Mutagenetix > Incidental Mutation

Incidental Mutation 'R7328:Or8g23'

569055

Institutional Source

Beutler Lab

Gene Symbol

Or8g23

Ensembl Gene

ENSMUSG00000094182

Gene Name

olfactory receptor family 8 subfamily G member 23

Synonyms

MOR171-24, GA_x6K02T2PVTD-32756567-32755632, Olfr937

MMRRC Submission

045421-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R7328 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

38971025-38971960 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 38971857 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 35 (Y35C)

Ref Sequence

ENSEMBL: ENSMUSP00000150274 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055567] [ENSMUST00000215049]

AlphaFold

Q9EQB4

Predicted Effect

probably damaging
Transcript: ENSMUST00000055567
AA Change: Y35C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058346
Gene: ENSMUSG00000094182
AA Change: Y35C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.8e-49	PFAM
Pfam:7tm_1	41	290	1.7e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215049
AA Change: Y35C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D14Rik	C	G	11: 72,060,606 (GRCm39)		probably null	Het
Abca13	T	A	11: 9,241,545 (GRCm39)	V1136E	probably benign	Het
Arl4c	C	A	1: 88,629,239 (GRCm39)	E50*	probably null	Het
Atxn7l1	T	C	12: 33,198,502 (GRCm39)		probably null	Het
Ctdsp1	A	T	1: 74,433,199 (GRCm39)	I115F	probably damaging	Het
Cyp2j5	A	G	4: 96,551,450 (GRCm39)	V91A	probably damaging	Het
Dscam	T	A	16: 96,446,235 (GRCm39)	K1469*	probably null	Het
Elf2	A	G	3: 51,174,198 (GRCm39)	C110R	probably damaging	Het
Ephb1	A	G	9: 102,072,438 (GRCm39)	Y114H	probably damaging	Het
Ephb2	C	T	4: 136,386,245 (GRCm39)		probably null	Het
Fbxw20	C	A	9: 109,061,383 (GRCm39)	C122F	probably damaging	Het
Flnb	T	C	14: 7,883,788 (GRCm38)	I338T	possibly damaging	Het
Flnb	T	A	14: 7,894,660 (GRCm38)	Y819*	probably null	Het
Foxo3	A	T	10: 42,073,258 (GRCm39)	S420T	probably benign	Het
Herpud1	T	C	8: 95,113,248 (GRCm39)	V10A	possibly damaging	Het
Hmcn1	A	T	1: 150,514,617 (GRCm39)	V3585E	possibly damaging	Het
Hsdl1	T	C	8: 120,292,830 (GRCm39)	T202A	probably benign	Het
Htr1d	G	A	4: 136,170,614 (GRCm39)	S281N	probably benign	Het
Igkv14-111	T	A	6: 68,233,709 (GRCm39)	I70N	probably damaging	Het
Igkv8-34	A	G	6: 70,021,328 (GRCm39)	S45P	probably damaging	Het
Inha	T	C	1: 75,486,760 (GRCm39)	Y352H	probably damaging	Het
Lats1	A	T	10: 7,581,311 (GRCm39)	M699L	possibly damaging	Het
Marchf9	T	C	10: 126,894,165 (GRCm39)	E146G	probably damaging	Het
Mcm8	T	C	2: 132,674,777 (GRCm39)	V443A	probably benign	Het
Melk	A	T	4: 44,332,931 (GRCm39)	S296C	probably benign	Het
Myo18a	T	C	11: 77,698,737 (GRCm39)	S4P		Het
Myof	T	C	19: 37,904,847 (GRCm39)	Y1646C	probably damaging	Het
Noc4l	C	A	5: 110,796,789 (GRCm39)	A498S	possibly damaging	Het
Nrxn3	T	C	12: 88,762,345 (GRCm39)	S131P	probably benign	Het
Or5ae2	T	C	7: 84,506,507 (GRCm39)	I312T	probably benign	Het
Or5ak23	A	G	2: 85,244,668 (GRCm39)	I185T	probably benign	Het
Or5j3	GTACTTTTT	GT	2: 86,128,338 (GRCm39)		probably null	Het
Pcp4l1	G	A	1: 171,002,034 (GRCm39)	A42V	possibly damaging	Het
Phldb2	T	A	16: 45,578,572 (GRCm39)		probably null	Het
Polr2b	C	T	5: 77,463,846 (GRCm39)	P81L	probably damaging	Het
Rbfa	C	A	18: 80,236,454 (GRCm39)	G215C	probably benign	Het
Rdh19	T	C	10: 127,692,896 (GRCm39)	S188P	probably damaging	Het
Scn9a	T	C	2: 66,314,931 (GRCm39)	M1596V	probably benign	Het
Sele	A	T	1: 163,876,844 (GRCm39)	Y40F	probably benign	Het
Setd1b	T	A	5: 123,290,442 (GRCm39)	V803D	unknown	Het
Siglecf	C	T	7: 43,001,691 (GRCm39)	T167I	possibly damaging	Het
Slc39a6	T	C	18: 24,733,987 (GRCm39)	E234G	probably benign	Het
Slco1a1	T	A	6: 141,882,134 (GRCm39)	D145V	possibly damaging	Het
Son	G	A	16: 91,455,278 (GRCm39)	V1342I	probably benign	Het
Sybu	G	A	15: 44,651,190 (GRCm39)	P38L	not run	Het
Taf15	C	T	11: 83,375,658 (GRCm39)	T41M	possibly damaging	Het
Tm4sf4	A	T	3: 57,333,925 (GRCm39)	N71Y	probably benign	Het
Tm7sf2	C	T	19: 6,114,156 (GRCm39)	V226I	possibly damaging	Het
Trim66	C	A	7: 109,056,958 (GRCm39)	Q1066H	probably damaging	Het
Tyw1	T	C	5: 130,291,685 (GRCm39)	V51A	probably benign	Het
Vav3	A	T	3: 109,410,744 (GRCm39)	I192L	probably benign	Het

Other mutations in Or8g23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Or8g23	APN	9	38,971,159 (GRCm39)	missense	probably benign	0.03
IGL01387:Or8g23	APN	9	38,971,617 (GRCm39)	missense	probably damaging	1.00
IGL01775:Or8g23	APN	9	38,971,763 (GRCm39)	missense	probably damaging	1.00
IGL02076:Or8g23	APN	9	38,971,881 (GRCm39)	missense	probably damaging	1.00
IGL02740:Or8g23	APN	9	38,971,585 (GRCm39)	missense	probably benign	0.22
IGL03115:Or8g23	APN	9	38,971,259 (GRCm39)	missense	probably damaging	0.99
R0121:Or8g23	UTSW	9	38,971,056 (GRCm39)	missense	probably damaging	1.00
R0908:Or8g23	UTSW	9	38,971,243 (GRCm39)	missense	probably damaging	1.00
R1559:Or8g23	UTSW	9	38,971,437 (GRCm39)	missense	probably benign	0.20
R2006:Or8g23	UTSW	9	38,971,729 (GRCm39)	missense	probably damaging	0.99
R2010:Or8g23	UTSW	9	38,971,395 (GRCm39)	missense	probably benign	0.05
R2191:Or8g23	UTSW	9	38,971,701 (GRCm39)	missense	probably benign
R3874:Or8g23	UTSW	9	38,971,470 (GRCm39)	missense	probably benign	0.00
R4970:Or8g23	UTSW	9	38,971,827 (GRCm39)	missense	probably benign	0.12
R5217:Or8g23	UTSW	9	38,971,065 (GRCm39)	missense	probably benign	0.00
R5836:Or8g23	UTSW	9	38,971,918 (GRCm39)	missense	probably benign
R5886:Or8g23	UTSW	9	38,971,678 (GRCm39)	missense	probably benign	0.00
R6109:Or8g23	UTSW	9	38,971,492 (GRCm39)	missense	probably benign	0.23
R7261:Or8g23	UTSW	9	38,971,504 (GRCm39)	missense	possibly damaging	0.64
R7345:Or8g23	UTSW	9	38,971,875 (GRCm39)	missense	probably damaging	1.00
R7419:Or8g23	UTSW	9	38,971,465 (GRCm39)	missense	probably benign	0.00
R9624:Or8g23	UTSW	9	38,971,453 (GRCm39)	missense	probably benign	0.40
X0022:Or8g23	UTSW	9	38,971,713 (GRCm39)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- ATGCATCCAGTGTAGGAAATGATG -3'
(R):5'- TGCTCACTGGCAGTATGTAATG -3'

Sequencing Primer
(F):5'- CCAGTGTAGGAAATGATGTTTTTCTC -3'
(R):5'- CACTGGCAGTATGTAATGTATCAAG -3'

Posted On

2019-09-13