Incidental Mutation 'R7341:Lrp6'
| ID |
569858 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp6
|
| Ensembl Gene |
ENSMUSG00000030201 |
| Gene Name |
low density lipoprotein receptor-related protein 6 |
| Synonyms |
ska, Cd, skax26, ska26 |
| MMRRC Submission |
045431-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.965)
|
| Stock # |
R7341 (G1)
|
| Quality Score |
164.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
134423439-134543876 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 134427781 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Threonine
at position 1604
(P1604T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032322]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032322
AA Change: P1604T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000032322
Gene: ENSMUSG00000030201
AA Change: P1604T
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
43 |
85 |
1.55e-2 |
SMART |
|
LY
|
87 |
129 |
1.91e-11 |
SMART |
|
LY
|
130 |
173 |
5.19e-13 |
SMART |
|
LY
|
174 |
216 |
1.39e-13 |
SMART |
|
LY
|
217 |
258 |
2.87e-6 |
SMART |
|
EGF
|
285 |
324 |
2.16e-1 |
SMART |
|
low complexity region
|
330 |
341 |
N/A |
INTRINSIC |
|
LY
|
352 |
394 |
1.29e-8 |
SMART |
|
LY
|
395 |
437 |
5.73e-15 |
SMART |
|
LY
|
438 |
481 |
1.07e-14 |
SMART |
|
LY
|
482 |
524 |
3.07e-15 |
SMART |
|
LY
|
525 |
565 |
4.66e-6 |
SMART |
|
EGF
|
591 |
628 |
1.47e-3 |
SMART |
|
LY
|
654 |
696 |
2.06e-7 |
SMART |
|
LY
|
697 |
739 |
3.73e-14 |
SMART |
|
LY
|
740 |
783 |
3.37e-12 |
SMART |
|
LY
|
784 |
825 |
1.17e-6 |
SMART |
|
LY
|
827 |
865 |
1.91e-2 |
SMART |
|
EGF
|
892 |
930 |
7.35e-4 |
SMART |
|
LY
|
957 |
999 |
1.41e-5 |
SMART |
|
LY
|
1005 |
1048 |
5.32e-1 |
SMART |
|
LY
|
1049 |
1093 |
5e-6 |
SMART |
|
LY
|
1094 |
1136 |
4.25e-9 |
SMART |
|
LY
|
1137 |
1177 |
1.91e-2 |
SMART |
|
EGF
|
1206 |
1250 |
1.23e1 |
SMART |
|
LDLa
|
1248 |
1287 |
2.42e-12 |
SMART |
|
LDLa
|
1288 |
1324 |
4.37e-10 |
SMART |
|
LDLa
|
1325 |
1362 |
1.66e-10 |
SMART |
|
transmembrane domain
|
1371 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1429 |
1438 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1457 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1524 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1573 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1608 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1468 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (92/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
PHENOTYPE: Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
C |
T |
2: 69,130,211 (GRCm39) |
D282N |
probably damaging |
Het |
| Adam3 |
T |
A |
8: 25,177,996 (GRCm39) |
N639I |
possibly damaging |
Het |
| Adamtsl3 |
T |
A |
7: 82,206,082 (GRCm39) |
C756S |
probably damaging |
Het |
| Arhgap31 |
C |
T |
16: 38,532,876 (GRCm39) |
|
probably null |
Het |
| Ascl4 |
G |
A |
10: 85,764,529 (GRCm39) |
A59T |
possibly damaging |
Het |
| Ash1l |
T |
A |
3: 88,889,066 (GRCm39) |
I315N |
possibly damaging |
Het |
| Atp6v0d2 |
T |
C |
4: 19,887,330 (GRCm39) |
D206G |
possibly damaging |
Het |
| Baz1b |
T |
A |
5: 135,251,970 (GRCm39) |
L923I |
probably damaging |
Het |
| Birc6 |
T |
A |
17: 74,919,069 (GRCm39) |
N1966K |
probably damaging |
Het |
| Bod1l |
T |
C |
5: 41,946,200 (GRCm39) |
N3025S |
probably benign |
Het |
| Bub1b |
C |
A |
2: 118,467,267 (GRCm39) |
H863Q |
possibly damaging |
Het |
| C1rb |
T |
A |
6: 124,554,411 (GRCm39) |
Y397* |
probably null |
Het |
| Ccdc180 |
A |
G |
4: 45,898,644 (GRCm39) |
E164G |
possibly damaging |
Het |
| Ccdc9 |
C |
T |
7: 16,014,552 (GRCm39) |
V230M |
probably damaging |
Het |
| Cchcr1 |
C |
A |
17: 35,837,610 (GRCm39) |
N437K |
probably benign |
Het |
| Cdhr2 |
T |
A |
13: 54,867,305 (GRCm39) |
L408Q |
probably damaging |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Chd1 |
T |
C |
17: 15,990,499 (GRCm39) |
S1684P |
probably damaging |
Het |
| CN725425 |
A |
G |
15: 91,126,873 (GRCm39) |
Y221C |
possibly damaging |
Het |
| Col4a2 |
T |
C |
8: 11,448,678 (GRCm39) |
V66A |
probably damaging |
Het |
| Cpd |
C |
A |
11: 76,737,779 (GRCm39) |
R5L |
unknown |
Het |
| Cpeb4 |
C |
T |
11: 31,868,807 (GRCm39) |
T422I |
possibly damaging |
Het |
| Cspg4b |
G |
T |
13: 113,454,706 (GRCm39) |
G251C |
|
Het |
| Cyp1a1 |
G |
T |
9: 57,608,107 (GRCm39) |
R245L |
probably damaging |
Het |
| Cyp4f39 |
A |
G |
17: 32,705,928 (GRCm39) |
T340A |
probably damaging |
Het |
| Cyp4v3 |
A |
T |
8: 45,774,787 (GRCm39) |
F122L |
probably benign |
Het |
| Drc1 |
T |
A |
5: 30,521,812 (GRCm39) |
L728Q |
probably damaging |
Het |
| Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
| Ecpas |
A |
T |
4: 58,809,415 (GRCm39) |
V1653D |
possibly damaging |
Het |
| Ermp1 |
T |
A |
19: 29,623,654 (GRCm39) |
H112L |
probably benign |
Het |
| Exoc8 |
T |
C |
8: 125,623,320 (GRCm39) |
D349G |
probably damaging |
Het |
| Fam151a |
T |
A |
4: 106,592,707 (GRCm39) |
M63K |
probably benign |
Het |
| Fmo9 |
C |
A |
1: 166,504,115 (GRCm39) |
G149V |
probably damaging |
Het |
| Fndc8 |
A |
G |
11: 82,789,603 (GRCm39) |
T254A |
possibly damaging |
Het |
| Foxi3 |
G |
A |
6: 70,937,862 (GRCm39) |
V365I |
probably benign |
Het |
| Frem2 |
C |
T |
3: 53,561,916 (GRCm39) |
G864S |
probably damaging |
Het |
| Fstl5 |
T |
A |
3: 76,389,704 (GRCm39) |
|
probably null |
Het |
| Garnl3 |
T |
A |
2: 32,924,141 (GRCm39) |
E247V |
probably damaging |
Het |
| Gdi1 |
G |
A |
X: 73,350,461 (GRCm39) |
R55H |
probably benign |
Het |
| Gorasp1 |
T |
A |
9: 119,766,600 (GRCm39) |
|
probably benign |
Het |
| Hcar2 |
T |
C |
5: 124,002,541 (GRCm39) |
N321D |
possibly damaging |
Het |
| Hoxb6 |
G |
T |
11: 96,190,395 (GRCm39) |
M131I |
probably damaging |
Het |
| Kif13a |
A |
G |
13: 46,980,221 (GRCm39) |
V177A |
probably damaging |
Het |
| Limch1 |
C |
T |
5: 67,191,545 (GRCm39) |
T794I |
probably benign |
Het |
| Lmbrd2 |
A |
G |
15: 9,165,906 (GRCm39) |
Y260C |
possibly damaging |
Het |
| Lmo7 |
A |
G |
14: 102,122,948 (GRCm39) |
N379S |
probably benign |
Het |
| Lrrc14 |
A |
T |
15: 76,598,711 (GRCm39) |
E449V |
probably damaging |
Het |
| Lrrc8c |
T |
C |
5: 105,755,133 (GRCm39) |
Y303H |
probably damaging |
Het |
| Mecr |
T |
G |
4: 131,570,986 (GRCm39) |
V58G |
probably null |
Het |
| Med12l |
T |
A |
3: 58,949,824 (GRCm39) |
D193E |
possibly damaging |
Het |
| Moap1 |
T |
C |
12: 102,709,438 (GRCm39) |
E37G |
probably damaging |
Het |
| Mrgprb2 |
T |
A |
7: 48,202,644 (GRCm39) |
Y27F |
probably benign |
Het |
| Ms4a6d |
G |
A |
19: 11,567,437 (GRCm39) |
Q155* |
probably null |
Het |
| Ndufs5 |
A |
T |
4: 123,609,744 (GRCm39) |
C43* |
probably null |
Het |
| Oaz2 |
A |
T |
9: 65,596,183 (GRCm39) |
D83V |
|
Het |
| Or2t29 |
A |
T |
11: 58,433,533 (GRCm39) |
Y269* |
probably null |
Het |
| Or5ac22 |
T |
A |
16: 59,135,512 (GRCm39) |
N86I |
possibly damaging |
Het |
| Palm |
A |
G |
10: 79,652,697 (GRCm39) |
T191A |
probably damaging |
Het |
| Pclo |
C |
A |
5: 14,725,850 (GRCm39) |
D1569E |
unknown |
Het |
| Ppid |
T |
A |
3: 79,507,604 (GRCm39) |
D264E |
probably benign |
Het |
| Ppp1r3a |
A |
G |
6: 14,718,749 (GRCm39) |
S722P |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,321,619 (GRCm39) |
S2639G |
possibly damaging |
Het |
| Rbak |
T |
C |
5: 143,161,827 (GRCm39) |
T68A |
probably benign |
Het |
| Rbm15b |
C |
T |
9: 106,762,246 (GRCm39) |
G641R |
probably benign |
Het |
| Rgsl1 |
A |
G |
1: 153,669,591 (GRCm39) |
I265T |
probably benign |
Het |
| Rmdn1 |
T |
A |
4: 19,586,837 (GRCm39) |
Y98* |
probably null |
Het |
| Sfxn3 |
T |
G |
19: 45,037,701 (GRCm39) |
N52K |
probably benign |
Het |
| Slc17a3 |
G |
T |
13: 24,030,867 (GRCm39) |
G182* |
probably null |
Het |
| Slc29a3 |
A |
T |
10: 60,586,437 (GRCm39) |
Y10N |
probably benign |
Het |
| Slc43a1 |
T |
C |
2: 84,693,278 (GRCm39) |
Y577H |
probably damaging |
Het |
| Smarcd3 |
T |
A |
5: 24,800,435 (GRCm39) |
I210F |
possibly damaging |
Het |
| Snapc4 |
A |
T |
2: 26,259,273 (GRCm39) |
S626T |
probably benign |
Het |
| Sp5 |
T |
A |
2: 70,307,041 (GRCm39) |
L242* |
probably null |
Het |
| Spata25 |
C |
G |
2: 164,669,582 (GRCm39) |
G143A |
probably damaging |
Het |
| Spata6 |
T |
A |
4: 111,625,935 (GRCm39) |
Y101* |
probably null |
Het |
| Tdp2 |
T |
G |
13: 25,016,059 (GRCm39) |
S89A |
probably benign |
Het |
| Tlr6 |
T |
C |
5: 65,110,972 (GRCm39) |
E645G |
probably benign |
Het |
| Tmem209 |
T |
C |
6: 30,494,794 (GRCm39) |
I355V |
probably benign |
Het |
| Trappc8 |
A |
T |
18: 20,985,704 (GRCm39) |
Y646N |
probably damaging |
Het |
| Tspoap1 |
A |
G |
11: 87,657,205 (GRCm39) |
N399S |
probably damaging |
Het |
| Ube4b |
A |
G |
4: 149,427,458 (GRCm39) |
Y897H |
probably damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,569,461 (GRCm39) |
|
probably benign |
Het |
| Usp9y |
A |
T |
Y: 1,315,759 (GRCm39) |
|
probably null |
Het |
| Vmn2r1 |
T |
C |
3: 64,012,877 (GRCm39) |
*913Q |
probably null |
Het |
| Vmn2r12 |
T |
A |
5: 109,234,113 (GRCm39) |
T700S |
possibly damaging |
Het |
| Vmn2r12 |
C |
T |
5: 109,239,811 (GRCm39) |
A251T |
possibly damaging |
Het |
| Wdr70 |
A |
C |
15: 7,953,725 (GRCm39) |
F389V |
possibly damaging |
Het |
| Wdr91 |
A |
T |
6: 34,868,395 (GRCm39) |
M442K |
possibly damaging |
Het |
| Ydjc |
T |
C |
16: 16,968,762 (GRCm39) |
C234R |
probably benign |
Het |
| Zfp87 |
A |
G |
13: 74,520,467 (GRCm39) |
Y204H |
possibly damaging |
Het |
|
| Other mutations in Lrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Lrp6
|
APN |
6 |
134,433,053 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL00765:Lrp6
|
APN |
6 |
134,518,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00898:Lrp6
|
APN |
6 |
134,456,702 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00916:Lrp6
|
APN |
6 |
134,461,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Lrp6
|
APN |
6 |
134,484,609 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01620:Lrp6
|
APN |
6 |
134,488,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01765:Lrp6
|
APN |
6 |
134,433,108 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02066:Lrp6
|
APN |
6 |
134,427,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Lrp6
|
APN |
6 |
134,457,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02169:Lrp6
|
APN |
6 |
134,490,290 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02281:Lrp6
|
APN |
6 |
134,434,697 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02484:Lrp6
|
APN |
6 |
134,518,886 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02724:Lrp6
|
APN |
6 |
134,461,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Lrp6
|
APN |
6 |
134,433,077 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03011:Lrp6
|
APN |
6 |
134,497,380 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03352:Lrp6
|
APN |
6 |
134,456,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Aileron
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Cielo
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
Coiled
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
flap
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
soar
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Swoop
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Upswing
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Wingman
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4494001:Lrp6
|
UTSW |
6 |
134,456,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0201:Lrp6
|
UTSW |
6 |
134,427,860 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Lrp6
|
UTSW |
6 |
134,434,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0370:Lrp6
|
UTSW |
6 |
134,456,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Lrp6
|
UTSW |
6 |
134,444,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Lrp6
|
UTSW |
6 |
134,484,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0468:Lrp6
|
UTSW |
6 |
134,462,624 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0492:Lrp6
|
UTSW |
6 |
134,457,481 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0584:Lrp6
|
UTSW |
6 |
134,433,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0631:Lrp6
|
UTSW |
6 |
134,456,738 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0738:Lrp6
|
UTSW |
6 |
134,519,008 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0907:Lrp6
|
UTSW |
6 |
134,484,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1273:Lrp6
|
UTSW |
6 |
134,444,470 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Lrp6
|
UTSW |
6 |
134,436,392 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1639:Lrp6
|
UTSW |
6 |
134,430,529 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1650:Lrp6
|
UTSW |
6 |
134,445,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1696:Lrp6
|
UTSW |
6 |
134,445,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Lrp6
|
UTSW |
6 |
134,441,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2013:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2015:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2165:Lrp6
|
UTSW |
6 |
134,436,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Lrp6
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2336:Lrp6
|
UTSW |
6 |
134,484,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2964:Lrp6
|
UTSW |
6 |
134,444,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Lrp6
|
UTSW |
6 |
134,484,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4370:Lrp6
|
UTSW |
6 |
134,483,321 (GRCm39) |
nonsense |
probably null |
|
|
R4521:Lrp6
|
UTSW |
6 |
134,462,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Lrp6
|
UTSW |
6 |
134,447,693 (GRCm39) |
nonsense |
probably null |
|
|
R4645:Lrp6
|
UTSW |
6 |
134,461,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Lrp6
|
UTSW |
6 |
134,488,230 (GRCm39) |
missense |
probably benign |
|
|
R4688:Lrp6
|
UTSW |
6 |
134,456,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4784:Lrp6
|
UTSW |
6 |
134,456,502 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5236:Lrp6
|
UTSW |
6 |
134,488,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Lrp6
|
UTSW |
6 |
134,436,259 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5508:Lrp6
|
UTSW |
6 |
134,441,479 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6001:Lrp6
|
UTSW |
6 |
134,441,481 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6319:Lrp6
|
UTSW |
6 |
134,518,798 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6537:Lrp6
|
UTSW |
6 |
134,457,458 (GRCm39) |
missense |
probably benign |
|
|
R6552:Lrp6
|
UTSW |
6 |
134,431,692 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6559:Lrp6
|
UTSW |
6 |
134,490,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Lrp6
|
UTSW |
6 |
134,518,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6585:Lrp6
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
R6700:Lrp6
|
UTSW |
6 |
134,456,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6724:Lrp6
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7159:Lrp6
|
UTSW |
6 |
134,484,514 (GRCm39) |
missense |
probably benign |
|
|
R7266:Lrp6
|
UTSW |
6 |
134,484,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7348:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7359:Lrp6
|
UTSW |
6 |
134,427,923 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7501:Lrp6
|
UTSW |
6 |
134,463,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Lrp6
|
UTSW |
6 |
134,484,471 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7652:Lrp6
|
UTSW |
6 |
134,488,208 (GRCm39) |
nonsense |
probably null |
|
|
R7771:Lrp6
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8717:Lrp6
|
UTSW |
6 |
134,434,711 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8726:Lrp6
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
R8792:Lrp6
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8812:Lrp6
|
UTSW |
6 |
134,433,141 (GRCm39) |
missense |
probably benign |
|
|
R8855:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8866:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8994:Lrp6
|
UTSW |
6 |
134,518,656 (GRCm39) |
missense |
probably benign |
|
|
R9021:Lrp6
|
UTSW |
6 |
134,518,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9089:Lrp6
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9154:Lrp6
|
UTSW |
6 |
134,518,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Lrp6
|
UTSW |
6 |
134,457,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Lrp6
|
UTSW |
6 |
134,483,259 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9545:Lrp6
|
UTSW |
6 |
134,483,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Lrp6
|
UTSW |
6 |
134,447,662 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9640:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lrp6
|
UTSW |
6 |
134,433,120 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1177:Lrp6
|
UTSW |
6 |
134,439,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTCTGTACAAATATCTCCAGCACC -3'
(R):5'- AGCACTGATGTCTGTGACAG -3'
Sequencing Primer
(F):5'- ACCCACCCACTTTATAATGTTAACTG -3'
(R):5'- GTGACAGTGACTATGCTCCTAGC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation