Incidental Mutation 'R7331:Ttc3'
| ID |
569259 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc3
|
| Ensembl Gene |
ENSMUSG00000040785 |
| Gene Name |
tetratricopeptide repeat domain 3 |
| Synonyms |
D16Ium21e, TPRD, 2610202A04Rik, D16Ium21 |
| MMRRC Submission |
045424-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.597)
|
| Stock # |
R7331 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
94171479-94270081 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 94195218 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 290
(F290L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113311
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117648]
[ENSMUST00000119131]
[ENSMUST00000122895]
[ENSMUST00000139513]
[ENSMUST00000141856]
[ENSMUST00000143145]
[ENSMUST00000145432]
[ENSMUST00000145883]
[ENSMUST00000147046]
[ENSMUST00000147352]
[ENSMUST00000149885]
[ENSMUST00000150097]
[ENSMUST00000150346]
[ENSMUST00000151770]
[ENSMUST00000152117]
[ENSMUST00000153062]
[ENSMUST00000153988]
[ENSMUST00000155692]
[ENSMUST00000231569]
[ENSMUST00000231915]
[ENSMUST00000232395]
[ENSMUST00000232660]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117648
|
| SMART Domains |
Protein: ENSMUSP00000112801
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
2e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1278 |
1291 |
N/A |
INTRINSIC |
|
coiled coil region
|
1472 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1876 |
1887 |
N/A |
INTRINSIC |
|
RING
|
1931 |
1970 |
7e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119131
AA Change: F290L
PolyPhen 2
Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000113311
Gene: ENSMUSG00000040785
AA Change: F290L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_11
|
229 |
285 |
1.1e-12 |
PFAM |
|
Pfam:TPR_1
|
232 |
264 |
2.1e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122895
|
| SMART Domains |
Protein: ENSMUSP00000123037
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127667
|
| SMART Domains |
Protein: ENSMUSP00000122425
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_11
|
22 |
89 |
4.7e-16 |
PFAM |
|
Pfam:TPR_2
|
24 |
57 |
5.7e-4 |
PFAM |
|
Pfam:TPR_1
|
25 |
57 |
3.5e-5 |
PFAM |
|
Pfam:TPR_9
|
35 |
103 |
3.2e-6 |
PFAM |
|
Pfam:TPR_1
|
58 |
89 |
2.1e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139513
|
| SMART Domains |
Protein: ENSMUSP00000117881
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
22 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141856
|
| SMART Domains |
Protein: ENSMUSP00000117369
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_1
|
90 |
121 |
1e-6 |
PFAM |
|
Pfam:TPR_2
|
90 |
121 |
7.9e-6 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143145
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145432
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145883
|
| SMART Domains |
Protein: ENSMUSP00000123442
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
42 |
64 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147046
|
| SMART Domains |
Protein: ENSMUSP00000119265
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
5.3e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147352
|
| SMART Domains |
Protein: ENSMUSP00000116097
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149885
|
| SMART Domains |
Protein: ENSMUSP00000122006
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_2
|
1 |
31 |
3.5e-4 |
PFAM |
|
Pfam:TPR_11
|
1 |
58 |
7.8e-16 |
PFAM |
|
Pfam:TPR_1
|
2 |
31 |
1.8e-5 |
PFAM |
|
Pfam:TPR_9
|
9 |
58 |
2.5e-6 |
PFAM |
|
Pfam:TPR_17
|
20 |
53 |
4.2e-7 |
PFAM |
|
Pfam:TPR_1
|
32 |
58 |
2.5e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150097
|
| SMART Domains |
Protein: ENSMUSP00000119035
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
1e-6 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150346
|
| SMART Domains |
Protein: ENSMUSP00000122726
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
9.6e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151770
|
| SMART Domains |
Protein: ENSMUSP00000121349
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
3e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152117
|
| SMART Domains |
Protein: ENSMUSP00000116896
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
SCOP:d1ihga1
|
69 |
201 |
6e-8 |
SMART |
|
Blast:TPR
|
175 |
208 |
1e-14 |
BLAST |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
635 |
649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153062
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153988
|
| SMART Domains |
Protein: ENSMUSP00000118763
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
3e-6 |
BLAST |
|
low complexity region
|
134 |
149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155692
|
| SMART Domains |
Protein: ENSMUSP00000122724
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
250 |
283 |
3.61e-2 |
SMART |
|
TPR
|
284 |
317 |
3.32e-1 |
SMART |
|
Blast:TPR
|
319 |
351 |
3e-12 |
BLAST |
|
low complexity region
|
463 |
478 |
N/A |
INTRINSIC |
|
TPR
|
595 |
628 |
2.55e-2 |
SMART |
|
low complexity region
|
739 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
784 |
815 |
N/A |
INTRINSIC |
|
low complexity region
|
1037 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231569
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231915
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232395
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232660
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (48/48) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 50 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
A |
T |
13: 77,331,728 (GRCm39) |
H47L |
possibly damaging |
Het |
| Adgrf5 |
T |
C |
17: 43,748,484 (GRCm39) |
S438P |
probably damaging |
Het |
| Atg16l2 |
C |
A |
7: 100,948,255 (GRCm39) |
K96N |
probably damaging |
Het |
| Bglap2 |
A |
T |
3: 88,285,567 (GRCm39) |
M35K |
possibly damaging |
Het |
| Btbd1 |
T |
A |
7: 81,465,720 (GRCm39) |
I209L |
probably damaging |
Het |
| Cdc34 |
T |
C |
10: 79,521,146 (GRCm39) |
Y148H |
probably damaging |
Het |
| Clcc1 |
A |
G |
3: 108,575,394 (GRCm39) |
D157G |
probably damaging |
Het |
| Csmd2 |
A |
T |
4: 128,458,021 (GRCm39) |
|
probably null |
Het |
| Ctsj |
G |
A |
13: 61,151,645 (GRCm39) |
S90L |
probably benign |
Het |
| Cycs |
A |
G |
6: 50,542,532 (GRCm39) |
F37L |
probably benign |
Het |
| Dync2li1 |
T |
A |
17: 84,955,086 (GRCm39) |
C248* |
probably null |
Het |
| Dzank1 |
A |
T |
2: 144,332,190 (GRCm39) |
I382N |
probably benign |
Het |
| Eif4a3l2 |
G |
A |
6: 116,529,130 (GRCm39) |
V336I |
probably benign |
Het |
| Enpp2 |
T |
C |
15: 54,739,066 (GRCm39) |
I406V |
probably damaging |
Het |
| Ero1b |
A |
G |
13: 12,615,015 (GRCm39) |
E282G |
probably damaging |
Het |
| Fastkd5 |
A |
T |
2: 130,457,647 (GRCm39) |
N314K |
possibly damaging |
Het |
| Fbh1 |
A |
T |
2: 11,768,797 (GRCm39) |
C300S |
probably benign |
Het |
| Fchsd1 |
T |
C |
18: 38,101,823 (GRCm39) |
I49V |
possibly damaging |
Het |
| Foxn1 |
A |
G |
11: 78,249,615 (GRCm39) |
Y637H |
probably damaging |
Het |
| Gabarap |
A |
G |
11: 69,885,298 (GRCm39) |
E101G |
possibly damaging |
Het |
| Gm7247 |
A |
G |
14: 51,601,792 (GRCm39) |
R22G |
probably damaging |
Het |
| Gm7694 |
A |
T |
1: 170,129,180 (GRCm39) |
D116E |
possibly damaging |
Het |
| Gm9508 |
A |
G |
10: 77,532,629 (GRCm39) |
C147R |
unknown |
Het |
| Gpr152 |
A |
G |
19: 4,192,608 (GRCm39) |
M50V |
probably damaging |
Het |
| Hunk |
T |
A |
16: 90,269,450 (GRCm39) |
N331K |
possibly damaging |
Het |
| Il1r2 |
A |
G |
1: 40,162,409 (GRCm39) |
T351A |
probably benign |
Het |
| Iqub |
A |
G |
6: 24,500,393 (GRCm39) |
V287A |
possibly damaging |
Het |
| Lix1 |
A |
T |
17: 17,647,474 (GRCm39) |
T47S |
probably benign |
Het |
| Lrp1b |
A |
T |
2: 40,553,622 (GRCm39) |
|
probably null |
Het |
| Nup107 |
G |
A |
10: 117,606,103 (GRCm39) |
T500I |
probably damaging |
Het |
| Phf21b |
G |
C |
15: 84,675,295 (GRCm39) |
R405G |
probably benign |
Het |
| Piezo2 |
A |
G |
18: 63,241,101 (GRCm39) |
V709A |
probably damaging |
Het |
| Psme3ip1 |
T |
A |
8: 95,309,564 (GRCm39) |
K143* |
probably null |
Het |
| Rfc1 |
T |
C |
5: 65,468,387 (GRCm39) |
T109A |
probably damaging |
Het |
| Rpa1 |
A |
G |
11: 75,203,941 (GRCm39) |
V302A |
probably damaging |
Het |
| Ryr2 |
A |
G |
13: 11,760,517 (GRCm39) |
I1522T |
probably benign |
Het |
| Ryr3 |
C |
A |
2: 112,594,010 (GRCm39) |
R2578L |
possibly damaging |
Het |
| Scgb2b18 |
C |
T |
7: 32,872,681 (GRCm39) |
W41* |
probably null |
Het |
| Sdccag8 |
C |
G |
1: 176,695,856 (GRCm39) |
Q387E |
possibly damaging |
Het |
| Slc25a17 |
G |
A |
15: 81,213,346 (GRCm39) |
T119M |
probably damaging |
Het |
| Slc45a4 |
G |
T |
15: 73,477,489 (GRCm39) |
Q16K |
probably benign |
Het |
| Slc4a1 |
G |
A |
11: 102,252,245 (GRCm39) |
|
probably benign |
Het |
| Slc7a14 |
T |
C |
3: 31,311,880 (GRCm39) |
T47A |
probably benign |
Het |
| Stard6 |
A |
G |
18: 70,616,553 (GRCm39) |
R71G |
probably damaging |
Het |
| Tecr |
A |
G |
8: 84,298,564 (GRCm39) |
V321A |
probably damaging |
Het |
| Uqcc1 |
A |
G |
2: 155,753,731 (GRCm39) |
V48A |
probably benign |
Het |
| V1rd19 |
T |
A |
7: 23,703,308 (GRCm39) |
I258N |
probably damaging |
Het |
| Zar1 |
T |
A |
5: 72,737,655 (GRCm39) |
E249V |
possibly damaging |
Het |
| Zfp101 |
T |
C |
17: 33,601,559 (GRCm39) |
T66A |
possibly damaging |
Het |
| Zyx |
A |
G |
6: 42,328,593 (GRCm39) |
H230R |
probably benign |
Het |
|
| Other mutations in Ttc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Ttc3
|
APN |
16 |
94,227,620 (GRCm39) |
splice site |
probably null |
|
|
IGL00979:Ttc3
|
APN |
16 |
94,257,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Ttc3
|
APN |
16 |
94,191,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01663:Ttc3
|
APN |
16 |
94,210,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01720:Ttc3
|
APN |
16 |
94,186,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01736:Ttc3
|
APN |
16 |
94,243,386 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02045:Ttc3
|
APN |
16 |
94,210,540 (GRCm39) |
splice site |
probably benign |
|
|
IGL02203:Ttc3
|
APN |
16 |
94,219,457 (GRCm39) |
splice site |
probably benign |
|
|
IGL02327:Ttc3
|
APN |
16 |
94,248,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02794:Ttc3
|
APN |
16 |
94,268,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02898:Ttc3
|
APN |
16 |
94,220,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Ttc3
|
UTSW |
16 |
94,211,765 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0064:Ttc3
|
UTSW |
16 |
94,223,106 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0098:Ttc3
|
UTSW |
16 |
94,191,124 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0112:Ttc3
|
UTSW |
16 |
94,186,181 (GRCm39) |
splice site |
probably benign |
|
|
R0135:Ttc3
|
UTSW |
16 |
94,263,127 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0480:Ttc3
|
UTSW |
16 |
94,232,863 (GRCm39) |
nonsense |
probably null |
|
|
R0513:Ttc3
|
UTSW |
16 |
94,227,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Ttc3
|
UTSW |
16 |
94,188,189 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Ttc3
|
UTSW |
16 |
94,257,644 (GRCm39) |
nonsense |
probably null |
|
|
R0742:Ttc3
|
UTSW |
16 |
94,260,739 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0905:Ttc3
|
UTSW |
16 |
94,257,648 (GRCm39) |
nonsense |
probably null |
|
|
R1118:Ttc3
|
UTSW |
16 |
94,217,127 (GRCm39) |
splice site |
probably benign |
|
|
R1355:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1370:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1486:Ttc3
|
UTSW |
16 |
94,248,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1598:Ttc3
|
UTSW |
16 |
94,223,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1641:Ttc3
|
UTSW |
16 |
94,244,176 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2092:Ttc3
|
UTSW |
16 |
94,243,691 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2232:Ttc3
|
UTSW |
16 |
94,260,831 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2339:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2342:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3117:Ttc3
|
UTSW |
16 |
94,243,422 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4194:Ttc3
|
UTSW |
16 |
94,223,136 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4329:Ttc3
|
UTSW |
16 |
94,267,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4431:Ttc3
|
UTSW |
16 |
94,211,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4530:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4531:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4532:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4533:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4588:Ttc3
|
UTSW |
16 |
94,243,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4625:Ttc3
|
UTSW |
16 |
94,189,131 (GRCm39) |
nonsense |
probably null |
|
|
R4676:Ttc3
|
UTSW |
16 |
94,243,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc3
|
UTSW |
16 |
94,240,100 (GRCm39) |
splice site |
probably null |
|
|
R4856:Ttc3
|
UTSW |
16 |
94,191,142 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4867:Ttc3
|
UTSW |
16 |
94,255,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4885:Ttc3
|
UTSW |
16 |
94,227,690 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4885:Ttc3
|
UTSW |
16 |
94,220,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Ttc3
|
UTSW |
16 |
94,230,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4997:Ttc3
|
UTSW |
16 |
94,253,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5023:Ttc3
|
UTSW |
16 |
94,230,218 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5105:Ttc3
|
UTSW |
16 |
94,267,793 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5205:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5287:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5338:Ttc3
|
UTSW |
16 |
94,184,900 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5347:Ttc3
|
UTSW |
16 |
94,230,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5403:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5460:Ttc3
|
UTSW |
16 |
94,258,241 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5739:Ttc3
|
UTSW |
16 |
94,240,183 (GRCm39) |
nonsense |
probably null |
|
|
R6242:Ttc3
|
UTSW |
16 |
94,243,554 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6253:Ttc3
|
UTSW |
16 |
94,258,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6455:Ttc3
|
UTSW |
16 |
94,219,482 (GRCm39) |
start codon destroyed |
probably null |
0.83 |
|
R6559:Ttc3
|
UTSW |
16 |
94,223,208 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6564:Ttc3
|
UTSW |
16 |
94,243,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6932:Ttc3
|
UTSW |
16 |
94,244,312 (GRCm39) |
missense |
probably benign |
|
|
R7497:Ttc3
|
UTSW |
16 |
94,219,541 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7610:Ttc3
|
UTSW |
16 |
94,228,697 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7738:Ttc3
|
UTSW |
16 |
94,188,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7970:Ttc3
|
UTSW |
16 |
94,258,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Ttc3
|
UTSW |
16 |
94,268,848 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8087:Ttc3
|
UTSW |
16 |
94,243,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8309:Ttc3
|
UTSW |
16 |
94,267,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8320:Ttc3
|
UTSW |
16 |
94,219,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Ttc3
|
UTSW |
16 |
94,255,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Ttc3
|
UTSW |
16 |
94,258,238 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8670:Ttc3
|
UTSW |
16 |
94,191,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8826:Ttc3
|
UTSW |
16 |
94,232,829 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8868:Ttc3
|
UTSW |
16 |
94,252,002 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8873:Ttc3
|
UTSW |
16 |
94,243,842 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8940:Ttc3
|
UTSW |
16 |
94,230,358 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8993:Ttc3
|
UTSW |
16 |
94,228,667 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9068:Ttc3
|
UTSW |
16 |
94,204,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9119:Ttc3
|
UTSW |
16 |
94,192,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9124:Ttc3
|
UTSW |
16 |
94,236,389 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9129:Ttc3
|
UTSW |
16 |
94,185,208 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9189:Ttc3
|
UTSW |
16 |
94,268,831 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9217:Ttc3
|
UTSW |
16 |
94,230,467 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9490:Ttc3
|
UTSW |
16 |
94,245,360 (GRCm39) |
missense |
probably benign |
|
|
R9564:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9631:Ttc3
|
UTSW |
16 |
94,171,581 (GRCm39) |
intron |
probably benign |
|
|
X0022:Ttc3
|
UTSW |
16 |
94,243,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
Y5378:Ttc3
|
UTSW |
16 |
94,212,988 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTCGAGCTCAGACGCTGTTC -3'
(R):5'- AATAGATGACCCTCTGCCTGC -3'
Sequencing Primer
(F):5'- CTCAGACGCTGTTCCTTAGTGAAAAC -3'
(R):5'- TGTTAATTCTGGACCTAGCCAG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation