Mutagenetix > Incidental Mutation

Incidental Mutation 'R7329:Dnah6'

569109

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

045422-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R7329 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

72994589-73198634 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 73121705 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 1426 (Q1426*)

Ref Sequence

ENSEMBL: ENSMUSP00000068758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000064948
AA Change: Q1426*

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: Q1426*

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000204053
AA Change: Q1426*

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: Q1426*

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

100% (78/78)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actb	T	C	5: 142,890,146 (GRCm39)	N252S	probably benign	Het
Adgrb1	C	A	15: 74,411,094 (GRCm39)	T330K	probably damaging	Het
Ahnak	A	G	19: 8,979,156 (GRCm39)	T147A	probably damaging	Het
Ankfy1	T	C	11: 72,603,034 (GRCm39)	V21A	probably damaging	Het
Arrdc4	T	A	7: 68,390,775 (GRCm39)	N322Y	probably damaging	Het
Bfsp2	C	A	9: 103,327,121 (GRCm39)	E205D	probably benign	Het
C2cd4b	T	A	9: 67,667,419 (GRCm39)	S138R	possibly damaging	Het
Camkk1	C	G	11: 72,917,873 (GRCm39)	N147K	probably damaging	Het
Ckap2l	T	A	2: 129,127,284 (GRCm39)	Q298L	possibly damaging	Het
Clstn2	G	T	9: 97,343,422 (GRCm39)	A675D	probably benign	Het
Cntnap2	G	A	6: 47,248,205 (GRCm39)	V1204M	possibly damaging	Het
Col4a1	C	T	8: 11,276,494 (GRCm39)		probably null	Het
Ctrc	T	C	4: 141,571,022 (GRCm39)	T73A	probably benign	Het
Cubn	A	G	2: 13,473,582 (GRCm39)	F454L	probably damaging	Het
Cuedc1	A	T	11: 88,060,692 (GRCm39)	S12C	unknown	Het
Cyb561a3	G	T	19: 10,565,268 (GRCm39)	G211C	probably damaging	Het
D5Ertd579e	A	T	5: 36,773,739 (GRCm39)	S219T	probably benign	Het
Dennd4c	T	A	4: 86,759,318 (GRCm39)	Y1783N	probably damaging	Het
Dennd4c	C	T	4: 86,698,111 (GRCm39)	P200S	possibly damaging	Het
Dync2h1	T	G	9: 7,011,247 (GRCm39)	T3649P	probably benign	Het
E2f8	T	C	7: 48,521,858 (GRCm39)	S415G	probably damaging	Het
Fbxo22	A	G	9: 55,122,261 (GRCm39)	I147V	probably benign	Het
Gclc	A	G	9: 77,683,473 (GRCm39)	Y110C	probably damaging	Het
Gstm5	A	G	3: 107,803,647 (GRCm39)	T27A	possibly damaging	Het
Heatr4	A	G	12: 84,024,856 (GRCm39)	S322P	probably benign	Het
Htt	T	A	5: 34,987,099 (GRCm39)	I1106N	probably benign	Het
Hunk	T	C	16: 90,183,570 (GRCm39)	V76A	probably benign	Het
Igkv12-98	C	T	6: 68,548,087 (GRCm39)	T72I	possibly damaging	Het
Igkv9-123	A	T	6: 67,931,629 (GRCm39)	W16R	possibly damaging	Het
Ipo7	T	C	7: 109,648,224 (GRCm39)	L674S	possibly damaging	Het
Kcnh6	T	C	11: 105,908,203 (GRCm39)	F273S	probably benign	Het
Lamb3	C	A	1: 193,002,848 (GRCm39)	Q98K	possibly damaging	Het
Lingo4	A	T	3: 94,310,162 (GRCm39)	T367S	probably benign	Het
Lypd6b	A	T	2: 49,832,512 (GRCm39)	I26F	probably benign	Het
Maneal	T	C	4: 124,750,512 (GRCm39)	T415A	probably benign	Het
Mapk1ip1l	A	G	14: 47,547,920 (GRCm39)	T23A	unknown	Het
Mrps17	T	A	5: 129,793,705 (GRCm39)		probably benign	Het
Mup13	T	G	4: 61,183,688 (GRCm39)	D45A	probably damaging	Het
Mycbpap	T	A	11: 94,400,073 (GRCm39)	D408V	probably damaging	Het
Myh10	A	G	11: 68,701,017 (GRCm39)	H1742R	probably benign	Het
Mylk4	A	G	13: 32,900,766 (GRCm39)	Y255H	probably damaging	Het
Nbeal1	A	G	1: 60,256,355 (GRCm39)	Q200R	probably benign	Het
Nkain2	TTTACTCGTT	TTT	10: 32,765,892 (GRCm39)		probably null	Het
Olfm4	T	C	14: 80,249,369 (GRCm39)	V162A	possibly damaging	Het
Or1j15	A	G	2: 36,458,708 (GRCm39)	T33A	probably benign	Het
Or51a8	T	C	7: 102,550,039 (GRCm39)	L155P	probably damaging	Het
Or5w8	T	C	2: 87,687,585 (GRCm39)	V22A	probably benign	Het
Or8c11	C	A	9: 38,289,456 (GRCm39)	T87K	probably benign	Het
Ovol3	T	A	7: 29,934,677 (GRCm39)	R43S	probably benign	Het
Pcbp1	A	G	6: 86,502,098 (GRCm39)	V267A	probably benign	Het
Phf20	T	A	2: 156,146,552 (GRCm39)	V903E	probably damaging	Het
Pi4k2b	T	G	5: 52,914,211 (GRCm39)	S316A	probably benign	Het
Pira1	G	A	7: 3,742,875 (GRCm39)		probably benign	Het
Pkhd1	A	T	1: 20,617,743 (GRCm39)	H947Q	probably damaging	Het
Ppip5k2	A	C	1: 97,678,478 (GRCm39)		probably null	Het
Prkca	T	A	11: 107,905,103 (GRCm39)	T212S	possibly damaging	Het
Psg16	A	T	7: 16,824,611 (GRCm39)	I41F	possibly damaging	Het
Rae1	T	A	2: 172,851,238 (GRCm39)	F204I	probably benign	Het
Rasef	T	A	4: 73,662,374 (GRCm39)	N192I	probably damaging	Het
Rfc1	T	A	5: 65,420,478 (GRCm39)	R1122S	unknown	Het
Rfx2	A	T	17: 57,110,681 (GRCm39)	S102T	probably benign	Het
Sez6l	A	G	5: 112,588,773 (GRCm39)	Y647H	probably damaging	Het
Siglecf	A	G	7: 43,001,395 (GRCm39)	Y121C	probably damaging	Het
Slc27a5	T	C	7: 12,725,089 (GRCm39)	T453A	possibly damaging	Het
Slc44a2	G	A	9: 21,254,048 (GRCm39)	R171Q	probably damaging	Het
Slc4a9	A	C	18: 36,673,874 (GRCm39)	E889A	possibly damaging	Het
Snx31	C	A	15: 36,555,621 (GRCm39)	R13L	probably benign	Het
Spag6l	A	T	16: 16,584,883 (GRCm39)	Y422N	probably benign	Het
Spmip5	T	C	19: 58,777,654 (GRCm39)	E52G	probably damaging	Het
Sulf2	T	C	2: 165,959,008 (GRCm39)	T67A	probably damaging	Het
Syne2	G	A	12: 76,013,758 (GRCm39)	R2983Q	probably benign	Het
Tmtc3	A	G	10: 100,283,281 (GRCm39)	I758T	probably benign	Het
Top2a	T	A	11: 98,895,072 (GRCm39)	I843L	possibly damaging	Het
Tph1	T	C	7: 46,306,285 (GRCm39)		probably null	Het
Trdmt1	A	G	2: 13,520,933 (GRCm39)	L323P	probably damaging	Het
Ush2a	A	T	1: 188,285,395 (GRCm39)	E1977V	probably damaging	Het
Utp4	A	G	8: 107,640,095 (GRCm39)	E468G	probably benign	Het
Uts2r	A	G	11: 121,051,558 (GRCm39)	T141A	possibly damaging	Het
Vmn1r230	A	G	17: 21,066,952 (GRCm39)	Y47C	probably damaging	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,172,720 (GRCm39)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,063,190 (GRCm39)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,172,744 (GRCm39)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,189,417 (GRCm39)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,100,754 (GRCm39)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,133,333 (GRCm39)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,010,509 (GRCm39)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,060,140 (GRCm39)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,150,373 (GRCm39)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,051,764 (GRCm39)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,042,708 (GRCm39)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,150,439 (GRCm39)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,069,161 (GRCm39)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,051,731 (GRCm39)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,001,235 (GRCm39)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,052,785 (GRCm39)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,053,643 (GRCm39)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,165,360 (GRCm39)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,042,759 (GRCm39)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,112,784 (GRCm39)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,009,552 (GRCm39)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,037,126 (GRCm39)	missense	probably benign
IGL02126:Dnah6	APN	6	73,080,149 (GRCm39)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	72,994,780 (GRCm39)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,110,633 (GRCm39)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,145,894 (GRCm39)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,078,881 (GRCm39)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,053,623 (GRCm39)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,004,431 (GRCm39)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	72,998,210 (GRCm39)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,072,087 (GRCm39)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,098,806 (GRCm39)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,185,582 (GRCm39)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,115,698 (GRCm39)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,009,570 (GRCm39)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,126,123 (GRCm39)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,121,987 (GRCm39)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,018,037 (GRCm39)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,121,683 (GRCm39)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,030,630 (GRCm39)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,060,068 (GRCm39)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,052,833 (GRCm39)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,140,487 (GRCm39)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,042,738 (GRCm39)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,185,624 (GRCm39)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,078,863 (GRCm39)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,091,565 (GRCm39)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,037,243 (GRCm39)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,015,717 (GRCm39)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,165,518 (GRCm39)	splice site	probably benign
R0165:Dnah6	UTSW	6	72,998,306 (GRCm39)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,059,906 (GRCm39)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,136,098 (GRCm39)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,150,541 (GRCm39)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,046,382 (GRCm39)	splice site	probably benign
R0345:Dnah6	UTSW	6	72,998,240 (GRCm39)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,165,342 (GRCm39)	missense	probably benign
R0362:Dnah6	UTSW	6	73,185,592 (GRCm39)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,060,107 (GRCm39)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,021,757 (GRCm39)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	72,999,395 (GRCm39)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,100,794 (GRCm39)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,106,457 (GRCm39)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,189,605 (GRCm39)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,064,585 (GRCm39)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,012,276 (GRCm39)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,101,740 (GRCm39)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,136,176 (GRCm39)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,121,948 (GRCm39)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,136,118 (GRCm39)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,101,692 (GRCm39)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,185,528 (GRCm39)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,168,602 (GRCm39)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,004,425 (GRCm39)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,026,031 (GRCm39)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,128,536 (GRCm39)	missense	probably benign
R1557:Dnah6	UTSW	6	73,026,114 (GRCm39)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,053,583 (GRCm39)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,044,452 (GRCm39)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,121,946 (GRCm39)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,077,095 (GRCm39)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,021,735 (GRCm39)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,132,279 (GRCm39)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,182,715 (GRCm39)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,106,523 (GRCm39)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,021,744 (GRCm39)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,137,965 (GRCm39)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,001,941 (GRCm39)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,158,780 (GRCm39)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,077,071 (GRCm39)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,158,745 (GRCm39)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,061,704 (GRCm39)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,098,953 (GRCm39)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,072,027 (GRCm39)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,069,175 (GRCm39)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,044,449 (GRCm39)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,150,402 (GRCm39)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,004,405 (GRCm39)	missense	probably benign
R2041:Dnah6	UTSW	6	73,050,422 (GRCm39)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	72,998,165 (GRCm39)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,121,018 (GRCm39)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,026,149 (GRCm39)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,066,729 (GRCm39)	splice site	probably null
R2193:Dnah6	UTSW	6	73,115,623 (GRCm39)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,077,068 (GRCm39)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,090,564 (GRCm39)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	72,998,092 (GRCm39)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,133,404 (GRCm39)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,068,950 (GRCm39)	splice site	probably null
R2436:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,150,333 (GRCm39)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,009,616 (GRCm39)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,168,481 (GRCm39)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,104,910 (GRCm39)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,066,575 (GRCm39)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,106,431 (GRCm39)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,126,467 (GRCm39)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,095,009 (GRCm39)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,106,274 (GRCm39)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,168,462 (GRCm39)	missense	probably benign
R4486:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,155,399 (GRCm39)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,169,388 (GRCm39)	missense	probably benign
R4573:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,129,695 (GRCm39)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,106,643 (GRCm39)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,047,580 (GRCm39)	missense	probably benign
R4653:Dnah6	UTSW	6	73,050,440 (GRCm39)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,014,671 (GRCm39)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,169,405 (GRCm39)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,001,995 (GRCm39)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,106,513 (GRCm39)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,072,057 (GRCm39)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,066,651 (GRCm39)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	72,999,407 (GRCm39)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,021,745 (GRCm39)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,098,771 (GRCm39)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,169,659 (GRCm39)	intron	probably benign
R4948:Dnah6	UTSW	6	73,030,672 (GRCm39)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,165,366 (GRCm39)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,121,798 (GRCm39)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,021,674 (GRCm39)	missense	probably benign
R5044:Dnah6	UTSW	6	73,014,605 (GRCm39)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,158,744 (GRCm39)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,172,617 (GRCm39)	missense	probably benign
R5186:Dnah6	UTSW	6	73,044,410 (GRCm39)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,172,715 (GRCm39)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,090,471 (GRCm39)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,104,844 (GRCm39)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,189,603 (GRCm39)	missense	probably benign
R5343:Dnah6	UTSW	6	73,189,599 (GRCm39)	missense	probably benign
R5375:Dnah6	UTSW	6	73,100,838 (GRCm39)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,014,598 (GRCm39)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,037,121 (GRCm39)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,052,717 (GRCm39)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,063,168 (GRCm39)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,069,140 (GRCm39)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,069,099 (GRCm39)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,167,402 (GRCm39)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,136,212 (GRCm39)	missense	probably benign
R5541:Dnah6	UTSW	6	73,169,971 (GRCm39)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,128,672 (GRCm39)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,126,508 (GRCm39)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	72,998,210 (GRCm39)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,037,262 (GRCm39)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,158,705 (GRCm39)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,063,149 (GRCm39)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,091,680 (GRCm39)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,165,477 (GRCm39)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,063,200 (GRCm39)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,168,588 (GRCm39)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,132,401 (GRCm39)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,051,569 (GRCm39)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,051,687 (GRCm39)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,021,715 (GRCm39)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,150,516 (GRCm39)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,030,678 (GRCm39)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,012,263 (GRCm39)	splice site	probably null
R6640:Dnah6	UTSW	6	73,001,276 (GRCm39)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,115,743 (GRCm39)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,014,532 (GRCm39)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,110,591 (GRCm39)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,110,525 (GRCm39)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,189,505 (GRCm39)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,158,738 (GRCm39)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,021,756 (GRCm39)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	72,998,161 (GRCm39)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,064,545 (GRCm39)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,112,663 (GRCm39)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,158,688 (GRCm39)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,150,528 (GRCm39)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,061,743 (GRCm39)	missense	probably damaging	1.00
R7387:Dnah6	UTSW	6	73,189,595 (GRCm39)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,169,300 (GRCm39)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,189,475 (GRCm39)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,104,887 (GRCm39)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,095,082 (GRCm39)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,004,423 (GRCm39)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,126,413 (GRCm39)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,069,151 (GRCm39)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,072,189 (GRCm39)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,101,742 (GRCm39)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,146,063 (GRCm39)	splice site	probably null
R7735:Dnah6	UTSW	6	73,046,412 (GRCm39)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,002,703 (GRCm39)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,104,902 (GRCm39)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,112,450 (GRCm39)	splice site	probably null
R8034:Dnah6	UTSW	6	73,106,208 (GRCm39)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,137,896 (GRCm39)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,002,769 (GRCm39)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,037,208 (GRCm39)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,014,549 (GRCm39)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,021,711 (GRCm39)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,145,810 (GRCm39)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,172,664 (GRCm39)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,053,582 (GRCm39)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,001,983 (GRCm39)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,051,634 (GRCm39)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,115,757 (GRCm39)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,155,440 (GRCm39)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,072,171 (GRCm39)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,145,850 (GRCm39)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,052,873 (GRCm39)	intron	probably benign
R8737:Dnah6	UTSW	6	73,044,428 (GRCm39)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,156,811 (GRCm39)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,042,756 (GRCm39)	missense	probably benign
R8809:Dnah6	UTSW	6	73,009,546 (GRCm39)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,104,937 (GRCm39)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,121,156 (GRCm39)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	72,998,131 (GRCm39)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,155,481 (GRCm39)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,121,734 (GRCm39)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,119,275 (GRCm39)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,061,640 (GRCm39)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,121,029 (GRCm39)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,044,469 (GRCm39)	missense	probably benign
R9106:Dnah6	UTSW	6	73,121,752 (GRCm39)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,037,186 (GRCm39)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,098,882 (GRCm39)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,121,924 (GRCm39)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,121,688 (GRCm39)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,004,497 (GRCm39)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,060,040 (GRCm39)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	72,998,261 (GRCm39)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,189,513 (GRCm39)	missense	probably benign
R9439:Dnah6	UTSW	6	73,012,330 (GRCm39)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,119,299 (GRCm39)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,115,750 (GRCm39)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,168,589 (GRCm39)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,078,872 (GRCm39)	missense	probably benign
RF020:Dnah6	UTSW	6	73,095,040 (GRCm39)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,155,501 (GRCm39)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,168,483 (GRCm39)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,014,656 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,110,542 (GRCm39)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,064,766 (GRCm39)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,009,509 (GRCm39)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	72,998,220 (GRCm39)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,132,255 (GRCm39)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,018,121 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGAAATATACTCGCAGACTCAGG -3'
(R):5'- AGTTTCTGAGCTGGTTCAAGCC -3'

Sequencing Primer
(F):5'- GCAGACTCAGGCGCACAAATC -3'
(R):5'- GGTTCAAGCCAAGGTAAATGCTTC -3'

Posted On

2019-09-13