Incidental Mutation 'R7340:Apc2'
| ID |
569783 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
045430-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R7340 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 80149316 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 1457
(K1457E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100996
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020341]
[ENSMUST00000020349]
[ENSMUST00000105359]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020341
|
| SMART Domains |
Protein: ENSMUSP00000020341
Gene: ENSMUSG00000020133
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UPF0449
|
6 |
103 |
7.5e-40 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000020349
AA Change: K1428E
PolyPhen 2
Score 0.565 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: K1428E
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105359
AA Change: K1457E
PolyPhen 2
Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: K1457E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (83/84) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
C |
T |
2: 69,130,211 (GRCm39) |
D282N |
probably damaging |
Het |
| Adam30 |
A |
T |
3: 98,069,637 (GRCm39) |
N490I |
probably benign |
Het |
| Ankrd55 |
A |
T |
13: 112,492,497 (GRCm39) |
I223F |
probably damaging |
Het |
| Ano8 |
T |
A |
8: 71,935,655 (GRCm39) |
E321V |
probably damaging |
Het |
| Asb15 |
T |
A |
6: 24,558,513 (GRCm39) |
V38E |
probably benign |
Het |
| Atp4a |
T |
C |
7: 30,416,155 (GRCm39) |
S417P |
possibly damaging |
Het |
| AY358078 |
A |
G |
14: 52,063,716 (GRCm39) |
N454S |
probably damaging |
Het |
| Cables2 |
A |
G |
2: 179,903,450 (GRCm39) |
Y245H |
|
Het |
| Cactin |
CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG |
CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG |
10: 81,157,152 (GRCm39) |
|
probably benign |
Het |
| Camsap3 |
G |
A |
8: 3,637,960 (GRCm39) |
|
probably null |
Het |
| Ccdc178 |
A |
T |
18: 22,150,518 (GRCm39) |
V705E |
probably benign |
Het |
| Ccdc47 |
T |
C |
11: 106,091,799 (GRCm39) |
Q472R |
possibly damaging |
Het |
| Ccdc62 |
A |
G |
5: 124,089,283 (GRCm39) |
D307G |
probably damaging |
Het |
| Cdcp3 |
A |
G |
7: 130,879,344 (GRCm39) |
T1788A |
unknown |
Het |
| Cdh23 |
A |
G |
10: 60,366,775 (GRCm39) |
I235T |
probably benign |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Cfap65 |
T |
C |
1: 74,960,742 (GRCm39) |
N743D |
probably benign |
Het |
| Cimap1b |
T |
A |
15: 89,262,610 (GRCm39) |
T116S |
probably benign |
Het |
| Clec16a |
A |
G |
16: 10,398,827 (GRCm39) |
N329S |
probably null |
Het |
| Col25a1 |
A |
G |
3: 130,340,006 (GRCm39) |
|
probably null |
Het |
| Daam1 |
T |
G |
12: 72,035,713 (GRCm39) |
D969E |
probably benign |
Het |
| Dntt |
A |
C |
19: 41,047,004 (GRCm39) |
|
probably null |
Het |
| Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
| Dst |
T |
A |
1: 34,229,810 (GRCm39) |
Y2468N |
probably benign |
Het |
| Exosc9 |
A |
G |
3: 36,615,297 (GRCm39) |
T262A |
possibly damaging |
Het |
| Exph5 |
G |
A |
9: 53,288,309 (GRCm39) |
A1797T |
probably damaging |
Het |
| Fbp2 |
A |
T |
13: 62,985,061 (GRCm39) |
Y287N |
probably damaging |
Het |
| Fmn2 |
CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC |
CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC |
1: 174,436,769 (GRCm39) |
|
probably benign |
Het |
| Fus |
T |
A |
7: 127,581,123 (GRCm39) |
|
probably null |
Het |
| Galnt9 |
T |
A |
5: 110,762,054 (GRCm39) |
N397K |
probably damaging |
Het |
| Gdi1 |
G |
A |
X: 73,350,461 (GRCm39) |
R55H |
probably benign |
Het |
| Gga1 |
A |
G |
15: 78,775,651 (GRCm39) |
T369A |
probably benign |
Het |
| Gp1ba |
T |
C |
11: 70,531,119 (GRCm39) |
I295T |
unknown |
Het |
| Hk2 |
T |
C |
6: 82,705,873 (GRCm39) |
E810G |
probably benign |
Het |
| Igsf10 |
A |
G |
3: 59,233,189 (GRCm39) |
V1848A |
probably damaging |
Het |
| Insrr |
G |
A |
3: 87,721,623 (GRCm39) |
|
probably null |
Het |
| Ip6k3 |
T |
A |
17: 27,367,504 (GRCm39) |
M231L |
probably benign |
Het |
| Itgb8 |
T |
C |
12: 119,155,939 (GRCm39) |
N171S |
probably benign |
Het |
| Ldlrad3 |
T |
C |
2: 101,897,184 (GRCm39) |
|
probably null |
Het |
| Ltbp1 |
T |
A |
17: 75,634,223 (GRCm39) |
C886* |
probably null |
Het |
| Mettl13 |
T |
C |
1: 162,366,547 (GRCm39) |
D444G |
probably benign |
Het |
| Mns1 |
A |
G |
9: 72,356,025 (GRCm39) |
Y224C |
probably damaging |
Het |
| Mri1 |
C |
T |
8: 84,983,525 (GRCm39) |
R122Q |
probably benign |
Het |
| Ms4a6d |
G |
A |
19: 11,567,437 (GRCm39) |
Q155* |
probably null |
Het |
| Myo5c |
A |
C |
9: 75,196,423 (GRCm39) |
K1290Q |
probably benign |
Het |
| Nlrp12 |
T |
G |
7: 3,281,755 (GRCm39) |
Q842H |
possibly damaging |
Het |
| Oga |
G |
A |
19: 45,755,895 (GRCm39) |
Q583* |
probably null |
Het |
| Or14c44 |
T |
C |
7: 86,061,957 (GRCm39) |
L129P |
possibly damaging |
Het |
| Or14j8 |
T |
A |
17: 38,263,413 (GRCm39) |
R167S |
probably benign |
Het |
| Or2t1 |
A |
T |
14: 14,328,401 (GRCm38) |
T97S |
possibly damaging |
Het |
| Or5d39 |
T |
C |
2: 87,979,620 (GRCm39) |
T248A |
possibly damaging |
Het |
| Otoa |
A |
G |
7: 120,729,288 (GRCm39) |
T554A |
probably benign |
Het |
| Per1 |
A |
G |
11: 68,994,008 (GRCm39) |
D438G |
probably damaging |
Het |
| Phactr3 |
G |
A |
2: 177,975,854 (GRCm39) |
R533H |
probably damaging |
Het |
| Phykpl |
T |
C |
11: 51,490,370 (GRCm39) |
F417S |
probably damaging |
Het |
| Pole |
A |
T |
5: 110,482,330 (GRCm39) |
T2057S |
probably benign |
Het |
| Polq |
A |
G |
16: 36,881,288 (GRCm39) |
T1151A |
probably benign |
Het |
| Polr1g |
T |
C |
7: 19,093,073 (GRCm39) |
T36A |
probably benign |
Het |
| Rbm26 |
A |
T |
14: 105,389,976 (GRCm39) |
V216E |
possibly damaging |
Het |
| Ryk |
T |
C |
9: 102,775,737 (GRCm39) |
I449T |
probably damaging |
Het |
| Sap25 |
A |
G |
5: 137,640,935 (GRCm39) |
T225A |
probably benign |
Het |
| Sart3 |
A |
G |
5: 113,882,728 (GRCm39) |
M864T |
probably benign |
Het |
| Sec31b |
T |
C |
19: 44,517,161 (GRCm39) |
S280G |
probably benign |
Het |
| Sema4d |
A |
T |
13: 51,877,598 (GRCm39) |
I78N |
probably damaging |
Het |
| Sgip1 |
G |
C |
4: 102,778,661 (GRCm39) |
R419S |
unknown |
Het |
| Slc13a3 |
T |
C |
2: 165,272,210 (GRCm39) |
I278V |
probably benign |
Het |
| Slc2a5 |
A |
G |
4: 150,224,439 (GRCm39) |
D312G |
probably benign |
Het |
| Slc39a2 |
A |
T |
14: 52,131,660 (GRCm39) |
Q77L |
possibly damaging |
Het |
| Srbd1 |
A |
T |
17: 86,443,782 (GRCm39) |
V148E |
probably benign |
Het |
| Syngr2 |
A |
G |
11: 117,703,322 (GRCm39) |
E46G |
probably damaging |
Het |
| Taok1 |
A |
G |
11: 77,470,643 (GRCm39) |
V54A |
possibly damaging |
Het |
| Tas2r106 |
T |
A |
6: 131,655,185 (GRCm39) |
H222L |
probably damaging |
Het |
| Tcaf3 |
A |
G |
6: 42,566,848 (GRCm39) |
I747T |
probably benign |
Het |
| Tmem151b |
G |
T |
17: 45,856,195 (GRCm39) |
P415Q |
probably benign |
Het |
| Tmf1 |
T |
C |
6: 97,145,061 (GRCm39) |
D659G |
possibly damaging |
Het |
| Tnn |
G |
T |
1: 159,973,592 (GRCm39) |
D258E |
probably damaging |
Het |
| Traj33 |
A |
G |
14: 54,422,862 (GRCm39) |
I16V |
unknown |
Het |
| Ttll13 |
G |
T |
7: 79,906,772 (GRCm39) |
C480F |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,714,415 (GRCm39) |
N8137S |
unknown |
Het |
| Vmn1r85 |
T |
C |
7: 12,819,073 (GRCm39) |
N24D |
probably damaging |
Het |
| Wdr81 |
T |
C |
11: 75,335,525 (GRCm39) |
Q649R |
probably null |
Het |
| Zan |
T |
C |
5: 137,382,092 (GRCm39) |
T5152A |
unknown |
Het |
| Zc3h6 |
A |
G |
2: 128,835,110 (GRCm39) |
D82G |
possibly damaging |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0501:Apc2
|
UTSW |
10 |
80,150,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1915:Apc2
|
UTSW |
10 |
80,151,701 (GRCm39) |
missense |
probably benign |
|
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Apc2
|
UTSW |
10 |
80,150,196 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4886:Apc2
|
UTSW |
10 |
80,150,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7384:Apc2
|
UTSW |
10 |
80,148,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7743:Apc2
|
UTSW |
10 |
80,140,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTACATGTTAGTGCCCG -3'
(R):5'- AAGCAGTACACAGCTTCCTC -3'
Sequencing Primer
(F):5'- GCTCGGGGTGATGACTCG -3'
(R):5'- ACAGCTTCCTCTGTGGGTG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation