Incidental Mutation 'R0645:Nsd3'
| ID |
57066 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nsd3
|
| Ensembl Gene |
ENSMUSG00000054823 |
| Gene Name |
nuclear receptor binding SET domain protein 3 |
| Synonyms |
Whsc1l1, WHISTLE |
| MMRRC Submission |
038830-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.303)
|
| Stock # |
R0645 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
26091617-26209694 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 26199096 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1219
(I1219V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117778
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084026]
[ENSMUST00000139966]
[ENSMUST00000142395]
[ENSMUST00000153597]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084026
AA Change: I1219V
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000081040
Gene: ENSMUSG00000054823
AA Change: I1219V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
963 |
1e-4 |
SMART |
|
PWWP
|
968 |
1030 |
8.62e-18 |
SMART |
|
AWS
|
1103 |
1154 |
2.61e-17 |
SMART |
|
SET
|
1155 |
1278 |
2.17e-41 |
SMART |
|
PostSET
|
1279 |
1295 |
2.63e-3 |
SMART |
|
low complexity region
|
1309 |
1326 |
N/A |
INTRINSIC |
|
PHD
|
1332 |
1375 |
4.32e-9 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129959
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139966
AA Change: I1170V
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000122096
Gene: ENSMUSG00000054823
AA Change: I1170V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
914 |
5.24e-8 |
SMART |
|
PWWP
|
919 |
981 |
8.62e-18 |
SMART |
|
AWS
|
1054 |
1105 |
2.61e-17 |
SMART |
|
SET
|
1106 |
1229 |
2.17e-41 |
SMART |
|
PostSET
|
1230 |
1246 |
2.63e-3 |
SMART |
|
low complexity region
|
1260 |
1277 |
N/A |
INTRINSIC |
|
PHD
|
1283 |
1326 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142395
AA Change: I1219V
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000117778
Gene: ENSMUSG00000054823
AA Change: I1219V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
963 |
1e-4 |
SMART |
|
PWWP
|
968 |
1030 |
8.62e-18 |
SMART |
|
AWS
|
1103 |
1154 |
2.61e-17 |
SMART |
|
SET
|
1155 |
1278 |
2.17e-41 |
SMART |
|
PostSET
|
1279 |
1295 |
2.63e-3 |
SMART |
|
low complexity region
|
1309 |
1326 |
N/A |
INTRINSIC |
|
PHD
|
1332 |
1375 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153597
AA Change: I257V
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000123028
Gene: ENSMUSG00000054823
AA Change: I257V
| Domain | Start | End | E-Value | Type |
|---|
|
PWWP
|
17 |
79 |
8.62e-18 |
SMART |
|
AWS
|
152 |
203 |
2.61e-17 |
SMART |
|
SET
|
204 |
327 |
2.17e-41 |
SMART |
|
PostSET
|
328 |
344 |
2.63e-3 |
SMART |
|
low complexity region
|
358 |
375 |
N/A |
INTRINSIC |
|
PHD
|
381 |
424 |
4.32e-9 |
SMART |
|
| Meta Mutation Damage Score |
0.0694 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the histone demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
|
| Allele List at MGI |
All alleles(5) : Gene trapped(5)
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam18 |
G |
T |
8: 25,162,136 (GRCm39) |
Y46* |
probably null |
Het |
| Adam26b |
A |
C |
8: 43,973,524 (GRCm39) |
C493G |
probably damaging |
Het |
| Ak5 |
A |
T |
3: 152,359,252 (GRCm39) |
L182Q |
probably damaging |
Het |
| Akt1s1 |
T |
C |
7: 44,498,645 (GRCm39) |
|
probably benign |
Het |
| Amhr2 |
G |
T |
15: 102,354,863 (GRCm39) |
G133C |
probably damaging |
Het |
| Btbd9 |
A |
T |
17: 30,743,941 (GRCm39) |
L187Q |
probably damaging |
Het |
| Ccdc117 |
A |
T |
11: 5,484,385 (GRCm39) |
|
probably benign |
Het |
| Ccdc138 |
A |
T |
10: 58,411,542 (GRCm39) |
I637F |
probably damaging |
Het |
| Ccdc162 |
A |
G |
10: 41,462,407 (GRCm39) |
|
probably benign |
Het |
| Cdc25b |
C |
A |
2: 131,033,533 (GRCm39) |
H157Q |
probably benign |
Het |
| Cdon |
A |
G |
9: 35,388,379 (GRCm39) |
|
probably null |
Het |
| Cdt1 |
G |
A |
8: 123,298,884 (GRCm39) |
|
probably benign |
Het |
| Cep350 |
C |
T |
1: 155,816,458 (GRCm39) |
|
probably null |
Het |
| Cfb |
T |
C |
17: 35,078,992 (GRCm39) |
K831R |
probably benign |
Het |
| Cldn4 |
C |
A |
5: 134,975,645 (GRCm39) |
|
probably benign |
Het |
| Cntnap5b |
T |
C |
1: 99,999,767 (GRCm39) |
|
probably benign |
Het |
| Cyp27b1 |
T |
G |
10: 126,884,967 (GRCm39) |
S77A |
probably benign |
Het |
| Dlc1 |
T |
C |
8: 37,041,203 (GRCm39) |
D1342G |
possibly damaging |
Het |
| Dlgap4 |
A |
G |
2: 156,603,799 (GRCm39) |
H887R |
probably damaging |
Het |
| Duox2 |
A |
G |
2: 122,123,139 (GRCm39) |
I503T |
probably damaging |
Het |
| Eml4 |
T |
C |
17: 83,770,922 (GRCm39) |
|
probably benign |
Het |
| Ermap |
A |
G |
4: 119,042,888 (GRCm39) |
S212P |
probably benign |
Het |
| Esrrg |
T |
A |
1: 187,775,538 (GRCm39) |
C22S |
probably benign |
Het |
| Evx2 |
T |
A |
2: 74,488,238 (GRCm39) |
Y194F |
possibly damaging |
Het |
| Fbn2 |
T |
G |
18: 58,191,461 (GRCm39) |
D1554A |
probably damaging |
Het |
| Flrt1 |
G |
A |
19: 7,074,508 (GRCm39) |
|
probably benign |
Het |
| Fndc5 |
A |
G |
4: 129,033,630 (GRCm39) |
|
probably benign |
Het |
| Frem1 |
A |
T |
4: 82,907,403 (GRCm39) |
I837N |
probably damaging |
Het |
| Fzd10 |
G |
T |
5: 128,679,662 (GRCm39) |
A461S |
possibly damaging |
Het |
| Ganab |
T |
A |
19: 8,888,477 (GRCm39) |
Y511N |
probably damaging |
Het |
| Gbp7 |
A |
G |
3: 142,243,926 (GRCm39) |
|
probably null |
Het |
| Gm5919 |
T |
A |
9: 83,765,436 (GRCm39) |
C91S |
unknown |
Het |
| Gpr31b |
A |
T |
17: 13,271,093 (GRCm39) |
C25* |
probably null |
Het |
| Grb10 |
A |
G |
11: 11,886,755 (GRCm39) |
S505P |
probably damaging |
Het |
| Grm4 |
A |
T |
17: 27,654,183 (GRCm39) |
V542E |
probably damaging |
Het |
| Gsta5 |
T |
C |
9: 78,206,303 (GRCm39) |
I75T |
possibly damaging |
Het |
| Hivep3 |
G |
A |
4: 119,954,531 (GRCm39) |
R949H |
possibly damaging |
Het |
| Hycc1 |
C |
T |
5: 24,184,506 (GRCm39) |
G242D |
probably damaging |
Het |
| Invs |
A |
T |
4: 48,407,653 (GRCm39) |
M543L |
probably benign |
Het |
| Kcnk2 |
T |
C |
1: 188,988,927 (GRCm39) |
|
probably null |
Het |
| Kdm6b |
A |
T |
11: 69,295,844 (GRCm39) |
S808T |
unknown |
Het |
| Klhl30 |
C |
T |
1: 91,283,228 (GRCm39) |
R277W |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 68,080,707 (GRCm39) |
Q1245R |
probably benign |
Het |
| Lingo3 |
G |
T |
10: 80,671,169 (GRCm39) |
H254N |
probably benign |
Het |
| Lzts1 |
A |
T |
8: 69,588,392 (GRCm39) |
H521Q |
possibly damaging |
Het |
| Map3k19 |
A |
C |
1: 127,749,919 (GRCm39) |
I1144S |
possibly damaging |
Het |
| Mast2 |
A |
G |
4: 116,165,184 (GRCm39) |
S1411P |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,170,043 (GRCm39) |
|
probably benign |
Het |
| Mesp1 |
G |
T |
7: 79,442,328 (GRCm39) |
S225R |
possibly damaging |
Het |
| Micu1 |
A |
G |
10: 59,675,503 (GRCm39) |
T366A |
possibly damaging |
Het |
| Mideas |
G |
T |
12: 84,205,077 (GRCm39) |
N834K |
possibly damaging |
Het |
| Mknk2 |
T |
C |
10: 80,507,742 (GRCm39) |
|
probably null |
Het |
| Msh5 |
A |
G |
17: 35,258,199 (GRCm39) |
L309P |
probably damaging |
Het |
| Myo7b |
T |
C |
18: 32,127,962 (GRCm39) |
I577V |
probably benign |
Het |
| Myom2 |
T |
A |
8: 15,167,698 (GRCm39) |
D1094E |
probably damaging |
Het |
| Nedd1 |
T |
C |
10: 92,527,693 (GRCm39) |
|
probably null |
Het |
| Neu4 |
T |
C |
1: 93,950,191 (GRCm39) |
L50S |
probably damaging |
Het |
| Noa1 |
T |
C |
5: 77,457,722 (GRCm39) |
Y61C |
probably benign |
Het |
| Nr1h4 |
A |
T |
10: 89,342,390 (GRCm39) |
M30K |
probably benign |
Het |
| Nup188 |
T |
A |
2: 30,233,478 (GRCm39) |
|
probably null |
Het |
| Or10ag2 |
T |
A |
2: 87,248,612 (GRCm39) |
Y71* |
probably null |
Het |
| Or5al5 |
A |
G |
2: 85,961,378 (GRCm39) |
S210P |
probably damaging |
Het |
| Or6c208 |
T |
A |
10: 129,224,162 (GRCm39) |
I220N |
possibly damaging |
Het |
| Or6k2 |
A |
T |
1: 173,986,920 (GRCm39) |
T194S |
probably benign |
Het |
| Pbk |
G |
A |
14: 66,051,245 (GRCm39) |
|
probably benign |
Het |
| Pcnx2 |
G |
A |
8: 126,487,459 (GRCm39) |
T1848M |
possibly damaging |
Het |
| Pdzd7 |
C |
T |
19: 45,033,914 (GRCm39) |
G57R |
possibly damaging |
Het |
| Pik3r4 |
C |
A |
9: 105,546,386 (GRCm39) |
|
probably benign |
Het |
| Plce1 |
A |
G |
19: 38,766,433 (GRCm39) |
S2153G |
probably damaging |
Het |
| Potefam1 |
C |
T |
2: 111,044,928 (GRCm39) |
|
probably null |
Het |
| Pphln1 |
G |
A |
15: 93,318,192 (GRCm39) |
V34M |
possibly damaging |
Het |
| Prrc2a |
T |
C |
17: 35,375,308 (GRCm39) |
D1114G |
probably damaging |
Het |
| Prss16 |
T |
C |
13: 22,193,546 (GRCm39) |
|
probably benign |
Het |
| Rtp3 |
T |
C |
9: 110,816,168 (GRCm39) |
K128E |
probably damaging |
Het |
| Scn3a |
T |
A |
2: 65,355,194 (GRCm39) |
I241F |
possibly damaging |
Het |
| Setd1a |
G |
A |
7: 127,386,382 (GRCm39) |
V336I |
probably damaging |
Het |
| Sfpq |
A |
G |
4: 126,916,762 (GRCm39) |
I320V |
possibly damaging |
Het |
| Skint5 |
A |
T |
4: 113,620,679 (GRCm39) |
D678E |
unknown |
Het |
| Slc12a9 |
G |
A |
5: 137,313,638 (GRCm39) |
P774S |
probably benign |
Het |
| Slc25a54 |
C |
G |
3: 109,019,481 (GRCm39) |
L362V |
possibly damaging |
Het |
| Smarcd1 |
A |
G |
15: 99,605,267 (GRCm39) |
|
probably null |
Het |
| Spata31e5 |
T |
A |
1: 28,816,011 (GRCm39) |
N674Y |
probably damaging |
Het |
| Suco |
A |
T |
1: 161,661,683 (GRCm39) |
M916K |
probably damaging |
Het |
| Tiam2 |
T |
C |
17: 3,564,973 (GRCm39) |
S1404P |
possibly damaging |
Het |
| Topors |
T |
C |
4: 40,260,333 (GRCm39) |
T984A |
unknown |
Het |
| Trabd2b |
A |
T |
4: 114,443,767 (GRCm39) |
K308M |
probably damaging |
Het |
| Trmo |
A |
T |
4: 46,377,083 (GRCm39) |
|
probably benign |
Het |
| Trpc3 |
A |
T |
3: 36,725,654 (GRCm39) |
D107E |
probably benign |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Uggt2 |
A |
C |
14: 119,295,010 (GRCm39) |
Y539D |
probably benign |
Het |
| Wwc2 |
T |
G |
8: 48,353,674 (GRCm39) |
|
probably benign |
Het |
| Zdbf2 |
T |
A |
1: 63,344,109 (GRCm39) |
D829E |
possibly damaging |
Het |
|
| Other mutations in Nsd3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00435:Nsd3
|
APN |
8 |
26,166,728 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL00718:Nsd3
|
APN |
8 |
26,196,562 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00727:Nsd3
|
APN |
8 |
26,131,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Nsd3
|
APN |
8 |
26,152,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01614:Nsd3
|
APN |
8 |
26,156,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01834:Nsd3
|
APN |
8 |
26,130,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Nsd3
|
APN |
8 |
26,203,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02229:Nsd3
|
APN |
8 |
26,200,775 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02481:Nsd3
|
APN |
8 |
26,181,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02686:Nsd3
|
APN |
8 |
26,156,086 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03394:Nsd3
|
APN |
8 |
26,165,765 (GRCm39) |
splice site |
probably benign |
|
|
Pine
|
UTSW |
8 |
26,169,952 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
D3080:Nsd3
|
UTSW |
8 |
26,203,572 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02802:Nsd3
|
UTSW |
8 |
26,130,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0136:Nsd3
|
UTSW |
8 |
26,149,870 (GRCm39) |
nonsense |
probably null |
|
|
R0195:Nsd3
|
UTSW |
8 |
26,170,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0207:Nsd3
|
UTSW |
8 |
26,173,273 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0471:Nsd3
|
UTSW |
8 |
26,138,450 (GRCm39) |
splice site |
probably benign |
|
|
R0511:Nsd3
|
UTSW |
8 |
26,168,732 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0524:Nsd3
|
UTSW |
8 |
26,190,605 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0581:Nsd3
|
UTSW |
8 |
26,200,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0589:Nsd3
|
UTSW |
8 |
26,131,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0664:Nsd3
|
UTSW |
8 |
26,204,267 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0738:Nsd3
|
UTSW |
8 |
26,168,725 (GRCm39) |
splice site |
probably null |
|
|
R1148:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1148:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1265:Nsd3
|
UTSW |
8 |
26,172,578 (GRCm39) |
missense |
probably benign |
|
|
R1298:Nsd3
|
UTSW |
8 |
26,169,952 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1424:Nsd3
|
UTSW |
8 |
26,190,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1493:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1528:Nsd3
|
UTSW |
8 |
26,188,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Nsd3
|
UTSW |
8 |
26,181,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2199:Nsd3
|
UTSW |
8 |
26,156,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3414:Nsd3
|
UTSW |
8 |
26,190,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3522:Nsd3
|
UTSW |
8 |
26,196,642 (GRCm39) |
missense |
probably benign |
|
|
R3623:Nsd3
|
UTSW |
8 |
26,152,835 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3624:Nsd3
|
UTSW |
8 |
26,152,835 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3798:Nsd3
|
UTSW |
8 |
26,188,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4345:Nsd3
|
UTSW |
8 |
26,131,333 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4370:Nsd3
|
UTSW |
8 |
26,138,524 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4421:Nsd3
|
UTSW |
8 |
26,131,288 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4583:Nsd3
|
UTSW |
8 |
26,200,703 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4664:Nsd3
|
UTSW |
8 |
26,188,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Nsd3
|
UTSW |
8 |
26,163,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Nsd3
|
UTSW |
8 |
26,181,161 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4888:Nsd3
|
UTSW |
8 |
26,188,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Nsd3
|
UTSW |
8 |
26,172,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Nsd3
|
UTSW |
8 |
26,168,855 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5632:Nsd3
|
UTSW |
8 |
26,169,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5760:Nsd3
|
UTSW |
8 |
26,149,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Nsd3
|
UTSW |
8 |
26,149,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Nsd3
|
UTSW |
8 |
26,172,685 (GRCm39) |
nonsense |
probably null |
|
|
R5860:Nsd3
|
UTSW |
8 |
26,156,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5911:Nsd3
|
UTSW |
8 |
26,156,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6168:Nsd3
|
UTSW |
8 |
26,181,188 (GRCm39) |
missense |
probably null |
1.00 |
|
R6467:Nsd3
|
UTSW |
8 |
26,130,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Nsd3
|
UTSW |
8 |
26,204,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6519:Nsd3
|
UTSW |
8 |
26,152,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6554:Nsd3
|
UTSW |
8 |
26,152,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7038:Nsd3
|
UTSW |
8 |
26,131,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7088:Nsd3
|
UTSW |
8 |
26,156,050 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7244:Nsd3
|
UTSW |
8 |
26,156,055 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7308:Nsd3
|
UTSW |
8 |
26,130,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7678:Nsd3
|
UTSW |
8 |
26,149,833 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7717:Nsd3
|
UTSW |
8 |
26,172,578 (GRCm39) |
missense |
probably benign |
|
|
R8064:Nsd3
|
UTSW |
8 |
26,190,698 (GRCm39) |
nonsense |
probably null |
|
|
R8242:Nsd3
|
UTSW |
8 |
26,196,567 (GRCm39) |
nonsense |
probably null |
|
|
R8312:Nsd3
|
UTSW |
8 |
26,153,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8547:Nsd3
|
UTSW |
8 |
26,184,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8954:Nsd3
|
UTSW |
8 |
26,163,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8995:Nsd3
|
UTSW |
8 |
26,131,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9026:Nsd3
|
UTSW |
8 |
26,172,576 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9281:Nsd3
|
UTSW |
8 |
26,152,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9320:Nsd3
|
UTSW |
8 |
26,199,088 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9563:Nsd3
|
UTSW |
8 |
26,204,230 (GRCm39) |
missense |
|
|
|
R9703:Nsd3
|
UTSW |
8 |
26,131,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0026:Nsd3
|
UTSW |
8 |
26,190,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Nsd3
|
UTSW |
8 |
26,131,018 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AACATGTGACCTGCTGCTGATCC -3'
(R):5'- AAGTAACGCCCAGTTGTCTGATCTG -3'
Sequencing Primer
(F):5'- ACCATCAGCAGTTTCTATGCAG -3'
(R):5'- TCTGAATAGACTCTCAGGGGC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation