Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00492:Dtwd2'

5713

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dtwd2

Ensembl Gene

ENSMUSG00000024505

Gene Name

DTW domain containing 2

Synonyms

8030470C17Rik, 1190002H09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

IGL00492

Quality Score

Status

Chromosome

Chromosomal Location

49829212-49888668 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 49856776 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 170 (Y170*)

Ref Sequence

ENSEMBL: ENSMUSP00000025383 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025383] [ENSMUST00000163590]

AlphaFold

Q9D0U1

Predicted Effect

probably null
Transcript: ENSMUST00000025383
AA Change: Y170*

SMART Domains

Protein: ENSMUSP00000025383
Gene: ENSMUSG00000024505
AA Change: Y170*

Domain	Start	End	E-Value	Type
low complexity region	10	26	N/A	INTRINSIC
low complexity region	32	45	N/A	INTRINSIC
DTW	65	260	4.42e-59	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139852

Predicted Effect

probably benign
Transcript: ENSMUST00000163590

SMART Domains

Protein: ENSMUSP00000128219
Gene: ENSMUSG00000024505

Domain	Start	End	E-Value	Type
low complexity region	10	26	N/A	INTRINSIC
low complexity region	32	45	N/A	INTRINSIC
DTW	65	164	3.12e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap29	G	T	3: 121,796,961 (GRCm39)	E108*	probably null	Het
Braf	A	T	6: 39,637,933 (GRCm39)		probably null	Het
Calr3	G	A	8: 73,185,240 (GRCm39)	Q112*	probably null	Het
Dis3	A	G	14: 99,320,110 (GRCm39)	I649T	probably damaging	Het
Dop1b	T	C	16: 93,577,670 (GRCm39)	V65A	probably benign	Het
Dpp4	A	G	2: 62,209,646 (GRCm39)	Y126H	probably damaging	Het
Efcab7	A	G	4: 99,719,700 (GRCm39)	T61A	probably benign	Het
Fbxl3	G	T	14: 103,332,730 (GRCm39)	L83M	probably damaging	Het
Fbxo17	A	C	7: 28,434,766 (GRCm39)	S184R	probably damaging	Het
Fcf1	T	C	12: 85,029,106 (GRCm39)		probably null	Het
Hcrtr2	T	C	9: 76,153,723 (GRCm39)	Y223C	probably damaging	Het
Kcnn1	A	G	8: 71,300,706 (GRCm39)	F432S	probably benign	Het
Kmt2a	C	T	9: 44,719,231 (GRCm39)		probably benign	Het
Lce1j	T	C	3: 92,696,713 (GRCm39)	T22A	unknown	Het
Lrfn5	T	A	12: 61,890,912 (GRCm39)	S734T	probably benign	Het
Lyst	T	A	13: 13,852,760 (GRCm39)	S2253R	possibly damaging	Het
Msantd5f1	C	T	4: 73,605,570 (GRCm39)	T327I	probably damaging	Het
Myrfl	G	A	10: 116,632,011 (GRCm39)	L645F	possibly damaging	Het
Nudt9	A	G	5: 104,209,628 (GRCm39)		probably benign	Het
Ostn	T	A	16: 27,140,132 (GRCm39)	M15K	possibly damaging	Het
Psg20	T	C	7: 18,408,536 (GRCm39)	T395A	possibly damaging	Het
Rpf1	G	A	3: 146,218,002 (GRCm39)	H171Y	probably benign	Het
Shprh	A	G	10: 11,063,902 (GRCm39)	E1325G	probably damaging	Het
Slc22a8	G	T	19: 8,571,499 (GRCm39)	V77L	probably benign	Het
Tbck	A	C	3: 132,428,501 (GRCm39)	K285N	probably benign	Het
Vmn1r86	C	T	7: 12,836,468 (GRCm39)	C86Y	possibly damaging	Het
Zdhhc20	A	G	14: 58,111,381 (GRCm39)	I73T	probably damaging	Het
Zfp512b	T	C	2: 181,228,862 (GRCm39)	D701G	probably damaging	Het
Zfp735	T	A	11: 73,602,192 (GRCm39)	Y379N	possibly damaging	Het
Znfx1	G	T	2: 166,878,843 (GRCm39)	H980Q	probably damaging	Het

Other mutations in Dtwd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00858:Dtwd2	APN	18	49,861,452 (GRCm39)	missense	probably damaging	1.00
R0575:Dtwd2	UTSW	18	49,831,539 (GRCm39)	missense	probably damaging	1.00
R0691:Dtwd2	UTSW	18	49,861,424 (GRCm39)	splice site	probably benign
R2336:Dtwd2	UTSW	18	49,833,320 (GRCm39)	splice site	probably benign
R4110:Dtwd2	UTSW	18	49,831,373 (GRCm39)	utr 3 prime	probably benign
R4543:Dtwd2	UTSW	18	49,857,175 (GRCm39)	splice site	probably null
R4920:Dtwd2	UTSW	18	49,831,507 (GRCm39)	missense	possibly damaging	0.89
R8246:Dtwd2	UTSW	18	49,831,492 (GRCm39)	missense	probably benign	0.21
R8722:Dtwd2	UTSW	18	49,833,385 (GRCm39)	missense	probably damaging	1.00
R9213:Dtwd2	UTSW	18	49,856,799 (GRCm39)	missense	probably benign	0.00

Posted On

2012-04-20