Incidental Mutation 'R7338:Med21'
ID 569642
Institutional Source Beutler Lab
Gene Symbol Med21
Ensembl Gene ENSMUSG00000030291
Gene Name mediator complex subunit 21
Synonyms 0610007L03Rik, Srb7, D6Ertd782e, Surb7
MMRRC Submission 045428-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7338 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 146544077-146552098 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 146544082 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145512 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032429] [ENSMUST00000111650] [ENSMUST00000204040]
AlphaFold Q9CQ39
Predicted Effect probably benign
Transcript: ENSMUST00000032429
SMART Domains Protein: ENSMUSP00000032429
Gene: ENSMUSG00000030291

DomainStartEndE-ValueType
Pfam:Med21 1 127 1.1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111650
SMART Domains Protein: ENSMUSP00000107277
Gene: ENSMUSG00000030291

DomainStartEndE-ValueType
Pfam:Med21 1 90 8.7e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204040
SMART Domains Protein: ENSMUSP00000145512
Gene: ENSMUSG00000030291

DomainStartEndE-ValueType
Pfam:Med21 1 127 1.1e-29 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
PHENOTYPE: Embryos homozygous for a targeted null mutation die at the blastocyst stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,595,717 (GRCm39) S357P possibly damaging Het
Arhgap28 T C 17: 68,203,106 (GRCm39) R166G probably damaging Het
Bcan T A 3: 87,901,550 (GRCm39) E384V probably damaging Het
Bcl9l A G 9: 44,420,005 (GRCm39) N1137S probably benign Het
Caprin1 A G 2: 103,609,768 (GRCm39) L170S probably benign Het
Card6 C T 15: 5,129,354 (GRCm39) E681K probably benign Het
Catsperb G A 12: 101,447,243 (GRCm39) V248I probably benign Het
Ccnj T A 19: 40,825,477 (GRCm39) H62Q probably damaging Het
Cd180 A C 13: 102,842,936 (GRCm39) I661L probably benign Het
Cdk11b A G 4: 155,732,008 (GRCm39) R473G unknown Het
Cep126 T C 9: 8,099,799 (GRCm39) T912A possibly damaging Het
Chek2 T A 5: 111,021,380 (GRCm39) V530E probably benign Het
Chga G T 12: 102,529,100 (GRCm39) S359I probably damaging Het
Cnrip1 T C 11: 17,004,657 (GRCm39) V69A probably damaging Het
Cyp2a5 A T 7: 26,542,372 (GRCm39) Q458L probably damaging Het
Cyp2j11 T A 4: 96,195,524 (GRCm39) T391S possibly damaging Het
Dhx16 T C 17: 36,199,036 (GRCm39) L794P probably damaging Het
Dscaml1 A G 9: 45,585,802 (GRCm39) T580A probably benign Het
Elmo1 A T 13: 20,464,982 (GRCm39) I184L probably benign Het
Gabra1 C T 11: 42,073,121 (GRCm39) G51S unknown Het
Gabrr3 C A 16: 59,268,439 (GRCm39) L351I possibly damaging Het
Gbp7 A T 3: 142,243,786 (GRCm39) N111I probably damaging Het
Gjd2 C T 2: 113,841,583 (GRCm39) R298H probably damaging Het
Gm5930 T C 14: 44,573,914 (GRCm39) Y141C probably damaging Het
Grin3a G T 4: 49,771,238 (GRCm39) N511K probably benign Het
Hdac7 T C 15: 97,707,903 (GRCm39) D122G probably benign Het
Ifi204 G A 1: 173,587,703 (GRCm39) T152I possibly damaging Het
Lrrc9 C T 12: 72,510,305 (GRCm39) probably null Het
Mmp19 A T 10: 128,634,952 (GRCm39) T523S probably benign Het
Nav3 G A 10: 109,605,073 (GRCm39) T1000I probably benign Het
Nherf2 T A 17: 24,869,182 (GRCm39) probably benign Het
Nin T C 12: 70,090,838 (GRCm39) D859G Het
Nip7 T G 8: 107,783,916 (GRCm39) L52R possibly damaging Het
Or10d1c A G 9: 38,893,816 (GRCm39) Y175H probably damaging Het
Or5al5 A T 2: 85,961,726 (GRCm39) F94I probably damaging Het
Or6b13 A T 7: 139,782,446 (GRCm39) V79E probably benign Het
Otop1 T A 5: 38,457,547 (GRCm39) Y435* probably null Het
Pak4 A G 7: 28,264,381 (GRCm39) S174P probably benign Het
Pcsk7 G A 9: 45,837,287 (GRCm39) R537Q probably benign Het
Podxl G A 6: 31,505,941 (GRCm39) S34F unknown Het
Prr36 G A 8: 4,266,212 (GRCm39) R113C probably damaging Het
Ptk7 T C 17: 46,890,525 (GRCm39) I436V probably benign Het
Slc13a5 C T 11: 72,157,310 (GRCm39) V28I probably benign Het
Slco6d1 A T 1: 98,349,097 (GRCm39) D56V probably benign Het
Spg11 G A 2: 121,885,858 (GRCm39) R2317W probably damaging Het
Stom T A 2: 35,213,760 (GRCm39) probably null Het
Svs5 T C 2: 164,174,728 (GRCm39) L8P possibly damaging Het
Tmem141 C A 2: 25,511,626 (GRCm39) V39F probably damaging Het
Tmprss6 A G 15: 78,344,019 (GRCm39) L181P probably damaging Het
Tnni3 A G 7: 4,524,379 (GRCm39) S40P probably benign Het
Tubgcp4 A G 2: 121,024,465 (GRCm39) I548V probably benign Het
Twf2 A G 9: 106,081,138 (GRCm39) probably benign Het
Wnt5b C A 6: 119,425,092 (GRCm39) probably null Het
Wrap73 A G 4: 154,237,043 (GRCm39) D210G probably benign Het
Yipf4 T G 17: 74,796,771 (GRCm39) S21A probably benign Het
Zscan20 A G 4: 128,481,943 (GRCm39) M573T probably benign Het
Other mutations in Med21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02647:Med21 APN 6 146,550,731 (GRCm39) missense probably benign 0.44
IGL03369:Med21 APN 6 146,544,143 (GRCm39) missense probably benign 0.21
R0049:Med21 UTSW 6 146,551,732 (GRCm39) missense probably damaging 0.99
R0049:Med21 UTSW 6 146,551,732 (GRCm39) missense probably damaging 0.99
R0967:Med21 UTSW 6 146,551,697 (GRCm39) missense probably benign 0.02
R2106:Med21 UTSW 6 146,550,710 (GRCm39) missense probably damaging 1.00
R4403:Med21 UTSW 6 146,550,680 (GRCm39) nonsense probably null
R4675:Med21 UTSW 6 146,551,691 (GRCm39) missense probably damaging 0.97
R4747:Med21 UTSW 6 146,550,700 (GRCm39) missense possibly damaging 0.58
R4749:Med21 UTSW 6 146,551,599 (GRCm39) splice site probably null
R4855:Med21 UTSW 6 146,549,690 (GRCm39) missense probably damaging 1.00
R5117:Med21 UTSW 6 146,548,781 (GRCm39) intron probably benign
R5344:Med21 UTSW 6 146,550,683 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- TAAACGCGAACCCGTAGCAG -3'
(R):5'- TCAAGTTCGCACCTCACCAG -3'

Sequencing Primer
(F):5'- TAGCAGCTCAGCCTGCAC -3'
(R):5'- TGTGGACTACGTGAGACCCAG -3'
Posted On 2019-09-13