Incidental Mutation 'R7366:Spag9'
| ID |
571822 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Spag9
|
| Ensembl Gene |
ENSMUSG00000020859 |
| Gene Name |
sperm associated antigen 9 |
| Synonyms |
JLP, Mapk8ip4, 3110018C07Rik, JIP4, 4733401I23Rik, syd1, 4831406C20Rik |
| MMRRC Submission |
045450-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.737)
|
| Stock # |
R7366 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
93886917-94016911 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 93999347 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Leucine
at position 1088
(V1088L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000042271
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000024979]
[ENSMUST00000041956]
[ENSMUST00000075695]
[ENSMUST00000092777]
[ENSMUST00000103168]
[ENSMUST00000132079]
[ENSMUST00000153076]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000024979
AA Change: V950L
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000024979
Gene: ENSMUSG00000020859
AA Change: V950L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
253 |
305 |
1e-25 |
PDB |
|
low complexity region
|
306 |
339 |
N/A |
INTRINSIC |
|
coiled coil region
|
572 |
606 |
N/A |
INTRINSIC |
|
low complexity region
|
735 |
751 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
823 |
969 |
3e-5 |
SMART |
|
Blast:WD40
|
924 |
964 |
8e-18 |
BLAST |
|
low complexity region
|
1132 |
1150 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000041956
AA Change: V1088L
PolyPhen 2
Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000042271
Gene: ENSMUSG00000020859
AA Change: V1088L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Jnk-SapK_ap_N
|
24 |
179 |
2e-61 |
PFAM |
|
Pfam:JIP_LZII
|
390 |
460 |
5.3e-32 |
PFAM |
|
coiled coil region
|
710 |
744 |
N/A |
INTRINSIC |
|
low complexity region
|
873 |
889 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
961 |
1107 |
1e-5 |
SMART |
|
Blast:WD40
|
1062 |
1102 |
1e-17 |
BLAST |
|
low complexity region
|
1270 |
1288 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075695
AA Change: V949L
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000075115
Gene: ENSMUSG00000020859
AA Change: V949L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
253 |
305 |
1e-25 |
PDB |
|
low complexity region
|
306 |
339 |
N/A |
INTRINSIC |
|
coiled coil region
|
571 |
605 |
N/A |
INTRINSIC |
|
low complexity region
|
734 |
750 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
822 |
968 |
3e-5 |
SMART |
|
Blast:WD40
|
923 |
963 |
7e-18 |
BLAST |
|
low complexity region
|
1131 |
1149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000092777
AA Change: V950L
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000090452
Gene: ENSMUSG00000020859
AA Change: V950L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
254 |
306 |
1e-25 |
PDB |
|
low complexity region
|
307 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
572 |
606 |
N/A |
INTRINSIC |
|
low complexity region
|
735 |
751 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
823 |
969 |
3e-5 |
SMART |
|
Blast:WD40
|
924 |
964 |
7e-18 |
BLAST |
|
low complexity region
|
1132 |
1150 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103168
AA Change: V945L
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000099457
Gene: ENSMUSG00000020859
AA Change: V945L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
249 |
301 |
1e-25 |
PDB |
|
low complexity region
|
302 |
335 |
N/A |
INTRINSIC |
|
coiled coil region
|
567 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
730 |
746 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
818 |
964 |
3e-5 |
SMART |
|
Blast:WD40
|
919 |
959 |
8e-18 |
BLAST |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132079
|
| SMART Domains |
Protein: ENSMUSP00000118850
Gene: ENSMUSG00000020859
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
394 |
N/A |
INTRINSIC |
|
low complexity region
|
523 |
539 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153076
AA Change: V669L
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000117502
Gene: ENSMUSG00000020859
AA Change: V669L
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2W83|D
|
1 |
25 |
4e-8 |
PDB |
|
low complexity region
|
26 |
59 |
N/A |
INTRINSIC |
|
coiled coil region
|
291 |
325 |
N/A |
INTRINSIC |
|
low complexity region
|
454 |
470 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
542 |
688 |
3e-5 |
SMART |
|
Blast:WD40
|
643 |
683 |
1e-17 |
BLAST |
|
low complexity region
|
864 |
882 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1163 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.1%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Male mice homozygous for a null mutation display reduced fertility with oligoasthenozoospermia. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted, knock-out(1) Gene trapped(4) |
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
C |
T |
8: 73,203,303 (GRCm39) |
P244S |
possibly damaging |
Het |
| 4930562C15Rik |
A |
G |
16: 4,653,633 (GRCm39) |
I61V |
unknown |
Het |
| Abcb11 |
C |
T |
2: 69,130,211 (GRCm39) |
D282N |
probably damaging |
Het |
| Acbd3 |
A |
G |
1: 180,562,064 (GRCm39) |
E181G |
probably benign |
Het |
| Ano3 |
T |
C |
2: 110,587,412 (GRCm39) |
Y43C |
probably damaging |
Het |
| Aspa |
T |
A |
11: 73,210,716 (GRCm39) |
|
probably null |
Het |
| AU018091 |
A |
T |
7: 3,206,170 (GRCm39) |
N620K |
probably damaging |
Het |
| Bicc1 |
G |
T |
10: 70,779,216 (GRCm39) |
T724K |
probably benign |
Het |
| Bmper |
T |
C |
9: 23,395,300 (GRCm39) |
I677T |
probably damaging |
Het |
| C3 |
T |
A |
17: 57,528,162 (GRCm39) |
T686S |
probably benign |
Het |
| Cc2d2a |
G |
T |
5: 43,887,332 (GRCm39) |
R1315L |
probably damaging |
Het |
| Ccdc150 |
G |
T |
1: 54,339,541 (GRCm39) |
E462* |
probably null |
Het |
| Ccdc88c |
C |
A |
12: 100,911,209 (GRCm39) |
R875L |
possibly damaging |
Het |
| Cd177 |
C |
T |
7: 24,456,147 (GRCm39) |
G207D |
probably damaging |
Het |
| Cdh23 |
A |
T |
10: 60,151,471 (GRCm39) |
Y2471* |
probably null |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Cmbl |
A |
T |
15: 31,590,002 (GRCm39) |
Y244F |
probably benign |
Het |
| Dcaf10 |
T |
C |
4: 45,373,919 (GRCm39) |
V448A |
probably damaging |
Het |
| Ddr2 |
A |
G |
1: 169,825,533 (GRCm39) |
W356R |
probably damaging |
Het |
| Depdc1a |
A |
G |
3: 159,228,849 (GRCm39) |
I534V |
probably benign |
Het |
| Dhtkd1 |
T |
A |
2: 5,922,717 (GRCm39) |
I481L |
probably benign |
Het |
| Dlst |
A |
T |
12: 85,175,089 (GRCm39) |
I260L |
probably benign |
Het |
| Dnajc13 |
T |
G |
9: 104,061,905 (GRCm39) |
K1350Q |
probably benign |
Het |
| Dpp4 |
T |
C |
2: 62,184,943 (GRCm39) |
Y520C |
probably damaging |
Het |
| Dr1 |
C |
A |
5: 108,423,594 (GRCm39) |
A127E |
unknown |
Het |
| Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
| E130308A19Rik |
T |
C |
4: 59,752,770 (GRCm39) |
C628R |
probably damaging |
Het |
| Edem3 |
T |
A |
1: 151,688,365 (GRCm39) |
|
probably null |
Het |
| Efcab15 |
T |
C |
11: 103,098,944 (GRCm39) |
|
probably null |
Het |
| Fam20a |
T |
A |
11: 109,564,168 (GRCm39) |
Q528H |
possibly damaging |
Het |
| Fanca |
T |
C |
8: 124,007,952 (GRCm39) |
E981G |
probably benign |
Het |
| Fbp2 |
A |
G |
13: 62,985,012 (GRCm39) |
V303A |
possibly damaging |
Het |
| Flii |
C |
T |
11: 60,611,945 (GRCm39) |
V353M |
possibly damaging |
Het |
| Gm10277 |
T |
A |
11: 77,676,584 (GRCm39) |
Y129F |
unknown |
Het |
| Gm3159 |
A |
T |
14: 4,398,525 (GRCm38) |
H72L |
probably benign |
Het |
| Gm5114 |
T |
G |
7: 39,058,768 (GRCm39) |
T284P |
possibly damaging |
Het |
| Gm7168 |
T |
C |
17: 14,170,147 (GRCm39) |
S505P |
probably damaging |
Het |
| Gnal |
T |
C |
18: 67,344,142 (GRCm39) |
V239A |
possibly damaging |
Het |
| Gtf2i |
C |
T |
5: 134,294,603 (GRCm39) |
E370K |
probably damaging |
Het |
| Hivep3 |
CGG |
CG |
4: 119,955,108 (GRCm39) |
1141 |
probably null |
Het |
| Il3 |
T |
A |
11: 54,156,709 (GRCm39) |
R93S |
probably benign |
Het |
| Itsn1 |
A |
G |
16: 91,705,338 (GRCm39) |
E1573G |
unknown |
Het |
| Kif26a |
G |
A |
12: 112,129,976 (GRCm39) |
|
probably null |
Het |
| Klb |
T |
C |
5: 65,529,774 (GRCm39) |
M434T |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,314,150 (GRCm39) |
R2194W |
probably damaging |
Het |
| Lrp6 |
G |
T |
6: 134,427,781 (GRCm39) |
P1604T |
probably damaging |
Het |
| Mak16 |
A |
G |
8: 31,656,127 (GRCm39) |
Y119H |
possibly damaging |
Het |
| Map3k19 |
T |
A |
1: 127,745,192 (GRCm39) |
M1421L |
probably damaging |
Het |
| Mbd5 |
A |
G |
2: 49,164,580 (GRCm39) |
I1186V |
probably benign |
Het |
| Mboat1 |
T |
A |
13: 30,386,345 (GRCm39) |
C120S |
possibly damaging |
Het |
| Mctp2 |
T |
A |
7: 71,908,962 (GRCm39) |
D117V |
probably benign |
Het |
| Mocos |
C |
A |
18: 24,809,673 (GRCm39) |
N425K |
probably damaging |
Het |
| Nav2 |
A |
G |
7: 49,203,951 (GRCm39) |
|
probably null |
Het |
| Ngfr |
A |
T |
11: 95,465,255 (GRCm39) |
W198R |
possibly damaging |
Het |
| Nr4a3 |
T |
G |
4: 48,051,290 (GRCm39) |
S15A |
possibly damaging |
Het |
| Obsl1 |
T |
C |
1: 75,479,608 (GRCm39) |
S596G |
probably damaging |
Het |
| Or2ag1 |
G |
T |
7: 106,472,603 (GRCm39) |
P283Q |
probably damaging |
Het |
| Or51g1 |
A |
T |
7: 102,633,723 (GRCm39) |
I216K |
probably damaging |
Het |
| Or52e3 |
T |
G |
7: 102,869,740 (GRCm39) |
Y272D |
probably benign |
Het |
| Or5v1b |
T |
A |
17: 37,841,708 (GRCm39) |
V280D |
probably damaging |
Het |
| Or6b3 |
A |
G |
1: 92,439,400 (GRCm39) |
S117P |
possibly damaging |
Het |
| Pithd1 |
T |
C |
4: 135,714,361 (GRCm39) |
Y29C |
probably benign |
Het |
| Plcb3 |
T |
C |
19: 6,939,389 (GRCm39) |
T530A |
probably benign |
Het |
| Prss40 |
A |
T |
1: 34,598,952 (GRCm39) |
Y70* |
probably null |
Het |
| Ralgps1 |
T |
C |
2: 33,214,700 (GRCm39) |
M61V |
possibly damaging |
Het |
| Rbp4 |
C |
T |
19: 38,113,410 (GRCm39) |
R36H |
possibly damaging |
Het |
| Rnf125 |
A |
G |
18: 21,107,490 (GRCm39) |
N7S |
not run |
Het |
| Rpe65 |
G |
A |
3: 159,330,366 (GRCm39) |
S511N |
probably benign |
Het |
| Rspo4 |
A |
T |
2: 151,709,793 (GRCm39) |
Y66F |
probably damaging |
Het |
| Ruvbl2 |
A |
G |
7: 45,071,573 (GRCm39) |
S437P |
probably benign |
Het |
| Sele |
C |
A |
1: 163,876,288 (GRCm39) |
R12S |
probably benign |
Het |
| Sgo2b |
T |
A |
8: 64,391,451 (GRCm39) |
K139* |
probably null |
Het |
| Shroom3 |
C |
A |
5: 93,112,465 (GRCm39) |
S1942* |
probably null |
Het |
| Slc12a9 |
G |
A |
5: 137,326,885 (GRCm39) |
R191* |
probably null |
Het |
| Sptb |
T |
G |
12: 76,650,968 (GRCm39) |
D1669A |
probably damaging |
Het |
| Sptlc2 |
A |
G |
12: 87,360,823 (GRCm39) |
|
probably null |
Het |
| Sult2a8 |
A |
T |
7: 14,150,254 (GRCm39) |
|
probably null |
Het |
| Synpo2 |
A |
G |
3: 122,907,690 (GRCm39) |
V542A |
probably damaging |
Het |
| Tecpr2 |
T |
C |
12: 110,881,914 (GRCm39) |
|
probably null |
Het |
| Tektip1 |
T |
C |
10: 81,200,025 (GRCm39) |
D165G |
possibly damaging |
Het |
| Tenm2 |
T |
C |
11: 35,960,241 (GRCm39) |
T1029A |
probably benign |
Het |
| Tgoln1 |
G |
C |
6: 72,593,261 (GRCm39) |
T73R |
probably benign |
Het |
| Tnfaip8l1 |
C |
A |
17: 56,478,897 (GRCm39) |
N62K |
probably damaging |
Het |
| Tollip |
A |
G |
7: 141,443,334 (GRCm39) |
S174P |
probably benign |
Het |
| Trp53tg5 |
A |
G |
2: 164,313,027 (GRCm39) |
I216T |
possibly damaging |
Het |
| Tssk5 |
A |
G |
15: 76,258,713 (GRCm39) |
S58P |
probably benign |
Het |
| Ttc9b |
T |
C |
7: 27,354,384 (GRCm39) |
Y157H |
probably damaging |
Het |
| Tuba8 |
A |
G |
6: 121,199,871 (GRCm39) |
Y185C |
probably damaging |
Het |
| Ubr2 |
C |
T |
17: 47,266,771 (GRCm39) |
A1127T |
probably damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,569,461 (GRCm39) |
|
probably benign |
Het |
| Yipf3 |
T |
A |
17: 46,559,855 (GRCm39) |
L57Q |
possibly damaging |
Het |
| Zbtb32 |
A |
C |
7: 30,289,606 (GRCm39) |
C19G |
probably damaging |
Het |
| Zfp735 |
A |
T |
11: 73,602,979 (GRCm39) |
H641L |
possibly damaging |
Het |
| Zfyve28 |
A |
T |
5: 34,389,571 (GRCm39) |
Y210N |
probably damaging |
Het |
| Zpr1 |
T |
A |
9: 46,184,671 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Spag9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00422:Spag9
|
APN |
11 |
93,988,692 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01776:Spag9
|
APN |
11 |
94,007,553 (GRCm39) |
splice site |
probably benign |
|
|
IGL02095:Spag9
|
APN |
11 |
93,999,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02307:Spag9
|
APN |
11 |
93,992,986 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02417:Spag9
|
APN |
11 |
94,007,567 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02480:Spag9
|
APN |
11 |
93,999,413 (GRCm39) |
nonsense |
probably null |
|
|
IGL02864:Spag9
|
APN |
11 |
93,997,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02976:Spag9
|
APN |
11 |
93,974,779 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02979:Spag9
|
APN |
11 |
93,988,190 (GRCm39) |
missense |
probably benign |
|
|
IGL03349:Spag9
|
APN |
11 |
93,984,335 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
dazzle
|
UTSW |
11 |
93,984,450 (GRCm39) |
nonsense |
probably null |
|
|
R0128:Spag9
|
UTSW |
11 |
93,984,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Spag9
|
UTSW |
11 |
93,982,579 (GRCm39) |
splice site |
probably benign |
|
|
R1463:Spag9
|
UTSW |
11 |
94,007,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Spag9
|
UTSW |
11 |
93,988,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1605:Spag9
|
UTSW |
11 |
93,939,365 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1649:Spag9
|
UTSW |
11 |
93,999,278 (GRCm39) |
splice site |
probably null |
|
|
R1697:Spag9
|
UTSW |
11 |
93,887,391 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1952:Spag9
|
UTSW |
11 |
93,988,184 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2011:Spag9
|
UTSW |
11 |
93,983,201 (GRCm39) |
nonsense |
probably null |
|
|
R2012:Spag9
|
UTSW |
11 |
93,983,201 (GRCm39) |
nonsense |
probably null |
|
|
R2351:Spag9
|
UTSW |
11 |
93,983,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2367:Spag9
|
UTSW |
11 |
94,007,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3027:Spag9
|
UTSW |
11 |
93,977,203 (GRCm39) |
missense |
probably null |
1.00 |
|
R3766:Spag9
|
UTSW |
11 |
93,951,109 (GRCm39) |
intron |
probably benign |
|
|
R3777:Spag9
|
UTSW |
11 |
93,989,852 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3937:Spag9
|
UTSW |
11 |
93,935,305 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3937:Spag9
|
UTSW |
11 |
93,935,243 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4417:Spag9
|
UTSW |
11 |
93,951,172 (GRCm39) |
intron |
probably benign |
|
|
R4445:Spag9
|
UTSW |
11 |
93,988,079 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4711:Spag9
|
UTSW |
11 |
94,005,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4799:Spag9
|
UTSW |
11 |
93,939,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4799:Spag9
|
UTSW |
11 |
93,939,342 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4816:Spag9
|
UTSW |
11 |
93,939,425 (GRCm39) |
intron |
probably benign |
|
|
R4843:Spag9
|
UTSW |
11 |
93,988,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5020:Spag9
|
UTSW |
11 |
93,988,612 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5119:Spag9
|
UTSW |
11 |
94,013,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5298:Spag9
|
UTSW |
11 |
93,990,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5305:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Spag9
|
UTSW |
11 |
93,982,577 (GRCm39) |
splice site |
probably null |
|
|
R5636:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5638:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5654:Spag9
|
UTSW |
11 |
93,981,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Spag9
|
UTSW |
11 |
94,005,079 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5814:Spag9
|
UTSW |
11 |
93,973,654 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5912:Spag9
|
UTSW |
11 |
93,935,251 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6038:Spag9
|
UTSW |
11 |
94,002,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Spag9
|
UTSW |
11 |
94,002,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6269:Spag9
|
UTSW |
11 |
93,935,333 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6294:Spag9
|
UTSW |
11 |
93,984,311 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6389:Spag9
|
UTSW |
11 |
93,977,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6420:Spag9
|
UTSW |
11 |
93,977,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6460:Spag9
|
UTSW |
11 |
93,959,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6482:Spag9
|
UTSW |
11 |
93,984,328 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6860:Spag9
|
UTSW |
11 |
93,972,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7086:Spag9
|
UTSW |
11 |
93,988,690 (GRCm39) |
missense |
probably benign |
|
|
R7179:Spag9
|
UTSW |
11 |
93,980,258 (GRCm39) |
splice site |
probably null |
|
|
R7225:Spag9
|
UTSW |
11 |
93,988,184 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7351:Spag9
|
UTSW |
11 |
93,983,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Spag9
|
UTSW |
11 |
94,005,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7401:Spag9
|
UTSW |
11 |
93,988,515 (GRCm39) |
missense |
probably benign |
|
|
R7506:Spag9
|
UTSW |
11 |
93,999,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7507:Spag9
|
UTSW |
11 |
93,958,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7513:Spag9
|
UTSW |
11 |
94,002,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7655:Spag9
|
UTSW |
11 |
93,887,389 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7656:Spag9
|
UTSW |
11 |
93,887,389 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7664:Spag9
|
UTSW |
11 |
93,992,986 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7665:Spag9
|
UTSW |
11 |
93,904,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7862:Spag9
|
UTSW |
11 |
94,002,892 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8074:Spag9
|
UTSW |
11 |
94,002,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8085:Spag9
|
UTSW |
11 |
93,989,870 (GRCm39) |
missense |
probably benign |
|
|
R8469:Spag9
|
UTSW |
11 |
93,982,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8547:Spag9
|
UTSW |
11 |
94,013,647 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8709:Spag9
|
UTSW |
11 |
93,958,916 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8732:Spag9
|
UTSW |
11 |
93,962,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8899:Spag9
|
UTSW |
11 |
93,983,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8983:Spag9
|
UTSW |
11 |
93,958,815 (GRCm39) |
missense |
probably benign |
|
|
R9043:Spag9
|
UTSW |
11 |
93,951,085 (GRCm39) |
missense |
|
|
|
R9050:Spag9
|
UTSW |
11 |
93,935,294 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9502:Spag9
|
UTSW |
11 |
93,959,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Spag9
|
UTSW |
11 |
93,962,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9667:Spag9
|
UTSW |
11 |
93,887,119 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9683:Spag9
|
UTSW |
11 |
93,988,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Spag9
|
UTSW |
11 |
94,005,062 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGATTGTTGTGCAGATTAGCAG -3'
(R):5'- TGTAGTTGTAGACCATCTGCTC -3'
Sequencing Primer
(F):5'- AATGTTGGATCCCCTGGAAC -3'
(R):5'- GTGCCACAACACTGCATAAAC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation