Incidental Mutation 'R7346:Kif26b'
ID 570177
Institutional Source Beutler Lab
Gene Symbol Kif26b
Ensembl Gene ENSMUSG00000026494
Gene Name kinesin family member 26B
Synonyms D230039L06Rik, N-11 kinesin
MMRRC Submission 045373-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7346 (G1)
Quality Score 189.009
Status Validated
Chromosome 1
Chromosomal Location 178356690-178766765 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 178358306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 139 (L139P)
Ref Sequence ENSEMBL: ENSMUSP00000124462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161017]
AlphaFold Q7TNC6
Predicted Effect probably damaging
Transcript: ENSMUST00000161017
AA Change: L139P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000124462
Gene: ENSMUSG00000026494
AA Change: L139P

DomainStartEndE-ValueType
low complexity region 58 123 N/A INTRINSIC
low complexity region 144 155 N/A INTRINSIC
low complexity region 220 228 N/A INTRINSIC
Blast:KISc 365 446 4e-8 BLAST
KISc 448 809 2.48e-42 SMART
low complexity region 810 822 N/A INTRINSIC
low complexity region 849 863 N/A INTRINSIC
low complexity region 907 913 N/A INTRINSIC
low complexity region 1007 1047 N/A INTRINSIC
low complexity region 1099 1109 N/A INTRINSIC
low complexity region 1269 1288 N/A INTRINSIC
low complexity region 1485 1495 N/A INTRINSIC
low complexity region 1741 1769 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.1%
Validation Efficiency 100% (71/71)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality with impaired kidney development due to loss of cortical nephrogenic zone mesenchyme and failure of ureteric buds to invade and branch into the mesenchyme. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik G A 9: 55,914,587 (GRCm39) P52S unknown Het
Adarb2 A G 13: 8,620,420 (GRCm39) E302G probably damaging Het
Adgrf5 T A 17: 43,762,070 (GRCm39) L1255H probably damaging Het
Adra1a T A 14: 66,875,733 (GRCm39) I236N probably benign Het
As3mt T C 19: 46,708,891 (GRCm39) F295S probably damaging Het
Bmp5 G A 9: 75,780,642 (GRCm39) R313Q probably damaging Het
Ccnj T A 19: 40,833,394 (GRCm39) S191T probably benign Het
Clk2 T A 3: 89,080,852 (GRCm39) probably null Het
Cpz T C 5: 35,675,000 (GRCm39) E83G probably damaging Het
Cts3 A G 13: 61,715,434 (GRCm39) I133T probably benign Het
Dars2 C T 1: 160,874,342 (GRCm39) probably null Het
Dsel A T 1: 111,788,798 (GRCm39) V579D probably damaging Het
Dync1h1 C A 12: 110,602,076 (GRCm39) A2038E probably damaging Het
Eaf1 A G 14: 31,216,777 (GRCm39) probably benign Het
Fsip2 A C 2: 82,828,524 (GRCm39) I6774L probably benign Het
Glis2 T C 16: 4,431,432 (GRCm39) F320L possibly damaging Het
Hcar1 A G 5: 124,017,693 (GRCm39) probably benign Het
Hectd1 A T 12: 51,797,104 (GRCm39) H2211Q probably benign Het
Hmcn1 A G 1: 150,559,496 (GRCm39) I2385T probably damaging Het
Ifi44 T A 3: 151,438,094 (GRCm39) M398L probably benign Het
Il16 C T 7: 83,293,249 (GRCm39) E1273K probably damaging Het
Inpp5j G A 11: 3,451,065 (GRCm39) T528I probably damaging Het
Kbtbd6 C T 14: 79,690,627 (GRCm39) P441S probably damaging Het
Kcnt1 C T 2: 25,753,855 (GRCm39) probably benign Het
Klb C T 5: 65,505,974 (GRCm39) Q74* probably null Het
L3mbtl1 G A 2: 162,808,926 (GRCm39) V600I probably benign Het
Lcp1 C T 14: 75,447,946 (GRCm39) A317V possibly damaging Het
Lipc C T 9: 70,720,029 (GRCm39) G326D probably damaging Het
Mbnl2 T A 14: 120,616,694 (GRCm39) F103I probably benign Het
Mdm1 G T 10: 118,000,193 (GRCm39) E609* probably null Het
Med16 A G 10: 79,744,650 (GRCm39) probably null Het
Mga T C 2: 119,766,008 (GRCm39) V1424A possibly damaging Het
Mocs2 G T 13: 114,964,710 (GRCm39) probably null Het
Morc1 C T 16: 48,451,263 (GRCm39) probably null Het
Mpc2 T A 1: 165,307,080 (GRCm39) W94R probably damaging Het
Mrm3 G A 11: 76,141,002 (GRCm39) V337I possibly damaging Het
N4bp3 T C 11: 51,536,433 (GRCm39) H133R probably benign Het
Ncam2 G T 16: 81,420,256 (GRCm39) G810V probably damaging Het
Nipbl T C 15: 8,373,090 (GRCm39) E1052G possibly damaging Het
Nlrp12 C T 7: 3,297,887 (GRCm39) V95M probably damaging Het
Nrip1 T C 16: 76,090,244 (GRCm39) N438D possibly damaging Het
Nsun4 C A 4: 115,909,035 (GRCm39) M508I probably benign Het
Pla2g2c T C 4: 138,461,650 (GRCm39) S40P probably damaging Het
Plec A G 15: 76,082,178 (GRCm39) probably null Het
Ppfia2 G T 10: 106,693,356 (GRCm39) M620I possibly damaging Het
Ppp6c A G 2: 39,116,229 (GRCm39) Y9H probably damaging Het
Prkd1 A T 12: 50,695,617 (GRCm39) I47N possibly damaging Het
Prr14l T C 5: 32,988,028 (GRCm39) D489G probably benign Het
Ptch2 T A 4: 116,971,849 (GRCm39) Y1124N probably benign Het
Ptpra T G 2: 130,395,320 (GRCm39) Y808D probably damaging Het
Rint1 T A 5: 24,020,651 (GRCm39) F558Y possibly damaging Het
Rnf215 T A 11: 4,089,792 (GRCm39) C268* probably null Het
Slc25a13 T C 6: 6,181,100 (GRCm39) E28G possibly damaging Het
Slc38a8 G T 8: 120,226,554 (GRCm39) Y78* probably null Het
Slc4a7 T C 14: 14,775,000 (GRCm38) M810T probably damaging Het
Slitrk1 A G 14: 109,150,591 (GRCm39) V40A possibly damaging Het
Sobp A T 10: 42,898,831 (GRCm39) S251R probably damaging Het
Spata31d1a G A 13: 59,851,015 (GRCm39) S371L probably benign Het
Tada2b T C 5: 36,634,180 (GRCm39) T133A possibly damaging Het
Tbc1d20 A G 2: 152,146,881 (GRCm39) D90G probably benign Het
Tek T A 4: 94,715,533 (GRCm39) I408K probably benign Het
Tgfb2 A G 1: 186,382,077 (GRCm39) F150S probably benign Het
Tmem63b T C 17: 45,977,517 (GRCm39) T370A probably benign Het
Tmem94 G T 11: 115,677,082 (GRCm39) R118L possibly damaging Het
Tspan17 C G 13: 54,940,434 (GRCm39) L34V probably benign Het
Vmn1r238 A T 18: 3,123,151 (GRCm39) Y88N probably damaging Het
Vmn1r85 A G 7: 12,818,964 (GRCm39) I60T probably damaging Het
Vmn2r96 T C 17: 18,803,029 (GRCm39) M313T probably benign Het
Zp3r G A 1: 130,511,217 (GRCm39) S387F probably benign Het
Other mutations in Kif26b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Kif26b APN 1 178,743,213 (GRCm39) missense probably damaging 1.00
IGL00425:Kif26b APN 1 178,743,866 (GRCm39) missense probably damaging 0.96
IGL00952:Kif26b APN 1 178,759,770 (GRCm39) missense probably damaging 1.00
IGL01100:Kif26b APN 1 178,744,809 (GRCm39) missense probably benign
IGL01347:Kif26b APN 1 178,698,240 (GRCm39) missense probably damaging 1.00
IGL01543:Kif26b APN 1 178,506,526 (GRCm39) missense probably benign 0.41
IGL01938:Kif26b APN 1 178,743,603 (GRCm39) missense probably damaging 0.99
IGL02100:Kif26b APN 1 178,743,512 (GRCm39) missense probably damaging 0.99
IGL02262:Kif26b APN 1 178,743,633 (GRCm39) missense probably benign 0.05
IGL02576:Kif26b APN 1 178,743,912 (GRCm39) missense probably benign
IGL02673:Kif26b APN 1 178,649,170 (GRCm39) missense probably damaging 1.00
IGL03078:Kif26b APN 1 178,698,291 (GRCm39) missense probably damaging 1.00
IGL03155:Kif26b APN 1 178,701,693 (GRCm39) missense probably damaging 1.00
IGL03157:Kif26b APN 1 178,743,930 (GRCm39) missense probably damaging 1.00
IGL03162:Kif26b APN 1 178,744,497 (GRCm39) missense probably benign
IGL03220:Kif26b APN 1 178,692,434 (GRCm39) missense probably damaging 1.00
IGL03299:Kif26b APN 1 178,649,125 (GRCm39) missense probably benign 0.09
IGL03368:Kif26b APN 1 178,743,773 (GRCm39) missense probably damaging 1.00
IGL03370:Kif26b APN 1 178,742,946 (GRCm39) missense probably benign 0.39
PIT4449001:Kif26b UTSW 1 178,745,651 (GRCm39) missense probably damaging 1.00
R0142:Kif26b UTSW 1 178,742,954 (GRCm39) missense probably damaging 1.00
R0621:Kif26b UTSW 1 178,743,218 (GRCm39) missense probably benign 0.02
R0987:Kif26b UTSW 1 178,649,185 (GRCm39) missense probably damaging 1.00
R1107:Kif26b UTSW 1 178,745,238 (GRCm39) missense probably benign 0.03
R1367:Kif26b UTSW 1 178,744,028 (GRCm39) missense probably damaging 1.00
R1386:Kif26b UTSW 1 178,743,209 (GRCm39) missense probably benign
R1619:Kif26b UTSW 1 178,744,043 (GRCm39) missense probably benign 0.00
R1664:Kif26b UTSW 1 178,759,704 (GRCm39) missense probably damaging 1.00
R2240:Kif26b UTSW 1 178,543,488 (GRCm39) missense probably benign 0.00
R2264:Kif26b UTSW 1 178,756,407 (GRCm39) critical splice acceptor site probably null
R2443:Kif26b UTSW 1 178,742,579 (GRCm39) missense probably damaging 0.99
R3023:Kif26b UTSW 1 178,692,433 (GRCm39) missense probably damaging 0.99
R3744:Kif26b UTSW 1 178,506,595 (GRCm39) missense probably benign 0.00
R3831:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3832:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3833:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3843:Kif26b UTSW 1 178,755,742 (GRCm39) missense probably damaging 1.00
R4108:Kif26b UTSW 1 178,744,530 (GRCm39) missense possibly damaging 0.88
R4181:Kif26b UTSW 1 178,742,991 (GRCm39) missense probably damaging 0.98
R4551:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4552:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4597:Kif26b UTSW 1 178,744,358 (GRCm39) missense probably damaging 1.00
R4599:Kif26b UTSW 1 178,358,024 (GRCm39) missense unknown
R4610:Kif26b UTSW 1 178,506,920 (GRCm39) missense probably damaging 1.00
R4746:Kif26b UTSW 1 178,701,546 (GRCm39) nonsense probably null
R4873:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R4875:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R5015:Kif26b UTSW 1 178,755,895 (GRCm39) missense probably damaging 0.99
R5060:Kif26b UTSW 1 178,358,195 (GRCm39) missense unknown
R5301:Kif26b UTSW 1 178,358,233 (GRCm39) missense unknown
R5368:Kif26b UTSW 1 178,743,449 (GRCm39) missense probably damaging 1.00
R5387:Kif26b UTSW 1 178,742,441 (GRCm39) missense probably benign 0.01
R5589:Kif26b UTSW 1 178,743,864 (GRCm39) missense probably benign 0.05
R6150:Kif26b UTSW 1 178,743,111 (GRCm39) missense probably damaging 1.00
R6259:Kif26b UTSW 1 178,744,970 (GRCm39) missense probably damaging 0.97
R6355:Kif26b UTSW 1 178,743,743 (GRCm39) missense probably damaging 1.00
R6408:Kif26b UTSW 1 178,745,133 (GRCm39) missense probably damaging 1.00
R6488:Kif26b UTSW 1 178,357,138 (GRCm39) missense unknown
R6546:Kif26b UTSW 1 178,755,871 (GRCm39) missense probably damaging 1.00
R6702:Kif26b UTSW 1 178,744,852 (GRCm39) missense possibly damaging 0.90
R6886:Kif26b UTSW 1 178,701,703 (GRCm39) missense probably damaging 1.00
R6953:Kif26b UTSW 1 178,701,637 (GRCm39) missense possibly damaging 0.89
R7262:Kif26b UTSW 1 178,745,219 (GRCm39) missense possibly damaging 0.84
R7291:Kif26b UTSW 1 178,506,611 (GRCm39) missense possibly damaging 0.86
R7383:Kif26b UTSW 1 178,358,275 (GRCm39) missense probably damaging 1.00
R7448:Kif26b UTSW 1 178,742,339 (GRCm39) missense probably damaging 1.00
R7506:Kif26b UTSW 1 178,357,064 (GRCm39) start gained probably benign
R7562:Kif26b UTSW 1 178,742,541 (GRCm39) missense probably damaging 1.00
R7583:Kif26b UTSW 1 178,358,010 (GRCm39) nonsense probably null
R7585:Kif26b UTSW 1 178,744,061 (GRCm39) missense probably benign 0.01
R7644:Kif26b UTSW 1 178,506,839 (GRCm39) missense probably benign 0.04
R7759:Kif26b UTSW 1 178,506,509 (GRCm39) missense probably damaging 1.00
R7775:Kif26b UTSW 1 178,692,441 (GRCm39) missense probably benign 0.15
R7954:Kif26b UTSW 1 178,696,944 (GRCm39) missense probably damaging 0.99
R7960:Kif26b UTSW 1 178,506,484 (GRCm39) missense probably damaging 1.00
R8012:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
R8152:Kif26b UTSW 1 178,506,794 (GRCm39) missense possibly damaging 0.46
R8320:Kif26b UTSW 1 178,711,641 (GRCm39) critical splice donor site probably null
R8360:Kif26b UTSW 1 178,743,938 (GRCm39) missense probably benign 0.18
R8428:Kif26b UTSW 1 178,744,923 (GRCm39) missense probably benign 0.09
R8670:Kif26b UTSW 1 178,741,349 (GRCm39) missense probably damaging 1.00
R8737:Kif26b UTSW 1 178,692,430 (GRCm39) missense probably damaging 0.99
R8788:Kif26b UTSW 1 178,357,090 (GRCm39) start gained probably benign
R8854:Kif26b UTSW 1 178,743,948 (GRCm39) missense possibly damaging 0.93
R8870:Kif26b UTSW 1 178,692,594 (GRCm39) missense probably damaging 1.00
R8963:Kif26b UTSW 1 178,743,714 (GRCm39) missense probably benign 0.00
R9232:Kif26b UTSW 1 178,742,511 (GRCm39) missense probably damaging 1.00
R9297:Kif26b UTSW 1 178,543,374 (GRCm39) nonsense probably null
R9338:Kif26b UTSW 1 178,744,058 (GRCm39) missense probably damaging 1.00
R9572:Kif26b UTSW 1 178,745,042 (GRCm39) missense probably benign
R9580:Kif26b UTSW 1 178,506,643 (GRCm39) nonsense probably null
R9694:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
X0021:Kif26b UTSW 1 178,755,724 (GRCm39) missense probably damaging 1.00
X0024:Kif26b UTSW 1 178,506,647 (GRCm39) missense probably benign 0.14
X0025:Kif26b UTSW 1 178,742,948 (GRCm39) missense possibly damaging 0.70
X0025:Kif26b UTSW 1 178,742,831 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,742,970 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,115 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,113 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- AAATGTGCTCGCCCACCAAG -3'
(R):5'- GGAGAACCTGTATGGCTAACCC -3'

Sequencing Primer
(F):5'- TCTCCTGAGAGCTGGTACC -3'
(R):5'- AGGCAGCATCCTAAGGT -3'
Posted On 2019-09-13