Incidental Mutation 'R7352:Ubr2'
ID 570698
Institutional Source Beutler Lab
Gene Symbol Ubr2
Ensembl Gene ENSMUSG00000023977
Gene Name ubiquitin protein ligase E3 component n-recognin 2
Synonyms ENSMUSG00000043296, E130209G04Rik, 9930021A08Rik
MMRRC Submission 045438-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.891) question?
Stock # R7352 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 47239221-47321482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 47241352 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 1734 (T1734I)
Ref Sequence ENSEMBL: ENSMUSP00000108961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113335] [ENSMUST00000113337]
AlphaFold Q6WKZ8
Predicted Effect probably benign
Transcript: ENSMUST00000113335
AA Change: T1734I

PolyPhen 2 Score 0.191 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000108961
Gene: ENSMUSG00000023977
AA Change: T1734I

DomainStartEndE-ValueType
ZnF_UBR1 97 167 3.14e-32 SMART
Pfam:ClpS 221 302 2.4e-23 PFAM
low complexity region 635 646 N/A INTRINSIC
low complexity region 749 760 N/A INTRINSIC
low complexity region 872 886 N/A INTRINSIC
coiled coil region 1019 1046 N/A INTRINSIC
RING 1108 1213 7.66e-1 SMART
low complexity region 1221 1235 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000113337
AA Change: T1734I

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000108963
Gene: ENSMUSG00000023977
AA Change: T1734I

DomainStartEndE-ValueType
ZnF_UBR1 97 167 3.14e-32 SMART
Pfam:ClpS 222 301 6.2e-26 PFAM
low complexity region 635 646 N/A INTRINSIC
low complexity region 749 760 N/A INTRINSIC
low complexity region 872 886 N/A INTRINSIC
coiled coil region 1019 1046 N/A INTRINSIC
RING 1108 1213 7.66e-1 SMART
low complexity region 1221 1235 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
PHENOTYPE: On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 100 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 C T 17: 24,508,028 (GRCm39) W1124* probably null Het
Acap3 G A 4: 155,990,168 (GRCm39) V783I possibly damaging Het
Alkbh8 A G 9: 3,345,796 (GRCm39) K172R probably damaging Het
Ankrd28 A G 14: 31,429,998 (GRCm39) L860P probably damaging Het
Arap3 G A 18: 38,106,331 (GRCm39) T1504I probably benign Het
Atad5 T C 11: 79,994,169 (GRCm39) probably null Het
Atp8a2 A G 14: 60,028,653 (GRCm39) V938A probably benign Het
AW551984 T C 9: 39,504,221 (GRCm39) M582V probably benign Het
Axdnd1 C T 1: 156,210,047 (GRCm39) V408I possibly damaging Het
Babam2 T A 5: 32,164,594 (GRCm39) Y326* probably null Het
Baiap2l1 T C 5: 144,261,436 (GRCm39) M20V probably benign Het
Bex6 A G 16: 32,005,034 (GRCm39) probably benign Het
Bicc1 G T 10: 70,783,730 (GRCm39) T469K probably benign Het
Cad T A 5: 31,215,422 (GRCm39) S78T probably damaging Het
Ccdc171 T A 4: 83,736,260 (GRCm39) D1210E possibly damaging Het
Ccnd1 T C 7: 144,491,124 (GRCm39) I161V possibly damaging Het
Cdc42bpb A T 12: 111,265,745 (GRCm39) F1396I probably damaging Het
Cep170 A T 1: 176,597,423 (GRCm39) D373E probably benign Het
Chrna4 A T 2: 180,679,267 (GRCm39) I60N probably damaging Het
Cntn2 T C 1: 132,450,137 (GRCm39) T586A probably benign Het
Csmd2 G T 4: 128,451,429 (GRCm39) V3396F Het
Cyp3a44 T A 5: 145,740,498 (GRCm39) L47F probably benign Het
D7Ertd443e A T 7: 133,951,123 (GRCm39) H183Q probably benign Het
Ddx27 T C 2: 166,871,433 (GRCm39) V510A probably benign Het
Dgat1 G T 15: 76,387,024 (GRCm39) C396* probably null Het
Dmpk A G 7: 18,819,997 (GRCm39) S83G probably damaging Het
Dsc2 T G 18: 20,168,392 (GRCm39) D689A probably benign Het
Eppk1 A T 15: 75,990,618 (GRCm39) W2088R probably benign Het
Exph5 A C 9: 53,287,022 (GRCm39) I1368L probably benign Het
Fadd T C 7: 144,134,396 (GRCm39) K163R probably benign Het
Fam149a T A 8: 45,794,034 (GRCm39) Q759L probably damaging Het
Foxo6 A T 4: 120,125,448 (GRCm39) M449K probably benign Het
Gad1 T C 2: 70,425,094 (GRCm39) F463L probably benign Het
Gad2 T A 2: 22,513,835 (GRCm39) F91I probably benign Het
Gcc2 T C 10: 58,116,520 (GRCm39) probably null Het
Gjd3 A C 11: 102,691,278 (GRCm39) C242G probably damaging Het
Gkn1 T C 6: 87,325,100 (GRCm39) E103G possibly damaging Het
Gm867 T C 10: 75,775,670 (GRCm39) T39A probably benign Het
Gpr108 A G 17: 57,543,944 (GRCm39) Y421H probably damaging Het
Gramd1b A C 9: 40,219,289 (GRCm39) V508G probably damaging Het
Grm1 A T 10: 10,595,237 (GRCm39) I797N probably damaging Het
Ice1 G A 13: 70,754,221 (GRCm39) Q622* probably null Het
Kcnb2 T A 1: 15,780,835 (GRCm39) V569E probably benign Het
Ksr2 T G 5: 117,827,706 (GRCm39) I495S probably benign Het
Litaf A T 16: 10,781,217 (GRCm39) M94K probably damaging Het
Lmod2 T C 6: 24,598,110 (GRCm39) S77P possibly damaging Het
Lrp2 G T 2: 69,302,741 (GRCm39) S2996Y probably benign Het
Ltf T C 9: 110,857,518 (GRCm39) S436P probably benign Het
Map4k4 T A 1: 40,001,387 (GRCm39) V58D unknown Het
Mapkapk3 C A 9: 107,134,269 (GRCm39) D332Y possibly damaging Het
Mroh1 C A 15: 76,335,674 (GRCm39) P1439Q probably benign Het
Ncor1 A G 11: 62,224,737 (GRCm39) V841A probably damaging Het
Nrxn3 A G 12: 88,817,063 (GRCm39) M248V probably benign Het
Olig2 A G 16: 91,023,577 (GRCm39) D97G probably benign Het
Or4a2 C A 2: 89,248,311 (GRCm39) G149W probably damaging Het
Or4a39 T C 2: 89,236,806 (GRCm39) M206V probably benign Het
Or4p8 T A 2: 88,727,062 (GRCm39) N293I probably damaging Het
Or5b95 A G 19: 12,658,115 (GRCm39) I214M possibly damaging Het
Or5g23 T C 2: 85,439,128 (GRCm39) N42S probably damaging Het
Or6f2 A T 7: 139,756,438 (GRCm39) Y135F probably damaging Het
Pcdha11 T A 18: 37,139,898 (GRCm39) V509E probably damaging Het
Pglyrp3 G A 3: 91,921,947 (GRCm39) W5* probably null Het
Phf14 A T 6: 11,961,637 (GRCm39) N425Y probably damaging Het
Phf3 G T 1: 30,843,407 (GRCm39) R1851S possibly damaging Het
Pigs A G 11: 78,219,638 (GRCm39) T39A probably damaging Het
Plin4 A G 17: 56,411,427 (GRCm39) M868T probably benign Het
Pnma2 A G 14: 67,153,870 (GRCm39) Q98R possibly damaging Het
Ppp4r3a G A 12: 101,008,091 (GRCm39) T782I probably damaging Het
Pramel52-ps A T 5: 94,531,743 (GRCm39) N209I probably damaging Het
Prickle2 T G 6: 92,387,871 (GRCm39) E566D probably benign Het
Pvr A G 7: 19,644,541 (GRCm39) I331T possibly damaging Het
Ranbp3l A T 15: 8,997,842 (GRCm39) probably benign Het
Rapgef4 T A 2: 72,010,435 (GRCm39) I331N probably damaging Het
Reg3g C T 6: 78,443,842 (GRCm39) W122* probably null Het
Rigi T A 4: 40,239,668 (GRCm39) Q10L probably benign Het
Rlbp1 A T 7: 79,031,428 (GRCm39) I100N probably damaging Het
Rnf213 T A 11: 119,334,405 (GRCm39) Y3206N Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,133 (GRCm39) probably benign Het
Rtl6 G T 15: 84,441,181 (GRCm39) R72S possibly damaging Het
Rufy3 T A 5: 88,785,053 (GRCm39) D408E possibly damaging Het
Scn3a T C 2: 65,356,045 (GRCm39) I230V possibly damaging Het
Slc23a4 A T 6: 34,925,214 (GRCm39) I507N possibly damaging Het
Slc4a8 A G 15: 100,688,865 (GRCm39) T392A probably damaging Het
Spaca7 T A 8: 12,635,742 (GRCm39) I86K probably benign Het
Syt10 G T 15: 89,698,659 (GRCm39) D228E probably benign Het
Tbx3 T A 5: 119,815,625 (GRCm39) N308K probably benign Het
Telo2 A G 17: 25,321,043 (GRCm39) V724A probably damaging Het
Tfip11 T C 5: 112,481,134 (GRCm39) V370A probably benign Het
Thbs3 A G 3: 89,132,587 (GRCm39) E843G probably benign Het
Tmprss11g T C 5: 86,644,401 (GRCm39) I148V not run Het
Trbv14 T A 6: 41,112,429 (GRCm39) D75E possibly damaging Het
Trio A G 15: 27,732,962 (GRCm39) V2973A probably damaging Het
Ttn T C 2: 76,624,828 (GRCm39) D15250G probably damaging Het
Ush2a G T 1: 188,198,321 (GRCm39) A1462S probably benign Het
Ushbp1 T G 8: 71,841,525 (GRCm39) T435P possibly damaging Het
Vps13c T C 9: 67,747,728 (GRCm39) V7A possibly damaging Het
Wnk4 T C 11: 101,155,244 (GRCm39) V385A probably damaging Het
Wnt2b C T 3: 104,854,493 (GRCm39) V322I probably benign Het
Zbtb8a C T 4: 129,253,874 (GRCm39) V207M probably benign Het
Zc3hav1l A G 6: 38,275,916 (GRCm39) M87T probably benign Het
Other mutations in Ubr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Ubr2 APN 17 47,296,986 (GRCm39) splice site probably benign
IGL00332:Ubr2 APN 17 47,301,916 (GRCm39) critical splice donor site probably null
IGL00518:Ubr2 APN 17 47,303,922 (GRCm39) missense probably damaging 1.00
IGL00693:Ubr2 APN 17 47,283,907 (GRCm39) missense probably benign 0.01
IGL00785:Ubr2 APN 17 47,255,791 (GRCm39) missense possibly damaging 0.69
IGL01144:Ubr2 APN 17 47,268,247 (GRCm39) missense probably damaging 1.00
IGL01459:Ubr2 APN 17 47,241,435 (GRCm39) splice site probably benign
IGL01637:Ubr2 APN 17 47,267,580 (GRCm39) missense probably damaging 1.00
IGL01710:Ubr2 APN 17 47,254,335 (GRCm39) missense probably benign 0.00
IGL01726:Ubr2 APN 17 47,303,907 (GRCm39) splice site probably benign
IGL01925:Ubr2 APN 17 47,265,875 (GRCm39) missense possibly damaging 0.92
IGL01960:Ubr2 APN 17 47,284,893 (GRCm39) missense probably benign 0.45
IGL02170:Ubr2 APN 17 47,278,123 (GRCm39) missense probably benign 0.05
IGL02308:Ubr2 APN 17 47,245,119 (GRCm39) missense probably damaging 1.00
IGL02387:Ubr2 APN 17 47,274,076 (GRCm39) missense probably benign
IGL02696:Ubr2 APN 17 47,274,691 (GRCm39) missense probably benign
IGL02726:Ubr2 APN 17 47,283,847 (GRCm39) missense probably damaging 1.00
IGL02750:Ubr2 APN 17 47,280,208 (GRCm39) missense probably benign 0.00
IGL02934:Ubr2 APN 17 47,268,266 (GRCm39) missense possibly damaging 0.50
IGL02959:Ubr2 APN 17 47,286,877 (GRCm39) missense probably damaging 0.96
IGL03018:Ubr2 APN 17 47,264,972 (GRCm39) missense possibly damaging 0.64
IGL03343:Ubr2 APN 17 47,262,844 (GRCm39) missense probably benign 0.00
PIT4280001:Ubr2 UTSW 17 47,255,789 (GRCm39) missense probably damaging 1.00
R0044:Ubr2 UTSW 17 47,303,911 (GRCm39) splice site probably benign
R0044:Ubr2 UTSW 17 47,303,911 (GRCm39) splice site probably benign
R0446:Ubr2 UTSW 17 47,294,224 (GRCm39) missense probably damaging 1.00
R0513:Ubr2 UTSW 17 47,297,705 (GRCm39) nonsense probably null
R0565:Ubr2 UTSW 17 47,266,812 (GRCm39) missense probably damaging 1.00
R0600:Ubr2 UTSW 17 47,278,174 (GRCm39) missense probably damaging 0.99
R0690:Ubr2 UTSW 17 47,249,579 (GRCm39) missense probably damaging 0.97
R0710:Ubr2 UTSW 17 47,249,607 (GRCm39) missense probably damaging 0.96
R0761:Ubr2 UTSW 17 47,294,242 (GRCm39) missense probably damaging 1.00
R0798:Ubr2 UTSW 17 47,280,102 (GRCm39) splice site probably benign
R0862:Ubr2 UTSW 17 47,278,009 (GRCm39) nonsense probably null
R0947:Ubr2 UTSW 17 47,252,038 (GRCm39) missense probably damaging 0.99
R0972:Ubr2 UTSW 17 47,245,187 (GRCm39) splice site probably null
R1500:Ubr2 UTSW 17 47,297,615 (GRCm39) missense possibly damaging 0.79
R1514:Ubr2 UTSW 17 47,311,749 (GRCm39) missense probably damaging 1.00
R1533:Ubr2 UTSW 17 47,278,173 (GRCm39) nonsense probably null
R1554:Ubr2 UTSW 17 47,283,877 (GRCm39) missense probably benign
R1575:Ubr2 UTSW 17 47,243,418 (GRCm39) missense probably damaging 1.00
R1602:Ubr2 UTSW 17 47,251,987 (GRCm39) missense probably benign 0.30
R1941:Ubr2 UTSW 17 47,284,952 (GRCm39) missense probably damaging 1.00
R1966:Ubr2 UTSW 17 47,265,845 (GRCm39) missense probably benign 0.05
R2041:Ubr2 UTSW 17 47,296,973 (GRCm39) missense probably damaging 1.00
R2067:Ubr2 UTSW 17 47,274,071 (GRCm39) critical splice donor site probably null
R2111:Ubr2 UTSW 17 47,274,071 (GRCm39) critical splice donor site probably null
R2189:Ubr2 UTSW 17 47,254,290 (GRCm39) missense probably benign 0.01
R2219:Ubr2 UTSW 17 47,296,968 (GRCm39) missense possibly damaging 0.94
R2307:Ubr2 UTSW 17 47,277,141 (GRCm39) nonsense probably null
R3426:Ubr2 UTSW 17 47,279,365 (GRCm39) missense probably damaging 1.00
R3428:Ubr2 UTSW 17 47,279,365 (GRCm39) missense probably damaging 1.00
R3608:Ubr2 UTSW 17 47,255,449 (GRCm39) missense probably damaging 1.00
R4080:Ubr2 UTSW 17 47,299,648 (GRCm39) missense probably benign 0.05
R4330:Ubr2 UTSW 17 47,278,204 (GRCm39) missense probably null 1.00
R4383:Ubr2 UTSW 17 47,250,313 (GRCm39) missense probably benign 0.01
R4460:Ubr2 UTSW 17 47,255,971 (GRCm39) critical splice donor site probably null
R4794:Ubr2 UTSW 17 47,241,371 (GRCm39) missense probably damaging 1.00
R4902:Ubr2 UTSW 17 47,296,922 (GRCm39) missense possibly damaging 0.91
R4913:Ubr2 UTSW 17 47,270,385 (GRCm39) splice site probably null
R5092:Ubr2 UTSW 17 47,280,173 (GRCm39) missense probably damaging 1.00
R5209:Ubr2 UTSW 17 47,279,350 (GRCm39) missense probably damaging 1.00
R5226:Ubr2 UTSW 17 47,294,196 (GRCm39) missense probably benign 0.04
R5250:Ubr2 UTSW 17 47,241,368 (GRCm39) missense probably benign 0.01
R5437:Ubr2 UTSW 17 47,274,623 (GRCm39) missense probably benign 0.00
R5607:Ubr2 UTSW 17 47,245,126 (GRCm39) nonsense probably null
R5848:Ubr2 UTSW 17 47,267,581 (GRCm39) missense possibly damaging 0.84
R6089:Ubr2 UTSW 17 47,293,218 (GRCm39) missense possibly damaging 0.95
R6382:Ubr2 UTSW 17 47,268,241 (GRCm39) missense possibly damaging 0.56
R6552:Ubr2 UTSW 17 47,277,194 (GRCm39) splice site probably null
R6630:Ubr2 UTSW 17 47,262,910 (GRCm39) missense possibly damaging 0.51
R6892:Ubr2 UTSW 17 47,245,034 (GRCm39) missense probably damaging 0.99
R6936:Ubr2 UTSW 17 47,283,957 (GRCm39) missense possibly damaging 0.94
R7039:Ubr2 UTSW 17 47,321,139 (GRCm39) missense probably benign 0.01
R7050:Ubr2 UTSW 17 47,272,528 (GRCm39) missense probably benign 0.30
R7078:Ubr2 UTSW 17 47,266,779 (GRCm39) missense possibly damaging 0.59
R7126:Ubr2 UTSW 17 47,284,982 (GRCm39) splice site probably null
R7219:Ubr2 UTSW 17 47,246,360 (GRCm39) nonsense probably null
R7262:Ubr2 UTSW 17 47,311,665 (GRCm39) missense probably damaging 0.97
R7366:Ubr2 UTSW 17 47,266,771 (GRCm39) missense probably damaging 0.99
R7449:Ubr2 UTSW 17 47,275,714 (GRCm39) missense probably damaging 1.00
R7496:Ubr2 UTSW 17 47,301,917 (GRCm39) critical splice donor site probably null
R7759:Ubr2 UTSW 17 47,296,974 (GRCm39) missense probably damaging 1.00
R7869:Ubr2 UTSW 17 47,301,934 (GRCm39) missense probably benign 0.00
R7916:Ubr2 UTSW 17 47,279,308 (GRCm39) critical splice donor site probably null
R8236:Ubr2 UTSW 17 47,262,835 (GRCm39) missense probably benign
R8376:Ubr2 UTSW 17 47,253,721 (GRCm39) missense probably benign 0.07
R9026:Ubr2 UTSW 17 47,245,041 (GRCm39) missense probably damaging 1.00
R9216:Ubr2 UTSW 17 47,292,285 (GRCm39) missense probably benign 0.36
R9339:Ubr2 UTSW 17 47,284,865 (GRCm39) missense probably benign 0.30
R9558:Ubr2 UTSW 17 47,262,843 (GRCm39) missense probably benign
R9606:Ubr2 UTSW 17 47,245,020 (GRCm39) missense probably damaging 1.00
R9644:Ubr2 UTSW 17 47,266,706 (GRCm39) critical splice donor site probably null
R9731:Ubr2 UTSW 17 47,274,071 (GRCm39) critical splice donor site probably null
X0027:Ubr2 UTSW 17 47,311,555 (GRCm39) missense probably damaging 0.99
X0061:Ubr2 UTSW 17 47,281,037 (GRCm39) missense possibly damaging 0.88
Z1177:Ubr2 UTSW 17 47,311,692 (GRCm39) missense possibly damaging 0.76
Z1177:Ubr2 UTSW 17 47,270,435 (GRCm39) missense probably benign
Z1177:Ubr2 UTSW 17 47,321,069 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- TTATCAGTCCCTGGAGCCAGAC -3'
(R):5'- ACACAGTTGGAAGCTAGTGC -3'

Sequencing Primer
(F):5'- CTGGAGCCAGACTAGAAAAATAAAAC -3'
(R):5'- GTGCTGTACACCTTTCCTGG -3'
Posted On 2019-09-13