Incidental Mutation 'R7356:Erbb4'
| ID |
570923 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
045442-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7356 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 68378514 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000119142
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000121473
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000153432
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acnat2 |
A |
T |
4: 49,383,507 (GRCm39) |
D15E |
probably damaging |
Het |
| Adamts16 |
G |
A |
13: 70,984,399 (GRCm39) |
T88I |
probably benign |
Het |
| Akap6 |
A |
C |
12: 52,958,647 (GRCm39) |
N801H |
probably damaging |
Het |
| Ankfn1 |
G |
T |
11: 89,325,599 (GRCm39) |
N524K |
probably damaging |
Het |
| Ap5s1 |
A |
G |
2: 131,054,582 (GRCm39) |
N131S |
probably damaging |
Het |
| Astn2 |
A |
T |
4: 66,103,503 (GRCm39) |
D303E |
unknown |
Het |
| Babam1 |
T |
C |
8: 71,852,208 (GRCm39) |
V132A |
probably benign |
Het |
| BC028528 |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
3: 95,795,448 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
CACTGGTT |
CACTGGTTCTATGGTGACTGGTT |
3: 95,795,495 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
TCTGTGGTCACTGGT |
TCTGTGGTCACTGGTCCTGTGGTCACTGGT |
3: 95,795,487 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
GGTCACTGGTTCTGT |
GGTCACTGGTTCTGTAGTCACTGGTTCTGT |
3: 95,795,477 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
GTTCTGTGGTCACTGGTTCTGTGGTCACTG |
GTTCTGTGGTCACTGCTTCTGTGGTCACTGGTTCTGTGGTCACTG |
3: 95,795,470 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
TGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCAC |
TGGTTCTGTGGTCACGGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCAC |
3: 95,795,453 (GRCm39) |
|
probably benign |
Het |
| Cnst |
C |
T |
1: 179,434,095 (GRCm39) |
P304S |
probably benign |
Het |
| Cog4 |
A |
T |
8: 111,576,498 (GRCm39) |
|
probably null |
Het |
| Cyp2j13 |
A |
T |
4: 95,965,655 (GRCm39) |
H17Q |
probably benign |
Het |
| Dock6 |
G |
A |
9: 21,721,195 (GRCm39) |
T1662I |
probably damaging |
Het |
| Dysf |
T |
C |
6: 84,044,443 (GRCm39) |
F270S |
probably damaging |
Het |
| Fam120b |
A |
T |
17: 15,627,958 (GRCm39) |
Q550L |
probably benign |
Het |
| Fam83b |
A |
T |
9: 76,400,135 (GRCm39) |
F323I |
probably benign |
Het |
| Far1 |
T |
A |
7: 113,167,349 (GRCm39) |
I478N |
possibly damaging |
Het |
| Gdpd5 |
T |
A |
7: 99,108,085 (GRCm39) |
I554N |
probably damaging |
Het |
| Glrx3 |
T |
C |
7: 137,054,453 (GRCm39) |
S79P |
probably damaging |
Het |
| Hltf |
T |
C |
3: 20,163,534 (GRCm39) |
I888T |
probably damaging |
Het |
| Hpx |
A |
G |
7: 105,240,917 (GRCm39) |
V452A |
probably damaging |
Het |
| Itk |
T |
G |
11: 46,258,659 (GRCm39) |
Q81P |
possibly damaging |
Het |
| Kdm6b |
G |
A |
11: 69,292,991 (GRCm39) |
Q1262* |
probably null |
Het |
| Lpcat2 |
T |
C |
8: 93,591,611 (GRCm39) |
V85A |
probably benign |
Het |
| Lrrk2 |
A |
T |
15: 91,622,947 (GRCm39) |
H1039L |
probably benign |
Het |
| Mapk3 |
T |
C |
7: 126,360,087 (GRCm39) |
|
probably null |
Het |
| Masp1 |
A |
T |
16: 23,288,993 (GRCm39) |
N602K |
possibly damaging |
Het |
| Myo7a |
T |
A |
7: 97,751,890 (GRCm39) |
Q40L |
probably benign |
Het |
| Nek1 |
A |
T |
8: 61,573,994 (GRCm39) |
M1081L |
probably benign |
Het |
| Nes |
T |
C |
3: 87,885,058 (GRCm39) |
S1106P |
possibly damaging |
Het |
| Nkpd1 |
A |
T |
7: 19,257,699 (GRCm39) |
I493F |
probably damaging |
Het |
| Npsr1 |
C |
G |
9: 24,009,557 (GRCm39) |
S21C |
probably benign |
Het |
| Oog1 |
G |
A |
12: 87,653,047 (GRCm39) |
|
probably null |
Het |
| Or11g1 |
G |
A |
14: 50,651,159 (GRCm39) |
V53M |
probably damaging |
Het |
| Or5g24-ps1 |
G |
A |
2: 85,463,782 (GRCm39) |
R3K |
probably benign |
Het |
| Or5k8 |
A |
T |
16: 58,644,718 (GRCm39) |
M118K |
probably damaging |
Het |
| Osbpl9 |
G |
T |
4: 108,925,677 (GRCm39) |
Y340* |
probably null |
Het |
| Pcyox1l |
A |
T |
18: 61,840,621 (GRCm39) |
L11Q |
probably null |
Het |
| Pdxdc1 |
G |
A |
16: 13,677,867 (GRCm39) |
R255C |
probably damaging |
Het |
| Pgap1 |
A |
G |
1: 54,569,293 (GRCm39) |
S358P |
probably benign |
Het |
| Pgm2l1 |
A |
G |
7: 99,917,326 (GRCm39) |
Y481C |
possibly damaging |
Het |
| Plekhf1 |
T |
C |
7: 37,921,545 (GRCm39) |
T8A |
possibly damaging |
Het |
| Plg |
G |
T |
17: 12,629,798 (GRCm39) |
G611C |
probably damaging |
Het |
| Prf1 |
A |
C |
10: 61,139,059 (GRCm39) |
D339A |
possibly damaging |
Het |
| Prph |
A |
G |
15: 98,954,807 (GRCm39) |
Y291C |
probably damaging |
Het |
| Rasal1 |
A |
G |
5: 120,792,890 (GRCm39) |
S48G |
possibly damaging |
Het |
| Rigi |
A |
G |
4: 40,226,600 (GRCm39) |
S231P |
probably benign |
Het |
| Ripk4 |
T |
A |
16: 97,544,349 (GRCm39) |
Q766L |
probably damaging |
Het |
| Scaf1 |
T |
C |
7: 44,657,208 (GRCm39) |
D557G |
unknown |
Het |
| Scaper |
A |
T |
9: 55,799,495 (GRCm39) |
M190K |
unknown |
Het |
| Scn8a |
A |
T |
15: 100,855,460 (GRCm39) |
I202F |
probably damaging |
Het |
| Siglecf |
A |
G |
7: 43,005,855 (GRCm39) |
I505V |
probably benign |
Het |
| Sirpb1c |
A |
G |
3: 15,886,297 (GRCm39) |
S360P |
probably benign |
Het |
| Sla2 |
C |
A |
2: 156,720,623 (GRCm39) |
|
probably null |
Het |
| Slc11a1 |
G |
T |
1: 74,424,648 (GRCm39) |
V544L |
probably benign |
Het |
| Slco1a5 |
T |
A |
6: 142,180,458 (GRCm39) |
K648I |
probably benign |
Het |
| Sorcs1 |
T |
A |
19: 50,163,595 (GRCm39) |
I1020F |
possibly damaging |
Het |
| Spen |
C |
A |
4: 141,199,235 (GRCm39) |
E3131* |
probably null |
Het |
| Sult2a7 |
A |
T |
7: 14,211,031 (GRCm39) |
W162R |
probably damaging |
Het |
| Sult3a1 |
G |
A |
10: 33,742,579 (GRCm39) |
E69K |
probably benign |
Het |
| Tcof1 |
G |
T |
18: 60,951,166 (GRCm39) |
D1119E |
unknown |
Het |
| Tom1l2 |
A |
T |
11: 60,139,853 (GRCm39) |
I272K |
probably damaging |
Het |
| Tspan5 |
C |
T |
3: 138,448,193 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
G |
2: 76,698,244 (GRCm39) |
L186P |
|
Het |
| Uap1l1 |
T |
C |
2: 25,251,696 (GRCm39) |
E496G |
possibly damaging |
Het |
| Ube2v1 |
A |
T |
2: 167,451,115 (GRCm39) |
I117N |
possibly damaging |
Het |
| Usp42 |
A |
G |
5: 143,702,842 (GRCm39) |
V593A |
possibly damaging |
Het |
| Virma |
T |
A |
4: 11,513,595 (GRCm39) |
I483N |
probably damaging |
Het |
| Vwde |
T |
A |
6: 13,192,641 (GRCm39) |
I421F |
probably damaging |
Het |
| Zfp345 |
G |
A |
2: 150,314,209 (GRCm39) |
H443Y |
probably damaging |
Het |
| Zfp760 |
A |
G |
17: 21,941,601 (GRCm39) |
T259A |
probably benign |
Het |
| Zfp941 |
T |
C |
7: 140,392,028 (GRCm39) |
I444V |
possibly damaging |
Het |
| Zfyve9 |
A |
C |
4: 108,576,212 (GRCm39) |
S290A |
probably benign |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCAAGCTGAATTAGAGATCGGCATC -3'
(R):5'- TAGCCAAGAATGTGTTTTGCAGC -3'
Sequencing Primer
(F):5'- GAATTAGAGATCGGCATCCTCATTCC -3'
(R):5'- CAAGAATGTGTTTTGCAGCTGTTTAC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation