Incidental Mutation 'R7338:Ifi204'
ID 569623
Institutional Source Beutler Lab
Gene Symbol Ifi204
Ensembl Gene ENSMUSG00000073489
Gene Name interferon activated gene 204
Synonyms p204
MMRRC Submission 045428-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R7338 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173574859-173594509 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 173587703 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 152 (T152I)
Ref Sequence ENSEMBL: ENSMUSP00000106845 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111214]
AlphaFold P0DOV2
Predicted Effect possibly damaging
Transcript: ENSMUST00000111214
AA Change: T152I

PolyPhen 2 Score 0.666 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000106845
Gene: ENSMUSG00000073489
AA Change: T152I

DomainStartEndE-ValueType
PYRIN 6 84 8.33e-14 SMART
low complexity region 120 154 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:HIN 225 393 6.2e-78 PFAM
Pfam:HIN 429 595 9.8e-78 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,595,717 (GRCm39) S357P possibly damaging Het
Arhgap28 T C 17: 68,203,106 (GRCm39) R166G probably damaging Het
Bcan T A 3: 87,901,550 (GRCm39) E384V probably damaging Het
Bcl9l A G 9: 44,420,005 (GRCm39) N1137S probably benign Het
Caprin1 A G 2: 103,609,768 (GRCm39) L170S probably benign Het
Card6 C T 15: 5,129,354 (GRCm39) E681K probably benign Het
Catsperb G A 12: 101,447,243 (GRCm39) V248I probably benign Het
Ccnj T A 19: 40,825,477 (GRCm39) H62Q probably damaging Het
Cd180 A C 13: 102,842,936 (GRCm39) I661L probably benign Het
Cdk11b A G 4: 155,732,008 (GRCm39) R473G unknown Het
Cep126 T C 9: 8,099,799 (GRCm39) T912A possibly damaging Het
Chek2 T A 5: 111,021,380 (GRCm39) V530E probably benign Het
Chga G T 12: 102,529,100 (GRCm39) S359I probably damaging Het
Cnrip1 T C 11: 17,004,657 (GRCm39) V69A probably damaging Het
Cyp2a5 A T 7: 26,542,372 (GRCm39) Q458L probably damaging Het
Cyp2j11 T A 4: 96,195,524 (GRCm39) T391S possibly damaging Het
Dhx16 T C 17: 36,199,036 (GRCm39) L794P probably damaging Het
Dscaml1 A G 9: 45,585,802 (GRCm39) T580A probably benign Het
Elmo1 A T 13: 20,464,982 (GRCm39) I184L probably benign Het
Gabra1 C T 11: 42,073,121 (GRCm39) G51S unknown Het
Gabrr3 C A 16: 59,268,439 (GRCm39) L351I possibly damaging Het
Gbp7 A T 3: 142,243,786 (GRCm39) N111I probably damaging Het
Gjd2 C T 2: 113,841,583 (GRCm39) R298H probably damaging Het
Gm5930 T C 14: 44,573,914 (GRCm39) Y141C probably damaging Het
Grin3a G T 4: 49,771,238 (GRCm39) N511K probably benign Het
Hdac7 T C 15: 97,707,903 (GRCm39) D122G probably benign Het
Lrrc9 C T 12: 72,510,305 (GRCm39) probably null Het
Med21 T A 6: 146,544,082 (GRCm39) probably benign Het
Mmp19 A T 10: 128,634,952 (GRCm39) T523S probably benign Het
Nav3 G A 10: 109,605,073 (GRCm39) T1000I probably benign Het
Nherf2 T A 17: 24,869,182 (GRCm39) probably benign Het
Nin T C 12: 70,090,838 (GRCm39) D859G Het
Nip7 T G 8: 107,783,916 (GRCm39) L52R possibly damaging Het
Or10d1c A G 9: 38,893,816 (GRCm39) Y175H probably damaging Het
Or5al5 A T 2: 85,961,726 (GRCm39) F94I probably damaging Het
Or6b13 A T 7: 139,782,446 (GRCm39) V79E probably benign Het
Otop1 T A 5: 38,457,547 (GRCm39) Y435* probably null Het
Pak4 A G 7: 28,264,381 (GRCm39) S174P probably benign Het
Pcsk7 G A 9: 45,837,287 (GRCm39) R537Q probably benign Het
Podxl G A 6: 31,505,941 (GRCm39) S34F unknown Het
Prr36 G A 8: 4,266,212 (GRCm39) R113C probably damaging Het
Ptk7 T C 17: 46,890,525 (GRCm39) I436V probably benign Het
Slc13a5 C T 11: 72,157,310 (GRCm39) V28I probably benign Het
Slco6d1 A T 1: 98,349,097 (GRCm39) D56V probably benign Het
Spg11 G A 2: 121,885,858 (GRCm39) R2317W probably damaging Het
Stom T A 2: 35,213,760 (GRCm39) probably null Het
Svs5 T C 2: 164,174,728 (GRCm39) L8P possibly damaging Het
Tmem141 C A 2: 25,511,626 (GRCm39) V39F probably damaging Het
Tmprss6 A G 15: 78,344,019 (GRCm39) L181P probably damaging Het
Tnni3 A G 7: 4,524,379 (GRCm39) S40P probably benign Het
Tubgcp4 A G 2: 121,024,465 (GRCm39) I548V probably benign Het
Twf2 A G 9: 106,081,138 (GRCm39) probably benign Het
Wnt5b C A 6: 119,425,092 (GRCm39) probably null Het
Wrap73 A G 4: 154,237,043 (GRCm39) D210G probably benign Het
Yipf4 T G 17: 74,796,771 (GRCm39) S21A probably benign Het
Zscan20 A G 4: 128,481,943 (GRCm39) M573T probably benign Het
Other mutations in Ifi204
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Ifi204 APN 1 173,587,197 (GRCm39) splice site probably benign
IGL01922:Ifi204 APN 1 173,589,288 (GRCm39) missense possibly damaging 0.51
IGL02296:Ifi204 APN 1 173,576,880 (GRCm39) missense possibly damaging 0.93
IGL02419:Ifi204 APN 1 173,576,946 (GRCm39) missense possibly damaging 0.71
IGL02505:Ifi204 APN 1 173,583,220 (GRCm39) missense probably benign 0.04
R0938:Ifi204 UTSW 1 173,579,311 (GRCm39) missense possibly damaging 0.85
R1363:Ifi204 UTSW 1 173,576,862 (GRCm39) missense probably benign 0.00
R1834:Ifi204 UTSW 1 173,575,172 (GRCm39) missense unknown
R2031:Ifi204 UTSW 1 173,580,343 (GRCm39) missense probably damaging 1.00
R2254:Ifi204 UTSW 1 173,589,296 (GRCm39) missense possibly damaging 0.95
R2379:Ifi204 UTSW 1 173,583,559 (GRCm39) nonsense probably null
R2408:Ifi204 UTSW 1 173,583,198 (GRCm39) missense possibly damaging 0.80
R3011:Ifi204 UTSW 1 173,579,217 (GRCm39) missense probably benign 0.01
R3617:Ifi204 UTSW 1 173,583,283 (GRCm39) missense possibly damaging 0.51
R3894:Ifi204 UTSW 1 173,576,774 (GRCm39) missense possibly damaging 0.86
R3916:Ifi204 UTSW 1 173,583,341 (GRCm39) missense possibly damaging 0.95
R4656:Ifi204 UTSW 1 173,587,927 (GRCm39) intron probably benign
R4657:Ifi204 UTSW 1 173,587,927 (GRCm39) intron probably benign
R4694:Ifi204 UTSW 1 173,576,825 (GRCm39) missense probably damaging 0.99
R4703:Ifi204 UTSW 1 173,587,927 (GRCm39) intron probably benign
R4704:Ifi204 UTSW 1 173,587,927 (GRCm39) intron probably benign
R4894:Ifi204 UTSW 1 173,587,808 (GRCm39) missense probably damaging 0.98
R4947:Ifi204 UTSW 1 173,583,316 (GRCm39) missense probably damaging 0.98
R5023:Ifi204 UTSW 1 173,579,306 (GRCm39) missense possibly damaging 0.93
R5036:Ifi204 UTSW 1 173,580,311 (GRCm39) missense possibly damaging 0.79
R5119:Ifi204 UTSW 1 173,583,234 (GRCm39) missense probably damaging 1.00
R5194:Ifi204 UTSW 1 173,576,910 (GRCm39) missense possibly damaging 0.86
R5762:Ifi204 UTSW 1 173,580,325 (GRCm39) missense probably damaging 0.98
R6063:Ifi204 UTSW 1 173,579,223 (GRCm39) missense probably benign 0.03
R6808:Ifi204 UTSW 1 173,589,269 (GRCm39) missense probably benign 0.27
R7311:Ifi204 UTSW 1 173,587,134 (GRCm39) missense probably benign 0.26
R7430:Ifi204 UTSW 1 173,583,247 (GRCm39) missense probably benign 0.43
R7528:Ifi204 UTSW 1 173,579,406 (GRCm39) missense probably benign 0.06
R7985:Ifi204 UTSW 1 173,587,772 (GRCm39) missense possibly damaging 0.50
R8021:Ifi204 UTSW 1 173,586,919 (GRCm39) intron probably benign
R8137:Ifi204 UTSW 1 173,589,188 (GRCm39) missense possibly damaging 0.65
R8141:Ifi204 UTSW 1 173,583,189 (GRCm39) missense possibly damaging 0.81
R8191:Ifi204 UTSW 1 173,579,226 (GRCm39) missense possibly damaging 0.71
R8487:Ifi204 UTSW 1 173,587,839 (GRCm39) missense probably damaging 0.99
R9075:Ifi204 UTSW 1 173,589,282 (GRCm39) missense possibly damaging 0.95
R9124:Ifi204 UTSW 1 173,579,193 (GRCm39) critical splice donor site probably null
R9311:Ifi204 UTSW 1 173,589,215 (GRCm39) missense possibly damaging 0.45
R9498:Ifi204 UTSW 1 173,583,537 (GRCm39) missense possibly damaging 0.81
R9712:Ifi204 UTSW 1 173,576,924 (GRCm39) missense probably damaging 0.99
Z1176:Ifi204 UTSW 1 173,579,194 (GRCm39) missense probably null 0.00
Predicted Primers PCR Primer
(F):5'- ACCATGTCTCAACCTGATTTTCAAG -3'
(R):5'- TCTCCACATCCTAGTAACAGGAG -3'

Sequencing Primer
(F):5'- GTCTCAACCTGATTTTCAAGTTCATG -3'
(R):5'- TCCTAGTAACAGGAGAAACATCACTG -3'
Posted On 2019-09-13