|Institutional Source||Beutler Lab|
|Gene Name||tripartite motif-containing 6|
|Is this an essential gene?||Probably non essential (E-score: 0.198)|
|Stock #||R7372 (G1)|
|Chromosomal Location||104218793-104235152 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 104232636 bp|
|Amino Acid Change||Alanine to Serine at position 391 (A391S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000095782 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000098180] [ENSMUST00000214578]|
|Predicted Effect||probably benign
AA Change: A391S
PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
AA Change: A391S
|Predicted Effect||possibly damaging
AA Change: A365S
PolyPhen 2 Score 0.758 (Sensitivity: 0.85; Specificity: 0.92)
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trim6||
(F):5'- GTGACACTGAATCCACAGACG -3'
(R):5'- TAAAAGGAGACCGTGCCAGC -3'
(F):5'- CTTGTCCTGTCGAAAAATCGGAGAC -3'
(R):5'- GTGCCAGCCTCACAGTCTAAG -3'