Incidental Mutation 'R7360:Brd9'
ID 571279
Institutional Source Beutler Lab
Gene Symbol Brd9
Ensembl Gene ENSMUSG00000057649
Gene Name bromodomain containing 9
Synonyms
MMRRC Submission 045446-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7360 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 74085930-74109014 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 74092942 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 311 (R311W)
Ref Sequence ENSEMBL: ENSMUSP00000096982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099384] [ENSMUST00000222399] [ENSMUST00000222749] [ENSMUST00000223238]
AlphaFold Q3UQU0
Predicted Effect probably benign
Transcript: ENSMUST00000099384
AA Change: R311W

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000096982
Gene: ENSMUSG00000057649
AA Change: R311W

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
coiled coil region 53 104 N/A INTRINSIC
low complexity region 116 127 N/A INTRINSIC
BROMO 134 242 1.52e-30 SMART
low complexity region 249 264 N/A INTRINSIC
Pfam:DUF3512 274 505 1.6e-82 PFAM
low complexity region 544 557 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000222399
AA Change: R310W

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000222749
Predicted Effect probably benign
Transcript: ENSMUST00000223238
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 G C 4: 106,606,548 (GRCm39) P534A possibly damaging Het
Arhgef26 T A 3: 62,355,626 (GRCm39) Y733N possibly damaging Het
Aste1 G T 9: 105,274,835 (GRCm39) M358I probably damaging Het
B4galnt3 C T 6: 120,209,940 (GRCm39) W61* probably null Het
Cdkn1c T C 7: 143,014,431 (GRCm39) D5G possibly damaging Het
Cerk A G 15: 86,043,327 (GRCm39) F158S probably damaging Het
Clec2m C T 6: 129,303,710 (GRCm39) R85H probably benign Het
Cnot4 T A 6: 35,041,941 (GRCm39) E235V probably damaging Het
Crmp1 T C 5: 37,433,624 (GRCm39) V275A possibly damaging Het
Dcbld2 C A 16: 58,285,683 (GRCm39) probably null Het
Dip2a T C 10: 76,114,394 (GRCm39) R1029G probably damaging Het
Dnaaf1 A G 8: 120,304,090 (GRCm39) T43A probably benign Het
Eaf2 C T 16: 36,648,514 (GRCm39) S2N probably benign Het
Eif2b4 T C 5: 31,348,719 (GRCm39) D164G probably benign Het
Fpgs T C 2: 32,584,005 (GRCm39) Y45C possibly damaging Het
Gm1527 C T 3: 28,968,691 (GRCm39) Q248* probably null Het
Gm29666 C T 15: 84,798,469 (GRCm39) A31T unknown Het
Gmip C A 8: 70,263,892 (GRCm39) A112D probably damaging Het
Hibadh C T 6: 52,617,197 (GRCm39) G13S probably benign Het
Hmcn1 A T 1: 150,494,597 (GRCm39) V4164D probably damaging Het
Kif15 A T 9: 122,820,202 (GRCm39) N580I probably benign Het
Krt25 G A 11: 99,208,232 (GRCm39) T332M probably benign Het
Krt88 G T 15: 101,345,643 (GRCm39) probably benign Het
Lrrk2 T C 15: 91,615,858 (GRCm39) probably null Het
Mapkapk5 A G 5: 121,675,169 (GRCm39) probably benign Het
Myh7b C T 2: 155,474,460 (GRCm39) S1725L probably benign Het
Nckap1l T G 15: 103,384,526 (GRCm39) probably null Het
Nphp3 A G 9: 103,893,277 (GRCm39) probably null Het
Obscn A C 11: 58,973,185 (GRCm39) V1996G probably damaging Het
Or14j8 T A 17: 38,263,900 (GRCm39) N5I probably damaging Het
Or4a66 A T 2: 88,531,331 (GRCm39) V114E probably damaging Het
Parp8 T C 13: 117,032,307 (GRCm39) T289A probably benign Het
Pcsk5 T C 19: 17,492,577 (GRCm39) K932R probably benign Het
Pde4dip T C 3: 97,625,632 (GRCm39) D1322G probably benign Het
Peli3 A T 19: 4,985,103 (GRCm39) M136K possibly damaging Het
Pgm5 A G 19: 24,812,181 (GRCm39) I117T probably damaging Het
Ppm1g T C 5: 31,360,621 (GRCm39) D478G probably damaging Het
Ppp2r5c A G 12: 110,541,272 (GRCm39) T474A probably benign Het
Ptger3 T C 3: 157,272,764 (GRCm39) V37A probably benign Het
Ptprz1 T C 6: 23,000,906 (GRCm39) S999P probably damaging Het
Pygl C T 12: 70,274,306 (GRCm39) G18S probably benign Het
Rest T C 5: 77,428,976 (GRCm39) V465A probably benign Het
Sart1 T C 19: 5,433,231 (GRCm39) D422G probably damaging Het
Sgk1 A G 10: 21,869,972 (GRCm39) M4V probably benign Het
Slc33a1 A G 3: 63,855,075 (GRCm39) V395A possibly damaging Het
Slc38a11 A T 2: 65,184,139 (GRCm39) S171T possibly damaging Het
Slc4a2 T A 5: 24,634,713 (GRCm39) S76T probably benign Het
Spata31h1 T C 10: 82,132,341 (GRCm39) D223G unknown Het
Ssc4d T A 5: 135,994,965 (GRCm39) S184C probably damaging Het
Tspoap1 A G 11: 87,669,347 (GRCm39) Y1540C probably benign Het
Ube3a T A 7: 58,926,383 (GRCm39) L408Q probably damaging Het
Usp43 C A 11: 67,767,155 (GRCm39) probably null Het
Zan A C 5: 137,385,232 (GRCm39) V5067G unknown Het
Zfp180 C A 7: 23,804,915 (GRCm39) L445I probably damaging Het
Other mutations in Brd9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Brd9 APN 13 74,086,666 (GRCm39) missense probably damaging 0.98
IGL01461:Brd9 APN 13 74,099,717 (GRCm39) nonsense probably null
IGL01928:Brd9 APN 13 74,103,630 (GRCm39) missense probably benign 0.02
R0379:Brd9 UTSW 13 74,090,802 (GRCm39) splice site probably benign
R0420:Brd9 UTSW 13 74,103,592 (GRCm39) missense probably benign
R0788:Brd9 UTSW 13 74,092,986 (GRCm39) splice site probably benign
R1539:Brd9 UTSW 13 74,092,862 (GRCm39) missense probably damaging 0.99
R4095:Brd9 UTSW 13 74,092,918 (GRCm39) missense probably benign 0.19
R4582:Brd9 UTSW 13 74,095,852 (GRCm39) missense probably benign 0.00
R4648:Brd9 UTSW 13 74,088,895 (GRCm39) missense probably benign 0.37
R4915:Brd9 UTSW 13 74,086,574 (GRCm39) missense probably damaging 0.99
R6054:Brd9 UTSW 13 74,088,860 (GRCm39) missense probably damaging 1.00
R6175:Brd9 UTSW 13 74,108,433 (GRCm39) missense probably damaging 0.98
R6462:Brd9 UTSW 13 74,088,788 (GRCm39) missense probably damaging 1.00
R6520:Brd9 UTSW 13 74,090,913 (GRCm39) missense probably benign 0.00
R7217:Brd9 UTSW 13 74,087,063 (GRCm39) missense probably damaging 1.00
R7422:Brd9 UTSW 13 74,102,697 (GRCm39) missense probably benign
R7556:Brd9 UTSW 13 74,092,886 (GRCm39) missense possibly damaging 0.83
R7844:Brd9 UTSW 13 74,086,652 (GRCm39) missense probably damaging 1.00
R9130:Brd9 UTSW 13 74,092,906 (GRCm39) missense probably damaging 0.97
Z1176:Brd9 UTSW 13 74,092,870 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGAACTGTTGATAAAAGCTACTGC -3'
(R):5'- AGGGCCTTCTAAAGCAATAGGG -3'

Sequencing Primer
(F):5'- CTACTGCTGTTGGGAATCAATG -3'
(R):5'- GCCTTCTAAAGCAATAGGGTCAGTC -3'
Posted On 2019-09-13