Incidental Mutation 'R7371:Kirrel1'
| ID |
572062 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kirrel1
|
| Ensembl Gene |
ENSMUSG00000041734 |
| Gene Name |
kirre like nephrin family adhesion molecule 1 |
| Synonyms |
6720469N11Rik, Neph1, Kirrel1, Kirrel |
| MMRRC Submission |
045454-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7371 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
86985900-87082054 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86995729 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 402
(T402A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125525
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041732]
[ENSMUST00000107618]
[ENSMUST00000159976]
|
| AlphaFold |
Q80W68 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041732
AA Change: T402A
PolyPhen 2
Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000043756
Gene: ENSMUSG00000041734
AA Change: T402A
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
59 |
149 |
3.62e-10 |
SMART |
|
IG_like
|
160 |
252 |
1.27e1 |
SMART |
|
IG_like
|
261 |
337 |
1.89e1 |
SMART |
|
IGc2
|
352 |
410 |
3.28e-8 |
SMART |
|
IG_like
|
430 |
522 |
5.71e0 |
SMART |
|
transmembrane domain
|
529 |
551 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107618
AA Change: T402A
PolyPhen 2
Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000103243
Gene: ENSMUSG00000041734
AA Change: T402A
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
59 |
149 |
3.62e-10 |
SMART |
|
IG_like
|
160 |
252 |
1.27e1 |
SMART |
|
IG_like
|
261 |
337 |
1.89e1 |
SMART |
|
IGc2
|
352 |
410 |
3.28e-8 |
SMART |
|
IG_like
|
430 |
522 |
5.71e0 |
SMART |
|
transmembrane domain
|
529 |
551 |
N/A |
INTRINSIC |
|
low complexity region
|
694 |
712 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159976
AA Change: T402A
PolyPhen 2
Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000125525
Gene: ENSMUSG00000041734
AA Change: T402A
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
59 |
149 |
3.62e-10 |
SMART |
|
IG_like
|
160 |
252 |
1.27e1 |
SMART |
|
IG_like
|
261 |
337 |
1.89e1 |
SMART |
|
IGc2
|
352 |
410 |
3.28e-8 |
SMART |
|
IG_like
|
430 |
522 |
5.71e0 |
SMART |
|
transmembrane domain
|
529 |
551 |
N/A |
INTRINSIC |
|
low complexity region
|
694 |
712 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
98% (88/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene trap insertion exhibit postnatal lethality and are small and sickly. Glomerular and tubular defects in the kidney result in severe proteinuria. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(121) : Targeted, other(2) Gene trapped(119) |
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam21 |
A |
C |
12: 81,607,064 (GRCm39) |
S233A |
probably damaging |
Het |
| Adcy8 |
T |
A |
15: 64,571,067 (GRCm39) |
H1222L |
probably benign |
Het |
| Aftph |
T |
C |
11: 20,676,836 (GRCm39) |
T258A |
probably benign |
Het |
| Ano3 |
A |
C |
2: 110,715,194 (GRCm39) |
|
probably null |
Het |
| Aox4 |
A |
G |
1: 58,303,013 (GRCm39) |
D1148G |
probably damaging |
Het |
| Bcl11b |
A |
T |
12: 107,955,750 (GRCm39) |
I133N |
probably damaging |
Het |
| Borcs7 |
T |
A |
19: 46,688,057 (GRCm39) |
D67E |
probably damaging |
Het |
| Cacna2d4 |
T |
A |
6: 119,285,670 (GRCm39) |
I774N |
probably benign |
Het |
| Catsperd |
A |
T |
17: 56,957,801 (GRCm39) |
Y236F |
probably benign |
Het |
| Cblc |
T |
C |
7: 19,526,828 (GRCm39) |
S135G |
probably benign |
Het |
| Ccdc168 |
C |
A |
1: 44,100,537 (GRCm39) |
R187L |
probably benign |
Het |
| Ccdc178 |
A |
G |
18: 22,263,195 (GRCm39) |
V138A |
probably benign |
Het |
| Cd300ld |
C |
T |
11: 114,878,186 (GRCm39) |
G109R |
probably damaging |
Het |
| Cdh3 |
T |
A |
8: 107,279,109 (GRCm39) |
N690K |
probably damaging |
Het |
| Ceacam1 |
T |
A |
7: 25,174,145 (GRCm39) |
Y170F |
possibly damaging |
Het |
| Ceacam9 |
A |
C |
7: 16,457,652 (GRCm39) |
H55P |
possibly damaging |
Het |
| Celsr1 |
C |
T |
15: 85,914,875 (GRCm39) |
V1033I |
possibly damaging |
Het |
| Cep97 |
T |
C |
16: 55,725,683 (GRCm39) |
S807G |
probably benign |
Het |
| Ces1b |
A |
G |
8: 93,783,982 (GRCm39) |
|
probably null |
Het |
| Chn1 |
T |
C |
2: 73,510,234 (GRCm39) |
T92A |
probably damaging |
Het |
| Cimap1b |
C |
A |
15: 89,263,365 (GRCm39) |
W6L |
probably damaging |
Het |
| Cngb3 |
A |
C |
4: 19,425,575 (GRCm39) |
Y461S |
possibly damaging |
Het |
| Col24a1 |
A |
G |
3: 145,049,459 (GRCm39) |
N629S |
probably benign |
Het |
| Cpd |
T |
C |
11: 76,737,437 (GRCm39) |
D119G |
probably benign |
Het |
| Cpsf1 |
T |
C |
15: 76,484,775 (GRCm39) |
D594G |
probably damaging |
Het |
| Cpsf7 |
C |
T |
19: 10,509,203 (GRCm39) |
A38V |
probably benign |
Het |
| Cry1 |
A |
T |
10: 84,983,783 (GRCm39) |
H224Q |
probably benign |
Het |
| Ctr9 |
T |
A |
7: 110,633,014 (GRCm39) |
D87E |
probably damaging |
Het |
| Cyp2u1 |
T |
A |
3: 131,087,144 (GRCm39) |
N479I |
probably benign |
Het |
| Dip2c |
A |
G |
13: 9,642,785 (GRCm39) |
N672D |
probably benign |
Het |
| Dnah14 |
T |
C |
1: 181,454,450 (GRCm39) |
V820A |
probably benign |
Het |
| Efnb2 |
T |
C |
8: 8,710,524 (GRCm39) |
I31V |
probably benign |
Het |
| Fgb |
T |
C |
3: 82,953,359 (GRCm39) |
Y137C |
probably damaging |
Het |
| Fkbp15 |
A |
G |
4: 62,239,293 (GRCm39) |
V604A |
possibly damaging |
Het |
| Flii |
A |
T |
11: 60,609,090 (GRCm39) |
N682K |
probably benign |
Het |
| Fmo3 |
A |
G |
1: 162,781,796 (GRCm39) |
L519P |
possibly damaging |
Het |
| Gapvd1 |
T |
A |
2: 34,607,385 (GRCm39) |
M538L |
probably benign |
Het |
| Gbp11 |
A |
G |
5: 105,489,971 (GRCm39) |
V69A |
probably benign |
Het |
| Ggn |
T |
A |
7: 28,871,605 (GRCm39) |
D364E |
probably benign |
Het |
| Gm10377 |
G |
A |
14: 42,614,853 (GRCm39) |
P171S |
probably benign |
Het |
| Gramd4 |
C |
T |
15: 86,019,607 (GRCm39) |
A625V |
probably benign |
Het |
| Il2ra |
T |
A |
2: 11,647,831 (GRCm39) |
M7K |
probably benign |
Het |
| Iqgap2 |
A |
T |
13: 95,836,846 (GRCm39) |
|
probably null |
Het |
| Itgb4 |
T |
C |
11: 115,888,906 (GRCm39) |
V1083A |
probably benign |
Het |
| Kcnma1 |
G |
A |
14: 23,544,638 (GRCm39) |
A573V |
possibly damaging |
Het |
| Krt15 |
A |
T |
11: 100,026,386 (GRCm39) |
V100E |
possibly damaging |
Het |
| Krt4 |
T |
A |
15: 101,828,823 (GRCm39) |
Q347L |
probably damaging |
Het |
| Map3k21 |
T |
A |
8: 126,661,804 (GRCm39) |
I467N |
probably damaging |
Het |
| Mastl |
A |
T |
2: 23,030,585 (GRCm39) |
S195T |
probably damaging |
Het |
| Mis18bp1 |
G |
T |
12: 65,205,368 (GRCm39) |
T268K |
probably benign |
Het |
| Mmp17 |
G |
A |
5: 129,682,836 (GRCm39) |
G492S |
probably null |
Het |
| Myc |
T |
A |
15: 61,860,031 (GRCm39) |
S236T |
probably damaging |
Het |
| Nlrp5 |
A |
T |
7: 23,117,848 (GRCm39) |
E524V |
probably damaging |
Het |
| Nopchap1 |
T |
C |
10: 83,201,680 (GRCm39) |
V151A |
probably benign |
Het |
| Npr3 |
T |
A |
15: 11,845,376 (GRCm39) |
|
probably null |
Het |
| Oog4 |
T |
C |
4: 143,165,346 (GRCm39) |
N267S |
possibly damaging |
Het |
| Or2a12 |
T |
A |
6: 42,904,469 (GRCm39) |
Y101* |
probably null |
Het |
| Or4l15 |
A |
T |
14: 50,198,563 (GRCm39) |
|
probably null |
Het |
| Or56a5 |
A |
G |
7: 104,793,086 (GRCm39) |
I138T |
possibly damaging |
Het |
| Pde4dip |
T |
C |
3: 97,664,587 (GRCm39) |
E425G |
probably benign |
Het |
| Piwil4 |
A |
C |
9: 14,638,729 (GRCm39) |
N312K |
probably benign |
Het |
| Pmepa1 |
A |
G |
2: 173,076,212 (GRCm39) |
M47T |
possibly damaging |
Het |
| Potefam1 |
A |
T |
2: 111,023,826 (GRCm39) |
S475T |
unknown |
Het |
| Prkcg |
G |
A |
7: 3,368,069 (GRCm39) |
G372D |
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,096,734 (GRCm39) |
H746R |
probably benign |
Het |
| Ptma |
GGAAGAAG |
GGAAGAAGAAG |
1: 86,457,261 (GRCm39) |
|
probably benign |
Het |
| Rab3gap2 |
C |
G |
1: 184,983,265 (GRCm39) |
A468G |
probably damaging |
Het |
| Ralb |
A |
G |
1: 119,400,129 (GRCm39) |
L123P |
|
Het |
| Ralgapa2 |
G |
A |
2: 146,189,046 (GRCm39) |
T1288I |
probably benign |
Het |
| Samd4b |
C |
A |
7: 28,122,926 (GRCm39) |
C44F |
probably benign |
Het |
| Satb1 |
C |
A |
17: 52,090,008 (GRCm39) |
E280* |
probably null |
Het |
| Sec1 |
T |
C |
7: 45,328,034 (GRCm39) |
T338A |
probably damaging |
Het |
| Sec16a |
T |
C |
2: 26,331,734 (GRCm39) |
T94A |
probably benign |
Het |
| Serpina1f |
G |
A |
12: 103,656,086 (GRCm39) |
R381W |
probably damaging |
Het |
| Sfswap |
A |
T |
5: 129,620,305 (GRCm39) |
T525S |
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,054,169 (GRCm39) |
|
probably null |
Het |
| Spc24 |
A |
G |
9: 21,668,664 (GRCm39) |
L111P |
probably damaging |
Het |
| St8sia2 |
T |
C |
7: 73,616,675 (GRCm39) |
D121G |
probably damaging |
Het |
| Tanc2 |
A |
G |
11: 105,689,422 (GRCm39) |
T195A |
probably benign |
Het |
| Tbc1d9 |
T |
A |
8: 83,997,890 (GRCm39) |
I1149N |
probably damaging |
Het |
| Tph2 |
A |
T |
10: 114,987,016 (GRCm39) |
L258Q |
probably damaging |
Het |
| Trpm3 |
A |
T |
19: 22,879,557 (GRCm39) |
M781L |
probably benign |
Het |
| Ubap2 |
G |
T |
4: 41,195,779 (GRCm39) |
P1005T |
probably benign |
Het |
| Upf2 |
A |
G |
2: 5,965,851 (GRCm39) |
E157G |
unknown |
Het |
| Urb2 |
C |
A |
8: 124,755,008 (GRCm39) |
D238E |
probably benign |
Het |
| Vipr1 |
T |
C |
9: 121,497,621 (GRCm39) |
S380P |
probably damaging |
Het |
| Zc3h18 |
T |
A |
8: 123,139,760 (GRCm39) |
S734T |
unknown |
Het |
| Zmym6 |
T |
A |
4: 126,998,106 (GRCm39) |
Y381N |
probably damaging |
Het |
| Zscan4e |
T |
C |
7: 11,041,251 (GRCm39) |
K207R |
probably benign |
Het |
|
| Other mutations in Kirrel1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01310:Kirrel1
|
APN |
3 |
86,997,182 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01865:Kirrel1
|
APN |
3 |
86,993,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01875:Kirrel1
|
APN |
3 |
87,003,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02337:Kirrel1
|
APN |
3 |
86,996,519 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02724:Kirrel1
|
APN |
3 |
86,997,780 (GRCm39) |
nonsense |
probably null |
|
|
IGL02825:Kirrel1
|
APN |
3 |
86,996,595 (GRCm39) |
splice site |
probably benign |
|
|
IGL02826:Kirrel1
|
APN |
3 |
86,995,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Kirrel1
|
APN |
3 |
86,990,807 (GRCm39) |
missense |
probably damaging |
0.98 |
|
D4043:Kirrel1
|
UTSW |
3 |
86,990,510 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0360:Kirrel1
|
UTSW |
3 |
86,997,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0364:Kirrel1
|
UTSW |
3 |
86,997,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Kirrel1
|
UTSW |
3 |
86,990,914 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0503:Kirrel1
|
UTSW |
3 |
87,005,109 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1112:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1116:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1144:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1147:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1147:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1190:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1226:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1501:Kirrel1
|
UTSW |
3 |
86,997,779 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1546:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1628:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1630:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1631:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1664:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1671:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1695:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1769:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1807:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1808:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1840:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1876:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R1995:Kirrel1
|
UTSW |
3 |
87,003,093 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2014:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2086:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2108:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2354:Kirrel1
|
UTSW |
3 |
86,995,792 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2407:Kirrel1
|
UTSW |
3 |
86,992,150 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2904:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2905:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2958:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2959:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2960:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R2961:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3026:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3028:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3034:Kirrel1
|
UTSW |
3 |
86,990,746 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R3149:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3195:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3196:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3499:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3699:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3720:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3721:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3788:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3793:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3876:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3877:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3901:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3910:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3911:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3912:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3913:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3930:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R3931:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4022:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4067:Kirrel1
|
UTSW |
3 |
86,995,774 (GRCm39) |
nonsense |
probably null |
|
|
R4077:Kirrel1
|
UTSW |
3 |
86,992,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4198:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4328:Kirrel1
|
UTSW |
3 |
86,992,081 (GRCm39) |
intron |
probably benign |
|
|
R4355:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4363:Kirrel1
|
UTSW |
3 |
86,997,792 (GRCm39) |
nonsense |
probably null |
|
|
R4378:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4386:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4460:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4468:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4469:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4650:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4652:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4734:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4748:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R4749:Kirrel1
|
UTSW |
3 |
86,996,458 (GRCm39) |
missense |
probably null |
0.46 |
|
R5304:Kirrel1
|
UTSW |
3 |
86,996,902 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5534:Kirrel1
|
UTSW |
3 |
86,997,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5604:Kirrel1
|
UTSW |
3 |
86,996,462 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7199:Kirrel1
|
UTSW |
3 |
86,990,695 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7221:Kirrel1
|
UTSW |
3 |
86,993,704 (GRCm39) |
nonsense |
probably null |
|
|
R7284:Kirrel1
|
UTSW |
3 |
86,990,694 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7332:Kirrel1
|
UTSW |
3 |
86,995,705 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7369:Kirrel1
|
UTSW |
3 |
87,048,391 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7508:Kirrel1
|
UTSW |
3 |
86,990,746 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7566:Kirrel1
|
UTSW |
3 |
86,995,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7567:Kirrel1
|
UTSW |
3 |
87,002,988 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7621:Kirrel1
|
UTSW |
3 |
86,995,528 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8030:Kirrel1
|
UTSW |
3 |
87,005,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8141:Kirrel1
|
UTSW |
3 |
86,993,735 (GRCm39) |
nonsense |
probably null |
|
|
R8261:Kirrel1
|
UTSW |
3 |
86,995,309 (GRCm39) |
intron |
probably benign |
|
|
R8477:Kirrel1
|
UTSW |
3 |
86,992,138 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8512:Kirrel1
|
UTSW |
3 |
86,995,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8954:Kirrel1
|
UTSW |
3 |
86,997,173 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8987:Kirrel1
|
UTSW |
3 |
86,992,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9058:Kirrel1
|
UTSW |
3 |
86,992,442 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9146:Kirrel1
|
UTSW |
3 |
87,003,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9311:Kirrel1
|
UTSW |
3 |
87,005,123 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9527:Kirrel1
|
UTSW |
3 |
86,996,912 (GRCm39) |
nonsense |
probably null |
|
|
R9629:Kirrel1
|
UTSW |
3 |
87,003,025 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Kirrel1
|
UTSW |
3 |
86,991,182 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCGCTGGAGATGATAGGAGGTC -3'
(R):5'- AGCCTGCTTAGAGTCTTAGGG -3'
Sequencing Primer
(F):5'- GTCCTATAGGCAGGAAGACCC -3'
(R):5'- CAGGAAGCCATTTACCTTCTGGG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation