
599 |
4.17e-3 |
SMART |
ZnF_C2H2
|
605 |
627 |
1.56e-2 |
SMART |
ZnF_C2H2
|
633 |
655 |
2.4e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
1.98e-4 |
SMART |
ZnF_C2H2
|
694 |
716 |
1.58e-3 |
SMART |
ZnF_C2H2
|
722 |
744 |
6.42e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000122285
|
SMART Domains |
Protein: ENSMUSP00000112559 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
152 |
1.59e-30 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000123866
|
SMART Domains |
Protein: ENSMUSP00000116748 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
148 |
2.38e-34 |
SMART |
ZnF_C2H2
|
267 |
290 |
4.4e-2 |
SMART |
ZnF_C2H2
|
302 |
324 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000129227
|
SMART Domains |
Protein: ENSMUSP00000118987 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
142 |
164 |
5.59e-4 |
SMART |
ZnF_C2H2
|
170 |
192 |
1.25e-1 |
SMART |
ZnF_C2H2
|
198 |
220 |
2.05e-2 |
SMART |
ZnF_C2H2
|
242 |
264 |
2.75e-3 |
SMART |
low complexity region
|
271 |
285 |
N/A |
INTRINSIC |
ZnF_C2H2
|
288 |
311 |
1.82e-3 |
SMART |
ZnF_C2H2
|
317 |
339 |
3.16e-3 |
SMART |
ZnF_C2H2
|
345 |
367 |
1.95e-3 |
SMART |
ZnF_C2H2
|
373 |
395 |
4.17e-3 |
SMART |
ZnF_C2H2
|
401 |
423 |
1.56e-2 |
SMART |
ZnF_C2H2
|
429 |
451 |
2.4e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
1.98e-4 |
SMART |
ZnF_C2H2
|
490 |
512 |
1.58e-3 |
SMART |
ZnF_C2H2
|
518 |
540 |
6.42e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000138487
|
SMART Domains |
Protein: ENSMUSP00000114341 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
SCAN
|
39 |
148 |
3.37e-34 |
SMART |
ZnF_C2H2
|
236 |
258 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000148062
|
SMART Domains |
Protein: ENSMUSP00000120876 Gene: ENSMUSG00000023902
Domain | Start | End | E-Value | Type |
Pfam:SCAN
|
37 |
88 |
7.5e-20 |
PFAM |
low complexity region
|
128 |
149 |
N/A |
INTRINSIC |
ZnF_C2H2
|
301 |
323 |
5.59e-4 |
SMART |
ZnF_C2H2
|
329 |
351 |
1.25e-1 |
SMART |
ZnF_C2H2
|
357 |
379 |
2.05e-2 |
SMART |
ZnF_C2H2
|
401 |
423 |
2.75e-3 |
SMART |
low complexity region
|
430 |
444 |
N/A |
INTRINSIC |
ZnF_C2H2
|
447 |
470 |
1.82e-3 |
SMART |
ZnF_C2H2
|
476 |
498 |
3.16e-3 |
SMART |
ZnF_C2H2
|
504 |
526 |
1.95e-3 |
SMART |
ZnF_C2H2
|
532 |
554 |
4.17e-3 |
SMART |
ZnF_C2H2
|
560 |
582 |
1.56e-2 |
SMART |
ZnF_C2H2
|
588 |
610 |
2.4e-3 |
SMART |
ZnF_C2H2
|
616 |
638 |
1.98e-4 |
SMART |
ZnF_C2H2
|
649 |
671 |
1.58e-3 |
SMART |
ZnF_C2H2
|
677 |
699 |
6.42e-4 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
100% (63/63) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele exhibit a pleiotropic phenotype including reduced weight, mild hypoplasia in the spleen, heart and long bones, eye malformations including microphthalmia, altered platelet counts, an activated immune status, and behavioral alterations. [provided by MGI curators]
|
Allele List at MGI |
All alleles(357) : Targeted(5) Gene trapped(352)
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aass |
A |
G |
6: 23,094,219 (GRCm39) |
S500P |
possibly damaging |
Het |
Aldh9a1 |
T |
A |
1: 167,184,965 (GRCm39) |
N292K |
probably benign |
Het |
Art2b |
A |
T |
7: 101,229,658 (GRCm39) |
S80R |
probably benign |
Het |
Atp6v1b2 |
G |
T |
8: 69,555,219 (GRCm39) |
A194S |
possibly damaging |
Het |
Bsnd |
T |
C |
4: 106,349,109 (GRCm39) |
M44V |
probably damaging |
Het |
Cadps2 |
A |
T |
6: 23,583,428 (GRCm39) |
V383E |
probably benign |
Het |
Cd93 |
T |
C |
2: 148,284,459 (GRCm39) |
T296A |
possibly damaging |
Het |
Cdk15 |
G |
T |
1: 59,304,814 (GRCm39) |
E138D |
probably benign |
Het |
Cdon |
A |
G |
9: 35,375,191 (GRCm39) |
I406V |
probably benign |
Het |
Cfhr4 |
A |
G |
1: 139,660,822 (GRCm39) |
V622A |
possibly damaging |
Het |
Cyp3a41a |
A |
G |
5: 145,642,663 (GRCm39) |
V232A |
probably benign |
Het |
Dbndd1 |
T |
A |
8: 124,235,860 (GRCm39) |
D130V |
probably damaging |
Het |
Dnah14 |
C |
T |
1: 181,532,094 (GRCm39) |
R2294* |
probably null |
Het |
Eddm3b |
A |
G |
14: 51,354,387 (GRCm39) |
Y125C |
probably damaging |
Het |
Eif1ad14 |
G |
A |
12: 87,886,492 (GRCm39) |
R46W |
possibly damaging |
Het |
Enah |
A |
T |
1: 181,749,957 (GRCm39) |
V294E |
probably damaging |
Het |
Farp2 |
A |
G |
1: 93,531,137 (GRCm39) |
E545G |
probably damaging |
Het |
Farsb |
T |
C |
1: 78,458,994 (GRCm39) |
E22G |
possibly damaging |
Het |
Fcsk |
G |
A |
8: 111,613,788 (GRCm39) |
P758S |
probably damaging |
Het |
Fezf1 |
A |
G |
6: 23,247,835 (GRCm39) |
V80A |
probably benign |
Het |
Fpr2 |
T |
C |
17: 18,113,533 (GRCm39) |
Y39H |
unknown |
Het |
Fsd1l |
C |
A |
4: 53,694,054 (GRCm39) |
R344S |
probably damaging |
Het |
Fxyd1 |
G |
T |
7: 30,751,401 (GRCm39) |
R90S |
unknown |
Het |
Galnt4 |
T |
A |
10: 98,944,466 (GRCm39) |
Y64N |
probably damaging |
Het |
Gatb |
C |
T |
3: 85,544,258 (GRCm39) |
Q409* |
probably null |
Het |
Glipr2 |
A |
C |
4: 43,968,667 (GRCm39) |
D73A |
possibly damaging |
Het |
Gm40460 |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,450 (GRCm39) |
|
probably benign |
Het |
Gpr88 |
C |
T |
3: 116,045,643 (GRCm39) |
V223I |
possibly damaging |
Het |
Gtf2h3 |
A |
G |
5: 124,722,067 (GRCm39) |
N55S |
probably benign |
Het |
Htr4 |
T |
A |
18: 62,570,498 (GRCm39) |
C184* |
probably null |
Het |
Ighv6-3 |
T |
A |
12: 114,355,475 (GRCm39) |
R71S |
probably benign |
Het |
Itpr2 |
G |
C |
6: 146,212,585 (GRCm39) |
I1510M |
possibly damaging |
Het |
Keap1 |
T |
C |
9: 21,145,134 (GRCm39) |
Q292R |
probably benign |
Het |
Mab21l4 |
T |
C |
1: 93,082,237 (GRCm39) |
N294S |
probably benign |
Het |
Malt1 |
A |
C |
18: 65,580,764 (GRCm39) |
E219D |
probably benign |
Het |
Manba |
T |
C |
3: 135,228,915 (GRCm39) |
V279A |
possibly damaging |
Het |
Map4k5 |
T |
A |
12: 69,921,095 (GRCm39) |
H41L |
probably benign |
Het |
Mcm2 |
T |
G |
6: 88,868,776 (GRCm39) |
Y327S |
probably damaging |
Het |
Nectin3 |
A |
G |
16: 46,215,484 (GRCm39) |
I503T |
possibly damaging |
Het |
Nqo1 |
T |
C |
8: 108,119,279 (GRCm39) |
I99M |
probably damaging |
Het |
Nrxn2 |
A |
G |
19: 6,540,582 (GRCm39) |
H845R |
probably damaging |
Het |
Otogl |
C |
T |
10: 107,599,061 (GRCm39) |
C2254Y |
probably damaging |
Het |
Pmm1 |
T |
C |
15: 81,840,415 (GRCm39) |
N110S |
probably damaging |
Het |
Poc1b |
G |
T |
10: 98,970,199 (GRCm39) |
C68F |
probably benign |
Het |
Polr1b |
A |
G |
2: 128,965,842 (GRCm39) |
Y828C |
possibly damaging |
Het |
Prl3d1 |
A |
G |
13: 27,282,619 (GRCm39) |
H119R |
probably damaging |
Het |
Pum3 |
A |
G |
19: 27,403,412 (GRCm39) |
S30P |
probably benign |
Het |
Rgl2 |
T |
C |
17: 34,153,964 (GRCm39) |
F457L |
possibly damaging |
Het |
Rusc1 |
T |
C |
3: 88,999,194 (GRCm39) |
E196G |
possibly damaging |
Het |
Sf3a3 |
A |
G |
4: 124,608,772 (GRCm39) |
K29E |
probably benign |
Het |
Slc13a1 |
A |
T |
6: 24,092,311 (GRCm39) |
I475K |
probably damaging |
Het |
Slc26a5 |
G |
T |
5: 22,042,244 (GRCm39) |
Y237* |
probably null |
Het |
Slc7a14 |
C |
T |
3: 31,281,212 (GRCm39) |
G366D |
probably damaging |
Het |
Tbc1d5 |
A |
G |
17: 51,107,110 (GRCm39) |
V482A |
probably benign |
Het |
Tdrd5 |
G |
T |
1: 156,087,505 (GRCm39) |
Q883K |
probably benign |
Het |
Tet2 |
T |
C |
3: 133,179,391 (GRCm39) |
Y1258C |
probably damaging |
Het |
Upf2 |
A |
G |
2: 6,028,131 (GRCm39) |
D739G |
unknown |
Het |
Vmn1r122 |
A |
T |
7: 20,867,820 (GRCm39) |
F78L |
probably benign |
Het |
Vmn1r75 |
A |
T |
7: 11,614,915 (GRCm39) |
K216* |
probably null |
Het |
Vmn2r11 |
A |
T |
5: 109,201,281 (GRCm39) |
Y408N |
probably damaging |
Het |
Wscd1 |
T |
A |
11: 71,679,543 (GRCm39) |
V472D |
probably damaging |
Het |
Zdbf2 |
G |
T |
1: 63,345,664 (GRCm39) |
V1348F |
possibly damaging |
Het |
Zfp442 |
G |
T |
2: 150,250,056 (GRCm39) |
H615Q |
possibly damaging |
Het |
Zfp457 |
C |
A |
13: 67,442,065 (GRCm39) |
C170F |
possibly damaging |
Het |
|
Other mutations in Zscan10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00572:Zscan10
|
APN |
17 |
23,828,435 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01353:Zscan10
|
APN |
17 |
23,828,574 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02327:Zscan10
|
APN |
17 |
23,826,546 (GRCm39) |
splice site |
probably benign |
|
IGL02556:Zscan10
|
APN |
17 |
23,827,119 (GRCm39) |
missense |
possibly damaging |
0.90 |
FR4737:Zscan10
|
UTSW |
17 |
23,828,419 (GRCm39) |
small deletion |
probably benign |
|
P0043:Zscan10
|
UTSW |
17 |
23,828,594 (GRCm39) |
nonsense |
probably null |
|
R0345:Zscan10
|
UTSW |
17 |
23,829,056 (GRCm39) |
missense |
probably damaging |
1.00 |
R0401:Zscan10
|
UTSW |
17 |
23,824,889 (GRCm39) |
missense |
probably damaging |
1.00 |
R0699:Zscan10
|
UTSW |
17 |
23,827,092 (GRCm39) |
missense |
probably damaging |
1.00 |
R0838:Zscan10
|
UTSW |
17 |
23,829,008 (GRCm39) |
missense |
possibly damaging |
0.83 |
R0919:Zscan10
|
UTSW |
17 |
23,828,981 (GRCm39) |
missense |
probably damaging |
0.99 |
R1940:Zscan10
|
UTSW |
17 |
23,828,826 (GRCm39) |
missense |
probably damaging |
1.00 |
R4647:Zscan10
|
UTSW |
17 |
23,829,314 (GRCm39) |
missense |
probably benign |
|
R4753:Zscan10
|
UTSW |
17 |
23,826,208 (GRCm39) |
missense |
probably damaging |
0.99 |
R4971:Zscan10
|
UTSW |
17 |
23,826,147 (GRCm39) |
missense |
possibly damaging |
0.67 |
R5110:Zscan10
|
UTSW |
17 |
23,828,606 (GRCm39) |
missense |
probably damaging |
1.00 |
R5410:Zscan10
|
UTSW |
17 |
23,829,395 (GRCm39) |
missense |
probably damaging |
1.00 |
R5516:Zscan10
|
UTSW |
17 |
23,828,333 (GRCm39) |
missense |
possibly damaging |
0.66 |
R5871:Zscan10
|
UTSW |
17 |
23,826,241 (GRCm39) |
intron |
probably benign |
|
R6109:Zscan10
|
UTSW |
17 |
23,826,103 (GRCm39) |
missense |
probably damaging |
0.98 |
R6626:Zscan10
|
UTSW |
17 |
23,824,831 (GRCm39) |
missense |
probably damaging |
1.00 |
R6750:Zscan10
|
UTSW |
17 |
23,826,164 (GRCm39) |
missense |
possibly damaging |
0.49 |
R6846:Zscan10
|
UTSW |
17 |
23,824,581 (GRCm39) |
missense |
probably damaging |
0.97 |
R7223:Zscan10
|
UTSW |
17 |
23,828,456 (GRCm39) |
missense |
probably benign |
0.00 |
R7436:Zscan10
|
UTSW |
17 |
23,828,979 (GRCm39) |
missense |
possibly damaging |
0.52 |
R8224:Zscan10
|
UTSW |
17 |
23,828,366 (GRCm39) |
missense |
probably benign |
|
R8366:Zscan10
|
UTSW |
17 |
23,828,952 (GRCm39) |
missense |
probably damaging |
1.00 |
R8787:Zscan10
|
UTSW |
17 |
23,829,011 (GRCm39) |
missense |
probably benign |
|
R8918:Zscan10
|
UTSW |
17 |
23,826,116 (GRCm39) |
missense |
probably benign |
0.24 |
R8924:Zscan10
|
UTSW |
17 |
23,824,580 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9266:Zscan10
|
UTSW |
17 |
23,828,385 (GRCm39) |
missense |
possibly damaging |
0.55 |
R9454:Zscan10
|
UTSW |
17 |
23,826,619 (GRCm39) |
critical splice donor site |
probably null |
|
R9786:Zscan10
|
UTSW |
17 |
23,828,330 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AGGGCTTAACCTGGATCAAACC -3'
(R):5'- GGATGTAGGGCTGGAATCTC -3'
Sequencing Primer
(F):5'- ACCATTAACTGTGTGTGCATGC -3'
(R):5'- GGAATCTCTTCTGAGGGCAACTC -3'
|
Posted On |
2019-08-23 |