Incidental Mutation 'R7351:Rnf145'
ID 570588
Institutional Source Beutler Lab
Gene Symbol Rnf145
Ensembl Gene ENSMUSG00000019189
Gene Name ring finger protein 145
Synonyms 3732413I11Rik
MMRRC Submission 045437-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # R7351 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 44409791-44456347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 44439623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 140 (V140I)
Ref Sequence ENSEMBL: ENSMUSP00000019333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019333] [ENSMUST00000101327]
AlphaFold Q5SWK7
Predicted Effect possibly damaging
Transcript: ENSMUST00000019333
AA Change: V140I

PolyPhen 2 Score 0.909 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000019333
Gene: ENSMUSG00000019189
AA Change: V140I

DomainStartEndE-ValueType
Pfam:TRC8_N 8 506 2.8e-156 PFAM
RING 537 574 2.12e-8 SMART
low complexity region 590 601 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000101327
AA Change: V140I

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000098881
Gene: ENSMUSG00000019189
AA Change: V140I

DomainStartEndE-ValueType
Pfam:TRC8_N 7 266 1.2e-70 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (56/57)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C A 3: 124,206,159 (GRCm39) G343V probably damaging Het
Adamts6 G A 13: 104,526,620 (GRCm39) S516N possibly damaging Het
Ahi1 A G 10: 20,841,832 (GRCm39) D301G probably damaging Het
Arhgef37 T A 18: 61,631,286 (GRCm39) L566F possibly damaging Het
AU040320 A G 4: 126,710,237 (GRCm39) N328D probably damaging Het
Bicc1 G T 10: 70,783,730 (GRCm39) T469K probably benign Het
Brk1 T C 6: 113,592,742 (GRCm39) S42P probably benign Het
Ccdc180 A G 4: 45,903,887 (GRCm39) E351G possibly damaging Het
Cenpo A T 12: 4,266,581 (GRCm39) F176I probably damaging Het
Cfap97d1 A G 11: 101,882,331 (GRCm39) E163G probably benign Het
Clec12b A G 6: 129,356,874 (GRCm39) probably null Het
Ddx42 A G 11: 106,138,508 (GRCm39) N769S probably benign Het
Drc7 A G 8: 95,785,135 (GRCm39) D165G probably benign Het
Dync2h1 A T 9: 7,167,145 (GRCm39) I486N probably damaging Het
Gmip A G 8: 70,270,034 (GRCm39) D679G probably benign Het
Gml2 T C 15: 74,693,225 (GRCm39) V76A possibly damaging Het
Gpr26 T C 7: 131,576,094 (GRCm39) C253R probably damaging Het
H2-Q4 A G 17: 35,601,854 (GRCm39) T239A possibly damaging Het
Hmcn1 T A 1: 150,543,640 (GRCm39) Y2845F probably damaging Het
Ift172 A G 5: 31,433,240 (GRCm39) Y550H probably damaging Het
Irgm2 G A 11: 58,110,431 (GRCm39) V41M possibly damaging Het
Lrp2 C T 2: 69,278,486 (GRCm39) G3956R probably damaging Het
Matn2 G A 15: 34,345,482 (GRCm39) R163H probably damaging Het
Mxd1 A G 6: 86,628,448 (GRCm39) S151P probably damaging Het
Or10ak16 T C 4: 118,751,033 (GRCm39) V251A probably benign Het
Or4a73 C T 2: 89,420,857 (GRCm39) G201S probably benign Het
Or5m10b G T 2: 85,694,415 (GRCm39) probably benign Het
Or8b3 C T 9: 38,314,739 (GRCm39) L190F probably damaging Het
Pierce1 TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC 2: 28,356,122 (GRCm39) probably benign Het
Plcg2 A G 8: 118,317,049 (GRCm39) E642G possibly damaging Het
Pramel6 T A 2: 87,340,672 (GRCm39) F335I probably benign Het
Psd G T 19: 46,310,869 (GRCm39) S393R probably benign Het
Pwwp2a A G 11: 43,573,107 (GRCm39) D63G probably benign Het
Rbm28 T C 6: 29,158,879 (GRCm39) T139A probably benign Het
Ripk2 T G 4: 16,155,048 (GRCm39) E157A probably damaging Het
Rnf38 T C 4: 44,149,102 (GRCm39) N114D probably benign Het
Samd9l G A 6: 3,374,157 (GRCm39) R1035C probably benign Het
Sec14l3 A G 11: 4,024,785 (GRCm39) T245A probably benign Het
Serpina10 A T 12: 103,595,194 (GRCm39) F8L probably benign Het
Slc16a8 T A 15: 79,137,841 (GRCm39) D56V probably damaging Het
Spag9 A T 11: 93,983,802 (GRCm39) E726D probably benign Het
Spg11 A G 2: 121,900,412 (GRCm39) F1547L possibly damaging Het
Sspo T C 6: 48,441,855 (GRCm39) I1955T possibly damaging Het
Stx18 T A 5: 38,196,755 (GRCm39) V27E probably benign Het
Taf1c A G 8: 120,325,739 (GRCm39) S708P probably damaging Het
Tas2r126 T C 6: 42,412,240 (GRCm39) F258L probably benign Het
Tdpoz2 C T 3: 93,559,900 (GRCm39) W24* probably null Het
Tmc8 T C 11: 117,674,654 (GRCm39) L123P probably damaging Het
Trmo A T 4: 46,387,716 (GRCm39) Y35N possibly damaging Het
Ttn C T 2: 76,598,030 (GRCm39) V19628I possibly damaging Het
Ttn G A 2: 76,770,274 (GRCm39) A2685V unknown Het
Usp15 A T 10: 122,968,904 (GRCm39) M349K probably damaging Het
Vmn2r89 A G 14: 51,693,739 (GRCm39) N363S probably benign Het
Vwa3a T A 7: 120,375,559 (GRCm39) I423N probably damaging Het
Zfp592 T C 7: 80,691,439 (GRCm39) V1206A probably benign Het
Zfp866 A T 8: 70,218,547 (GRCm39) Y358N probably damaging Het
Other mutations in Rnf145
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Rnf145 APN 11 44,446,039 (GRCm39) missense possibly damaging 0.90
IGL02972:Rnf145 APN 11 44,454,865 (GRCm39) missense probably benign 0.26
IGL03168:Rnf145 APN 11 44,445,985 (GRCm39) missense probably damaging 1.00
IGL03185:Rnf145 APN 11 44,422,157 (GRCm39) missense probably damaging 1.00
IGL02980:Rnf145 UTSW 11 44,452,484 (GRCm39) missense probably benign
R0112:Rnf145 UTSW 11 44,454,978 (GRCm39) missense probably benign
R0346:Rnf145 UTSW 11 44,445,991 (GRCm39) missense probably damaging 1.00
R0415:Rnf145 UTSW 11 44,415,965 (GRCm39) missense probably damaging 0.99
R0452:Rnf145 UTSW 11 44,452,587 (GRCm39) missense probably damaging 1.00
R0487:Rnf145 UTSW 11 44,446,056 (GRCm39) missense probably benign 0.21
R0598:Rnf145 UTSW 11 44,439,770 (GRCm39) missense probably damaging 1.00
R0631:Rnf145 UTSW 11 44,450,851 (GRCm39) missense probably damaging 0.99
R0837:Rnf145 UTSW 11 44,415,815 (GRCm39) missense probably benign 0.00
R1611:Rnf145 UTSW 11 44,442,625 (GRCm39) missense probably damaging 1.00
R1971:Rnf145 UTSW 11 44,439,642 (GRCm39) missense probably damaging 1.00
R1991:Rnf145 UTSW 11 44,452,293 (GRCm39) missense possibly damaging 0.90
R2157:Rnf145 UTSW 11 44,445,997 (GRCm39) missense probably damaging 1.00
R2340:Rnf145 UTSW 11 44,422,205 (GRCm39) missense probably benign 0.04
R3855:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R4483:Rnf145 UTSW 11 44,455,104 (GRCm39) missense probably benign 0.10
R4564:Rnf145 UTSW 11 44,439,635 (GRCm39) missense probably benign 0.25
R4922:Rnf145 UTSW 11 44,448,063 (GRCm39) unclassified probably benign
R5633:Rnf145 UTSW 11 44,450,915 (GRCm39) missense probably damaging 1.00
R5672:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5673:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5701:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5915:Rnf145 UTSW 11 44,433,549 (GRCm39) critical splice donor site probably null
R6128:Rnf145 UTSW 11 44,446,018 (GRCm39) missense probably damaging 1.00
R6502:Rnf145 UTSW 11 44,415,932 (GRCm39) missense probably damaging 0.98
R6717:Rnf145 UTSW 11 44,452,317 (GRCm39) missense probably benign 0.00
R6963:Rnf145 UTSW 11 44,455,104 (GRCm39) missense probably benign 0.10
R7035:Rnf145 UTSW 11 44,452,583 (GRCm39) missense probably damaging 1.00
R7154:Rnf145 UTSW 11 44,415,822 (GRCm39) missense probably damaging 1.00
R7639:Rnf145 UTSW 11 44,422,184 (GRCm39) missense probably damaging 1.00
R8074:Rnf145 UTSW 11 44,448,263 (GRCm39) missense probably damaging 0.98
R8536:Rnf145 UTSW 11 44,450,942 (GRCm39) missense probably damaging 1.00
R8861:Rnf145 UTSW 11 44,445,984 (GRCm39) missense probably damaging 1.00
R9123:Rnf145 UTSW 11 44,450,819 (GRCm39) missense probably damaging 1.00
R9125:Rnf145 UTSW 11 44,450,819 (GRCm39) missense probably damaging 1.00
R9172:Rnf145 UTSW 11 44,448,262 (GRCm39) missense possibly damaging 0.95
R9520:Rnf145 UTSW 11 44,452,336 (GRCm39) missense possibly damaging 0.91
R9711:Rnf145 UTSW 11 44,415,830 (GRCm39) nonsense probably null
R9801:Rnf145 UTSW 11 44,448,112 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTCTTTAGACTTATTCAAAAGCTGTGA -3'
(R):5'- CGGTATGCAGACTTAGCGAGG -3'

Sequencing Primer
(F):5'- TAACATAGGTCCTCAGGCTTGAC -3'
(R):5'- TGCAGACTTAGCGAGGTTATAC -3'
Posted On 2019-09-13