Incidental Mutation 'R7367:Or5m5'
ID 571858
Institutional Source Beutler Lab
Gene Symbol Or5m5
Ensembl Gene ENSMUSG00000044923
Gene Name olfactory receptor family 5 subfamily M member 5
Synonyms MOR196-2, Olfr1030, GA_x6K02T2Q125-47462755-47463693
MMRRC Submission 045451-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R7367 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 85809656-85815142 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85814687 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 168 (W168R)
Ref Sequence ENSEMBL: ENSMUSP00000053309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056849]
AlphaFold Q8VFL5
Predicted Effect possibly damaging
Transcript: ENSMUST00000056849
AA Change: W168R

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923
AA Change: W168R

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh1 A G 3: 137,996,312 (GRCm39) T374A probably benign Het
Agps T A 2: 75,698,657 (GRCm39) H348Q possibly damaging Het
Ankrd34b C A 13: 92,574,795 (GRCm39) T9K probably benign Het
Atp10b A G 11: 43,138,328 (GRCm39) Q1203R probably damaging Het
B4galnt4 A G 7: 140,644,388 (GRCm39) N123D probably damaging Het
Ccn6 A G 10: 39,034,261 (GRCm39) C114R probably damaging Het
Cep250 A G 2: 155,811,227 (GRCm39) T358A probably benign Het
Cfh A T 1: 140,014,259 (GRCm39) H1188Q probably damaging Het
Cisd1 A G 10: 71,172,190 (GRCm39) Y31H probably damaging Het
Cnga1 G A 5: 72,762,701 (GRCm39) S271F possibly damaging Het
Cntnap5a A G 1: 116,370,025 (GRCm39) T881A probably benign Het
Cracd T A 5: 77,004,449 (GRCm39) L270Q unknown Het
Cyp2s1 A T 7: 25,505,398 (GRCm39) D355E possibly damaging Het
Dnaaf10 A G 11: 17,182,712 (GRCm39) Y291C probably damaging Het
Dnah11 T A 12: 117,951,177 (GRCm39) R3044W possibly damaging Het
Dnah17 T C 11: 118,006,022 (GRCm39) D730G probably benign Het
Dsel C T 1: 111,789,303 (GRCm39) G411S probably damaging Het
Epha7 C T 4: 28,871,937 (GRCm39) S422L probably benign Het
Flacc1 A T 1: 58,706,023 (GRCm39) I282N probably benign Het
Fsd2 A G 7: 81,184,928 (GRCm39) I656T probably damaging Het
Gm40460 GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG 7: 141,794,171 (GRCm39) probably benign Het
Gm45871 A T 18: 90,609,224 (GRCm39) H154L probably benign Het
Golgb1 T A 16: 36,718,908 (GRCm39) N312K probably benign Het
H2ac4 A G 13: 23,935,333 (GRCm39) D73G possibly damaging Het
Hsd17b4 T A 18: 50,288,252 (GRCm39) H227Q probably damaging Het
Hsd17b6 A T 10: 127,829,492 (GRCm39) S237T probably benign Het
Htra4 A T 8: 25,523,713 (GRCm39) V284E probably damaging Het
Kcnv1 C T 15: 44,972,638 (GRCm39) C415Y probably damaging Het
Kif11 T A 19: 37,408,789 (GRCm39) L1037H probably benign Het
Lama5 T C 2: 179,834,751 (GRCm39) T1347A probably benign Het
Lrrc32 G T 7: 98,148,086 (GRCm39) E289* probably null Het
Lrrc66 T C 5: 73,765,724 (GRCm39) T440A probably benign Het
Neurl4 T C 11: 69,799,408 (GRCm39) L928P probably damaging Het
Nos2 G A 11: 78,840,916 (GRCm39) C788Y possibly damaging Het
Or2c1 A G 16: 3,657,166 (GRCm39) T110A probably damaging Het
Or4x11 A G 2: 89,868,156 (GRCm39) S298G probably benign Het
Pafah1b3 A G 7: 24,995,491 (GRCm39) C156R probably benign Het
Pak1ip1 T G 13: 41,162,371 (GRCm39) N151K probably damaging Het
Pax7 G A 4: 139,507,060 (GRCm39) P326S probably benign Het
Pex11b G A 3: 96,543,994 (GRCm39) A21T probably damaging Het
Pkn2 A G 3: 142,516,488 (GRCm39) V546A probably benign Het
Ppat T A 5: 77,067,711 (GRCm39) R260* probably null Het
Ppp1r13l C G 7: 19,104,081 (GRCm39) S187R probably benign Het
Pwp2 C T 10: 78,018,314 (GRCm39) G126R probably damaging Het
R3hdm1 A G 1: 128,081,129 (GRCm39) D55G possibly damaging Het
Rev1 A T 1: 38,113,488 (GRCm39) Y526* probably null Het
Rp1 A G 1: 4,418,221 (GRCm39) W964R probably benign Het
Sarnp A G 10: 128,669,247 (GRCm39) I35V probably damaging Het
Sec23a T C 12: 59,013,785 (GRCm39) N730S probably benign Het
Sh3d19 A G 3: 86,011,535 (GRCm39) K374E probably benign Het
Sh3tc2 A G 18: 62,122,577 (GRCm39) D446G probably benign Het
Sugct T A 13: 17,819,399 (GRCm39) I149F probably damaging Het
Tle2 A G 10: 81,416,152 (GRCm39) N142S probably damaging Het
Tpsg1 G T 17: 25,592,184 (GRCm39) G86V probably damaging Het
Trpm1 T A 7: 63,918,549 (GRCm39) Y1514N probably benign Het
Ubr4 C T 4: 139,180,002 (GRCm39) S259L unknown Het
Utp20 A T 10: 88,631,305 (GRCm39) L892Q probably benign Het
Zfp956 C T 6: 47,940,853 (GRCm39) T404M probably damaging Het
Other mutations in Or5m5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01775:Or5m5 APN 2 85,815,014 (GRCm39) missense probably damaging 0.99
IGL01795:Or5m5 APN 2 85,814,478 (GRCm39) missense probably damaging 1.00
IGL02395:Or5m5 APN 2 85,814,426 (GRCm39) missense possibly damaging 0.76
IGL03277:Or5m5 APN 2 85,814,517 (GRCm39) missense probably damaging 0.99
PIT4468001:Or5m5 UTSW 2 85,814,792 (GRCm39) missense probably benign 0.10
R0458:Or5m5 UTSW 2 85,814,600 (GRCm39) missense probably benign 0.00
R1114:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R1642:Or5m5 UTSW 2 85,814,201 (GRCm39) missense probably benign 0.00
R2189:Or5m5 UTSW 2 85,814,412 (GRCm39) missense probably damaging 1.00
R4094:Or5m5 UTSW 2 85,814,562 (GRCm39) missense probably damaging 1.00
R4246:Or5m5 UTSW 2 85,814,624 (GRCm39) missense possibly damaging 0.90
R4677:Or5m5 UTSW 2 85,814,315 (GRCm39) missense possibly damaging 0.61
R5537:Or5m5 UTSW 2 85,814,570 (GRCm39) missense possibly damaging 0.83
R6018:Or5m5 UTSW 2 85,815,148 (GRCm39) utr 3 prime probably benign
R6531:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R7611:Or5m5 UTSW 2 85,814,407 (GRCm39) nonsense probably null
R7693:Or5m5 UTSW 2 85,814,979 (GRCm39) missense probably damaging 1.00
R7753:Or5m5 UTSW 2 85,815,060 (GRCm39) missense possibly damaging 0.75
R8940:Or5m5 UTSW 2 85,814,543 (GRCm39) missense probably benign
R8961:Or5m5 UTSW 2 85,814,610 (GRCm39) missense probably damaging 1.00
R9049:Or5m5 UTSW 2 85,814,235 (GRCm39) missense possibly damaging 0.49
R9202:Or5m5 UTSW 2 85,814,801 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATGCTGCGTGTTTAGTCCAG -3'
(R):5'- CCTCAAGATGGCAATGAGAATG -3'

Sequencing Primer
(F):5'- ATGGCCATCTGTAACCCT -3'
(R):5'- CTCAAGATGGCAATGAGAATGAACAG -3'
Posted On 2019-09-13