Incidental Mutation 'R7329:Dennd4c'
| ID |
569095 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
045422-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7329 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
86666792-86768840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 86698111 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 200
(P200S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045512
AA Change: P200S
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: P200S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000082026
AA Change: P200S
PolyPhen 2
Score 0.619 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: P200S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000142837
AA Change: P200S
PolyPhen 2
Score 0.811 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: P200S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0680 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
100% (78/78) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actb |
T |
C |
5: 142,890,146 (GRCm39) |
N252S |
probably benign |
Het |
| Adgrb1 |
C |
A |
15: 74,411,094 (GRCm39) |
T330K |
probably damaging |
Het |
| Ahnak |
A |
G |
19: 8,979,156 (GRCm39) |
T147A |
probably damaging |
Het |
| Ankfy1 |
T |
C |
11: 72,603,034 (GRCm39) |
V21A |
probably damaging |
Het |
| Arrdc4 |
T |
A |
7: 68,390,775 (GRCm39) |
N322Y |
probably damaging |
Het |
| Bfsp2 |
C |
A |
9: 103,327,121 (GRCm39) |
E205D |
probably benign |
Het |
| C2cd4b |
T |
A |
9: 67,667,419 (GRCm39) |
S138R |
possibly damaging |
Het |
| Camkk1 |
C |
G |
11: 72,917,873 (GRCm39) |
N147K |
probably damaging |
Het |
| Ckap2l |
T |
A |
2: 129,127,284 (GRCm39) |
Q298L |
possibly damaging |
Het |
| Clstn2 |
G |
T |
9: 97,343,422 (GRCm39) |
A675D |
probably benign |
Het |
| Cntnap2 |
G |
A |
6: 47,248,205 (GRCm39) |
V1204M |
possibly damaging |
Het |
| Col4a1 |
C |
T |
8: 11,276,494 (GRCm39) |
|
probably null |
Het |
| Ctrc |
T |
C |
4: 141,571,022 (GRCm39) |
T73A |
probably benign |
Het |
| Cubn |
A |
G |
2: 13,473,582 (GRCm39) |
F454L |
probably damaging |
Het |
| Cuedc1 |
A |
T |
11: 88,060,692 (GRCm39) |
S12C |
unknown |
Het |
| Cyb561a3 |
G |
T |
19: 10,565,268 (GRCm39) |
G211C |
probably damaging |
Het |
| D5Ertd579e |
A |
T |
5: 36,773,739 (GRCm39) |
S219T |
probably benign |
Het |
| Dnah6 |
G |
A |
6: 73,121,705 (GRCm39) |
Q1426* |
probably null |
Het |
| Dync2h1 |
T |
G |
9: 7,011,247 (GRCm39) |
T3649P |
probably benign |
Het |
| E2f8 |
T |
C |
7: 48,521,858 (GRCm39) |
S415G |
probably damaging |
Het |
| Fbxo22 |
A |
G |
9: 55,122,261 (GRCm39) |
I147V |
probably benign |
Het |
| Gclc |
A |
G |
9: 77,683,473 (GRCm39) |
Y110C |
probably damaging |
Het |
| Gstm5 |
A |
G |
3: 107,803,647 (GRCm39) |
T27A |
possibly damaging |
Het |
| Heatr4 |
A |
G |
12: 84,024,856 (GRCm39) |
S322P |
probably benign |
Het |
| Htt |
T |
A |
5: 34,987,099 (GRCm39) |
I1106N |
probably benign |
Het |
| Hunk |
T |
C |
16: 90,183,570 (GRCm39) |
V76A |
probably benign |
Het |
| Igkv12-98 |
C |
T |
6: 68,548,087 (GRCm39) |
T72I |
possibly damaging |
Het |
| Igkv9-123 |
A |
T |
6: 67,931,629 (GRCm39) |
W16R |
possibly damaging |
Het |
| Ipo7 |
T |
C |
7: 109,648,224 (GRCm39) |
L674S |
possibly damaging |
Het |
| Kcnh6 |
T |
C |
11: 105,908,203 (GRCm39) |
F273S |
probably benign |
Het |
| Lamb3 |
C |
A |
1: 193,002,848 (GRCm39) |
Q98K |
possibly damaging |
Het |
| Lingo4 |
A |
T |
3: 94,310,162 (GRCm39) |
T367S |
probably benign |
Het |
| Lypd6b |
A |
T |
2: 49,832,512 (GRCm39) |
I26F |
probably benign |
Het |
| Maneal |
T |
C |
4: 124,750,512 (GRCm39) |
T415A |
probably benign |
Het |
| Mapk1ip1l |
A |
G |
14: 47,547,920 (GRCm39) |
T23A |
unknown |
Het |
| Mrps17 |
T |
A |
5: 129,793,705 (GRCm39) |
|
probably benign |
Het |
| Mup13 |
T |
G |
4: 61,183,688 (GRCm39) |
D45A |
probably damaging |
Het |
| Mycbpap |
T |
A |
11: 94,400,073 (GRCm39) |
D408V |
probably damaging |
Het |
| Myh10 |
A |
G |
11: 68,701,017 (GRCm39) |
H1742R |
probably benign |
Het |
| Mylk4 |
A |
G |
13: 32,900,766 (GRCm39) |
Y255H |
probably damaging |
Het |
| Nbeal1 |
A |
G |
1: 60,256,355 (GRCm39) |
Q200R |
probably benign |
Het |
| Nkain2 |
TTTACTCGTT |
TTT |
10: 32,765,892 (GRCm39) |
|
probably null |
Het |
| Olfm4 |
T |
C |
14: 80,249,369 (GRCm39) |
V162A |
possibly damaging |
Het |
| Or1j15 |
A |
G |
2: 36,458,708 (GRCm39) |
T33A |
probably benign |
Het |
| Or51a8 |
T |
C |
7: 102,550,039 (GRCm39) |
L155P |
probably damaging |
Het |
| Or5w8 |
T |
C |
2: 87,687,585 (GRCm39) |
V22A |
probably benign |
Het |
| Or8c11 |
C |
A |
9: 38,289,456 (GRCm39) |
T87K |
probably benign |
Het |
| Ovol3 |
T |
A |
7: 29,934,677 (GRCm39) |
R43S |
probably benign |
Het |
| Pcbp1 |
A |
G |
6: 86,502,098 (GRCm39) |
V267A |
probably benign |
Het |
| Phf20 |
T |
A |
2: 156,146,552 (GRCm39) |
V903E |
probably damaging |
Het |
| Pi4k2b |
T |
G |
5: 52,914,211 (GRCm39) |
S316A |
probably benign |
Het |
| Pira1 |
G |
A |
7: 3,742,875 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,617,743 (GRCm39) |
H947Q |
probably damaging |
Het |
| Ppip5k2 |
A |
C |
1: 97,678,478 (GRCm39) |
|
probably null |
Het |
| Prkca |
T |
A |
11: 107,905,103 (GRCm39) |
T212S |
possibly damaging |
Het |
| Psg16 |
A |
T |
7: 16,824,611 (GRCm39) |
I41F |
possibly damaging |
Het |
| Rae1 |
T |
A |
2: 172,851,238 (GRCm39) |
F204I |
probably benign |
Het |
| Rasef |
T |
A |
4: 73,662,374 (GRCm39) |
N192I |
probably damaging |
Het |
| Rfc1 |
T |
A |
5: 65,420,478 (GRCm39) |
R1122S |
unknown |
Het |
| Rfx2 |
A |
T |
17: 57,110,681 (GRCm39) |
S102T |
probably benign |
Het |
| Sez6l |
A |
G |
5: 112,588,773 (GRCm39) |
Y647H |
probably damaging |
Het |
| Siglecf |
A |
G |
7: 43,001,395 (GRCm39) |
Y121C |
probably damaging |
Het |
| Slc27a5 |
T |
C |
7: 12,725,089 (GRCm39) |
T453A |
possibly damaging |
Het |
| Slc44a2 |
G |
A |
9: 21,254,048 (GRCm39) |
R171Q |
probably damaging |
Het |
| Slc4a9 |
A |
C |
18: 36,673,874 (GRCm39) |
E889A |
possibly damaging |
Het |
| Snx31 |
C |
A |
15: 36,555,621 (GRCm39) |
R13L |
probably benign |
Het |
| Spag6l |
A |
T |
16: 16,584,883 (GRCm39) |
Y422N |
probably benign |
Het |
| Spmip5 |
T |
C |
19: 58,777,654 (GRCm39) |
E52G |
probably damaging |
Het |
| Sulf2 |
T |
C |
2: 165,959,008 (GRCm39) |
T67A |
probably damaging |
Het |
| Syne2 |
G |
A |
12: 76,013,758 (GRCm39) |
R2983Q |
probably benign |
Het |
| Tmtc3 |
A |
G |
10: 100,283,281 (GRCm39) |
I758T |
probably benign |
Het |
| Top2a |
T |
A |
11: 98,895,072 (GRCm39) |
I843L |
possibly damaging |
Het |
| Tph1 |
T |
C |
7: 46,306,285 (GRCm39) |
|
probably null |
Het |
| Trdmt1 |
A |
G |
2: 13,520,933 (GRCm39) |
L323P |
probably damaging |
Het |
| Ush2a |
A |
T |
1: 188,285,395 (GRCm39) |
E1977V |
probably damaging |
Het |
| Utp4 |
A |
G |
8: 107,640,095 (GRCm39) |
E468G |
probably benign |
Het |
| Uts2r |
A |
G |
11: 121,051,558 (GRCm39) |
T141A |
possibly damaging |
Het |
| Vmn1r230 |
A |
G |
17: 21,066,952 (GRCm39) |
Y47C |
probably damaging |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,723,724 (GRCm39) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,717,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,721,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,732,036 (GRCm39) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,725,672 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,717,778 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,743,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,692,490 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,739,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,692,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,707,057 (GRCm39) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,696,140 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,696,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,696,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,725,663 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,717,701 (GRCm39) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,699,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,699,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,744,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,731,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,730,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,707,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,763,145 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,725,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,729,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,692,769 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,704,331 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,725,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Dennd4c
|
UTSW |
4 |
86,721,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,743,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,755,634 (GRCm39) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,729,764 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,699,881 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,743,557 (GRCm39) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,698,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,692,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,725,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,716,312 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,738,200 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,743,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4923:Dennd4c
|
UTSW |
4 |
86,725,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,699,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,713,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,729,693 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,713,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,729,690 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,744,223 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,709,589 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,743,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,723,828 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,743,686 (GRCm39) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,717,626 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,754,694 (GRCm39) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,717,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,730,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,725,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,721,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,747,975 (GRCm39) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,759,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Dennd4c
|
UTSW |
4 |
86,692,568 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,717,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,692,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Dennd4c
|
UTSW |
4 |
86,729,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,713,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,704,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,747,179 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7790:Dennd4c
|
UTSW |
4 |
86,717,754 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,763,213 (GRCm39) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,744,109 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,759,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,744,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,754,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,739,702 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,743,349 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,755,637 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,738,170 (GRCm39) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,747,208 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,713,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,743,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,754,625 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGGGTGCTGGAATTGAATTC -3'
(R):5'- GCTTGCCCGGACAGAAGTTT -3'
Sequencing Primer
(F):5'- GGGATTACTGGCAGATATTACCCC -3'
(R):5'- GCCCGGACAGAAGTTTAAATTTAAC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation