Incidental Mutation 'R7154:Adgre1'
ID 568649
Institutional Source Beutler Lab
Gene Symbol Adgre1
Ensembl Gene ENSMUSG00000004730
Gene Name adhesion G protein-coupled receptor E1
Synonyms DD7A5-7, EGF-TM7, Emr1, Ly71, F4/80, TM7LN3
MMRRC Submission 045256-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.188) question?
Stock # R7154 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 57665691-57790527 bp(+) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) G to A at 57751087 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000083971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004850] [ENSMUST00000086763]
AlphaFold Q61549
Predicted Effect probably null
Transcript: ENSMUST00000004850
SMART Domains Protein: ENSMUSP00000004850
Gene: ENSMUSG00000004730

DomainStartEndE-ValueType
low complexity region 19 32 N/A INTRINSIC
EGF 35 80 1.43e-1 SMART
EGF_CA 81 122 3.59e-7 SMART
EGF_CA 133 172 4.56e-9 SMART
EGF_CA 173 221 1.29e-8 SMART
EGF_CA 222 271 2.31e-10 SMART
EGF_CA 272 318 1.06e-9 SMART
EGF_CA 319 367 1.18e-7 SMART
GPS 591 641 2.57e-19 SMART
Pfam:7tm_2 644 885 2.1e-63 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000086763
SMART Domains Protein: ENSMUSP00000083971
Gene: ENSMUSG00000004730

DomainStartEndE-ValueType
low complexity region 19 32 N/A INTRINSIC
EGF 35 80 1.43e-1 SMART
EGF_CA 81 122 3.59e-7 SMART
EGF_CA 133 172 4.56e-9 SMART
EGF_CA 173 221 1.29e-8 SMART
EGF_CA 222 271 2.31e-10 SMART
EGF_CA 272 318 1.06e-9 SMART
EGF_CA 319 367 1.18e-7 SMART
GPS 591 641 2.57e-19 SMART
Pfam:7tm_2 644 885 2.1e-63 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(3) Chemically induced(1)

Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
8030423J24Rik T C 13: 71,032,344 (GRCm39) F139L unknown Het
Agap2 A G 10: 126,927,524 (GRCm39) D1135G probably benign Het
Akp3 T C 1: 87,052,946 (GRCm39) L45P probably damaging Het
Arfgap3 A T 15: 83,220,905 (GRCm39) W71R probably damaging Het
Asic3 G A 5: 24,618,660 (GRCm39) probably benign Het
Asph A T 4: 9,630,930 (GRCm39) N139K possibly damaging Het
Atr T A 9: 95,747,098 (GRCm39) C127S probably benign Het
Auts2 A T 5: 131,480,731 (GRCm39) S255T Het
Bcl6 G A 16: 23,784,976 (GRCm39) R675* probably null Het
Cacnb1 A G 11: 97,895,959 (GRCm39) L443P probably damaging Het
Cbfa2t3 G A 8: 123,364,883 (GRCm39) Q300* probably null Het
Ccer1 A T 10: 97,530,201 (GRCm39) D288V unknown Het
Col18a1 G A 10: 76,908,799 (GRCm39) P611S probably benign Het
Cpa6 T A 1: 10,407,694 (GRCm39) D281V possibly damaging Het
Cyp2e1 A G 7: 140,350,050 (GRCm39) Y245C probably damaging Het
Cyp4a31 T C 4: 115,431,963 (GRCm39) probably null Het
Efcab3 T A 11: 104,589,966 (GRCm39) probably null Het
Entpd1 T C 19: 40,713,430 (GRCm39) Y188H probably damaging Het
Epb42 T C 2: 120,863,843 (GRCm39) D111G probably benign Het
Espl1 A G 15: 102,232,484 (GRCm39) D2064G probably damaging Het
Fat3 A C 9: 15,908,160 (GRCm39) V2614G probably damaging Het
Fos A T 12: 85,520,931 (GRCm39) M40L probably benign Het
Frmd4b T A 6: 97,283,707 (GRCm39) E434V probably damaging Het
Galnt6 A T 15: 100,591,345 (GRCm39) D586E probably benign Het
Gapvd1 T C 2: 34,615,075 (GRCm39) K474R probably damaging Het
Gimap8 T A 6: 48,633,122 (GRCm39) F314I probably damaging Het
Gm14393 T G 2: 174,903,576 (GRCm39) K110N probably damaging Het
Gm4131 C A 14: 62,718,382 (GRCm39) A75S probably damaging Het
Heatr6 G A 11: 83,668,067 (GRCm39) V854I probably benign Het
Hic2 T A 16: 17,076,806 (GRCm39) M545K possibly damaging Het
Ift70b C T 2: 75,768,405 (GRCm39) R116H possibly damaging Het
Ip6k1 A G 9: 107,922,861 (GRCm39) Y331C probably damaging Het
Kalrn C T 16: 34,032,527 (GRCm39) probably null Het
Kxd1 T C 8: 70,968,084 (GRCm39) K88E probably damaging Het
Lrrc37a A C 11: 103,393,682 (GRCm39) V581G probably benign Het
Mex3d A T 10: 80,222,584 (GRCm39) V224E Het
Mtx2 T A 2: 74,706,762 (GRCm39) C246S probably damaging Het
Mybbp1a A G 11: 72,338,468 (GRCm39) probably null Het
Myh6 A G 14: 55,197,764 (GRCm39) I458T probably benign Het
Ndufs6 A G 13: 73,468,411 (GRCm39) V96A possibly damaging Het
Nemf A T 12: 69,363,515 (GRCm39) probably null Het
Notch1 T C 2: 26,349,950 (GRCm39) S2397G probably benign Het
Or4c15b A G 2: 89,113,204 (GRCm39) I91T probably damaging Het
Or6ae1 T C 7: 139,741,997 (GRCm39) I289V probably benign Het
Osbpl1a T C 18: 12,901,649 (GRCm39) E619G probably benign Het
Pfkl T C 10: 77,837,289 (GRCm39) R95G probably benign Het
Plat T A 8: 23,268,521 (GRCm39) I391K possibly damaging Het
Ppp1r21 A G 17: 88,862,314 (GRCm39) H244R probably damaging Het
Rapgef3 G C 15: 97,651,758 (GRCm39) H578Q probably benign Het
Rnf145 C A 11: 44,415,822 (GRCm39) N12K probably damaging Het
Sfxn5 C T 6: 85,309,405 (GRCm39) C100Y unknown Het
Sh3rf1 T A 8: 61,825,748 (GRCm39) L581Q possibly damaging Het
Sipa1l2 T C 8: 126,195,078 (GRCm39) K887E probably benign Het
Spopfm2 A G 3: 94,083,526 (GRCm39) I95T probably benign Het
Stard9 C A 2: 120,531,795 (GRCm39) T2684N probably benign Het
Stard9 A C 2: 120,535,023 (GRCm39) Q3760P probably benign Het
Stpg2 A G 3: 138,921,056 (GRCm39) E87G probably benign Het
Syne2 A G 12: 76,106,231 (GRCm39) Q792R possibly damaging Het
Taf7 T C 18: 37,775,601 (GRCm39) D322G possibly damaging Het
Tbc1d1 A G 5: 64,331,156 (GRCm39) S112G possibly damaging Het
Tbx3 A G 5: 119,810,093 (GRCm39) M5V possibly damaging Het
Tmem45b A T 9: 31,339,328 (GRCm39) I215N possibly damaging Het
Tpd52 G A 3: 9,028,916 (GRCm39) Q43* probably null Het
Trpa1 T A 1: 14,952,457 (GRCm39) N858I possibly damaging Het
Ttll5 A G 12: 85,972,538 (GRCm39) D767G probably damaging Het
Vmn2r3 G A 3: 64,194,732 (GRCm39) T62I probably benign Het
Wdr59 A T 8: 112,185,367 (GRCm39) N874K Het
Other mutations in Adgre1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Adgre1 APN 17 57,757,055 (GRCm39) missense probably benign 0.00
IGL00966:Adgre1 APN 17 57,726,335 (GRCm39) missense probably benign 0.04
IGL01680:Adgre1 APN 17 57,709,620 (GRCm39) missense unknown
IGL01724:Adgre1 APN 17 57,751,064 (GRCm39) nonsense probably null
IGL02172:Adgre1 APN 17 57,785,879 (GRCm39) missense probably damaging 1.00
IGL02260:Adgre1 APN 17 57,754,891 (GRCm39) missense probably benign 0.01
IGL02272:Adgre1 APN 17 57,757,021 (GRCm39) nonsense probably null
IGL02336:Adgre1 APN 17 57,718,024 (GRCm39) nonsense probably null
IGL02346:Adgre1 APN 17 57,750,919 (GRCm39) missense probably benign 0.15
IGL02398:Adgre1 APN 17 57,709,824 (GRCm39) nonsense probably null
IGL02618:Adgre1 APN 17 57,751,021 (GRCm39) missense possibly damaging 0.66
IGL02690:Adgre1 APN 17 57,787,921 (GRCm39) missense probably damaging 1.00
IGL02936:Adgre1 APN 17 57,785,833 (GRCm39) missense probably benign 0.26
IGL03112:Adgre1 APN 17 57,755,029 (GRCm39) splice site probably null
IGL03350:Adgre1 APN 17 57,708,908 (GRCm39) missense probably benign 0.16
F480 UTSW 17 57,751,063 (GRCm39) missense probably damaging 1.00
lomax UTSW 17 57,709,811 (GRCm39) missense unknown
Onion UTSW 17 57,709,841 (GRCm39) nonsense probably null
Scallion UTSW 17 57,708,977 (GRCm39) missense possibly damaging 0.90
R0049:Adgre1 UTSW 17 57,709,841 (GRCm39) nonsense probably null
R0153:Adgre1 UTSW 17 57,750,939 (GRCm39) missense possibly damaging 0.92
R0277:Adgre1 UTSW 17 57,751,060 (GRCm39) missense probably benign 0.00
R0278:Adgre1 UTSW 17 57,754,872 (GRCm39) missense probably benign 0.07
R0323:Adgre1 UTSW 17 57,751,060 (GRCm39) missense probably benign 0.00
R0389:Adgre1 UTSW 17 57,713,839 (GRCm39) missense possibly damaging 0.80
R0492:Adgre1 UTSW 17 57,709,742 (GRCm39) missense unknown
R0621:Adgre1 UTSW 17 57,748,359 (GRCm39) missense probably damaging 0.98
R0647:Adgre1 UTSW 17 57,718,003 (GRCm39) missense probably damaging 1.00
R1310:Adgre1 UTSW 17 57,754,936 (GRCm39) missense probably benign 0.00
R1601:Adgre1 UTSW 17 57,748,353 (GRCm39) missense probably benign 0.01
R1689:Adgre1 UTSW 17 57,756,921 (GRCm39) missense probably benign 0.31
R1708:Adgre1 UTSW 17 57,708,974 (GRCm39) missense possibly damaging 0.93
R1796:Adgre1 UTSW 17 57,748,350 (GRCm39) missense probably benign 0.43
R1839:Adgre1 UTSW 17 57,748,299 (GRCm39) missense probably benign 0.00
R1860:Adgre1 UTSW 17 57,748,363 (GRCm39) missense probably benign 0.00
R2165:Adgre1 UTSW 17 57,726,338 (GRCm39) missense probably damaging 0.97
R2219:Adgre1 UTSW 17 57,708,912 (GRCm39) missense possibly damaging 0.92
R2519:Adgre1 UTSW 17 57,717,956 (GRCm39) missense probably damaging 1.00
R3874:Adgre1 UTSW 17 57,708,925 (GRCm39) missense probably benign 0.08
R3911:Adgre1 UTSW 17 57,754,860 (GRCm39) missense probably damaging 1.00
R4190:Adgre1 UTSW 17 57,709,811 (GRCm39) missense unknown
R4439:Adgre1 UTSW 17 57,754,954 (GRCm39) missense probably damaging 1.00
R4513:Adgre1 UTSW 17 57,717,947 (GRCm39) missense probably benign 0.34
R4529:Adgre1 UTSW 17 57,727,519 (GRCm39) missense possibly damaging 0.92
R4543:Adgre1 UTSW 17 57,713,874 (GRCm39) missense probably benign 0.07
R4610:Adgre1 UTSW 17 57,757,073 (GRCm39) missense possibly damaging 0.50
R4665:Adgre1 UTSW 17 57,787,947 (GRCm39) missense probably benign 0.20
R4911:Adgre1 UTSW 17 57,754,832 (GRCm39) missense possibly damaging 0.57
R4928:Adgre1 UTSW 17 57,751,064 (GRCm39) nonsense probably null
R4942:Adgre1 UTSW 17 57,713,903 (GRCm39) missense probably damaging 1.00
R4946:Adgre1 UTSW 17 57,750,918 (GRCm39) missense probably benign 0.33
R4953:Adgre1 UTSW 17 57,748,321 (GRCm39) missense probably damaging 0.99
R5107:Adgre1 UTSW 17 57,708,977 (GRCm39) missense possibly damaging 0.90
R5366:Adgre1 UTSW 17 57,709,817 (GRCm39) missense probably benign 0.39
R5590:Adgre1 UTSW 17 57,752,034 (GRCm39) missense probably damaging 1.00
R5619:Adgre1 UTSW 17 57,727,437 (GRCm39) missense probably benign 0.15
R5699:Adgre1 UTSW 17 57,788,007 (GRCm39) missense probably benign 0.43
R5734:Adgre1 UTSW 17 57,750,990 (GRCm39) missense probably benign 0.00
R5860:Adgre1 UTSW 17 57,752,034 (GRCm39) missense probably damaging 1.00
R6039:Adgre1 UTSW 17 57,713,859 (GRCm39) missense probably benign 0.28
R6039:Adgre1 UTSW 17 57,713,859 (GRCm39) missense probably benign 0.28
R6149:Adgre1 UTSW 17 57,752,018 (GRCm39) missense probably benign 0.08
R6478:Adgre1 UTSW 17 57,708,955 (GRCm39) missense possibly damaging 0.81
R6709:Adgre1 UTSW 17 57,713,917 (GRCm39) missense probably benign 0.10
R6864:Adgre1 UTSW 17 57,785,879 (GRCm39) missense probably damaging 1.00
R6945:Adgre1 UTSW 17 57,727,399 (GRCm39) missense probably benign 0.39
R6945:Adgre1 UTSW 17 57,717,844 (GRCm39) missense probably benign 0.01
R6988:Adgre1 UTSW 17 57,715,445 (GRCm39) missense probably benign 0.00
R7019:Adgre1 UTSW 17 57,717,945 (GRCm39) missense probably damaging 0.98
R7347:Adgre1 UTSW 17 57,727,441 (GRCm39) missense probably damaging 1.00
R7459:Adgre1 UTSW 17 57,756,933 (GRCm39) missense probably damaging 1.00
R7709:Adgre1 UTSW 17 57,709,519 (GRCm39) missense unknown
R7939:Adgre1 UTSW 17 57,756,938 (GRCm39) missense probably damaging 0.98
R7977:Adgre1 UTSW 17 57,754,987 (GRCm39) missense possibly damaging 0.54
R7987:Adgre1 UTSW 17 57,754,987 (GRCm39) missense possibly damaging 0.54
R8187:Adgre1 UTSW 17 57,727,349 (GRCm39) missense probably benign 0.00
R8210:Adgre1 UTSW 17 57,752,061 (GRCm39) missense possibly damaging 0.94
R8223:Adgre1 UTSW 17 57,668,692 (GRCm39) missense probably damaging 0.99
R8344:Adgre1 UTSW 17 57,715,459 (GRCm39) missense probably benign 0.12
R8698:Adgre1 UTSW 17 57,709,003 (GRCm39) missense probably benign 0.05
R9236:Adgre1 UTSW 17 57,709,782 (GRCm39) nonsense probably null
R9262:Adgre1 UTSW 17 57,754,941 (GRCm39) missense probably damaging 1.00
R9303:Adgre1 UTSW 17 57,748,275 (GRCm39) missense probably benign 0.00
R9305:Adgre1 UTSW 17 57,748,275 (GRCm39) missense probably benign 0.00
R9605:Adgre1 UTSW 17 57,718,083 (GRCm39) missense probably benign 0.00
R9661:Adgre1 UTSW 17 57,748,368 (GRCm39) missense possibly damaging 0.70
R9678:Adgre1 UTSW 17 57,750,997 (GRCm39) missense probably damaging 0.96
R9751:Adgre1 UTSW 17 57,757,101 (GRCm39) missense probably null 0.06
R9785:Adgre1 UTSW 17 57,785,930 (GRCm39) missense probably damaging 1.00
Z1176:Adgre1 UTSW 17 57,668,729 (GRCm39) missense possibly damaging 0.76
Z1177:Adgre1 UTSW 17 57,726,374 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CCAGGAGTGGCTTTTGTCTC -3'
(R):5'- TGAACACTTGTTGCATTGTAGG -3'

Sequencing Primer
(F):5'- GTCTCATTTGCACACATGGAATCAG -3'
(R):5'- GTAGTGTGTCACTATTGAGGAAAC -3'
Posted On 2019-09-05