Incidental Mutation 'R7339:Fcgr1'
ID 569685
Institutional Source Beutler Lab
Gene Symbol Fcgr1
Ensembl Gene ENSMUSG00000015947
Gene Name Fc receptor, IgG, high affinity I
Synonyms CD64, FcgammaRI
MMRRC Submission 045429-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.177) question?
Stock # R7339 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 96190225-96201285 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 96191615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 398 (G398R)
Ref Sequence ENSEMBL: ENSMUSP00000029748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029748]
AlphaFold P26151
Predicted Effect not run
Transcript: ENSMUST00000029748
AA Change: G398R
SMART Domains Protein: ENSMUSP00000029748
Gene: ENSMUSG00000015947
AA Change: G398R

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IG 38 111 1.8e-5 SMART
IGc2 125 184 6.11e-8 SMART
IG 206 290 7.3e-6 SMART
transmembrane domain 298 320 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results immune response defects including a decreased inflammatory response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik T C 5: 113,330,938 (GRCm39) D1092G probably benign Het
Abcb11 C T 2: 69,130,211 (GRCm39) D282N probably damaging Het
Ahnak A T 19: 8,985,529 (GRCm39) N2271I possibly damaging Het
Amz1 A G 5: 140,727,306 (GRCm39) S90G probably benign Het
Arhgap5 A G 12: 52,564,481 (GRCm39) E484G possibly damaging Het
Arid3c A G 4: 41,729,883 (GRCm39) probably null Het
Atp1a1 T C 3: 101,497,188 (GRCm39) I373V probably benign Het
Barhl1 T C 2: 28,799,899 (GRCm39) E242G probably damaging Het
Bltp2 G A 11: 78,163,210 (GRCm39) probably null Het
Cactin CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG 10: 81,157,152 (GRCm39) probably benign Het
Casz1 T A 4: 149,036,202 (GRCm39) V1488E probably damaging Het
Ccdc175 C A 12: 72,182,815 (GRCm39) Q401H probably damaging Het
Cfap36 T C 11: 29,175,925 (GRCm39) Y191C probably benign Het
Chmp2b G A 16: 65,342,232 (GRCm39) Q119* probably null Het
Cps1 T A 1: 67,236,174 (GRCm39) I969N possibly damaging Het
Dennd5a A G 7: 109,500,366 (GRCm39) F920L probably damaging Het
Dnah12 A T 14: 26,594,277 (GRCm39) T3410S probably benign Het
Fbxo42 T G 4: 140,927,455 (GRCm39) S578R possibly damaging Het
Foxa3 A T 7: 18,748,794 (GRCm39) Y111N probably damaging Het
Gabbr2 T C 4: 46,846,340 (GRCm39) K190E probably benign Het
Gbp10 T C 5: 105,367,964 (GRCm39) Y403C possibly damaging Het
Hsd3b5 A G 3: 98,529,390 (GRCm39) I80T probably damaging Het
Kri1 T G 9: 21,197,883 (GRCm39) Q89P Het
Lrp6 G T 6: 134,427,781 (GRCm39) P1604T probably damaging Het
Metap1 T C 3: 138,171,898 (GRCm39) probably null Het
Mkrn3 C T 7: 62,069,530 (GRCm39) R87H probably benign Het
Ms4a6d G A 19: 11,567,437 (GRCm39) Q155* probably null Het
Myh6 T C 14: 55,199,025 (GRCm39) probably null Het
Naip6 G T 13: 100,452,527 (GRCm39) P178Q probably damaging Het
Ncapg2 A G 12: 116,378,454 (GRCm39) E160G probably damaging Het
Nek6 G A 2: 38,450,977 (GRCm39) A127T probably damaging Het
Nell1 T C 7: 49,929,297 (GRCm39) V264A probably benign Het
Nlrp2 T A 7: 5,330,627 (GRCm39) I590F possibly damaging Het
Or13j1 C T 4: 43,706,080 (GRCm39) A163T probably benign Het
Or2y17 G A 11: 49,231,875 (GRCm39) R172Q not run Het
Or4f57 A T 2: 111,790,956 (GRCm39) M154K probably benign Het
Or4f6 A G 2: 111,838,820 (GRCm39) L237P probably damaging Het
Or52n4b A C 7: 108,144,107 (GRCm39) D125A probably damaging Het
Otop3 T A 11: 115,237,204 (GRCm39) L556Q probably damaging Het
Padi1 T C 4: 140,556,545 (GRCm39) D190G probably null Het
Pald1 T C 10: 61,159,110 (GRCm39) S774G possibly damaging Het
Pde10a C T 17: 8,975,860 (GRCm39) T55I probably benign Het
Pla2g4d T C 2: 120,109,459 (GRCm39) M197V probably benign Het
Prom1 C A 5: 44,258,995 (GRCm39) probably benign Het
Ptdss1 A G 13: 67,111,426 (GRCm39) H164R possibly damaging Het
Rrh A T 3: 129,604,262 (GRCm39) I313N probably damaging Het
Slc35b4 A G 6: 34,144,591 (GRCm39) I88T probably damaging Het
Slc38a11 C T 2: 65,156,914 (GRCm39) V353I probably benign Het
Spata31e3 A T 13: 50,401,204 (GRCm39) I374N possibly damaging Het
Spdef T A 17: 27,939,219 (GRCm39) E42D probably benign Het
Tgoln1 G C 6: 72,593,261 (GRCm39) T73R probably benign Het
Tmx1 A G 12: 70,505,624 (GRCm39) D129G probably benign Het
Trav13n-4 A T 14: 53,601,435 (GRCm39) Y68F probably benign Het
Trp53 T C 11: 69,480,015 (GRCm39) S238P probably damaging Het
Trp53bp1 T C 2: 121,066,950 (GRCm39) D592G probably benign Het
Ttll5 T C 12: 85,904,238 (GRCm39) probably null Het
Urb1 CACTTAC CAC 16: 90,569,461 (GRCm39) probably benign Het
Vmn2r43 A T 7: 8,258,306 (GRCm39) Y302* probably null Het
Vps13d C T 4: 144,847,938 (GRCm39) V2478I Het
Vps35l A T 7: 118,409,194 (GRCm39) I612F probably damaging Het
Wsb1 A G 11: 79,131,184 (GRCm39) V404A probably damaging Het
Zfc3h1 A G 10: 115,239,205 (GRCm39) D539G probably damaging Het
Zfp318 T C 17: 46,722,173 (GRCm39) V1392A probably damaging Het
Other mutations in Fcgr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01490:Fcgr1 APN 3 96,191,686 (GRCm39) missense probably benign 0.01
IGL02142:Fcgr1 APN 3 96,191,893 (GRCm39) missense probably benign 0.41
IGL03086:Fcgr1 APN 3 96,191,814 (GRCm39) nonsense probably null
F5770:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
FR4737:Fcgr1 UTSW 3 96,194,410 (GRCm39) missense probably benign 0.01
FR4737:Fcgr1 UTSW 3 96,191,820 (GRCm39) frame shift probably null
R0323:Fcgr1 UTSW 3 96,193,145 (GRCm39) missense possibly damaging 0.84
R0594:Fcgr1 UTSW 3 96,199,628 (GRCm39) missense probably damaging 1.00
R0926:Fcgr1 UTSW 3 96,199,682 (GRCm39) missense possibly damaging 0.79
R1951:Fcgr1 UTSW 3 96,194,386 (GRCm39) missense probably damaging 1.00
R1953:Fcgr1 UTSW 3 96,194,386 (GRCm39) missense probably damaging 1.00
R1993:Fcgr1 UTSW 3 96,193,184 (GRCm39) missense probably damaging 0.98
R2255:Fcgr1 UTSW 3 96,193,233 (GRCm39) missense possibly damaging 0.88
R3941:Fcgr1 UTSW 3 96,193,349 (GRCm39) missense probably benign 0.13
R4004:Fcgr1 UTSW 3 96,191,668 (GRCm39) missense probably benign 0.00
R4409:Fcgr1 UTSW 3 96,191,893 (GRCm39) missense probably benign 0.41
R5046:Fcgr1 UTSW 3 96,194,302 (GRCm39) missense probably damaging 0.99
R5047:Fcgr1 UTSW 3 96,193,200 (GRCm39) missense probably benign 0.38
R6970:Fcgr1 UTSW 3 96,191,936 (GRCm39) critical splice acceptor site probably null
R7992:Fcgr1 UTSW 3 96,191,897 (GRCm39) missense probably benign 0.23
R8554:Fcgr1 UTSW 3 96,199,788 (GRCm39) missense probably damaging 1.00
R9269:Fcgr1 UTSW 3 96,193,154 (GRCm39) missense probably benign 0.01
R9396:Fcgr1 UTSW 3 96,194,390 (GRCm39) nonsense probably null
V7581:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
V7582:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
V7583:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
X0028:Fcgr1 UTSW 3 96,193,343 (GRCm39) missense probably benign 0.29
Predicted Primers
Posted On 2019-09-13